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Zeitschrift Fur Rheumatologie May 2024Hughes-Stovin syndrome (HSS) is a systemic inflammatory condition of unknown origin that is considered to be part of the Behçet's syndrome (BS) spectrum. Recurrent... (Review)
Review
Hughes-Stovin syndrome (HSS) is a systemic inflammatory condition of unknown origin that is considered to be part of the Behçet's syndrome (BS) spectrum. Recurrent venous thrombosis and superficial thrombophlebitis in combination with bilateral pulmonary artery aneurysms (PAA) represent the hallmark of HSS. The diagnostic evaluation includes computed tomography pulmonary angiography to detect signs of pulmonary vasculitis. The management of HSS is based on the European Alliance of Associations for Rheumatology (EULAR) recommendations for BS and mainly comprises immunosuppressive therapy with glucocorticoids and cyclophosphamide. In addition to drug therapy, PAA should be evaluated for interventional treatment. Spontaneous PAA rupture due to fragile vessel architecture can occur even in cases of remission and/or PAA regression.
Topics: Humans; Aneurysm; Behcet Syndrome; Diagnosis, Differential; Evidence-Based Medicine; Glucocorticoids; Immunosuppressive Agents; Pulmonary Artery; Thrombophlebitis; Treatment Outcome; Venous Thrombosis
PubMed: 37280333
DOI: 10.1007/s00393-023-01371-0 -
Cureus Apr 2023Superficial thrombophlebitis, also known as superficial venous thrombosis, is an inflammatory condition involving the veins just below the surface of the skin secondary...
Superficial thrombophlebitis, also known as superficial venous thrombosis, is an inflammatory condition involving the veins just below the surface of the skin secondary to clotted blood within that vein. The majority of cases are self-limited or resolve with a short course of anti-inflammatory medications and the application of warm compresses. Due to the self-limited nature of this disease process, clinically significant complications have rarely been described but are being seen more often in recent literature. This case report discusses an instance of superficial thrombophlebitis that occurred secondary to a routine blood draw and progressed to potentially life-threatening deep vein thrombosis. This case highlights the need for physicians to be aware of the potential complications of superficial thrombophlebitis and the importance of delivering strict return precautions to every patient with this condition.
PubMed: 37122971
DOI: 10.7759/cureus.38260 -
Journal of Cutaneous and Aesthetic... 2022
PubMed: 37035593
DOI: 10.4103/JCAS.JCAS_246_20 -
Indian Journal of Dermatology 2022Previous studies have shown that erythema nodosum-like lesions in patients with Behçet's disease show cutaneous vasculitis of either phlebitis or dermal venulitis. To...
Previous studies have shown that erythema nodosum-like lesions in patients with Behçet's disease show cutaneous vasculitis of either phlebitis or dermal venulitis. To analyse the clinicopathological characteristics of superficial thrombophlebitis as well as cutaneous venulitis in Behçet's disease. We re-evaluated the histopathological features of superficial thrombophlebitis in patients with Behçet's disease. Five patients, one man and four women, developed superficial thrombophlebitis on the lower extremities. Two of the patients had vascular Behçet's disease, both also developed deep vein thrombosis. One patient had intestinal Behçet's disease. In all cases, venulitis in the overlying lower dermis or adjacent subcutis spreading from the main affected subcutaneous thrombophlebitis lesions was observed. Both neutrophilic venulitis (n = 2) and lymphocytic venulitis (n = 3) were observed at the same depth level or upper/lower location of the thrombophlebitis in the same specimens. In addition, concurrent venulitis with fibrin thrombus and fibrinoid necrosis was observed in one case, suggesting that fibrin thrombus affected both venules and muscular veins. By contrast, arteritis or arteriolitis at the same depth level was not observed. Our results showed histopathological features of coexistent thrombophlebitis and venulitis without involvement of either arteries or arterioles in the biopsied specimens of superficial thrombophlebitis. Further studies are necessary to support that those unique histopathological findings are the characteristic features and significant diagnostic indicators of Behçet's disease.
PubMed: 36998880
DOI: 10.4103/ijd.ijd_229_22 -
European Journal of Vascular and... Jun 2023
Topics: Humans; Thrombophlebitis; Foreign Bodies
PubMed: 36958481
DOI: 10.1016/j.ejvs.2023.03.031 -
Cureus Nov 2022A 60-year-old male patient presented to the emergency department of our hospital with right-sided chest wall pain and a palpable subcutaneous cord-like structure along...
A 60-year-old male patient presented to the emergency department of our hospital with right-sided chest wall pain and a palpable subcutaneous cord-like structure along the right anterior chest wall. Examination revealed tenderness over the cord-like structure, and the skin overlying the structure was freely mobile and did not have any sign of infection or inflammation. Bedside ultrasonography revealed an uncompressible tubular structure with the absence of a color Doppler flow signal. The patient's presentation was suggestive of Mondor's disease. The patient was discharged with instructions to utilize anti-inflammatory drugs, perform warm compresses, and seek primary care follow-up to ensure resolution. Mondor's disease is a rare disorder characterized by a superficial thrombophlebitis of the subcutaneous veins of the chest wall. For its diagnosis, a thorough examination of the patient's medical history and physical condition is suggested; further, the performance of point-of-care ultrasonography has also been suggested. Once recognized, further emergency department workup is typically unnecessary in cases of primary Mondor's disease. Despite being a mostly self-limited condition, greater awareness of this rare disease entity is required to ensure and coordinate close outpatient follow-up as well as monitor resolution due to its association with secondary causes such as vascular and breast carcinoma, vasculitis, and hypercoagulable disorders.
PubMed: 36579201
DOI: 10.7759/cureus.31894