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JAMA Network Open Jun 2024Major concerns regarding individuals who adhere to a vegan diet are whether they meet protein and essential amino acid recommendations and how reliant they are on...
IMPORTANCE
Major concerns regarding individuals who adhere to a vegan diet are whether they meet protein and essential amino acid recommendations and how reliant they are on ultraprocessed foods.
OBJECTIVES
To investigate whether individuals who adhere to a vegan diet meet protein and essential amino acid recommendations and, as secondary objectives, to determine ultraprocessed food intake and potential factors associated with inadequate protein intake in this population.
DESIGN, SETTING, AND PARTICIPANTS
This cross-sectional survey study was conducted between September 2021 and January 2023 in Brazil among male and female adults (aged 18 years or older) who adhered to a vegan diet recruited from social media platforms.
EXPOSURE
Adherence to a vegan diet and unprocessed and minimally processed foods and ultraprocessed food consumption.
MAIN OUTCOMES AND MEASURES
Protein and essential amino acid intake and food consumption by processing level were assessed using a 1-day food diary. Nutrient adequacy ratios were calculated by dividing nutrient intake by its recommendation (using scores truncated at 1) for each participant and then finding the mean across participants for each nutrient. The mean adequacy ratio was the mean of all nutrient adequacy ratios.
RESULTS
Of 1014 participants who completed the survey, 774 individuals (median [IQR] age, 29 [24-35] years; 637 female [82.3%]) were confirmed as adhering to a vegan diet and provided adequate food recalls, among whom 558 individuals reported body weight and so had relative protein and amino acid intake values available. The median (IQR) body mass index (calculated as weight in kilograms divided by height in meters squared) of participants was 22.6 (20.3-24.8). The nutrient adequacy ratio of protein was 0.93 (95% CI, 0.91-0.94); for essential amino acids, ratios ranged from 0.90 (95% CI, 0.89-0.92) for lysine to 0.98 (95% CI, 0.97-0.99) for phenylalanine and tyrosine. The mean adequacy ratio for protein and all amino acids was 0.95 (95% CI, 0.94-0.96). The median intake level was 66.5% (95% CI, 65.0%-67.9%) of total energy intake for unprocessed and minimally processed food and 13.2% (95% CI, 12.4%-14.4%) of total energy intake for ultraprocessed food. Adjusted logistic regression models showed that consuming protein supplements (odds ratio [OR], 0.06 [95% CI 0.02-0.14]; P < .001) or textured soy protein (OR, 0.32 [95% CI, 0.17-0.59]; P < .001) was associated with decreased odds of inadequate protein intake. Higher ultraprocessed food intake levels were also associated with decreased odds of inadequate protein intake (eg, fourth vs first quartile of intake: OR, 0.16 [95% CI, 0.07-0.33]; P < .001), and higher unprocessed and minimally processed protein intake levels were associated with increased odds of inadequate protein intake (eg, fourth vs first quartile of intake: OR, 12.42 [95% CI, 5.56-29.51]; P < .001).
CONCLUSIONS AND RELEVANCE
In this study, most individuals who adhered to a vegan diet attained protein and essential amino acid intake recommendations, largely based their diet of unprocessed and minimally processed food, and had a significantly lower proportion of ultraprocessed food intake compared with previous reports. Participants consuming less ultraprocessed food were more likely to have inadequate protein intake, suggesting a significant reliance on ultraprocessed proteins for this population.
Topics: Humans; Female; Male; Adult; Brazil; Cross-Sectional Studies; Dietary Proteins; Vegans; Young Adult; Diet, Vegan; Food Handling; Middle Aged; Eating; Amino Acids; Amino Acids, Essential
PubMed: 38913373
DOI: 10.1001/jamanetworkopen.2024.18226 -
Cell Jun 2024The gut microbiota influences the clinical responses of cancer patients to immunecheckpoint inhibitors (ICIs). However, there is no consensus definition of detrimental...
