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Biomimetics (Basel, Switzerland) Aug 2023The Mayfly Optimization Algorithm (MOA), as a new biomimetic metaheuristic algorithm with superior algorithm framework and optimization methods, plays a remarkable role...
The Mayfly Optimization Algorithm (MOA), as a new biomimetic metaheuristic algorithm with superior algorithm framework and optimization methods, plays a remarkable role in solving optimization problems. However, there are still shortcomings of convergence speed and local optimization in this algorithm. This paper proposes a metaheuristic algorithm for continuous and constrained global optimization problems, which combines the MOA, the Aquila Optimizer (AO), and the opposition-based learning (OBL) strategy, called AOBLMOA, to overcome the shortcomings of the MOA. The proposed algorithm first fuses the high soar with vertical stoop method and the low flight with slow descent attack method in the AO into the position movement process of the male mayfly population in the MOA. Then, it incorporates the contour flight with short glide attack and the walk and grab prey methods in the AO into the positional movement of female mayfly populations in the MOA. Finally, it replaces the gene mutation behavior of offspring mayfly populations in the MOA with the OBL strategy. To verify the optimization ability of the new algorithm, we conduct three sets of experiments. In the first experiment, we apply AOBLMOA to 19 benchmark functions to test whether it is the optimal strategy among multiple combined strategies. In the second experiment, we test AOBLMOA by using 30 CEC2017 numerical optimization problems and compare it with state-of-the-art metaheuristic algorithms. In the third experiment, 10 CEC2020 real-world constrained optimization problems are used to demonstrate the applicability of AOBLMOA to engineering design problems. The experimental results show that the proposed AOBLMOA is effective and superior and is feasible in numerical optimization problems and engineering design problems.
PubMed: 37622986
DOI: 10.3390/biomimetics8040381 -
Annals of Surgery Open : Perspectives... Mar 2023
Comment on: Pancreatectomy With Islet-Autotransplantation As Alternative for Pancreatoduodenectomy in Patients With a High-Risk for Postoperative Pancreatic Fistula: The Jury Is Still Out.
PubMed: 37600874
DOI: 10.1097/AS9.0000000000000247 -
Annals of Surgical Oncology Nov 2023Gastric venous congestion (GVC) after total pancreatectomy (TP) is rarely studied despite its high 5% to 28% incidence and possible association with mortality. This... (Observational Study)
Observational Study
Risk Factors, Management, and Outcome of Gastric Venous Congestion After Total Pancreatectomy: An Underestimated Complication Requiring Standardized Identification, Grading, and Management.
BACKGROUND
Gastric venous congestion (GVC) after total pancreatectomy (TP) is rarely studied despite its high 5% to 28% incidence and possible association with mortality. This study aimed to provide insight about incidence, risk factors, management, and outcome of GVC after TP.
METHODS
This retrospective observational single-center study included all patients undergoing elective TP from 2008 to 2021. The exclusion criteria ruled out a history of gastric resection, concomitant (sub)total gastrectomy for oncologic indication(s) or celiac axis resection, and postoperative (sub)total gastrectomy for indication(s) other than GVC.
RESULTS
The study enrolled 268 patients. The in-hospital major morbidity (Clavien-Dindo grade ≥IIIa) rate was 28%, and the 90-day mortality rate was 3%. GVC was identified in 21% of patients, particularly occurring during index surgery (93%). Intraoperative GVC was managed with (sub)total gastrectomy for 55% of the patients. The major morbidity rate was higher for the patients with GVC (44% vs 24%; p = 0.003), whereas the 90-day mortality did not differ significantly (5% vs 3%; p = 0.406). The predictors for major morbidity were intraoperative GVC (odds ratio [OR], 2.207; 95% confidence interval [CI], 1.142-4.268) and high TP volume (> 20 TPs/year: OR, 0.360; 95% CI, 0.175-0.738). The predictors for GVC were portomesenteric venous resection (PVR) (OR, 2.103; 95% CI, 1.034-4.278) and left coronary vein ligation (OR, 11.858; 95% CI, 5.772-24.362).
