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Scientific Reports Jun 2024Optimized production of Aspergillus niger ATCC 26011 endo-β-mannanase (ManAn) on copra meal resulted in 2.46-fold increase (10,028 U/gds). Purified ManAn (47 kDa)...
Optimized production of Aspergillus niger ATCC 26011 endo-β-mannanase (ManAn) on copra meal resulted in 2.46-fold increase (10,028 U/gds). Purified ManAn (47 kDa) showed high affinity towards guar gum (GG) as compared to konjac gum and locust bean gum with K 2.67, 3.25 and 4.07 mg/mL, respectively. ManAn efficiently hydrolyzed GG and liberated mannooligosaccharides (MOS). Changes occurring in the rheological and compositional aspects of GG studied using Differential scanning calorimetry (DSC), Thermal gravimetric analysis (TGA) and X-ray diffraction (XRD) revealed increased thermal stability and crystallinity of the partially hydrolyzed guar gum (PHGG). Parametric optimization of the time and temperature dependent hydrolysis of GG (1% w/v) with 100 U/mL of ManAn at 60 °C and pH: 5.0 resulted in 12.126 mg/mL of mannotetraose (M4) in 5 min. Enhanced growth of probiotics Lactobacilli and production of short chain fatty acids (SCFA) that inhibited enteropathogens, confirmed the prebiotic potential of PHGG and M4.
Topics: Mannans; Plant Gums; Galactans; Aspergillus niger; Prebiotics; Oligosaccharides; Hydrolysis; beta-Mannosidase; Hydrogen-Ion Concentration; Fatty Acids, Volatile; X-Ray Diffraction; Temperature; Lactobacillus; Probiotics
PubMed: 38890382
DOI: 10.1038/s41598-024-63803-4 -
Frontiers in Nutrition 2024It remains unclear if choline intake is associated with colorectal cancer. Therefore, we examined data from the National Health and Nutrition Examination Survey (NHANES).
BACKGROUND
It remains unclear if choline intake is associated with colorectal cancer. Therefore, we examined data from the National Health and Nutrition Examination Survey (NHANES).
METHODS
This cross-sectional study included 32,222 U.S. adults in the 2005-2018 NHANE cycles, among whom 227 reported colorectal cancer. Dietary choline was derived from 24-h recalls. Logistic regression estimated odds of colorectal cancer across increasing intake levels, adjusting for potential confounders.
RESULTS
After adjusting for sociodemographic variables, BMI, alcohol use, smoking status, comorbidities, and dietary factors (energy, fat, fiber, and cholesterol), the odds ratio (OR) for colorectal cancer was 0.86 (95% CI: 0.69-1.06, = 0.162) per 100 mg higher choline intake. Across increasing quartiles of choline intake, a non-significant inverse trend was observed (Q4 vs. Q1 OR: 0.76, 95%CI: 0.37 ~ 1.55, -trend = 0.23). Subgroup analyses revealed largely consistent associations, with a significant interaction by hypertension status (-interaction =0.022).
CONCLUSION
In this large, nationally representative sample of U.S. adults, higher dietary choline intake was not significantly associated with colorectal cancer odds after adjusting for potential confounders. However, a non-significant inverse trend was observed. Further prospective studies are needed to confirm these findings and elucidate the underlying mechanisms.
PubMed: 38887505
DOI: 10.3389/fnut.2024.1352535 -
Frontiers in Nutrition 2024Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of early-onset CRC attributable to dietary...
The global burden and trends analysis of early-onset colorectal cancer attributable to dietary risk factors in 204 countries and territories, 1990-2019: a secondary analysis for the global burden of disease study 2019.
BACKGROUND
Rising trends in early-onset colorectal cancer (CRC) burden have been observed, but the distribution and temporal patterns of early-onset CRC attributable to dietary risks remain unclear.
OBJECTIVES
This study aimed to estimate the burden of early-onset CRC attributable to dietary risk factors globally, regionally, and nationally, by age and sex, from 1990 to 2019.