The gut microbiota influences the clinical responses of cancer patients to immunecheckpoint inhibitors (ICIs). However, there is no consensus definition of detrimental dysbiosis. Based on metagenomics (MG) sequencing of 245 non-small cell lung cancer (NSCLC) patient feces, we constructed species-level co-abundance networks that were clustered into species-interacting groups (SIGs) correlating with overall survival. Thirty-seven and forty-five MG species (MGSs) were associated with resistance (SIG1) and response (SIG2) to ICIs, respectively. When combined with the quantification of Akkermansia species, this procedure allowed a person-based calculation of a topological score (TOPOSCORE) that was validated in an additional 254 NSCLC patients and in 216 genitourinary cancer patients. Finally, this TOPOSCORE was translated into a 21-bacterial probe set-based qPCR scoring that was validated in a prospective cohort of NSCLC patients as well as in colorectal and melanoma patients. This approach could represent a dynamic diagnosis tool for intestinal dysbiosis to guide personalized microbiota-centered interventions.
Topics: Humans; Gastrointestinal Microbiome; Immunotherapy; Carcinoma, Non-Small-Cell Lung; Female; Lung Neoplasms; Male; Dysbiosis; Feces; Middle Aged; Metagenomics; Immune Checkpoint Inhibitors; Treatment Outcome; Aged; Melanoma; Akkermansia; Colorectal Neoplasms; Neoplasms
PubMed: 38906102
DOI: 10.1016/j.cell.2024.05.029 -
Journal of Diabetes Research 2024Tracking of blood glucose levels by patients and care providers remains an integral component in the management of diabetes mellitus (DM). Evidence, primarily from... (Randomized Controlled Trial)
Randomized Controlled Trial
Impact of Self-Monitoring Blood Glucose on Glycaemic Control Among Insulin-Treated Patients With Diabetes Mellitus in Northeastern Tanzania: A Randomised Controlled Trial.
Tracking of blood glucose levels by patients and care providers remains an integral component in the management of diabetes mellitus (DM). Evidence, primarily from high-income countries, has illustrated the effectiveness of self-monitoring of blood glucose (SMBG) in controlling DM. However, there is limited data on the feasibility and impact of SMBG among patients in the rural regions of sub-Saharan Africa. This study is aimed at assessing SMBG, its adherence, and associated factors on the effect of glycaemic control among insulin-treated patients with DM in northeastern Tanzania. This was a single-blinded, randomised clinical trial conducted from December 2022 to May 2023. The study included patients with DM who had already been on insulin treatment for at least 3 months. A total of 85 participants were recruited into the study and categorised into the intervention and control groups by a simple randomization method using numbered envelopes. The intervention group received glucose metres, test strips, logbooks, and extensive SMBG training. The control group received the usual care at the outpatient clinic. Each participant was followed for a period of 12 weeks, with glycated haemoglobin (HbA) and fasting blood glucose (FBG) being checked both at the beginning and at the end of the study follow-up. The primary and secondary outcomes were adherence to the SMBG schedule, barriers associated with the use of SMBG, and the ability to self-manage DM, logbook data recording, and change in HbA. The analysis included descriptive statistics, paired -tests, and logistic regression. Eighty participants were analysed: 39 in the intervention group and 41 in the control group. In the intervention group, 24 (61.5%) of patients displayed favourable adherence to SMBG, as evidenced by tests documented in the logbooks and glucometer readings. Education on SMBG was significantly associated with adherence. Structured SMBG improved glycaemic control with a HbA reduction of -1.01 (95% confidence interval (CI) -1.39, -0.63) in the intervention group within 3 months from baseline compared to controls of 0.18 (95% CI -0.07, 0.44) ( < 0.001). Structured SMBG positively impacted glycaemic control among insulin-treated patients with DM in the outpatient clinic. The results suggest that implementing a structured testing programme can lead to significant reductions in HbA and FBG levels. Pan African Clinical Trials Registry identifier: PACTR202402642155729.
Topics: Humans; Blood Glucose Self-Monitoring; Male; Female; Tanzania; Middle Aged; Blood Glucose; Glycemic Control; Insulin; Glycated Hemoglobin; Hypoglycemic Agents; Adult; Single-Blind Method; Aged; Diabetes Mellitus, Type 2; Diabetes Mellitus; Patient Compliance; Treatment Outcome
PubMed: 38899147
DOI: 10.1155/2024/6789672 -
Frontiers in Microbiology 2024Climate change is one of the main challenges, and it poses a tough challenge to the agriculture industry globally. Additionally, greenhouse gas (GHG) emissions are the...