CONCLUSIONS
After TP, GVC is rather common (in 1 of 5 patients). GVC during index surgery is predictive for major morbidity, although not translating into higher mortality. Left coronary vein ligation and PVR are predictive for GVC, requiring vigilance during and after surgery, although gastric resection is not always necessary. More evidence on prevention, identification, classification, and management of GVC is needed.
Topics: Humans; Pancreatectomy; Retrospective Studies; Hyperemia; Stomach Neoplasms; Risk Factors; Gastrectomy; Postoperative Complications
PubMed: 37596448
DOI: 10.1245/s10434-023-13847-z -
Communications Biology Aug 2023The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body...
The body temperature of mice is higher at night than during the day. We show here that global deletion of acid-sensing ion channel 1a (ASIC1a) results in lower body temperature during a part of the night. ASICs are pH sensors that modulate neuronal activity. The deletion of ASIC1a decreased the voluntary activity at night of mice that had access to a running wheel but did not affect their spontaneous activity. Daily rhythms of thyrotropin-releasing hormone mRNA in the hypothalamus and of thyroid-stimulating hormone β mRNA in the pituitary, and of prolactin mRNA in the hypothalamus and pituitary were suppressed in ASIC1a mice. The serum thyroid hormone levels were however not significantly changed by ASIC1a deletion. Our findings indicate that ASIC1a regulates activity and signaling in the hypothalamus and pituitary. This likely leads to the observed changes in body temperature by affecting the metabolism or energy expenditure.
Topics: Animals; Mice; Acid Sensing Ion Channels; Body Temperature; Energy Metabolism; Hypothalamus; RNA, Messenger
PubMed: 37591947
DOI: 10.1038/s42003-023-05221-2 -
Annals of Surgical Oncology Nov 2023
PubMed: 37561344
DOI: 10.1245/s10434-023-13979-2 -
ALTEX Jan 2024While the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the...
While the original definition of replacement focuses on the replacement of the use of animals in science, a more contemporary definition focuses on accelerating the development and use of predictive and robust models, based on the latest science and technologies, to address scientific questions without the use of animals. The transition to animal free innovation is on the political agenda in and outside the European Union. The Beyond Animal Testing Index (BATI) is a benchmarking instrument designed to provide insight into the activities and contributions of research institutes to the transition to animal free innovation. The BATI allows participating organizations to learn from each other and stimulates continuous improvement. The BATI was modelled after the Access to Medicine Index, which benchmarks pharmaceutical companies on their efforts to make medicines widely available in developing countries. A prototype of the BATI was field-tested with three Dutch academic medical centers and two universities in 2020-2021. The field test demonstrated the usability and effectiveness of the BATI as a benchmarking tool. Analyses were performed across five different domains. The participating institutes concluded that the BATI served as an internal as well as an external stimulus to share, learn, and improve institutional strategies towards the transition to animal free innovation. The BATI also identified gaps in the development and implementation of 3R technologies. Hence, the BATI might be a suitable instrument for monitoring the effectiveness of policies. BATI version 1.0 is ready to be used for benchmarking at a larger scale.
Topics: Animals; Benchmarking; Animal Testing Alternatives; European Union; Medicine
PubMed: 37560926
DOI: 10.14573/altex.2304161 -
Scientific Reports Aug 2023This study suggests a new nature-inspired metaheuristic optimization algorithm called the red-tailed hawk algorithm (RTH). As a predator, the red-tailed hawk has a...
