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Materials (Basel, Switzerland) Jun 2024Surface treatment of implants facilitates osseointegration, with nanostructured surfaces exhibiting accelerated peri-implant bone regeneration. This study compared...
Surface treatment of implants facilitates osseointegration, with nanostructured surfaces exhibiting accelerated peri-implant bone regeneration. This study compared bone-to-implant contact (BIC) in implants with hydroxyapatite (HA), sand-blasted and acid-etched (SLA), and SLA with calcium (Ca)-coated (XPEED) surfaces. Seventy-five disk-shaped grade 4 Ti specimens divided into three groups were prepared, with 16 implants per group tested in New Zealand white rabbits. Surface characterization was performed using X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM), digital microscopy, and a contact angle analyzer. Cell viability, proliferation, and adhesion were assessed using MC3T3-E1 cells. Apatite formation was evaluated using modified simulated body fluid (m-SBF) incubation. After 4 weeks of healing, the outcomes reviewed were BIC, bone area (BA), removal torque tests, and histomorphometric evaluation. A microstructure analysis revealed irregular pores across all groups, with the XPEED group exhibiting a nanostructured Ca-coated surface. Surface characterization showed a crystalline CaTiO layer on XPEED surfaces, with evenly distributed Ca penetrating the implants. All surfaces provided excellent environments for cell growth. The XPEED and SLA groups showed significantly higher cell density and viability with superior osseointegration than HA ( < 0.05); XPEED exhibited the highest absorbance values. Thus, XPEED surface treatment improved implant performance, biocompatibility, stability, and osseointegration.
PubMed: 38893971
DOI: 10.3390/ma17112707 -
Materials (Basel, Switzerland) May 2024The main motivation for this research was to improve the properties of geopolymers by reinforcement using synthetic and natural fibers, and to gain new knowledge...
The main motivation for this research was to improve the properties of geopolymers by reinforcement using synthetic and natural fibers, and to gain new knowledge regarding how the nature and/or the quantity of reinforcement fibers influences the properties of the final geopolymers. The main objective was to investigate the effects of different types of reinforcement fibers on the properties of the geopolymers. These reinforcement fibers were mainly environmentally friendly materials that can be used as alternatives to ordinary Portland cement. The authors used fly ash and river sand as the raw materials for the matrix, and added carbon fibers (CF), flax fibers (FF), or a hybrid of both (CFM) as reinforcements. The samples were prepared by mixing, casting, and curing, and then subjected to various tests. The main research methods used were compressive strength (CS), flexural strength (FS), water absorption (WA), abrasion resistance (Böhme's disk method), microstructure analysis (SEM), chemical composition (XRF), and crystal structure analysis (XRD). The results showed that the addition of fibers partially improved the mechanical properties of the geopolymers, as well as reducing microcracks. The CF-reinforced geopolymers exhibited the highest compressive strength, while the FF-reinforced geopolymers showed the lowest water absorption. The authors, based on previous research, also discussed the factors that influence fiber-matrix adhesion, and the optimal fiber content for geopolymers.
PubMed: 38893897
DOI: 10.3390/ma17112633 -
Journal of Clinical Medicine Jun 2024This report investigates late-stage internal derangement (ID) of the temporomandibular joint (TMJ) with the aim of establishing a more effective and personalized...
This report investigates late-stage internal derangement (ID) of the temporomandibular joint (TMJ) with the aim of establishing a more effective and personalized treatment protocol to improve patients' quality of life (QoL). A consensus was reached among maxillofacial surgeons specializing in LSID, based on a literature research and collective expert experience following the Delphi method. Consensus was considered to be achieved when a response received at least 80% of votes. Four expert groups were established, respectively, focusing on diagnosis, minimally invasive surgery (MIS), open surgery and joint replacement. A comprehensive approach to late-stage ID of the TMJ requires a consensus report. This underscores the need for a personalized treatment plan, considering the variability in clinical presentations and progression of this pathology. Our recommendations aim to optimize clinical outcomes and enhance patient QoL.