Climate change is one of the main challenges, and it poses a tough challenge to the agriculture industry globally. Additionally, greenhouse gas (GHG) emissions are the main contributor to climate change; however, croplands are a prominent source of GHG emissions. Yet this complex challenge can be mitigated through climate-smart agricultural practices. Conservation tillage is commonly known to preserve soil and mitigate environmental change by reducing GHG emissions. Nonetheless, there is still a paucity of information on the influences of conservation tillage on wheat yield, soil properties, and GHG flux, particularly in the semi-arid Dingxi belt. Hence, in order to fill this gap, different tillage systems, namely conventional tillage (CT) control, straw incorporation with conventional tillage (CTS), no-tillage (NT), and stubble return with no-tillage (NTS), were laid at Dingxi, Gansu province of China, under a randomized complete block design with three replications to examine their impacts on yield, soil properties, and GHG fluxes. Results depicted that different conservative tillage systems (CTS, NTS, and NT) significantly ( < 0.05) increased the plant height, number of spikes per plant, seed number per meter square, root yield, aboveground biomass yield, thousand-grain weight, grain yield, and dry matter yield compared with CT. Moreover, these conservation tillage systems notably improved the soil properties (soil gravimetric water content, water-filled pore space, water storage, porosity, aggregates, saturated hydraulic conductivity, organic carbon, light fraction organic carbon, carbon storage, microbial biomass carbon, total nitrogen, available nitrogen storage, microbial biomass nitrogen, total phosphorous, available phosphorous, total potassium, available potassium, microbial counts, urease, alkaline phosphatase, invertase, cellulase, and catalase) while decreasing the soil temperature and bulk density over CT. However, CTS, NTS, and NT had non-significant effects on ECe, pH, and stoichiometric properties (C:N ratio, C:P ratio, and N:P ratio). Additionally, conservation-based tillage regimes NTS, NT, and CTS significantly ( < 0.05) reduced the emission and net global warming potential of greenhouse gases (carbon dioxide, methane, and nitrous oxide) by 23.44, 19.57, and 16.54%, respectively, and decreased the greenhouse gas intensity by 23.20, 29.96, and 18.72%, respectively, over CT. We conclude that NTS is the best approach to increasing yield, soil and water conservation, resilience, and mitigation of agroecosystem capacity.
PubMed: 38894971
DOI: 10.3389/fmicb.2024.1356426 -
Sensors (Basel, Switzerland) Jun 2024This study investigated biomechanical assessments in trail running, comparing two wearable devices-Stryd Power Meter and GARMIN. With the growing popularity of trail... (Comparative Study)
Comparative Study
This study investigated biomechanical assessments in trail running, comparing two wearable devices-Stryd Power Meter and GARMIN. With the growing popularity of trail running and the complexities of varied terrains, there is a heightened interest in understanding metabolic pathways, biomechanics, and performance factors. The research aimed to assess the inter- and intra-device agreement for biomechanics under ecological conditions, focusing on power, speed, cadence, vertical oscillation, and contact time. The participants engaged in trail running sessions while wearing two Stryd and two Garmin devices. The intra-device reliability demonstrated high consistency for both GARMIN and Stryd, with strong correlations and minimal variability. However, distinctions emerged in inter-device agreement, particularly in power and contact time uphill, and vertical oscillation downhill, suggesting potential variations between GARMIN and Stryd measurements for specific running metrics. The study underscores that caution should be taken in interpreting device data, highlighting the importance of measuring with the same device, considering contextual and individual factors, and acknowledging the limited research under real-world trail conditions. While the small sample size and participant variations were limitations, the strength of this study lies in conducting this investigation under ecological conditions, significantly contributing to the field of biomechanical measurements in trail running.
Topics: Humans; Running; Wearable Electronic Devices; Biomechanical Phenomena; Male; Adult; Female; Young Adult; Reproducibility of Results
PubMed: 38894361
DOI: 10.3390/s24113570 -
Sensors (Basel, Switzerland) May 2024Sprinting plays a significant role in determining the results of road cycling races worldwide. However, currently, there is a lack of systematic research into the...
