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Frontiers in Behavioral Neuroscience 2024
PubMed: 38645836
DOI: 10.3389/fnbeh.2024.1388886 -
Journal of Environmental Management May 2024The energy crisis caused by the lack of supply from some countries involved in armed conflicts, coupled with society's continuous demand for energy production, is...
The energy crisis caused by the lack of supply from some countries involved in armed conflicts, coupled with society's continuous demand for energy production, is leading to the proposal of new energy sources, such as the development of uranium mines to increase nuclear energy production. Mine projects (MPs) trigger numerous conflicts in the local societies involved. While for some people, they represent an opportunity for development and benefits, for others these proposals are perceived as a threat and a health risk. However, energy scarcity and price increases create a social dilemma that moderates the established relationships between the perceived risks and benefits and the valuation of energy proposals. This research aims to analyze both the weight of the factors influencing the acceptance of a uranium MP and the moderating role of the energy crisis on these factors. A total of 629 people participated in this study (371 before and 258 after the energy crisis). The participants answered a questionnaire assessing their socio-demographic characteristics, beliefs about the environment, the perceived risks and benefits, and their emotional balance, as well as their level of knowledge and acceptance of the uranium mine proposal. The results show that age, gender, and level of education and knowledge both directly and indirectly influence the acceptance of a mine. In addition, the perception of risks and benefits is associated with the emotional balance generated, explaining the level of final acceptance of the proposal. The moderation-mediated energy crisis hypothesis influences the relationship between the perceived risks and acceptance of the uranium mine. The results are discussed in order to determine factors for intervention to alleviate the social conflicts created by new energy proposals.
Topics: Uranium; Mining; Humans; Surveys and Questionnaires; Male; Female; Adult
PubMed: 38631166
DOI: 10.1016/j.jenvman.2024.120900 -
Alzheimer's & Dementia : the Journal of... May 2024Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We...
INTRODUCTION
Effective longitudinal biomarkers that track disease progression are needed to characterize the presymptomatic phase of genetic frontotemporal dementia (FTD). We investigate the utility of cerebral perfusion as one such biomarker in presymptomatic FTD mutation carriers.
METHODS
We investigated longitudinal profiles of cerebral perfusion using arterial spin labeling magnetic resonance imaging in 42 C9orf72, 70 GRN, and 31 MAPT presymptomatic carriers and 158 non-carrier controls. Linear mixed effects models assessed perfusion up to 5 years after baseline assessment.
RESULTS
Perfusion decline was evident in all three presymptomatic groups in global gray matter. Each group also featured its own regional pattern of hypoperfusion over time, with the left thalamus common to all groups. Frontal lobe regions featured lower perfusion in those who symptomatically converted versus asymptomatic carriers past their expected age of disease onset.
DISCUSSION
Cerebral perfusion is a potential biomarker for assessing genetic FTD and its genetic subgroups prior to symptom onset.
HIGHLIGHTS
Gray matter perfusion declines in at-risk genetic frontotemporal dementia (FTD). Regional perfusion decline differs between at-risk genetic FTD subgroups . Hypoperfusion in the left thalamus is common across all presymptomatic groups. Converters exhibit greater right frontal hypoperfusion than non-converters past their expected conversion date. Cerebral hypoperfusion is a potential early biomarker of genetic FTD.
Topics: Humans; Frontotemporal Dementia; Female; Male; Middle Aged; Longitudinal Studies; Magnetic Resonance Imaging; Cerebrovascular Circulation; C9orf72 Protein; tau Proteins; Gray Matter; Progranulins; Biomarkers; Disease Progression; Brain; Heterozygote; Mutation; Aged; Spin Labels; Adult
PubMed: 38623902
DOI: 10.1002/alz.13750 -
Alzheimer's & Dementia (Amsterdam,... 2024We aimed to expand the range of the frontotemporal dementia (FTD) phenotypes assessed by the Clinical Dementia Rating Dementia Staging Instrument plus National...
INTRODUCTION
We aimed to expand the range of the frontotemporal dementia (FTD) phenotypes assessed by the Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains (CDR plus NACC FTLD).
METHODS
Neuropsychiatric and motor domains were added to the standard CDR plus NACC FTLD generating a new CDR plus NACC FTLD-NM scale. This was assessed in 522 mutation carriers and 310 mutation-negative controls from the Genetic Frontotemporal dementia Initiative (GENFI).
