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Indian Journal of Ophthalmology Oct 2019
Topics: Animals; Anthelmintics; Antibodies, Helminth; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Eye Infections, Parasitic; Female; Glucocorticoids; Humans; Magnetic Resonance Imaging; Methylprednisolone; Ophthalmologic Surgical Procedures; Orbital Diseases; Paragonimiasis; Paragonimus; Praziquantel
PubMed: 31546545
DOI: 10.4103/ijo.IJO_295_19 -
The Journal of Veterinary Medical... Aug 2019Paragonimiasis is an important food-borne zoonosis caused by Paragonimus flukes and is endemic to western Japan. However, there have been few epidemiological studies in...
Paragonimiasis is an important food-borne zoonosis caused by Paragonimus flukes and is endemic to western Japan. However, there have been few epidemiological studies in the Tohoku district of northeastern Japan. In this study, Paragonimus metacercariae (mc) was detected in Geothelphusa dehaani (Japanese freshwater crab or Sawagani) in Iwate Prefecture. Out of the 207 Sawagani collected from 35 localities, 12 individuals from six localities were infected with Paragonimus mc. The mc were identified as P. skrjabini miyazakii based on the sequences of nuclear ribosomal internal transcribed spacer 2 and mitochondrial cytochrome c oxidase I. This is the first report of P. s. miyazakii mc infection in Sawagani in Iwate Prefecture.
Topics: Animals; Brachyura; Japan; Metacercariae; Molecular Typing; Paragonimiasis; Paragonimus
PubMed: 31189784
DOI: 10.1292/jvms.19-0164 -
The American Journal of Tropical... Jul 2019We report an unusual case of paragonimiasis in a Nepali patient presenting with massive pericardial effusion and pericardial tamponade. The patient reported neither the...
We report an unusual case of paragonimiasis in a Nepali patient presenting with massive pericardial effusion and pericardial tamponade. The patient reported neither the consumption of crabs or crayfish nor the consumption of wild animal meat, which are the usual sources of infection. It is suspected that the source of infection was instead the ingestion of raw live slugs as part of a traditional medicine treatment.
Topics: Animals; Anthelmintics; Cardiac Tamponade; Female; Gastropoda; Humans; Medicine, Traditional; Middle Aged; Paragonimiasis; Praziquantel
PubMed: 31094314
DOI: 10.4269/ajtmh.19-0018 -
Journal of Korean Medical Science Feb 2019
Topics: Animals; Bronchopneumonia; Diagnosis, Differential; Eosinophils; Female; Humans; Lymph Nodes; Middle Aged; Ovum; Paragonimiasis; Praziquantel; Stomach Neoplasms; Tomography, X-Ray Computed; Trematoda; Trematode Infections
PubMed: 31044572
DOI: 10.3346/jkms.2019.34.e45 -
Open Forum Infectious Diseases Apr 2019Large pericardial effusion (PE) and bilateral pleural effusion were found in a 4-year-old Chinese boy. An emergent surgery was performed. The biopsy showed massive...
Large pericardial effusion (PE) and bilateral pleural effusion were found in a 4-year-old Chinese boy. An emergent surgery was performed. The biopsy showed massive eosinophil infiltration. Serologic test for was positive. Postoperative praziquantel therapy was effective.
PubMed: 31041346
DOI: 10.1093/ofid/ofz145 -
Turkish Neurosurgery 2020To investigate the clinical manifestations and radiologic characteristics in diagnosing and treating hemorrhagic cerebral paragonimiasis. (Review)
Review
AIM
To investigate the clinical manifestations and radiologic characteristics in diagnosing and treating hemorrhagic cerebral paragonimiasis.
MATERIAL AND METHODS
The study retrospectively analyzed the data of three cases of hemorrhagic paragonimiasis who received treatment in the hospital from January 2014 to March 2017. All three patients were diagnosed with paragonimiasis by positive detection of paragonimiasis antibody. Based on the imaging data, the disease was confirmed as hemorrhagic cerebral paragonimiasis. One of the three patients was treated with oral praziquantel alone, one with praziquantel and thoracentesis, and one with praziquantel in combination with closed thoracic drainage and craniotomy.
