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The Journal of Toxicological Sciences Feb 2005Ketoprofen has been reported to have such side effects as photosensitive dermatitis in humans (The Ministry of Health, Labour and Welfare, 2001). In the present study,...
Ketoprofen has been reported to have such side effects as photosensitive dermatitis in humans (The Ministry of Health, Labour and Welfare, 2001). In the present study, as part of a safety evaluation of Miltax, an application drug containing ketoprofen, phototoxicity of Miltax was examined in guinea pigs. In the present skin phototoxicity study, Miltax was applied for 12 hr. Ultraviolet (UV) rays were irradiated to examine whether or not Miltax elicited skin reaction. Two kinds of UV-A plus UV-B dual irradiation and UV-A single irradiation were used for the elicitation. With UV-A plus UV-B dual irradiation on the Miltax application site, no skin reaction was observed at UV irradiation side in any animals, in contrast to the case of the positive control article, 8-methoxypsoralen (8-MOP). Similar results were obtained with UV-A single irradiation. From these results, Miltax that contained ketoprofen did not show any skin phototoxicity in the guinea pig.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Dermatitis, Phototoxic; Dose-Response Relationship, Drug; Erythema; Guinea Pigs; Ketoprofen; Male
PubMed: 15800399
DOI: 10.2131/jts.30.19 -
CMAJ : Canadian Medical Association... Feb 2004
Topics: Canada; Financing, Government; Humans; National Health Programs; Politics; Social Responsibility
PubMed: 14757674
DOI: No ID Found -
The Journal of Toxicological Sciences Dec 2003Although the patch test for visual skin observation is widely used clinically, it does not allow the mechanisms of side effects to be assessed. In this study, we... (Comparative Study)
Comparative Study
Although the patch test for visual skin observation is widely used clinically, it does not allow the mechanisms of side effects to be assessed. In this study, we examined poultice-type KP801 and tape-type KP-T patches containing ketoprofen. The parameters to measure side effects on skin were peeling intensity, amount of stripped stratum corneum, skin moisture and redness of skin color under various mechanical conditions. Since the amount of stripped stratum corneum with the tape-type KP-T patch was higher than with the poultice-type KP801 patch, the bio-adhesive strength of the latter was concluded to be lower. A clear relationship exists between the amount of stripped stratum corneum and skin moisture after tape-type patch removal, but this was not found with the poultice-type patch because of its hydration effects. Peeling intensity, one parameter to predict pain at the time of patch removal, was higher with the KP-T. As for mechanical conditions, when the patch is removed, it is important to remove it as slowly as possible and horizontally, and to avoid any rise in skin temperature. Finally, when a patch is applied to a region with little skin moisture, the amount of stripped stratum corneum may increase accordingly.
Topics: Administration, Cutaneous; Adult; Anti-Inflammatory Agents, Non-Steroidal; Delayed-Action Preparations; Human Experimentation; Humans; Ketoprofen; Male; Middle Aged; Patch Tests; Skin Irritancy Tests
PubMed: 14746345
DOI: 10.2131/jts.28.415 -
BMJ (Clinical Research Ed.) Aug 2003
Topics: Brassica; Humans; Inflammation; Medicine, Traditional; Phytotherapy; Plant Leaves
PubMed: 12933752
DOI: 10.1136/bmj.327.7412.451-c -
The Ulster Medical Journal Jun 1998
Topics: Bandages; History, 15th Century; History, 16th Century; History, 17th Century; History, 18th Century; History, 19th Century; History, 20th Century; History, Ancient; History, Medieval; Larva; Medicine, Traditional; Northern Ireland; Wound Healing
PubMed: 9807955
DOI: No ID Found -
Genitourinary Medicine Dec 1995To assess the prevalence of self-treatment in men with new episode non gonococcal urethritis (NGU).
OBJECTIVE
To assess the prevalence of self-treatment in men with new episode non gonococcal urethritis (NGU).
METHOD
Three hundred consecutive men with new episode NGU attending an open access genitourinary medicine clinic were interviewed using a semi-structured questionnaire. Details of treatment used before attending the clinic were obtained.
RESULTS
Thirty (10%) men had used treatment, for an average of 7 days, prior to the clinic attendance. Agents used included antibiotics (11), savion or iodine (4), vitamin tablets (4), cisapride (2), local anaesthetic gel (2), antiseptic cream (2), cod liver oil (1), ferrous sulphate (1), naproxen (1), clotrimazole cream (1) and a poultice (1). Over 70% of the men reporting antibiotic use had self-medicated and in one case a fixed drug eruption had ensued.
CONCLUSION
A significant number of men with NGU self-treat. In addition to the adverse effects of such treatment and the potential effect on culture tests, clinic attendance may be postponed, the use of appropriate therapy delayed, and sexual contacts will remain at risk. Early attendance for treatment and contact tracing is essential and should be actively promoted.
Topics: Adult; Anti-Bacterial Agents; Humans; Male; Middle Aged; Self Medication; Urethritis
PubMed: 8566983
DOI: 10.1136/sti.71.6.400 -
The Hospital Jul 1907
PubMed: 29811658
DOI: No ID Found -
The Southern Medical Record Nov 1897
PubMed: 36025877
DOI: No ID Found -
The Hospital Oct 1893
PubMed: 29831266
DOI: No ID Found