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BMC Cancer Jun 2010Myxofibrosarcoma is common in the extremities of elderly people and is characterized by a high frequency of local recurrence.
BACKGROUND
Myxofibrosarcoma is common in the extremities of elderly people and is characterized by a high frequency of local recurrence.
CASE PRESENTATION
We report a 37 year old female who presented with a 4-month history of facial pain and a 3-month history of painful progressive swelling in the preauricular area. She underwent a total parotidectomy. The tumor was histopathologically and immunohistochemically diagnosed as a low-grade myxofibrosarcoma. The patient was free of disease 9 months after surgery with uneventful post-operative clinical course.
CONCLUSIONS
Parotid area swelling should always alert doctors. To our knowledge, this is the first case of parotid myxofibrosarcoma. It should be added to the differential diagnosis of diseases of the parotid. We have to recognize this disease and seek adequate treatment for it.
Topics: Adult; Female; Fibrosarcoma; Humans; Myxosarcoma; Parotid Neoplasms
PubMed: 20513245
DOI: 10.1186/1471-2407-10-246 -
Circulation Journal : Official Journal... Aug 2009Primary sarcomas of the pulmonary vein are extremely rare. Although myxomas are the most common intracavitary tumor of the left atrium, some findings should alert the...
Primary sarcomas of the pulmonary vein are extremely rare. Although myxomas are the most common intracavitary tumor of the left atrium, some findings should alert the clinician to the probability of malignancy. A 28-year-old woman developed hemoptysis, night fever, generalized malaise, anorexia and weight loss for 2 months, with progressive dyspnea for 2 weeks. She was preoperatively diagnosed as left atrial myxoma with a concurrent right lower lung tumor.
Topics: Adult; Diagnosis, Differential; Female; Heart Atria; Humans; Lung Neoplasms; Myxoma; Myxosarcoma; Pulmonary Veins
PubMed: 19139592
DOI: 10.1253/circj.cj-08-0269 -
Korean Journal of Radiology 2007Chondrosarcomas are malignant tumors of cartilage that rarely involve the sinonasal region, and myxoid chondrosarcoma is a rare histologic variant of chondrosarcoma that...
Chondrosarcomas are malignant tumors of cartilage that rarely involve the sinonasal region, and myxoid chondrosarcoma is a rare histologic variant of chondrosarcoma that usually occurs in the soft tissue of extremities. Although several case reports and results of small series of chondrosarcomas in the sinonasal region in children are available, myxoid type chondrosarcoma is extremely rare. We recently experienced a case of low grade myxoid chondrosarcoma involving the sinonasal cavity in a 10-year-old boy, and here we report its radiologic-pathologic findings. In this case, chondroid calcification on CT and septal and marginal enhancement on MRI suggested a chondrosarcoma. Whole body PET-CT demonstrated no definite metastatic lesion and a low peak standardized uptake value primary tumor. However, no definite distinguishing imaging features were observed that distinguished low grade myxoid chondrosarcoma from conventional chondrosarcoma.
Topics: Bone Neoplasms; Child; Chondrosarcoma; Diagnosis, Differential; Follow-Up Studies; Humans; Magnetic Resonance Imaging; Male; Myxosarcoma; Nasal Cavity; Paranasal Sinuses; Positron-Emission Tomography; Rare Diseases; Tomography, X-Ray Computed; Whole Body Imaging
PubMed: 17923790
DOI: 10.3348/kjr.2007.8.5.452 -
Clinical Cardiology Jun 2007We report the case of a 32-year-old patient with a left atrium myxosarcoma, presenting with congestive heart failure. It is a rare cardiac malignant primary tumor that...
We report the case of a 32-year-old patient with a left atrium myxosarcoma, presenting with congestive heart failure. It is a rare cardiac malignant primary tumor that seems to derive from the same cellular line as myxomas, but the prognosis is very different. These tumors present local recidives and distance metastasis, so the mean survival is about 1 year, independent of any therapeutical option.
Topics: Adult; Diagnosis, Differential; Echocardiography, Transesophageal; Fatal Outcome; Heart Atria; Heart Failure; Heart Neoplasms; Humans; Male; Myxoma; Myxosarcoma; Neoplasm Recurrence, Local; Prognosis
PubMed: 17551954
DOI: 10.1002/clc.20045 -
Texas Heart Institute Journal 2007Primary cardiac myxosarcoma is a rare disease; it is exceedingly rare for symptoms of systemic metastasis to precede diagnosis of the primary cardiac tumor. We describe...
Primary cardiac myxosarcoma is a rare disease; it is exceedingly rare for symptoms of systemic metastasis to precede diagnosis of the primary cardiac tumor. We describe the case of a previously healthy 60-year-old man with left atrial myxosarcoma, who had first presented with jejunal intussusception due to intestinal polyposis. Three months after resection of the jejunum, the patient experienced cerebral infarction and pulmonary edema. Further physical evaluation, which included echocardiography for the 1st time, revealed a mass in the left atrium that protruded through the mitral valve into the left ventricle. At emergency cardiac surgery, we found that the tumor involved multiple sites of the left atrium, the pulmonary veins, and the mitral anterior leaflet. Two months after surgery, the patient died of massive cerebral hemorrhage. Necropsy disclosed multiple recurrences of the cardiac myxosarcoma and widespread metastatic lesions. The intestinal polyps that had been resected originally were diagnosed, on retrospective histopathologic examination, as metastases of the myxosarcoma. In this unusual case, the metastatic lesions were the 1st clinical manifestations of a malignant cardiac tumor.
