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SAGE Open Medicine 2024Heparin-induced thrombocytopenia can occur in obese subjects. The medical comorbidities associated with obesity may contribute to the pathogenesis of this disease. It is...
OBJECTIVES
Heparin-induced thrombocytopenia can occur in obese subjects. The medical comorbidities associated with obesity may contribute to the pathogenesis of this disease. It is unknown, however, which specific medical comorbidities and if higher odds of thrombosis are present in obese heparin-induced thrombocytopenia patients. We sought to determine whether obese heparin-induced thrombocytopenia subjects had higher odds of both comorbidities and thrombosis, hypothesizing that this patient population would have higher odds of both these conditions.
METHODS
This was a multi-center retrospective study utilizing TriNetX, an electronic health record database, in subjects aged 18-99 years diagnosed with heparin-induced thrombocytopenia. The cohort was divided into two groups (1) non-obese (body mass index < 30 kg/m) and (2) obese (body mass index ⩾ 30 kg/m). We evaluated patient characteristics, diagnostic, laboratory, medication, and procedure codes.
RESULTS
A total of 1583 subjects (696 (44.0%) non-obese and 887 (56.0%) obese) were included. Obese subjects had higher odds of diabetes with complications (OR = 1.73, 95% CI = 1.35-2.22, < 0.001) and without complications (OR = 1.81, 95% CI = 1.47-2.22, < 0.001). This association was still present after correcting for demographic and clinical factors. There were no increased odds of thrombosis observed in the obesity group.
CONCLUSIONS
Our study found that obese heparin-induced thrombocytopenia subjects had higher odds of having a diabetes mellitus comorbidity, but did not have higher odds of thrombosis. Given obesity is considered a hypercoagulable state, further study may be needed to understand why obese subjects diagnosed with heparin-induced thrombocytopenia do not have higher rates of thrombosis.
PubMed: 38711468
DOI: 10.1177/20503121241247471 -
Environmental Science and Pollution... May 2024Cesium removal from aqueous solutions of radioactive waste streams is a challenge in the field of radioactive waste management; this is due to the small atomic radii of...
Cesium removal from aqueous solutions of radioactive waste streams is a challenge in the field of radioactive waste management; this is due to the small atomic radii of Cs metal ions and their high migration ability. So, the development of a withstand system for the removal of Cs is crucial. In the current study, the removal of radioactive cesium from aqueous solutions using an RO-TLC membrane was studied. Two modifications were conducted; the first is to enlarge the cesium metal ion radii by interacting with mono- and dibasic acids, namely, stearic acid, tartaric acid, citric acid, and EDTA, and the second is the modification of the RO membrane pore size via reaction with the same acids. The modification was confirmed using SEM, FTIR, and EDX analysis techniques. The Cs and K rejection capacities and water permeability across the membrane at 1.5 bars were evaluated. Along with using the above-mentioned acids, the Cs metal ion retention index (R) was also obtained. It was found that employing EDTA as a chelating agent in an amount of 1.5 g/L in conjunction with the variation of feed content since it provided the highest value of R ~ 98% when used. Moreover, the elution of Cs using water, EDTA, ammonia, and HCl is also investigated. The optimal value of the eluent concentration was (0.25 M) HCl. Finally, Langmuir and Freundlich isotherm models were applied for a better understanding of the sorption process. The results of the present work more closely match the Langmuir isotherm model to determine the dominance of the chemical sorption mechanism.
Topics: Cesium Radioisotopes; Osmosis; Radioactive Waste; Membranes, Artificial; Water Pollutants, Radioactive
PubMed: 38696009
DOI: 10.1007/s11356-024-33426-3 -
The Science of the Total Environment Jul 2024Reverse osmosis (RO) systems offer a viable solution for treating brackish water (BW), a common but underutilized water resource. However, the energy-intensive nature of...
Optimizing energy efficiency in brackish water reverse osmosis (BWRO): A comprehensive study on prioritizing critical operating parameters for specific energy consumption minimization.
