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Human Vaccines & Immunotherapeutics Dec 2023Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and...
Since March 2020, the pandemic caused by SARS-CoV-2 has affected nearly all aspects of daily life. In this study, we investigated the age-stratified prevalence and genotype distribution of human papillomavirus (HPV) among females in Shandong province (eastern China) and aimed to provide guidance on HPV-based cervical cancer screening and vaccination. The distribution of HPV genotypes was analyzed using PCR-Reverse Dot Hybridization. The overall infection rate of HPV was 16.4%, which was dominated by high-risk genotypes. The most prevalent genotype was HPV16 (2.9%), followed by HPV52 (2.3%), HPV53 (1.8%), HPV58 (1.5%), and HPV51 (1.3%). Among the positive cases with HPV infection, single-genotype infection was significantly higher than that of multi-genotype infection. In subgroup analyses by age (≤25, 26-35, 36-45, 46-55, >55), HPV16, 52, and 53 were consistently the three most common hrHPV genotypes in all age groups. The infection rate of multi-genotypes in the ≤25 and >55 age groups was significantly higher than that in other age groups. A bimodal distribution of HPV infection rate was observed in different age groups. Among lrHPV genotypes, HPV6, HPV11, and HPV81 were the three most common types in the ≤25 age group, while in other age groups, HPV81, HPV42, and HPV43 are the three most common lrHPV genotypes. This study provides basic information on the distribution and genotypes of HPV in the female population in eastern China, which could improve the application of HPV diagnostic probes and vaccines.
Topics: Humans; Female; Uterine Cervical Neoplasms; Papillomavirus Infections; Human Papillomavirus Viruses; Pandemics; Prevalence; Early Detection of Cancer; COVID-19; SARS-CoV-2; Genotype; Papillomaviridae; Human papillomavirus 16; China
PubMed: 37226673
DOI: 10.1080/21645515.2023.2212571 -
The Eurasian Journal of Medicine Jun 2023Controversy exists around the world as experts disagree on what artificial intelligence will imply for humanity in the future. Medical experts are starting to share...
Anesthesiologists' Perspective on the Use of Artificial Intelligence in Ultrasound-Guided Regional Anaesthesia in Terms of Medical Ethics and Medical Education: A Survey Study.
OBJECTIVE
Controversy exists around the world as experts disagree on what artificial intelligence will imply for humanity in the future. Medical experts are starting to share perspectives on artificial intelligence with ethical and legal concerns appearing to prevail. The purpose of this study was to determine how anesthesiology and reanimation specialists in Turkey perceive the use of artificial intelligence in ultrasound-guided regional anesthetic applications in terms of medical ethics and education, as well as their perspectives on potential ethical issues.
MATERIALS AND METHODS
This descriptive and cross-sectional survey was conducted across Turkey between July 1 and August 31. Data were collected through an online questionnaire distributed by national associations and social media platforms. The questionnaire included questions about the descriptive features of the participants and the possible ethical problems that may be encountered in the use of artificial intelligence in regional anesthesia and 20 statements that were requested to be evaluated.
RESULTS
The average age of the 285 anesthesiologists who took part in the study was 42.00 ± 7.51, 144 of them were male, the average years spent in the field was 10.95 ± 7.15 years, 59.3% were involved in resident training, and 74.7% habitually used ultrasound guidance regional anesthetic applications. Of the participants, 80% thought artificial intelligence would benefit patients, 86.7% thought it would benefit resident training, 81.4% thought it would benefit post-graduate medical education, and 80.7% thought it would decrease complications in practice. There will be no ethical issues if sonographic data are captured anonymously, according to 78.25%, while 67% are concerned about who will be held accountable for inaccuracies.
CONCLUSION
The majority of anesthetists believe that using artificial intelligence in regional anesthetic applications will decrease complications. Although ethical concerns about privacy and data governance are low, participants do have ethical worries about "accountability for errors."
PubMed: 37161553
DOI: 10.5152/eurasianjmed.2023.22254 -
Psychology Research and Behavior... 2023Based on the interpersonal theory of depression and resilience framework theory, this study tested the association between interpersonal sensitivity and depression in...