METHODS
The absolute number and age-specific rates (ASR) of diet-related early-onset CRC burden, as well as summary exposure value (SEV) of attributable dietary risk factors, were extracted from the Global Burden of Disease (GBD) Study 2019. The temporal changes in the burden between 1990 and 2019 were analyzed by calculating the percentage change in the absolute number of burden and the estimated annual percentage change (EAPC) in ASR of burden. The annualized rates of change (ARC) were calculated to evaluate the variation trend of SEV.
RESULTS
In 2019, diet-related early-onset CRC caused 30,096 (95% UI: 23,148 to 36,091) death cases and 1,465,755 (95% UI: 1,126,489 to 1,761,661) DALYs worldwide, accounting for 34.8% deaths and 34.4% DALYs of overall early-onset CRC, respectively. Moreover, a diet low in milk (responsible for 16.5% [95% UI: 11.1 to 21.9%] of DALYs in 2019), low in whole grains (15.2% [95% UI: 5.9 to 19.9%]), low in calcium (14.3% [95% UI: 10.7 to 18.9%]), high in red meat (5.3% [95% UI: 1.7 to 9.5%]), high in processed meat (2.5% [95% UI: 0.9 to 4.0%]), and low in fiber (2.3% [95% UI: 0.9 to 4.2%]) were early-onset CRC attributable dietary risk factors. The age-specific DALYs rate of early-onset CRC attributable to each dietary risk factor generally showed an increasing trend globally between 1990 and 2019, except for low intake of fiber (EAPC = -0.57, 95% CI: -0.76 to -0.38). In addition, from 1990 to 2019, males have a higher burden than females and this gap may continue to widen due to the increasing difference between the sexes in most dietary risk factors. Furthermore, dietary risks-attributable early-onset CRC burden has shifted from regions with high socio-demographic index (SDI) to high-middle and middle SDI quintiles with uncontrolled dietary risks.
CONCLUSION
Early-onset CRC remains a concerning issue globally, and effective prevention and modification of dietary risk factors holds great promise to reduce early-onset CRC-related burden. Prioritizing diet improvement for males is critical and urgent for CRC control efforts, particularly for those living in developing countries with ongoing dietary pattern transition.
PubMed: 38883856
DOI: 10.3389/fnut.2024.1384352 -
ARYA Atherosclerosis Jul 2023Dietary modification significantly impacts reducing myocardial infarction (MI) mortality and its recurrence. This study aimed to investigate the effect of education on...
INTRODUCTION
Dietary modification significantly impacts reducing myocardial infarction (MI) mortality and its recurrence. This study aimed to investigate the effect of education on the dietary intake of patients with MI based on the health belief model.
METHOD
This quasi-experimental study was conducted on patients with MI from October 2021 to January 2022. A total of 72 MI cases were randomly divided into intervention and control groups. The intervention group received an educational intervention based on the health belief model for three months in four sessions. The structures of the health belief model were measured using a questionnaire before the intervention and one and three months following it. Dietary intake was measured with a three-day dietary record before and after three months of the intervention.
RESULTS
After the educational intervention, a significant difference was observed between the two groups in terms of the average scores of awareness, perceived susceptibility, perceived severity, perceived benefits, and self-efficacy (P<0.01). However, no significant difference was observed concerning the perceived obstacles. Although there were no significant differences between dietary intake at the baseline, the intake of energy, cholesterol, and energy percent from carbohydrate, total fat, and saturated fatty acids were lower, and fiber intake was higher in the intervention group versus the control group after the intervention (all P<0.05).
CONCLUSION
Given the positive effect of the health belief model in this study, it is suggested to use this model for designing education for MI patients focusing on nutrition.
PubMed: 38881992
DOI: 10.48305/arya.2022.41123.2848 -
The Journal of Nutrition Jun 2024Consumption of whole grains is associated with a reduction in chronic diseases and offers benefits for cardiovascular health and metabolic regulation. The relationship...