Topics: Fatal Outcome; Heart Atria; Heart Neoplasms; Heart Ventricles; Humans; Intestinal Neoplasms; Intestinal Polyposis; Intussusception; Jejunal Diseases; Male; Middle Aged; Mitral Valve; Myxosarcoma; Pulmonary Veins
PubMed: 17420810
DOI: No ID Found -
Archives of Pathology & Laboratory... Oct 2005
Topics: Adult; Biopsy, Needle; Diagnosis, Differential; Fasciitis; Fibrosarcoma; Fingers; Giant Cell Tumor of Bone; Granuloma, Plasma Cell; Humans; Male; Myxosarcoma; Soft Tissue Neoplasms; Tenosynovitis
PubMed: 16196529
DOI: 10.5858/2005-129-1343-LMIAYM -
The New England Journal of Medicine Feb 2005
Topics: Fatal Outcome; Female; Heart Neoplasms; Heart Ventricles; Humans; Middle Aged; Myxosarcoma; Neoplasm Recurrence, Local; Pulmonary Artery; Tomography, X-Ray Computed; Vascular Neoplasms
PubMed: 15703425
DOI: 10.1056/NEJMicm040835 -
Journal of Korean Medical Science Jun 2004A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast....
A case of primary malignant fibrous histiocytoma of the breast is reported. The patient was a 48-yr-old woman with a huge tumor involving almost the entire left breast. The central portion of her left breast was already rotted by extensive necrosis and inflammation. She was treated by radical mastectomy and axillary lymphadenectomy to level I. Pathologic examination supported by an immunohistochemical staining confirmed the tumor as malignant fibrous histiocytoma of giant cell type. Axillary lymph nodes were free from tumor metastasis. She had not taken any postoperative adjuvant therapy. The metastasis to lungs was found 2 months after the operation, and she died within 6 months.
Topics: Breast; Breast Neoplasms; Female; Giant Cells; Histiocytoma, Benign Fibrous; Humans; Immunohistochemistry; Lung Neoplasms; Middle Aged; Myxosarcoma; Necrosis; Neoplasm Metastasis; Sarcoma
PubMed: 15201521
DOI: 10.3346/jkms.2004.19.3.477 -
Journal of Korean Medical Science Apr 2003The authors present a case of primary intracranial extraosseous myxoid chondrosarcoma without any attachment to the cranium or the meninges. The clinical and...
The authors present a case of primary intracranial extraosseous myxoid chondrosarcoma without any attachment to the cranium or the meninges. The clinical and radiological findings of the primary intraparenchymal tumor are described with a review of the literature concerning cranial and intracranial myxoid chondrosarcoma.
Topics: Adolescent; Adult; Biomarkers, Tumor; Bone Neoplasms; Child; Chondrosarcoma; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Myxosarcoma
PubMed: 12692436
DOI: 10.3346/jkms.2003.18.2.301 -
American Journal of Veterinary Research Jul 2001To evaluate results of centrosome hyperamplification in naturally developing tumors of dogs.
OBJECTIVE
To evaluate results of centrosome hyperamplification in naturally developing tumors of dogs.
SAMPLE POPULATION
Tumor specimens from 9 dogs with tumors (rhabdomyosarcoma, osteosarcoma, chondrosarcoma, myxosarcoma, and mammary gland tumor) and 2 canine osteosarcoma cell lines.
PROCEDURE
3 antibodies for centrosome proteins (ie, anti-gamma-tubulin, anti-BRCA1, and anti-pericentrin) were used for immunohistochemical analysis. Double immunostaining for centrosomes was used to confirm the specificity of these antibodies for centrosomes. Mutational analysis of the canine p53 gene was carried out by polymerase chain reaction-single-strand conformation polymorphism analysis, and expression of canine MDM2 protein was evaluated by use of immunohistochemical analysis, using anti-MDM2 antibody.
RESULTS
Immunohistochemical analysis of dog osteosarcoma cell lines with apparent aneuploidy revealed frequent hyperamplification of centrosomes in the osteosarcoma cell lines. Similar hyperamplified centrosomes were detected in the tumor tissues from all of the 9 tumors. The frequency of cells with hyperamplified centrosomes (3 to 20/cell) in each tumor tissue ranged from 9.50 to 48.1%, whereas centrosome hyperamplification was not observed in normal lymph nodes from these dogs. In 8 of the 9 tumors, mutation of p53 gene or overexpression of MDM2, or both, was detected.
CONCLUSIONS AND CLINICAL RELEVANCE
Various types of naturally developing tumors in dogs often have hyperamplification of centrosomes associated with chromosome instability. Hyperamplification of centrosomes is a novel tumor marker for use in cytologic and histologic examinations of clinical specimens obtained from dogs.
Topics: Animals; Centrosome; Chromosome Aberrations; DNA, Neoplasm; Dog Diseases; Dogs; Female; Gene Expression Regulation, Neoplastic; Genes, p53; Immunohistochemistry; Male; Mammary Neoplasms, Animal; Nuclear Proteins; Polymorphism, Single-Stranded Conformational; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; RNA, Neoplasm; Reverse Transcriptase Polymerase Chain Reaction; Sarcoma; Sequence Analysis, DNA; Tumor Cells, Cultured
PubMed: 11453492
DOI: 10.2460/ajvr.2001.62.1134