PURPOSE
Based on the interpersonal theory of depression and resilience framework theory, this study tested the association between interpersonal sensitivity and depression in college students in the context of the COVID-19 pandemic. Additionally, the mediating role of resilience and the moderating role of the COVID-19 lockdown were investigated.
METHODS
A total of 5193 South Chinese college students (M=19.27, SD = 1.18) were included in the study. According to which campus they were living on, the subjects were categorized as members of a lockdown group or a nonlockdown group. They completed the interpersonal sensitivity subscales of the Symptom Checklist 90 (SCL-90), Beck Depression Inventory (BDI), and Connor-Davidson Resilience Scale (CD-RISC). SPSS 26.0 statistical software was used to analyse the descriptive statistics, reliability, and correlation. Specifically, a moderated mediation model was analysed by multivariate logistic regression.
RESULTS
Interpersonal sensitivity was significantly associated with depression ( = 0.517, < 0.01), which was mediated by resilience ( = 0.12, 95% CI = [0.10, 0.13]). Lockdown status was shown to have a moderating effect on the relationship between resilience and depression ( = 0.03, = 2.71, < 0.01).
CONCLUSION
The high levels of interpersonal sensitivity displayed by South Chinese college students caused low resilience and then facilitated depression. The COVID-19 lockdown strengthened the effect of low resilience on depression. Lower resilience was more strongly associated with higher depression for students under lockdown conditions compared to students who were not in lockdown.
PubMed: 37095846
DOI: 10.2147/PRBM.S407430 -
Patient Education and Counseling Jul 2023To identify and synthesise the experiences and benefits of addressing vocational issues in the provision of healthcare for young people (YP) with long-term conditions... (Review)
Review
Addressing education and employment outcomes in the provision of healthcare for young people with physical long-term conditions: A systematic review and mixed methods synthesis.
OBJECTIVE
To identify and synthesise the experiences and benefits of addressing vocational issues in the provision of healthcare for young people (YP) with long-term conditions (LTCs).
METHODS
We searched 10 bibliographic databases. Restrictions were applied on publication date (1996-2020) and language (English). Two reviewers independently screened records against eligibility criteria. Articles reporting relevant qualitative and/or quantitative research were included. Quality appraisal was undertaken following study selection. Qualitative data were synthesised thematically, and quantitative data narratively. A cross-study synthesis integrated qualitative and quantitative findings.
RESULTS
43 articles were included. Thematic synthesis of qualitative studies (n = 23) resulted in seven recommendations for intervention (psychological support; information/signposting; skills training; career advice; healthcare-school/workplace collaboration; social support; flexible/responsive care). The narrative synthesis summarised results of 17 interventions (n = 20 quantitative studies). The cross-study synthesis mapped interventions against recommendations. Transitional care was the intervention type that most comprehensively met our proposed recommendations.
CONCLUSIONS
Evidence from YP perspectives highlights that vocational development is an important area to address in healthcare provision. Robust intervention studies in this area are lacking.
PRACTICE IMPLICATIONS
Our evidence-based recommendations for intervention can support health professionals to better address vocational issues/outcomes. With minimal adaptations, transitional care interventions would be particularly well suited to deliver this.
Topics: Humans; Adolescent; Health Personnel; Educational Status; Social Support; Workplace; Delivery of Health Care
PubMed: 37086594
DOI: 10.1016/j.pec.2023.107765 -
Molecules (Basel, Switzerland) Mar 2023The development of Dai medicine is relatively slow, and has great economic and medicinal value. It is still difficult to obtain medicinal components from the...
Bioactivity-Guided High Performance Counter-Current Chromatography and Following Semi-Preparative Liquid Chromatography Method for Rapid Isolation of Anti-Inflammatory Lignins from Dai Medicinal Plant, var. .
The development of Dai medicine is relatively slow, and has great economic and medicinal value. It is still difficult to obtain medicinal components from the low-polarity parts of belonging to Dai medicine. In this study, we introduced one simple and quick strategy of separating target compounds from the barks of var. by high-performance countercurrent chromatography (HPCCC) with an off-line anti-inflammatory activity screening mode. The development of this strategy was based on the TLC-based generally useful estimation of solvent systems (GUESS) method and HPCCC in combination. This paper presented a rapid method for obtaining target anti-inflammatory compounds. Three lignins were enriched by HPCCC with an off-line inhibition mode of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophage cells, using petroleum ether-ethyl acetate-methanol-water (3:2:3:2) as the solvent system. The results showed that this method was simple and practical and could be applied to trace the anti-inflammatory components of the low-polarity part in Dai medicine.