BACKGROUND
Consumption of whole grains is associated with a reduction in chronic diseases and offers benefits for cardiovascular health and metabolic regulation. The relationship between whole grain corn and corn bran with the gut microbiota (GM) remains an area of growing interest, particularly regarding their influence on cardio-metabolic health.
OBJECTIVE
To investigate the effects of different corn flours on cardio-metabolic outcomes and GM changes in adults with elevated low-density lipoprotein cholesterol (LDL-c) concentrations.
METHODS
In this crossover study, 36 adults with LDL-c above 110 mg/dL consumed 48 g/day of three corn flour types for four weeks: whole-grain corn meal (WCM), refined corn meal (RCM), and a blend of RCM and corn bran (RCM+B). We assessed the impact on cardio-metabolic markers (LDL-c, high-density lipoprotein cholesterol [HDL-c], total cholesterol [TC], and triglycerides [TG]) and GM composition and estimated function. Statistical analyses included mixed-effects modeling and responder (> 5% decrease in LDL-c) analysis to evaluate changes in GM related to lipid profile improvements.
RESULTS
Of the three corn flour types, only RCM+B significantly decreased LDL-c over time (-10.4±3.6 mg/dL, P = 0.005) and marginally decreased TC (-9.2±3.9, P = 0.072) over time. There were no significant effects on HDL-c or TG concentrations. No significant changes were observed in GM alpha diversity, while beta diversity metrics indicated individual variability. Two genera, unclassified Lachnospiraceae and Agathobaculum (P ≤ 0.096), differed significantly by treatment, but only Agathobaculum remained significantly elevated in the WCM, compared to RCM and RCM+B, after adjustment for multiple comparisons.
CONCLUSIONS
The type of corn flour, particularly RCM+B, notably influenced LDL-c concentrations in adults with elevated LDL-c. This study suggests that incorporating milled fractions (e.g. bran) of whole grain corn with refined corn flour may be a viable alternative to supplementing manufactured grain products with isolated or synthetic fibers for improved metabolic health.
CLINICALTRIALS
gov ID: NCT03967990.
PubMed: 38880174
DOI: 10.1016/j.tjnut.2024.06.003 -
NPJ Science of Food Jun 2024The stalk of Allium fistulosum contains dietary fibers with complicated monosaccharide composition and glycosidic bond linkages, which renders it a better dietary fiber...
The stalk of Allium fistulosum contains dietary fibers with complicated monosaccharide composition and glycosidic bond linkages, which renders it a better dietary fiber supplement. However, the unfavorable odor, majorly contributed by allicin, limits its applications. Although many physical and chemical methods have been developed to remove allicin, there is currently no comparison between their efficiencies. Here, we comprehensively compare all these methods of eliminating allicin in the Allium stalk by starting with optimization of the allicin extraction method. Results indicate that incubation of the chopped Allium stalk with water for 20 min and extraction with 75% ethanol reached a maximal extraction yield. Different methods of allicin elimination are examined, and physical removal of allicin by blanching at 100 °C reaches a maximal clearance rate of 73.3%, rendering it the most efficient and effective method eliminating allicin from the stalk of Allium fistulosum for the preparation of a totally green dietary fiber.
PubMed: 38877017
DOI: 10.1038/s41538-024-00275-w -
Renal Failure Dec 2024To investigate the dietary nutrient intake of Maintenance hemodialysis (MHD) patients, identify influencing factors, and explore the correlation between dietary nutrient...
PURPOSE
To investigate the dietary nutrient intake of Maintenance hemodialysis (MHD) patients, identify influencing factors, and explore the correlation between dietary nutrient intake and nutritional and disease control indicators.
METHODS
This was a multicenter cross-sectional study. A dietary survey was conducted using a three-day dietary record method, and a self-designed diet management software was utilized to calculate the daily intake of dietary nutrients. The nutritional status and disease control indicators were assessed using subjective global assessment, handgrip strength, blood test indexes, and dialysis adequacy.