RESULTS
All the lesions disappeared after computed tomography scan during the follow-up. Two of the three patients had no dysneuria, and one had mild dysneuria.
CONCLUSION
Hemorrhagic cerebral paragonimiasis should be diagnosed as early as possible using antibodies against paragonimiasis for patients with unexplained intracerebral hemorrhage, especially young patients with atypical imaging findings and multiple systemic lesions. It is possible to avoid craniotomy and improve the cure rate by the early, full-dose, and sufficient course of anti-parasitic treatment.
Topics: Cerebral Hemorrhage; Child; Combined Modality Therapy; Craniotomy; Humans; Male; Paragonimiasis; Praziquantel; Retrospective Studies; Tomography, X-Ray Computed; Young Adult
PubMed: 30984986
DOI: 10.5137/1019-5149.JTN.22666-18.3 -
Acta Tropica Jun 2019Foodborne Neglected Zoonotic Helminths (FNZH) are parasites of both economic and public health importance. They include Taenia solium, Echinococcus granulosus sensu...
BACKGROUND
Foodborne Neglected Zoonotic Helminths (FNZH) are parasites of both economic and public health importance. They include Taenia solium, Echinococcus granulosus sensu lato, Echinococcus multilocularis and Foodborne trematodes (FBT). FNZH are earmarked for major interventions for control, elimination and eradication. This systematic review highlights the progress towards development of rapid tests for the diagnosis of FNZH since 2010 when they were listed as neglected tropical diseases.
METHODOLOGY
A systematic search was conducted in three databases, World of Science, Embase and PubMed using the same search phrase. The search produced 480 hits. Three studies from back referencing were included. Only 22 of these met the inclusion criteria. Data was extracted from these and presented qualitatively.
RESULTS
Twenty-five rapid diagnostic tests were found to have been developed since 2010, eight for diagnosis of T. solium infections, eight for echinococcosis and nine for FBT infections. The rapid tests for diagnosing T. solium infections included six antibody detecting and two antigen detecting tests. They constitute a combination among them, with some tests providing qualitative, others quantitative results. Similarly, seven out of the eight rapid tests developed for Echinococcus infections were antibody detecting tests save for one loop mediated isothermal amplification test. All of them were qualitative tests. For FBT infections, nine rapid tests were described; two antibody and one nucleic acid detecting test for diagnosis of Fascioliasis; three nucleic acid detecting tests for Opisthorchiasis; one antibody detecting test for Paragonimiasis; and for Clonorchiasis, one antibody and one nucleic acid detecting test. The FBT infection rapid tests were all qualitative in nature. Most of these tests have not undergone field evaluation in endemic areas where they will be used most.
CONCLUSION
This review describes the development and evaluation of rapid diagnostic tests, while highlighting the need for in depth validations of the tools to determine how well they can perform in endemic areas.
Topics: Animals; Diagnostic Tests, Routine; Food Parasitology; Helminthiasis; Helminths; Humans; Neglected Diseases; Time Factors; Zoonoses
PubMed: 30946810
DOI: 10.1016/j.actatropica.2019.03.030 -
International Journal of Infectious... Jun 2019The pericardial effusion (PE) caused by paragonimiasis is rarely reported. This study aims to present experience in the diagnosis and surgical management of PE due to...
OBJECTIVES
The pericardial effusion (PE) caused by paragonimiasis is rarely reported. This study aims to present experience in the diagnosis and surgical management of PE due to paragonimiasis.
METHODS
Medical records of 57 children who were diagnosed with PE due to paragonimiasis and underwent surgery at Children's Hospital of Chongqing Medical University between January 2012 and August 2018 were retrospectively reviewed.