Topics: Countercurrent Distribution; Lignin; Plants, Medicinal; Zanthoxylum; Chromatography, High Pressure Liquid; Anti-Inflammatory Agents; Solvents; Plant Extracts
PubMed: 36985565
DOI: 10.3390/molecules28062592 -
International Journal of Environmental... Mar 2023This research has been conducted to determine the effect of tourists' beliefs of climate change on the NEP and ecotourism attitudes. In addition to this purpose, the...
This research has been conducted to determine the effect of tourists' beliefs of climate change on the NEP and ecotourism attitudes. In addition to this purpose, the moderator role of green self-identity in the effect of the NEP on ecological attitudes has also been examined. The research data were obtained from the tourists visiting the Alanya destination, which is one of the centers that attract the most tourists in Turkey. When the results of the research were examined, it could be determined that the belief in climate change is effective on all dimensions of the NEP, and similarly, all dimensions of the NEP have also affected the tourists' ecological attitude. Further, green self-identity has a moderator role in the effect of ecocentric and anthropocentric sub-dimensions on eco-tourism attitudes. As a consequence of the findings, a number of theoretical and practical implications have been developed for sector managers, destination management organizations, and academicians.
Topics: Tourism; Climate Change; Attitude; Medical Tourism; Turkey
PubMed: 36981873
DOI: 10.3390/ijerph20064967 -
Behavioral Sciences (Basel, Switzerland) Mar 2023Adolescents who have to make decisions regarding their future career or academic path can be greatly influenced by parental expectations and other individual and...
Adolescents who have to make decisions regarding their future career or academic path can be greatly influenced by parental expectations and other individual and contextual factors. The aim of this study is to explore the impact of adolescent-parent career congruence on adolescents' well-being and future intention to enroll in a university course. The recruitment of participants took place through a combination of convenience sampling and snowball sampling. A sample of 142 high school students who are managing their decisions for the future completed an online questionnaire. Data were analyzed through a path analysis (SEM) with observed variables, and different indices were evaluated to check the model goodness of fit. The data show that congruence with parents' wishes has a significant effect on academic motivation, work hope and mattering, which in turn have a positive and significant effect on both future intentions to undertake university studies and on the participants' occupational well-being. In line with past studies, our results demonstrate correlations between adolescent-parent career congruence in career exploration and decision making, pointing out in particular the influence due to complementary congruence with mothers. Furthermore, our study underscores the important role played by both individual and contextual factors in adolescent well-being and intentions for their future. Finally, implications for the practice of vocational guidance practitioners are discussed.
PubMed: 36975258
DOI: 10.3390/bs13030233 -
Journal of Molecular Modeling Mar 2023The COVID-19 epidemic is raging around the world, with the emergence of viral mutant strains such as Delta and Omicron, posing severe challenges to people's health...
OBJECTIVE
The COVID-19 epidemic is raging around the world, with the emergence of viral mutant strains such as Delta and Omicron, posing severe challenges to people's health and quality of life. A full understanding life cycle of the virus in host cells helps to reveal inactivation mechanism of antibody and provide inspiration for the development of a new-generation vaccines.
METHODS
In this work, molecular recognitions and conformational changes of SARS-CoV-2 spike protein mutants (i.e., Delta, Mu, and Omicron) and three essential partners (i.e., membrane receptor hACE2, protease TMPRSS2, and antibody C121) both were compared and analyzed using molecular simulations.
RESULTS
Water basin and binding free energy calculations both show that the three mutants possess higher affinity for hACE2 than WT, exhibiting stronger virus transmission. The descending order of cleavage ability by TMPRSS2 is Mu, Delta, Omicron, and WT, which is related to the new S1/S2 cutting site induced by transposition effect. The inefficient utilization of TMPRSS2 by Omicron is consistent with its primary entry into cells via the endosomal pathway. In addition, RBD-directed antibody C121 showed obvious resistance to Omicron, which may have originated from high fluctuation of approaching angles, high flexibility of I472-F490 loop, and reduced binding ability.