RESULTS
The new scale led to higher global severity scores than the CDR plus NACC FTLD: 1.4% of participants were now considered prodromal rather than asymptomatic, while 1.3% were now considered symptomatic rather than asymptomatic or prodromal. No participants with a clinical diagnosis of an FTD spectrum disorder were classified as asymptomatic using the new scales.
DISCUSSION
Adding new domains to the CDR plus NACC FTLD leads to a scale that encompasses the wider phenotypic spectrum of FTD with further work needed to validate its use more widely.
HIGHLIGHTS
The new Clinical Dementia Rating Dementia Staging Instrument plus National Alzheimer's Coordinating Center Behavior and Language Domains neuropsychiatric and motor (CDR plus NACC FTLD-NM) rating scale was significantly positively correlated with the original CDR plus NACC FTLD and negatively correlated with the FTD Rating Scale (FRS).No participants with a clinical diagnosis in the frontotemporal dementia spectrum were classified as asymptomatic with the new CDR plus NACC FTLD-NM rating scale.Individuals had higher global severity scores with the addition of the neuropsychiatric and motor domains.A receiver operating characteristic analysis of symptomatic diagnosis showed nominally higher areas under the curve for the new scales.
PubMed: 38623386
DOI: 10.1002/dad2.12571 -
Science Progress 2024In alignment with the distributional hypothesis of language, the work "Quantum Projections on Conceptual Subspaces" (Martínez-Mingo A, Jorge-Botana G, Martinez-Huertas...
In alignment with the distributional hypothesis of language, the work "Quantum Projections on Conceptual Subspaces" (Martínez-Mingo A, Jorge-Botana G, Martinez-Huertas JÁ, et al. Quantum projections on conceptual subspaces. Cogn Syst Res 2023; 82: 101154) proposed a methodology for generating conceptual subspaces from textual information based on previous work (Martinez-Mingo A, Jorge-Botana G and Olmos R. Quantum approach for similarity evaluation in LSA vector space models. 2020). These subspaces enable the utilization of the quantum model of similarity put forth by Pothos and Busemeyer (Pothos E, Busemeyer J. A quantum probability explanation for violations of symmetry in similarity judgments. In , 2011, Vol. 33, No. 33), allowing for the empirical examination of the violations of assumptions concerning symmetry and triangular inequality (Tversky A. Features of similarity. Psychol Rev 1977; 84: 327-352; Yearsley JM, Barque-Duran A, Scerrati E, et al. The triangle inequality constraint in similarity judgments. Prog Biophys Mol Biol 2017; 130: 26-32), as well as the diagnosticity effect (Tversky A. Features of similarity. 1977; 84: 327-352; Yearsley JM, Pothos EM, Barque-Duran A, et al. Context effects in similarity judgments. 2022; 151: 711-717), within a environment. These psychological biases, deeply studied by authors such as Tversky and Kahneman, inform us about the limitations of modeling psychological similarity measures using tools from classical geometry. This commentary aims to offer methodological clarifications, discuss theoretical and practical implications, and speculate on future directions in this field of research. Concretely, it aims to propose the use of different contours (conceptual or contextual) to generate the subspaces, which lead to subspaces of terms or contexts. Once these contours are defined, a differentiation is proposed between (ATSs), (ACSs), and (AFSs) depending on whether we define the subspaces by grouping the terms or contexts within the contour, or from the latent dimensions of the semantic space obtained in the contour window. Finally, new data is provided on the violation of the triangular inequality assumption through the application of the quantum similarity model to ATSs.