Reverse osmosis (RO) systems offer a viable solution for treating brackish water (BW), a common but underutilized water resource. However, the energy-intensive nature of brackish water reverse osmosis (BWRO) systems poses affordability challenges to water supply, necessitating a focus on minimizing their energy consumption to support SDG6's goal of providing safe and affordable drinking water for all. This study addresses the critical need to minimize the specific energy consumption (SEC) of a typical BWRO system, defined as the energy consumed per unit of water recovered, mathematically and experimentally. Empirical models were developed proving there is a global minimum SEC while adjusting the operating conditions. Furthermore, we identified the key operating factors influencing SEC and their priority levels, along with their interactive effects. Notably, no prior study has discussed the significance and interaction of these operating factors (e.g., feed water salinity, temperature, pressure, flowrate and membrane permeability) on SEC of a BWRO system. Employing a full factorial experimental design with mixed levels of operating parameters, the study developed regression models that elucidate the mechanistic interaction between these parameters and system performance. Moreover, the models were validated experimentally, with a new dataset demonstrating their accuracy and reliability. ANOVA statistical analysis identified feed salinity, pressure, flow rate, feed flow rate×pressure, salinity×pressure, and temperature as influential operating parameters in reducing SEC, in descending order of importance. Operating within the determined optimum range resulted in a 36 % decrease in SEC and a more than fourfold increase in water recovery. The study's systematic approach and findings can be extrapolated to optimize the performance of other desalination technologies and diverse feed water types, contributing significantly to global water sustainability efforts.
PubMed: 38688362
DOI: 10.1016/j.scitotenv.2024.172772 -
Membranes Apr 2024Modern society and industrial development rely heavily on the availability of freshwater and minerals. Seawater reverse osmosis (SWRO) has been widely adopted for...
Modern society and industrial development rely heavily on the availability of freshwater and minerals. Seawater reverse osmosis (SWRO) has been widely adopted for freshwater supply, although many questions have arisen about its environmental sustainability owing to the disposal of hypersaline rejected solutions (brine). This scenario has accelerated significant developments towards the hybridization of SWRO with membrane distillation-crystallization (MD-MCr), which can extract water and minerals from spent brine. Nevertheless, the substantial specific energy consumption associated with MD-MCr remains a significant limitation. In this work, energy harvesting was secured from renewables by hotspots embodied in the membranes, implementing the revolutionary approach of brine mining via photothermal membrane crystallization (PhMCr). This method employs self-heating nanostructured interfaces under solar radiation to enhance water evaporation, creating a carefully controlled supersaturated environment responsible for the extraction of minerals. Photothermal mixed matrix photothermal membranes (MMMs) were developed by incorporating graphene oxide (GO) or carbon black (CB) into polyvinylidene fluoride (PVDF) solubilized in an eco-friendly solvent (i.e., triethyl phosphate (TEP)). MMMs were prepared using non-solvent-induced phase separation (NIPS). The effect of GO or GB on the morphology of MMMs and the photothermal behavior was examined. Light-to-heat conversion was used in PhMCr experiments to facilitate the evaporation of water from the SWRO brine to supersaturation, leading to sodium chloride (NaCl) nucleation and crystallization. Overall, the results indicate exciting perspectives of PhMCr in brine valorization for a sustainable desalination industry.
PubMed: 38668115
DOI: 10.3390/membranes14040087 -
Cureus Mar 2024Wound healing is an intricate process of tissue regeneration that depends on the simultaneous presence of immunological and microenvironmental factors. The significant...
Wound healing is an intricate process of tissue regeneration that depends on the simultaneous presence of immunological and microenvironmental factors. The significant role of platelets and their granules in the wound-healing process has led to extensive research on their potential as a therapeutic intervention in different areas, including chronic wounds and aesthetic therapies. Saltwater aids in purification and promotes healing by utilizing osmosis. Sodium chloride, the chemical component present in salt, induces the extrusion of fluids from cells upon contact. If the liquids in issue are bacterial, they will also be ejected, assisting in the cleansing of the skin. Desiccation, often known as the drying out of injured cells, is well-known for its antibacterial properties and subsequent ability to reduce inflammation. This case series aims to investigate the advantages of using saltwater dressing following platelet-rich plasma therapy for chronic wounds.