Sprinting plays a significant role in determining the results of road cycling races worldwide. However, currently, there is a lack of systematic research into the kinematics of sprint cycling, especially in an outdoor, environmentally valid setting. This study aimed to describe selected joint kinematics during a cycling sprint outdoors. Three participants were recorded sprinting over 60 meters in both standing and seated sprinting positions on an outdoor course with a baseline condition of seated cycling at 20 km/h. The participants were recorded using array-based inertial measurement units to collect joint excursions of the upper and lower limbs including the trunk. A high-rate GPS unit was used to record velocity during each recorded condition. Kinematic data were analyzed in a similar fashion to running gait, where multiple pedal strokes were identified, delineated, and averaged to form a representative (average ± SD) waveform. Participants maintained stable kinematics in most joints studied during the baseline condition, but variations in ranges of movement were recorded during seated and standing sprinting. Discernable patterns started to emerge for several kinematic profiles during standing sprinting. Alternate sprinting strategies emerged between participants and bilateral asymmetries were also recorded in the individuals tested. This approach to studying road cycling holds substantial potential for researchers wishing to explore this sport.
Topics: Humans; Biomechanical Phenomena; Bicycling; Male; Adult; Joints; Gait; Running; Female
PubMed: 38894244
DOI: 10.3390/s24113453 -
Sensors (Basel, Switzerland) May 2024(1) Background: The study aimed to determine the most important activities of the knee joints related to gait re-education in patients in the subacute period after a...
(1) Background: The study aimed to determine the most important activities of the knee joints related to gait re-education in patients in the subacute period after a stroke. We focused on the tests that a physiotherapist could perform in daily clinical practice. (2) Methods: Twenty-nine stroke patients (SG) and 29 healthy volunteers (CG) were included in the study. The patients underwent the 5-meter walk test (5mWT) and the Timed Up and Go test (TUG). Tests such as step up, step down, squat, step forward, and joint position sense test (JPS) were also performed, and the subjects were assessed using wireless motion sensors. (3) Results: We observed significant differences in the time needed to complete the 5mWT and TUG tests between groups. The results obtained in the JPS show a significant difference between the paretic and the non-paretic limbs compared to the CG group. A significantly smaller range of knee joint flexion (ROM) was observed in the paretic limb compared to the non-paretic and control limbs in the step down test and between the paretic and non-paretic limbs in the step forward test. (4) Conclusions: The described functional tests are useful in assessing a stroke patient's motor skills and can be performed in daily clinical practice.
Topics: Humans; Stroke Rehabilitation; Male; Female; Middle Aged; Gait; Stroke; Algorithms; Aged; Knee Joint; Range of Motion, Articular; Adult
PubMed: 38894207
DOI: 10.3390/s24113416 -
Diagnostics (Basel, Switzerland) May 2024The severity of pulpitis is a crucial factor in determining the suitable treatment. There are no clear objective indicators to assess the stage of pulp inflammation that...
The severity of pulpitis is a crucial factor in determining the suitable treatment. There are no clear objective indicators to assess the stage of pulp inflammation that could be used in clinical practice. The change in blood pH of the pulp during the inflammatory phase could hypothetically serve as an indicator of the pulp inflammation severity. The aim of this study was to assess the pH values in the pulpal blood of mature teeth in patients with symptomatic pulpitis, in comparison with the healthy controls. The study included patients with symptoms of pulpitis in premolar or molar teeth (Test group; = 24, mean age 36.04, SD 7.10), and healthy controls (Control group, = 6, mean age 24.5, SD 5.94) referred for extraction of premolars or third molars, for orthodontic reasons. The pulpal blood was taken at the opening of the endodontic access cavity, and the pH value was measured in both groups. Statistical analysis was performed using the SPSS 27.0 program with a significance level of ≤ 0.05. The Mann-Whitney test for dependent samples was performed to evaluate the statistical difference between the groups. The patients with symptomatic pulpitis had significantly decreased pulpal blood pH compared to the healthy controls ( ≤ 0.05). The mean pulpal blood pH was 7.27 (SD 0.06) and 7.40 (SD 0.02) in Test and Control groups, respectively. In the Test group, the pulpal blood pH values were significantly lower in the patients who had symptoms for 3 days or more (7.25, SD 0.05) than in those who had symptoms for up to 3 days (7.33, SD 0.03) ( < 0.001). The pH value of the pulpal blood gradually declines in cases of symptomatic pulpitis, along with increasing duration of the symptoms.