PubMed: 38893029
DOI: 10.3390/jcm13113319 -
Cells May 2024has been implicated in various gastrointestinal disorders, including functional dyspepsia. This study aimed to compare the anti- activity and gastroprotective effects... (Comparative Study)
Comparative Study
has been implicated in various gastrointestinal disorders, including functional dyspepsia. This study aimed to compare the anti- activity and gastroprotective effects of three typical herbal formulas used for gastrointestinal disorders in Korea: Shihosogan-tang (ST), Yijung-tang (YT), and Pyeongwi-san (PS). Firstly, we assessed the total phenolic and flavonoid contents, as well as the antioxidative capacity. Additionally, we evaluated the antibacterial effect on using an ammonia assay, minimum inhibitory concentration (MIC) test, and the disk agar diffusion method. Furthermore, we examined alterations in the gene expression of tight junction proteins, pro-inflammatory cytokines, and cellular vacuolation using an AGS cell model infected with . While ST exhibited a higher total phenolic content, superior free radical scavenging, and inhibition of compared to YT and PS, YT more evidently inhibited gastric cellular morphological changes such as vacuolation. All formulations significantly ameliorated changes in inflammatory and gastric inflammation-related genes and cellular morphological alterations induced by infection. Overall, the present in vitro study suggests that all three herbal formulas possess potential for ameliorating gastrointestinal disorders, with ST relatively excelling in inhibiting infection and inflammation, while YT potentially shows greater efficacy in directly protecting the gastric mucosa.
Topics: Helicobacter pylori; Dyspepsia; Humans; Anti-Bacterial Agents; Helicobacter Infections; Antioxidants; Flavonoids; Microbial Sensitivity Tests; Gastric Mucosa; Plant Extracts; Protective Agents; Drugs, Chinese Herbal
PubMed: 38891033
DOI: 10.3390/cells13110901 -
Visual Field Prognosis From Macula and Circumpapillary Spectral Domain Optical Coherence Tomography.Translational Vision Science &... Jun 2024To explore the structural-functional loss relationship from optic-nerve-head- and macula-centred spectral-domain (SD) Optical Coherence Tomography (OCT) images in the...
PURPOSE
To explore the structural-functional loss relationship from optic-nerve-head- and macula-centred spectral-domain (SD) Optical Coherence Tomography (OCT) images in the full spectrum of glaucoma patients using deep-learning methods.
METHODS
A cohort comprising 5238 unique eyes classified as suspects or diagnosed with glaucoma was considered. All patients underwent ophthalmologic examination consisting of standard automated perimetry (SAP), macular OCT, and peri-papillary OCT on the same day. Deep learning models were trained to estimate G-pattern visual field (VF) mean deviation (MD) and cluster MD using retinal thickness maps from seven layers: retinal nerve fiber layer (RNFL), ganglion cell layer and inner plexiform layer (GCL + IPL), inner nuclear layer and outer plexiform layer (INL + OPL), outer nuclear layer (ONL), photoreceptors and retinal pigmented epithelium (PR + RPE), choriocapillaris and choroidal stroma (CC + CS), total retinal thickness (RT).
RESULTS
The best performance on MD prediction is achieved by RNFL, GCL + IPL and RT layers, with R2 scores of 0.37, 0.33, and 0.31, respectively. Combining macular and peri-papillary scans outperforms single modality prediction, achieving an R2 value of 0.48. Cluster MD predictions show promising results, notably in central clusters, reaching an R2 of 0.56.
CONCLUSIONS
The combination of multiple modalities, such as optic-nerve-head circular B-scans and retinal thickness maps from macular SD-OCT images, improves the performance of MD and cluster MD prediction. Our proposed model demonstrates the highest level of accuracy in predicting MD in the early-to-mid stages of glaucoma.
TRANSLATIONAL RELEVANCE
Objective measures recorded with SD-OCT can optimize the number of visual field tests and improve individualized glaucoma care by adjusting VF testing frequency based on deep-learning estimates of functional damage.
Topics: Tomography, Optical Coherence; Humans; Female; Middle Aged; Male; Visual Fields; Macula Lutea; Prognosis; Deep Learning; Aged; Retinal Ganglion Cells; Glaucoma; Nerve Fibers; Visual Field Tests; Optic Disk
PubMed: 38884547
DOI: 10.1167/tvst.13.6.10 -
Journal of Pharmacy & Bioallied Sciences Apr 2024To evaluate the effect of lasers on the shear bond strength of Giomer and G-aenial flo composite using three different etching techniques.