PubMed: 38650806
DOI: 10.7759/cureus.56758 -
PloS One 2024Electroosmosis has been proposed as a technique to reduce moisture and thus increase the stability of soft clay. However, its high energy consumption and uneven...
Electroosmosis has been proposed as a technique to reduce moisture and thus increase the stability of soft clay. However, its high energy consumption and uneven reinforcement effect has limited its popularization and application in practical engineering. This paper presents the results of some electrokinetic tests performed on clayey specimens with different electrification time and anode boundary conditions. The results indicate that the timing of the formation of electroosmotic flow (EF) by the water originally contained in different soil cross sections, from the anode to the cathode, varies. The measuring soil cross section nearest the anode first reached the limiting water content of 22%±3% and electroosmosis had to be stopped. Water injection into the anode during electroosmosis enhanced further drainage of other four measuring soil cross sections until the second soil cross section from the anode reached the limiting water content of 30%±2%. Electroosmosis with water injection into the anode technique provides more uniform reinforcement, increasing EF, and environmental protection. The experimental results highlighted the relevant and expected contribution of water injection into the anode on the effectiveness of the electroosmotic treatment as a soft clay improvement technique.
Topics: Clay; Electroosmosis; Soil Pollutants; Soil; Water
PubMed: 38625994
DOI: 10.1371/journal.pone.0302150 -
Journal of Mathematical Biology Apr 2024We present a mathematical model of an experiment in which cells are cultured within a gel, which in turn floats freely within a liquid nutrient medium. Traction forces...
We present a mathematical model of an experiment in which cells are cultured within a gel, which in turn floats freely within a liquid nutrient medium. Traction forces exerted by the cells on the gel cause it to contract over time, giving a measure of the strength of these forces. Building upon our previous work (Reoch et al. in J Math Biol 84(5):31, 2022), we exploit the fact that the gels used frequently have a thin geometry to obtain a reduced model for the behaviour of a thin, two-dimensional cell-seeded gel. We find that steady-state solutions of the reduced model require the cell density and volume fraction of polymer in the gel to be spatially uniform, while the gel height may vary spatially. If we further assume that all three of these variables are initially spatially uniform, this continues for all time and the thin film model can be further reduced to solving a single, non-linear ODE for gel height as a function of time. The thin film model is further investigated for both spatially-uniform and varying initial conditions, using a combination of analytical techniques and numerical simulations. We show that a number of qualitatively different behaviours are possible, depending on the composition of the gel (i.e., the chemical potentials) and the strength of the cell traction forces. However, unlike in the earlier one-dimensional model, we do not observe cases where the gel oscillates between swelling and contraction. For the case of initially uniform cell and gel density, our model predicts that the relative change in the gels' height and length are equal, which justifies an assumption previously used in the work of Stevenson et al. (Biophys J 99(1):19-28, 2010). Conversely, however, even for non-uniform initial conditions, we do not observe cases where the length of the gel changes whilst its height remains constant, which have been reported in another model of osmotic swelling by Trinschek et al. (AIMS Mater Sci 3(3):1138-1159, 2016; Phys Rev Lett 119:078003, 2017).
Topics: Gels; Nutrients; Polymers; Seeds
PubMed: 38607408
DOI: 10.1007/s00285-024-02072-1 -
Cells Mar 2024Absorption spectra of red blood cell (RBC) suspensions are investigated in an osmolarity range in the medium from 200 mOsm to 900 mOsm. Three spectral parameters are...
Absorption spectra of red blood cell (RBC) suspensions are investigated in an osmolarity range in the medium from 200 mOsm to 900 mOsm. Three spectral parameters are used to characterize the process of swelling or shrinkage of RBC-the absorbance at 700 nm, the Soret peak height relative to the spectrum background, and the Soret peak wavelength. We show that with an increase in the osmolarity, the absorbance at 700 nm increases and the Soret peak relative height decreases. These changes are related to the changes in the RBC volume and the resulting increase in the hemoglobin intracellular concentration and index of refraction. Confocal microscopy and flow cytometry measurements supported these conclusions. The maximum wavelength of the Soret peak increases with increasing osmolarity due to changes in the oxygenation state of hemoglobin. Using these spectrum parameters, the process of osmosis in RBCs can be followed in real time, but it can also be applied to various processes, leading to changes in the volume and shape of RBCs. Therefore, we conclude that UV-Vis absorption spectrophotometry offers a convenient, easily accessible, and cost-effective method to monitor changes in RBC, which can find applications in the field of drug discovery and diagnostics of RBC and hemoglobin disorders.