PubMed: 38893654
DOI: 10.3390/diagnostics14111128 -
Journal of Neuroengineering and... Jun 2024Recently, the use of inertial measurement units (IMUs) in quantitative gait analysis has been widely developed in clinical practice. Numerous methods have been developed...
BACKGROUND
Recently, the use of inertial measurement units (IMUs) in quantitative gait analysis has been widely developed in clinical practice. Numerous methods have been developed for the automatic detection of gait events (GEs). While many of them have achieved high levels of efficiency in healthy subjects, detecting GEs in highly degraded gait from moderate to severely impaired patients remains a challenge. In this paper, we aim to present a method for improving GE detection from IMU recordings in such cases.
METHODS
We recorded 10-meter gait IMU signals from 13 healthy subjects, 29 patients with multiple sclerosis, and 21 patients with post-stroke equino varus foot. An instrumented mat was used as the gold standard. Our method detects GEs from filtered acceleration free from gravity and gyration signals. Firstly, we use autocorrelation and pattern detection techniques to identify a reference stride pattern. Next, we apply multiparametric Dynamic Time Warping to annotate this pattern from a model stride, in order to detect all GEs in the signal.
RESULTS
We analyzed 16,819 GEs recorded from healthy subjects and achieved an F1-score of 100%, with a median absolute error of 8 ms (IQR [3-13] ms). In multiple sclerosis and equino varus foot cohorts, we analyzed 6067 and 8951 GEs, respectively, with F1-scores of 99.4% and 96.3%, and median absolute errors of 18 ms (IQR [8-39] ms) and 26 ms (IQR [12-50] ms).
CONCLUSIONS
Our results are consistent with the state of the art for healthy subjects and demonstrate a good accuracy in GEs detection for pathological patients. Therefore, our proposed method provides an efficient way to detect GEs from IMU signals, even in degraded gaits. However, it should be evaluated in each cohort before being used to ensure its reliability.
Topics: Humans; Male; Female; Multiple Sclerosis; Adult; Middle Aged; Gait Disorders, Neurologic; Gait Analysis; Gait; Aged; Stroke; Accelerometry; Young Adult
PubMed: 38890696
DOI: 10.1186/s12984-024-01405-x -
Frontiers in Public Health 2024This study aimed to explore the potential effects of 8-week parents-accompanied swimming on the physical capacity and intelligence of preschool children in China....
This study aimed to explore the potential effects of 8-week parents-accompanied swimming on the physical capacity and intelligence of preschool children in China. Thirty-six boys (mean age 3.56 ± 0.27 years) were divided into three groups: the traditional physical exercise group (TP, = 12), the accompanied swimming group (AS, = 12) and the independent swimming group (IS, = 12). Participants' physical capacity was assessed before and after the intervention using the following indicators: height, weight, distance of tennis ball throw, standing long jump distance, time for the 10-meter shuttle run, time for a two-legged continuous jump, sit-and-reach distance, and time on the walking balance beam. Intelligence was assessed at three points: pre-test, mid-test after 4 weeks, and post-test. Data were analyzed using a two-way repeated measures ANOVA, Bonferroni test ( < 0.05) and effect size. The time of the AS and IS groups to walk the balance beam was significantly lower than the TP group, with a difference of 1.81 s ( < 0.01, [95% CI -3.22 to -0.40], ES = 1.53) and 1.25 s ( < 0.05, [95% CI -2.66 to 0.16], ES = 0.81). At the mid-test, the IQ scores of the TP group were lower than the AS group ( < 0.05, [95% CI -12.45 to -0.96], ES = 0.89). Additionally, at post-test, the IQ scores of the TP group were significantly lower than those of both AS ( < 0.01, [95% CI -14.12 to -2.74], ES = 1.15) and IS groups ( < 0.01, [95% CI -12.53 to -3.31], ES = 1.21). Swimming enhances children's balance and IQ scores more than traditional physical exercises. Involving parents in swimming leads to a more significant increase in IQ scores within 4 weeks of initial swimming exercise.
Topics: Humans; Male; Child, Preschool; Intelligence; Swimming; China; Parents; Exercise; Physical Fitness
PubMed: 38883199
DOI: 10.3389/fpubh.2024.1410707