PubMed: 38614464
DOI: 10.1177/00368504241238773 -
Cancers Mar 2024(1) Background: The relationship between periodontitis and systemic pathologies continues to grow. Recently, the presence of periodontal pathogens has been linked to an... (Review)
Review
(1) Background: The relationship between periodontitis and systemic pathologies continues to grow. Recently, the presence of periodontal pathogens has been linked to an increased risk of pancreatic cancer (PC) and its mortality. Thus, a systematic review is needed to identify whether an association between the two diseases can be established. The objective of this review is to elucidate the mechanisms responsible for this association. (2) Methods: A systematic review was carried out using three databases (PubMed, Embase and Scopus) with the following keywords "Periodontitis AND pancreatic cancer". A total of 653 articles were retrieved; before selection and screening, the inclusion and exclusion criteria were defined, resulting in a total of 13 articles being included in the review. (3) Results: The increase in low-grade systemic inflammation, pH changes, and the cytotoxicity of certain periodontopathogenic bacteria were found in the scientific literature reviewed as mechanisms linking periodontitis with the risk of PC. (4) Conclusions: Through this systematic review, we have seen how periodontitis can be related to PC and how it worsens its prognosis. Knowing the behavior of periodontopathogenic bacteria and the influence they have on our immune and inflammatory system may help to achieve an interdisciplinary approach to both pathologies.
PubMed: 38610935
DOI: 10.3390/cancers16071257 -
European Journal of Criminology May 2023To compare the observed and forecasted crime trends in Barcelona, using crime statistics from January 2018 to March 2021.
OBJECTIVES
To compare the observed and forecasted crime trends in Barcelona, using crime statistics from January 2018 to March 2021.
METHODS
We trained (seasonal) auto-regressive integrated moving average modelling (95% confidence intervals) using daily recorded crimes from January 2018 to February 2020. These models were then used to forecast crime data from March 2020 to March 2021 across four periods (lockdown, summer, fall and winter). Crime data were organized into two categories: property (burglary, theft) and violent crimes (robbery, assault, domestic violence and sexual offenses [rape, assault or abuse]).
RESULTS
Overall, crime levels for property and violent crimes during lockdown declined sharply from the forecasted levels. Theft, burglary, assault, robbery and sexual offenses exhibited general decreases throughout the study period, with the same sharp declines during the lockdown, progressive recovery in the summer, and steady or slight reductions from fall to March 2021. Only domestic violence differed, reaching the forecasted levels for all periods and surpassing the forecast for summer 2020.
CONCLUSIONS
Our findings show how the pandemic has affected mid-term crime trends. They help to place the measures applied in the last year into context and to determine the most suitable policies to reduce crime during societal change.
PubMed: 38602935
DOI: 10.1177/14773708231156326 -
Anesthesiology Jul 2024Dynamic changes in neuronal activity and in noradrenergic locus coeruleus (LC) projections have been proposed during the transition from acute to chronic pain. Thus, the...
BACKGROUND
Dynamic changes in neuronal activity and in noradrenergic locus coeruleus (LC) projections have been proposed during the transition from acute to chronic pain. Thus, the authors explored the cellular cFos activity of the LC and its projections in conjunction with spontaneous pain-like behavior in neuropathic rats.
METHODS
Tyrosine hydroxylase:Cre and wild-type Long-Evans rats, males and females, were subjected to chronic constriction injury (CCI) for 2 (short-term, CCI-ST) or 30 days (long-term, CCI-LT), evaluating cFos and Fluoro-Gold expression in the LC, and its projections to the spinal cord (SC) and rostral anterior cingulate cortex (rACC). These tests were carried out under basal conditions (unstimulated) and after noxious mechanical stimulation. LC activity was evaluated through chemogenetic and pharmacologic approaches, as were its projections, in association with spontaneous pain-like behaviors.
RESULTS
CCI-ST enhanced basal cFos expression in the LC and in its projection to the SC, which increased further after noxious stimulation. Similar basal activation was found in the neurons projecting to the rACC, although this was not modified by stimulation. Strong basal cFos expression was found in CCI-LT, specifically in the projection to the rACC, which was again not modified by stimulation. No cFos expression was found in the CCI-LT LCipsilateral (ipsi)/contralateral (contra)→SC. Chemogenetics showed that CCI-ST is associated with greater spontaneous pain-like behavior when the LCipsi is blocked, or by selectively blocking the LCipsi→SC projection. Activation of the LCipsi or LCipsi/contra→SC dampened pain-like behavior. Moreover, Designer Receptor Exclusively Activated by Designer Drugs (DREADDs)-mediated inactivation of the CCI-ST LCipsi→rACC or CCI-LT LCipsi/contra→rACC pathway, or intra-rACC antagonism of α-adrenoreceptors, also dampens pain-like behavior.