AIM
To evaluate the effect of lasers on the shear bond strength of Giomer and G-aenial flo composite using three different etching techniques.
MATERIALS AND METHODS
60 Samples (extracted human premolar teeth) are cut horizontally using a diamond disk to expose a flat occlusal surface involving enamel and dentin. On exposed occlusal surfaces, etching is done by various methods. These were divided into six groups of ten samples each as follows: group I (acid etched for Giomer), group II (acid etched for G-aenial flo composite), group III (laser etched for Giomer), group IV (Laser etched for G-aenial flo composite), group V (air abrasion etched for Giomer), group VI (Air abrasion etched for G-aenial flo composite). Then, restorative material is placed and cured with light for 20 seconds. The samples were thermocycled to simulate the oral environment. The samples were subjected to a universal testing machine for bond strength testing at a cross-head speed of 3 mm/min until the restoration will fracture.
RESULTS
The intergroup comparison between both the materials using Student's -test gives insignificant results. The intergroup comparison between different etching techniques using two-way ANOVA tests gives insignificant results.
CONCLUSION
Within the limitation of this study, it can be concluded that Giomer and G-aenial flo composite achieved the same shear bond strength in all the etching techniques.
PubMed: 38882892
DOI: 10.4103/jpbs.jpbs_797_23 -
Journal of Pharmacy & Bioallied Sciences Apr 2024In pediatric dentistry, the esthetically pleasing materials have tremendously changed the concept of restorative practice.
INTRODUCTION
In pediatric dentistry, the esthetically pleasing materials have tremendously changed the concept of restorative practice.
AIM AND OBJECTIVES
1. The aim of the study is to evaluate the effect of child health drinks on color stability of various esthetic restorative materials via spectrophotometric analysis and to identify the esthetic restorative material that is color-stable against child health drinks.
MATERIALS AND METHODS
A total of 120 disk-shaped specimens with a diameter of 12 mm and a thickness of 2 mm were made from a composite (Dyract), giomer (Shofu), and composite (GC). Each group of 40 specimens of each material was divided into four sub-groups. Each sub-group was stored in different solutions, distilled water, Bournvita, Horlicks, and Pediasure, for 60 days. The color change measurement was done using a spectrophotometer both before and after staining.
RESULT
One-way analysis of variance depicted that when the ΔE values of the restorative material were tested against each of the child health drink, there was a statistically significant difference between all child health drinks ( < 0.00001). When restorative materials were compared with the staining agent on 60 days duration, except Pediasure and Control, others (i.e. Horlicks and Bournvita) showed a statistically high significance ( < 0.05).
CONCLUSION
Bournvita caused the highest color changes in 60 days time interval, followed by Horlicks and Pediasure. When the discoloration of several materials is studied, the highest level of discoloration was observed in the compomer, followed by the giomer, and the lowest level in the composite.
PubMed: 38882833
DOI: 10.4103/jpbs.jpbs_808_23 -
ACS Omega Jun 2024A new series of 1,2,3-triazole-8-quinolinol hybrids were synthesized in good yields using monosubstituted acetonitriles and 5-azidomethyl-8-quinolinol as the starting...
A new series of 1,2,3-triazole-8-quinolinol hybrids were synthesized in good yields using monosubstituted acetonitriles and 5-azidomethyl-8-quinolinol as the starting reagents via a one-step protocol. The structures of 1,2,3-triazole-8-quinolinol hybrids were characterized by nuclear magnetic resonance (H and C NMR) spectroscopy and elemental analysis. Antibacterial activity in vitro of all the synthesized hybrids was investigated against (), (), (), and () applying the methods of disk diffusion and minimal inhibition concentration (MIC). Hybrid exhibited excellent antibacterial capacity, with an MIC value of 10 μg/mL against and 20 μg/mL against , , and , which were comparable to those that of the standard antibiotic nitroxoline. A structure-activity relationship (SAR) study of 1,2,3-triazole-8-quinolinol hybrids showed that introducing electron-donating substituents in the 1,2,3-triazole ring at the 4-position is important for activity. Quantum chemical calculations have been undertaken to employ the Gaussian software in the B3LYP, HF, and M062X basis sets using 3-21g, 6-31g, and SDD levels to further explain linkages within the antibacterial findings. Furthermore, molecular docking investigations were also conducted to investigate the binding affinities as well as the interactions of some hybrids with the target proteins. An absorption, distribution, metabolism, excretion, and toxicity (ADME/T) investigation was carried out to scrutinize the viability of employing the 1,2,3-triazole-8-quinolinol hybrids as medicines.