Topics: Osmotic Pressure; Erythrocytes; Hemoglobins; Spectrophotometry; Osmolar Concentration
PubMed: 38607028
DOI: 10.3390/cells13070589 -
JPMA. the Journal of the Pakistan... Mar 2024To assess awareness, perceptions and use related to evidence-based revision methods by undergraduate medical students.
OBJECTIVE
To assess awareness, perceptions and use related to evidence-based revision methods by undergraduate medical students.
METHODS
The descriptive cross-sectional study was conducted in three medical colleges of Rawalpindi, Islamabad, Pakistan, from December 01, 2019, to January 31, 2020, after approval from the ethics review committee of Army Medical College, Rawalpindi. The sample comprised undergraduate medical students of either gender. Data was collected online using a 10-item standardised questionnaire. Students were asked about the revision methods they used routinely and their perceptions of conventional and evidence-based revision methods. Data was analysed using SPSS 23.
RESULTS
Of the total 136 respondents, 92(67%) were females and 44(32.3%) were male students. The response from preclinical and clinical years was 67 (50.7%) and 69(49.2%), respectively. Highlighting was the most widely used revision method among students (70 (51%) students), followed by re-reading important points (65 (47.7%) students). 126 (92%) students had the opinion that conventional revision methods were effective learning tools. Only 52 (38.2%) students were aware of the term 'evidence-based revision methods'. Digital tools based on principles of evidence-based revision were used by a minority of students which included use of online question banks by 21 (15.4%) students, osmosis by 40 (29.4%) students, sketchy pharma by 35 (25%)students, flashcards by 19 (14%) and picmonic by only 3 (2.2%). More than 114 (80%) students responded that they wanted evidence-based revision methods to be incorporated into curriculum, and 116 (85%) students said they would like to have a workshop on these techniques.
CONCLUSION
Most medical students were not aware of and were not using evidence-based revision methods, and relied on conventional revision tools. They were, however, eager to learn about newer revision strategies.
Topics: Female; Humans; Male; Students, Medical; Education, Medical, Undergraduate; Cross-Sectional Studies; Curriculum; Learning
PubMed: 38591286
DOI: 10.47391/JPMA.9307 -
Scientific Reports Apr 2024Recently, hydrogels have been widely applied as draw agents in forward osmosis (FO) desalination. This work aims to synthesize bioartificial hydrogel from a blend of...
Recently, hydrogels have been widely applied as draw agents in forward osmosis (FO) desalination. This work aims to synthesize bioartificial hydrogel from a blend of sodium alginate (SA) and polyvinyl alcohol (PVA) using epichlorohydrin (ECH) as a crosslinker. Then this prepared hydrogel was applied as a draw agent with cellulose triacetate membrane in a batch (FO) cell. The effects of the PVA content in the polymer blend and the crosslinker dose on the hydrogel's swelling capacity were investigated to optimize the hydrogel's composition. Furthermore, the water flux and the reverse solute flux of the optimum SA/PVA hydrogel were evaluated in a batch (FO) unit under the effect of the hydrogel's particle size, feed solution (FS) temperature, FS concentration, and membrane orientation. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD) and compression strength tests were used to characterize the prepared hydrogel. Results revealed that the equilibrium swelling ratio (%) of 5228 was achieved with a hydrogel that had 25% PVA and a crosslinking ratio of 0.8. FO experiments revealed that the maximum water flux of 0.845 LMH achieved, when distilled water was used as FS, average hydrogel's particle size was 60 µm, and the FS temperature was 40 °C.
PubMed: 38589408
DOI: 10.1038/s41598-024-58533-6