RESULTS
A total of 382 MHD patients were included in this study. Among them, 225 (58.9%) and 233 (61.0%) patients' protein and energy intake did not meet the recommendations outlined in the National Kidney Foundation's Kidney Disease Outcomes Quality Initiative Clinical Practice Guideline for Nutrition in Chronic Kidney Disease (2020 update). The average protein and energy intake for these patients were 0.99 ± 0.32 g/kg/d and 29.06 ± 7.79 kcal/kg/d, respectively. Multiple linear regression analysis showed that comorbidity-diabetes had a negative influence on normalized daily energy intake (nDEI = DEI / ideal body weight) (B = -2.880, = 0.001) and normalized daily protein intake (nDPI = DPI / ideal body weight) (B = -0.109, = 0.001). Pearson correlation analysis revealed that dietary DPI ( = -0.109, < 0.05), DEI ( = -0.226, < 0.05) and phosphorus ( = -0.195, < 0.001) intake were statistically correlated to Kt/V; dietary nDPI ( = 0.101, < 0.05) and sodium ( = -0.144, < 0.001) intake were statistically correlated to serum urea nitrogen; dietary DPI ( = 0.200, < 0.001), DEI ( = 0.241, < 0.001), potassium ( = 0.129, < 0.05), phosphorus ( = 0.199, < 0.001), and fiber ( = 0.157, < 0.001) intake were statistically correlated to serum creatinine; dietary phosphorus ( = 0.117, < 0.05) and fiber ( = 0.142, < 0.001) intake were statistically correlated to serum phosphorus; dietary nDPI ( = 0.125, < 0.05), DPI ( = 0.135, < 0.05), nDEI ( = 0.116, < 0.05), DEI ( = 0.125, < 0.05), potassium ( = 0.148, < 0.001), and phosphorus ( = 0.156, < 0.001) intake were statistically correlated to subjective global assessment scores; dietary nDPI ( = 0.215, < 0.001), DPI ( = 0.341, < 0.001), nDEI ( = 0.142, < 0.05), DEI ( = 0.241, < 0.001), potassium ( = 0.166, < 0.05), phosphorus ( = 0.258, < 0.001), and fiber ( = 0.252, < 0.001) intake were statistically correlated to handgrip strength in males; dietary fiber ( = 0.190, < 0.05) intake was statistically correlated to handgrip strength in females.
CONCLUSIONS
The dietary nutrient intake of MHD patients need improvement. Inadequate dietary nutrient intake among MHD patients could have a detrimental effect on their blood test indexes and overall nutritional status. It is crucial to address and optimize the dietary intake of nutrients in this patient population to enhance their health outcomes and well-being.
Topics: Humans; Cross-Sectional Studies; Male; Renal Dialysis; Female; Middle Aged; Nutritional Status; Energy Intake; Aged; Dietary Proteins; Adult; Linear Models; Kidney Failure, Chronic; Hand Strength; Diet Records; Renal Insufficiency, Chronic
PubMed: 38874093
DOI: 10.1080/0886022X.2024.2363589 -
Food Science & Nutrition Jun 2024Metabolic Syndrome (MetS) is a constellation of risk factors including abdominal obesity, high triglycerides, low HDL cholesterol (HDL-C), elevated blood pressure, and...
Metabolic Syndrome (MetS) is a constellation of risk factors including abdominal obesity, high triglycerides, low HDL cholesterol (HDL-C), elevated blood pressure, and elevated fasting glucose. In Spain, according to WHO criteria, the MetS prevalence is shown to be 32% in men and 29% in women. The role of dietary habits is one of the main therapeutic strategies for the management of MetS but the most effective dietary pattern has not been established yet. This study aimed to analyze the effect of on body composition, serum lipids, and MetS components of a high-MUFA and high-fiber diet (HMFD). A case-control study was performed considering 40 cohabiting women. Participants were randomly assigned to HMFD group or high mono-unsaturated diet (HMD) group to receive one of the two proposed dietary interventions. All data (serum lipids, blood pressure, height, weight, body composition, and waist circumference) were collected fasting at baseline, 55, 98, and 132 days. The HMFD group showed higher decrease in waist circumference than in the HMD group. LDL-C dropped in both groups. Triglycerides in the HMFD group dropped during the intervention, but once the intervention was over, they returned to baseline values. The mean systolic blood pressure was lower in HMFD group. A HMFD from a weekly consumption of processed meat (Torrezno de Soria) deeply fried in extra virgin olive oil in combination with vegetables logged in a Mediterranean diet can improve MetS risk factors in healthy overweight women.