CONCLUSIONS
In the short term, activation of the LC after CCI attenuates spontaneous pain-like behaviors via projections to the SC while increasing nociception via projections to the rACC. In the long term, only the projections from the LC to the rACC contribute to modulate pain-like behaviors in this model.
Topics: Animals; Locus Coeruleus; Rats; Male; Rats, Long-Evans; Female; Behavior, Animal; Time Factors; Neuralgia; Disease Models, Animal
PubMed: 38602502
DOI: 10.1097/ALN.0000000000005006 -
Internet Interventions Jun 2024Despite the increasing number of mobile-based interventions to quit smoking over the last years, few studies have investigated the efficacy of smoking cessation...
Despite the increasing number of mobile-based interventions to quit smoking over the last years, few studies have investigated the efficacy of smoking cessation interventions blended with smartphone Apps. The present pilot study aims to examine the preliminary effectiveness and acceptability of a cognitive-behavioral treatment combined with a smartphone App, compared to the same psychological treatment without the App. The sample comprised 206 treatment-seeking smokers, who were assigned to: 1) an experimental group receiving a cognitive-behavioral intervention combined with the "Non Fumo" App ( = 102), and 2) a control group receiving only the cognitive-behavioral intervention to quit smoking ( = 104). Results concerning the primary outcomes showed no significant differences between conditions in point-prevalence abstinence rates at 12-month follow-up (35.30 % in the experimental group vs. 31.70 % in the control group) and in treatment acceptability. Regarding the secondary outcomes, both groups obtained similar point-prevalence abstinence rates at the end of treatment (61.80 % vs. 65.40 %), at 3-month (42.20 % vs. 45.20 %, respectively) and 6-month follow-ups (37.30 % vs. 37.50 %). No significant differences were found between conditions in prolonged abstinence rates at 6-month (35.3 % vs. 35.6 %) and 12-month follow-ups (30.4 % vs. 26.9 %). Overall, good abstinence rates and treatment acceptability were obtained, although there were no significant differences between conditions. More research is needed to establish clear conclusions about the efficacy of psychological smoking cessation treatments blended with smartphone Apps.
PubMed: 38596255
DOI: 10.1016/j.invent.2024.100737 -
BMC Public Health Apr 2024Despite multiple recommendations and strategies implemented at a national and international level, cigarette smoking, alcohol consumption, and cannabis use during...
BACKGROUND
Despite multiple recommendations and strategies implemented at a national and international level, cigarette smoking, alcohol consumption, and cannabis use during pregnancy remains high in most countries. The objective of this study was to examine key stakeholders' perception of the treatment interventions adopted in Spain, to identify political, organizational and personal factors associated with successful implementation, and to propose strategies for improvement.
METHODS
A qualitative study with a phenomenological approach was conducted in 2022. The target groups were: (1) clinical decision makers in the field of addiction science, (2) health professionals who carry out treatment interventions, and (3) pregnant individuals who use tobacco, alcohol or cannabis. Two focus groups and eight in-depth interviews were conducted, recorded, and transcribed. Exploratory analysis and inductive open coding was performed, codes were merged into categories, and subcategories were identified.
RESULTS
The analysis resulted in 10 subcategories which were further merged into three main categories: (1) Degree of adoption and utility of treatment interventions implemented; (2) Needs and demands with respect to the organization of treatment interventions; and, (3) Personal barriers to and facilitators for treatment. Respondents reported that despite multiple national and regional cessation initiatives, treatment interventions were rarely adopted in clinical practice. Health care administrators demanded reliable records to quantify substance use for better planning of activities. Health care professionals advocated for additional time and training and both echoed the importance of integrating cessation interventions into routine prenatal care and creating in-house specialized units. The difficulty in quitting, lack of awareness of risk for foetus and child and the controversial advice were identified as barriers by pregnant individuals.
CONCLUSIONS
Consistent with previous work, this study found that cessation strategies implemented by the health authorities are not effective if they are not accompanied by organizational and behavioral changes. The current study identifies a set of factors that could be pivotal in ensuring the success of treatment interventions targeting tobacco, alcohol and cannabis use among pregnant individuals.
Topics: Female; Humans; Pregnancy; Decision Making; Ethanol; Perception; Prenatal Care; Qualitative Research; Smoking Cessation
PubMed: 38594646
DOI: 10.1186/s12889-024-18397-x