RESULTS
The average age of this group was 7.6 ± 3.0 years. Patients were mainly from Chongqing and Sichuan areas. ELISA for Paragonimus skrjabini in all 57 patients showed positive results. Moderate or large PE were identified in 12 and 45 patients, respectively. All patients underwent surgery either by pericardectomy or thoracoscopic surgery. Pathological exams indicated massive eosinophil infiltration in all 57 specimens. After 3-4 courses of praziquantel therapy, the clinical outcomes were satisfactory.
CONCLUSIONS
Typical endemic history, eosinophilia and multiple serous effusion raise suspicions of paragonimiasis. Once moderate to large PE is identified in patients with paragonimiasis, surgical treatment is necessary.
Topics: Adolescent; Animals; Anthelmintics; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Eosinophilia; Female; Humans; Male; Paragonimiasis; Paragonimus; Pericardial Effusion; Praziquantel; Retrospective Studies
PubMed: 30930185
DOI: 10.1016/j.ijid.2019.03.032 -
The Korean Journal of Parasitology Feb 2019
Topics: Animals; History, 20th Century; History, 21st Century; Host-Parasite Interactions; Humans; Paragonimiasis; Paragonimus; Parasitology; Republic of Korea; Sparganosis; Sparganum; Taenia solium; Taeniasis
PubMed: 30840805
DOI: 10.3347/kjp.2019.57.1.77 -
Infectious Diseases of Poverty Oct 2018Paragonimiasis, caused by helminths of the genus Paragonimus spp., is a neglected tropical disease. Human suffering from paragonimiasis is often misunderstood and its... (Review)
Review
BACKGROUND
Paragonimiasis, caused by helminths of the genus Paragonimus spp., is a neglected tropical disease. Human suffering from paragonimiasis is often misunderstood and its quantification by the disability weight of the disability-adjusted life years largely varies in different global burden of disease (GBD) estimates. This paper is to systematically review clinical paragonimiasis cases and requantify the disability weight of human paragonimiasis.
METHODS
A systematic analysis was conducted using articles from the following databases: PubMed, Institute for Scientific Information Web of Science, China National Knowledge Infrastructure, the Chinese scientific journal databases Wanfang Data and CQVIP, Africa Journal Online, and the System for Information on Grey Literature in Europe. Search terms were the combination of "paragonim*" with "clinical" or "infection". Only articles fulfilling the following conditions were recruited for this study: the occurrence of clinical signs and symptoms of paragonimiasis in human beings were reported; diagnosis was confirmed; no comorbidities were reported; the reviewed clinical cases or epidemiological findings were not already included in any other articles. The information and frequencies of paragonimiasis outcomes from included articles using predefined data fields were extracted two times by two separate individuals. Outcome disability weights were selected mainly from the GBD 2004 and GBD 2013 datasets. Frequencies and disability weights of paragonimiasis outcomes were modelled into a decision tree using the additive approach and multiplicative approach, respectively. Monte Carlo simulations were run 5000 times for an uncertainty analysis.
RESULTS
The disability weight estimates of paragonimiasis were simulated with 5302 clinical cases from 80 general articles. The overall disability weight was estimated at 0.1927 (median 0.1956) with a 95% uncertainty interval (UI) of 0.1632-0.2378 using the additive approach, and 0.1791 (median 0.1816) with a 95% UI of 0.1530-0.2182 using the multiplicative approach. The simulated disability weights of Paragonimus westermani cases were higher than that of P. skrjabini cases. Lung outcomes and headache were the top two contributors to disability weight for both species.
CONCLUSIONS
The use of paragonimiasis disability weight needs to be reconsidered with regard to availability of morbidity data and species variation. Calculating the disease burden of paragonimiasis requires further modification and thus has considerable implications for public health prioritization in research, monitoring, and control.
Topics: Animals; Cost of Illness; Decision Making; Decision Trees; Disabled Persons; Humans; Paragonimiasis; Paragonimus; Patient Outcome Assessment
PubMed: 30342548
DOI: 10.1186/s40249-018-0485-5