PubMed: 38882066
DOI: 10.1021/acsomega.4c03906 -
BMC Ophthalmology Jun 2024Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL)...
BACKGROUND
Quantitative analysis of retinal nerve fibers is important for the diagnosis and treatment of optic nerve diseases. Peripapillary retinal nerve fiber layer (RNFL) cross-sectional area may give a more accurate quantitative assessment of retinal nerve fibers than RNFL thickness but there have been no previous reports of the peripapillary RNFL cross-sectional area or other parameters. The purpose of the current study was to determine peripapillary RNFL cross-sectional area and its association with other factors in an adult Chinese population.
METHODS
RNFL cross-sectional area was measured during peripapillary circular optical coherence tomography (OCT) scan with a diameter of 12° centered on the optic disc. Correlation between RNFL cross-sectional area and other parameters was evaluated by linear regression analysis in a cross-sectional study of an adult Chinese population.
RESULTS
A total of 2404 eyes from 2404 subjects were examined. Multivariate linear regression analysis showed that larger RNFL cross-sectional area correlated with younger age (p < 0.001), female gender (p = 0.001), no history of diabetes (p = 0.012) and larger optic disc area (p < 0.001).
CONCLUSIONS
Peripapillary RNFL cross-sectional area is correlated positively with optic disc area, suggesting that eyes with larger optic discs have thicker RNFL. Further studies are needed to confirm whether this correlation is due to differences in the numbers of retinal nerve fibers or other factors.
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Young Adult; China; Cross-Sectional Studies; East Asian People; Nerve Fibers; Optic Disk; Retinal Ganglion Cells; Tomography, Optical Coherence
PubMed: 38880871
DOI: 10.1186/s12886-024-03481-y -
Biomaterials Advances Jun 2024Multifunctional wound dressings based on hydrogels are an efficacious and practicable strategy in therapeutic processes and accelerated chronic wound healing. Here,...
Multifunctional wound dressings based on hydrogels are an efficacious and practicable strategy in therapeutic processes and accelerated chronic wound healing. Here, copper (Cu) nanoparticles were added to chitosan/sodium alginate (CS/SA) hydrogels to improve the antibacterial properties of the prepared wound dressings. Due to the super-hydrophobicity of Cu nanoparticles, polyethylene glycol (PEG) was used as a surfactant, and then added to the CS/SA-based hydrogels. The CS/SA/Cu hydrogels were synthesized with 0, 2, 3.5, and 5 wt% Cu nanoparticles. The structural and morphological properties in presence of PEG were evaluated using Fourier-transform infrared spectroscopy (FTIR), Differential scanning calorimetry (DSC), and field emission scanning electron microscopy (FESEM). The biodegradation and swelling properties of the hydrogels were investigated in phosphate buffer saline (PBS) at 37 °C for up to 30 days. Cell viability and adhesion, as well as antibacterial behavior, were investigated via MTT assay, FESEM, and disk diffusion method, respectively. The obtained results showed that PEG provided new intra- and intermolecular bonds that affected significantly the hydrogels' degradation and swelling ratio, which increased up to ~1200 %. Cell viability reached ~110 % and all samples showed remarkable antibacterial behavior when CS/SA/Cu containing 2 wt% was introduced. This study provided new insights regarding the use of PEG as a surfactant for Cu nanoparticles in CS/SA hydrogel wound dressing, ultimately affecting the chemical bonding and various properties of the prepared hydrogels.
PubMed: 38880016
DOI: 10.1016/j.bioadv.2024.213918