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Microbial Pathogenesis Apr 2019Legionella pneumophila is the main cause for community-acquired pneumonia especially in hospital environments. In this systematic review and meta-analysis, we evaluated... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Legionella pneumophila is the main cause for community-acquired pneumonia especially in hospital environments. In this systematic review and meta-analysis, we evaluated the prevalence of L. pneumophila in clinical samples obtained from Iranian patients.
METHODS
The studies reporting L. pneumophila prevalence in Iranian clinical samples that were published between January 2000 and July 2016 were recruited. Comprehensive Meta-Analysis Software (version 3.3.070) was used for quantitative data analysis. Because of high heterogeneity between the studies according to the Cochrane Q and I statistics, a random-effects model was used for meta-analysis.
RESULTS
Sixteen studies encompassing 1956 subjects were included in the meta-analysis. The overall prevalence of L. pneumophila was 9.6% in clinical samples obtained from the Iranian patients. The age spectrum ranged from 6 months to 80 years old. Dyspnea and cough comprised the most common clinical manifestations. In the subgroup analysis, the prevalence of L. pneumophila was higher in studies with sample size ≤100 (12.9%) in comparison with studies with sample size >100 (8.4%). In addition, the prevalence of L. pneumophila was higher in the years 2009-2016 (9.2%) compared with 2000-2008 (0.7%).
CONCLUSION
L. pneumophila is a major cause of community- and hospital-acquired pneumonia. It is of pivotal importance to implement sensitive and reliable molecular and culture-based techniques to detect and control this infection in healthcare environments.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Community-Acquired Infections; Cross Infection; Female; Humans; Infant; Iran; Legionella pneumophila; Legionnaires' Disease; Male; Middle Aged; Prevalence; Young Adult
PubMed: 30738817
DOI: 10.1016/j.micpath.2019.02.008 -
Ciencia & Saude Coletiva Mar 2019The scope of this paper is to review the available scientific literature about the effects on health of occupational exposure to Legionella spp. A systematic review of...
The scope of this paper is to review the available scientific literature about the effects on health of occupational exposure to Legionella spp. A systematic review of the scientific literature retrieved from the MEDLINE (via PubMed), ISI-Web of Science (Institute for Scientific Information), Cochrane Library, LILCAS and SCOPUS databases through February 2015 was conducted. The key words used were ««Legionnaires' Disease» «Legionellosis» «Occupational Exposure» «Occupational Diseases». Two hundred and twenty-two references were retrieved of which, after applying inclusion/exclusion criteria, 13 complete articles were selected. Of these, 9 describe pneumonia, 4 list Pontiac Fever, 1 reveals legionellosis and 3 result in death. The main causative agent of disease in workers exposed was Legionella pneumophila serogroup 1. Legionella spp infection is closely related to professions where there is nebulization with water, mainly among workers subjected to long exposure or even re-exposure. Outbreaks occurs seasonally, especially in the hottest months.
Topics: Adult; Disease Outbreaks; Humans; Legionella; Legionella pneumophila; Legionellosis; Legionnaires' Disease; Occupational Diseases; Occupational Exposure; Water Microbiology
PubMed: 30892501
DOI: 10.1590/1413-81232018243.29272016