PubMed: 38873480
DOI: 10.1002/fsn3.4042 -
Food Science & Nutrition Jun 2024Quinoa is a nutrient-dense pseudocereal that has garnered global attention for its potential to bolster food security and nutrition. Despite its celebrated status, the...
Quinoa is a nutrient-dense pseudocereal that has garnered global attention for its potential to bolster food security and nutrition. Despite its celebrated status, the detailed nutritional profiles of various quinoa varieties remain poorly understood, which poses a significant barrier to the strategic cultivation and utilization of quinoa's genetic diversity to combat malnutrition. The impetus for this research lies in the urgent need to identify superior quinoa strains that can be tailored to meet specific nutritional requirements and adapt to diverse agro-ecological zones. Our findings reveal substantial variation in nutrient content across different quinoa varieties, highlighting the variety ZLZX-8 as a particularly nutrient-rich strain with the highest levels of protein, fat, essential fatty acids, amino acids, and key minerals such as Mg, K, and Zn. Moreover, ZLZX-8's exceptional antioxidant capacity suggests it may have additional health benefits beyond its macronutrient profile. In contrast, ZLZX-7 stands out for its dietary fiber and phenolic content, which are critical for digestive health and disease prevention, respectively. Meanwhile, ZLZX-5, with its high starch content, could be better suited for energy production in dietary applications. Notably, the study also uncovers a correlation between grain color and nutrient profile, with colored quinoa varieties exhibiting superior fiber, inositol, phenolic content, and antioxidant activity compared to their white counterparts. This work lays the groundwork for an informed selection of quinoa varieties that can enhance dietary quality, support local and global food systems, and contribute to the fight against malnutrition.
PubMed: 38873460
DOI: 10.1002/fsn3.4113 -
Food Science & Nutrition Jun 2024The current study pioneers a comprehensive exploration into the influence of ripening stages on the nutritional composition and antioxidant attributes of the New Zealand...
The current study pioneers a comprehensive exploration into the influence of ripening stages on the nutritional composition and antioxidant attributes of the New Zealand damson plums (). Sampled at early-, mid-, and late-ripening stages from randomly selected plum trees, the investigation unveiled notable significant ( < .05) declines in multiple parameters as ripening progressed. Noteworthy reductions in dry matter (from 21% to 19.33%), stone weight (from 30.23% to 24.30%), total dietary fiber (from 3.15% to 2.5%), energy content (from 280 to 263 kJ/100 g), vitamin D3 (from 1.67 to 1.53 μg/100 g), vitamin A (from 4.2 to 3.87 μg/100 g), and specific minerals (e.g., Ca, Mg, and P) emerged as a hallmark of this progression. Additionally, plums harvested at the advanced ripening stage exhibited heightened moisture content in contrast to their early-stage counterparts. Conversely, ash, protein, carbohydrates, total sugar, and minerals (including K, Na, Zn, and Se) demonstrated no significant alteration ( > .05) across ripening stages. Remarkably, damson plums that were harvested at the end of the ripening stage displayed reduced phenolic content and total antioxidant activity compared to those acquired at the early-mid ripening phase. This research collectively highlights the substantive impact of harvesting time and ripening stage on the nutritional and antioxidant profiles of damson plums cultivated in New Zealand.
PubMed: 38873447
DOI: 10.1002/fsn3.4097