This study suggests a new nature-inspired metaheuristic optimization algorithm called the red-tailed hawk algorithm (RTH). As a predator, the red-tailed hawk has a hunting strategy from detecting the prey until the swoop stage. There are three stages during the hunting process. In the high soaring stage, the red-tailed hawk explores the search space and determines the area with the prey location. In the low soaring stage, the red-tailed moves inside the selected area around the prey to choose the best position for the hunt. Then, the red-tailed swings and hits its target in the stooping and swooping stages. The proposed algorithm mimics the prey-hunting method of the red-tailed hawk for solving real-world optimization problems. The performance of the proposed RTH algorithm has been evaluated on three classes of problems. The first class includes three specific kinds of optimization problems: 22 standard benchmark functions, including unimodal, multimodal, and fixed-dimensional multimodal functions, IEEE Congress on Evolutionary Computation 2020 (CEC2020), and IEEE CEC2022. The proposed algorithm is compared with eight recent algorithms to confirm its contribution to solving these problems. The considered algorithms are Farmland Fertility Optimizer (FO), African Vultures Optimization Algorithm (AVOA), Mountain Gazelle Optimizer (MGO), Gorilla Troops Optimizer (GTO), COOT algorithm, Hunger Games Search (HGS), Aquila Optimizer (AO), and Harris Hawks optimization (HHO). The results are compared regarding the accuracy, robustness, and convergence speed. The second class includes seven real-world engineering problems that will be considered to investigate the RTH performance compared to other published results profoundly. Finally, the proton exchange membrane fuel cell (PEMFC) extraction parameters will be performed to evaluate the algorithm with a complex problem. The proposed algorithm will be compared with several published papers to approve its performance. The ultimate results for each class confirm the ability of the proposed RTH algorithm to provide higher performance for most cases. For the first class, the RTH mostly got the optimal solutions for most functions with faster convergence speed. The RTH provided better performance for the second and third classes when resolving the real word engineering problems or extracting the PEMFC parameters.
PubMed: 37558724
DOI: 10.1038/s41598-023-38778-3 -
IScience Jul 2023Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the...
Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells. Here we analyzed the expression of galectin-1 and found upregulation of galectin-1 in the extracellular matrix across multiple tumors. Performing an in-depth and dynamic proteomic and phosphoproteomic analysis of human macrophages stimulated with galectin-1, we show that galectin-1 induces a tumor-associated macrophage phenotype with increased expression of key immune checkpoint protein programmed cell death 1 ligand 1 (PD-L1/CD274) and immunomodulator indoleamine 2,3-dioxygenase-1 (IDO1). Galectin-1 induced IDO1 and its active metabolite kynurenine in a dose-dependent manner through JAK/STAT signaling. In a 3D organotypic tissue model system equipped with genetically engineered tumorigenic epithelial cells, we analyzed the cellular source of galectin-1 in the extracellular matrix and found that galectin-1 is derived from epithelial and stromal cells. Our results highlight the potential of targeting galectin-1 in immunotherapeutic treatment of human cancers.
PubMed: 37534161
DOI: 10.1016/j.isci.2023.106984 -
Bone & Joint Open Aug 2023United Classification System (UCS) B2 and B3 periprosthetic fractures in total hip arthroplasties (THAs) have been commonly managed with modular tapered stems. No study...
AIMS
United Classification System (UCS) B2 and B3 periprosthetic fractures in total hip arthroplasties (THAs) have been commonly managed with modular tapered stems. No study has evaluated the use of monoblock fluted tapered titanium stems for this indication. This study aimed to evaluate the effects of a monoblock stems on implant survivorship, postoperative outcomes, radiological outcomes, and osseointegration following treatment of THA UCS B2 and B3 periprosthetic fractures.
METHODS
A retrospective review was conducted of all patients who underwent revision THA (rTHA) for periprosthetic UCS B2 and B3 periprosthetic fracture who received a single design monoblock fluted tapered titanium stem at two large, tertiary care, academic hospitals. A total of 72 patients met inclusion and exclusion criteria (68 UCS B2, and four UCS B3 fractures). Primary outcomes of interest were radiological stem subsidence (> 5 mm), radiological osseointegration, and fracture union. Sub-analysis was also done for 46 patients with minimum one-year follow-up.
RESULTS
For the total cohort, stem osseointegration, fracture union, and stem subsidence were 98.6%, 98.6%, and 6.9%, respectively, at latest follow-up (mean follow-up 27.0 months (SD 22.4)). For patients with minimum one-year of follow-up, stem osseointegration, fracture union, and stem subsidence were 97.8%, 97.8%, and 6.5%, respectively.
CONCLUSION
Monoblock fluted stems can be an acceptable modality for the management of UCS B2 periprosthetic fractures in rTHAs due to high rates of stem osseointegration and survival, and the low rates of stem subsidence, and revision. Further research on the use of this stem for UCS B3 periprosthetic fractures is warranted to determine if the same conclusion can be made for this fracture pattern.
PubMed: 37524356
DOI: 10.1302/2633-1462.48.BJO-2022-0160.R1