CONCLUSIONS
According to the overall characteristics of the three mutants, high infectivity, high immune escape, and low virulence may be the future evolutionary selection of SARS-CoV-2. In a word, this work not only proposes the possible resistance mechanism of SARS-CoV-2 mutants, but also provides theoretical guidance for the subsequent drug design against COVID-19 based on S protein structure.
Topics: Humans; COVID-19; Quality of Life; SARS-CoV-2; Spike Glycoprotein, Coronavirus; Mutation
PubMed: 36964244
DOI: 10.1007/s00894-023-05509-4 -
Systematic Reviews Mar 2023Comfort is a primary patient objective and central to patient experience, and thus, maximising comfort is a universal goal for healthcare. However, comfort is a complex...
BACKGROUND
Comfort is a primary patient objective and central to patient experience, and thus, maximising comfort is a universal goal for healthcare. However, comfort is a complex concept that is difficult to operationalise and evaluate, resulting in a lack of scientific and standardised comfort care practices. The Comfort Theory developed by Kolcaba has been the most widely known for its systematisation and projection and most of the global publications regarding comfort care were based on this theory. To develop international guidance on theory-informed comfort care, a better understanding about the evidence on the effects of interventions guided by the Comfort Theory is needed.
OBJECTIVES
To map and present the available evidence on the effects of interventions underpinned by Kolcaba's Comfort theory in healthcare settings.
METHODS
The mapping review will follow Campbell Evidence and Gap Maps guideline and Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews Protocols guidelines. An intervention-outcome framework has been developed based on Comfort Theory and the classification of pharmacological and non-pharmacological interventions via consultation with stakeholders. Eleven electronic databases (MEDLINE, CINAHL, PsycINFO, Embase, AMED, Cochrane Library, JBI Library of Systematic Reviews, Web of Science, Scopus, CNKI and Wan Fang) and grey literature sources (Google Scholar, Baidu Scholar and The Comfort Line) will be searched for primary studies and systematic reviews between 1991 and 2023 written in English and Chinese as the papers regarding Comfort Theory were first published in 1991. Additional studies will be identified by reference list review of included studies. Key authors will be contacted for unpublished or ongoing studies. Two independent reviewers will screen and extract data using piloted forms with discrepancies resolved by discussion with a third reviewer. A matrix map with filters of study characteristics will be generated and presented through software of EPPI-Mapper and NVivo.
DISCUSSION
More informed use of theory can strengthen improvement programmes and facilitate the evaluation of their effectiveness. Findings from the evidence and gap map will present the existing evidence base for researchers, practitioners and policy-makers and inform further research as well as clinical practices aiming at patients' comfort enhancement.
Topics: Adult; Humans; Databases, Factual; Treatment Outcome; Quality Assurance, Health Care
PubMed: 36879339
DOI: 10.1186/s13643-023-02202-8 -
Frontiers in Psychology 2023Student engagement is a best predictor variable of student' development and success. It can be highly influenced by internal and external environmental factors, such as...
INTRODUCTION
Student engagement is a best predictor variable of student' development and success. It can be highly influenced by internal and external environmental factors, such as perceived teacher support.
METHODS
In order to explore the influence of perceived teacher support on student engagement among higher vocational students, this study conducted a questionnaire on 1,136 Chinese higher vocational students using perceived teacher support, basic psychological needs satisfaction, learning drive, student engagement and Optimistic attributional styles for explaining positive events (OAS_P) five scales.
RESULTS
The results show that: (1) Perceived teacher support can't indirectly predict the student engagement among higher vocational students through basic psychological needs satisfaction; (2) Perceived teacher support can indirectly predict student engagement through learning drive; (3) Perceived teacher support can indirectly predict student engagement through basic psychological needs satisfaction and learning drive; (4) OAS_P has a significant moderation effect on both learning drive and student engagement.
DISCUSSION
The finding of this study stated that perceived teacher support has a significant influence on student engagement. So in the teaching process, teachers should pay attention to their learning psychology, provide them with various support and encouragement and beneficial guidance, stimulate their learning drive, help them form a positive and optimistic attribution style, and make them actively participate in learning and school life.
PubMed: 36874858
DOI: 10.3389/fpsyg.2023.1116932