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Medicine Nov 2022Philadelphia chromosome (Ph) positive myelodysplastic syndrome (MDS) is a very rare disease. At present, the specific role of Ph in MDS is not clear, but such patients...
INTRODUCTION
Philadelphia chromosome (Ph) positive myelodysplastic syndrome (MDS) is a very rare disease. At present, the specific role of Ph in MDS is not clear, but such patients seem to have a poor prognosis, so the disease deserves attention. Here, we describe the history of a woman with Ph-positive MDS and perform a systematic review of related literature.
PATIENT CONCERNS AND DIAGNOSIS
We report a 38-year-old woman with Ph-positive MDS.
INTERVENTIONS AND OUTCOMES
She received chemotherapy with decitabine, cytarabine, aclarubicin, and granulocyte colony-stimulating factor (DCAG) combined with imatinib mesylate and achieved a bone marrow remission. She then underwent an allogeneic hematopoietic stem cell transplant. The condition is good and no recurrence of the disease has been observed.
CONCLUSION
Ph-positive MDS is a very rare disease. Ph may aid in the malignant progression of MDS leaving such patients with a very poor prognosis. Tyrosine kinase inhibitors (TKIs) plus chemotherapy followed by allogeneic hematopoietic stem cell transplantation has provided these patients with satisfactory outcomes.
Topics: Humans; Female; Adult; Philadelphia Chromosome; Transplantation, Homologous; Rare Diseases; Myelodysplastic Syndromes; Hematopoietic Stem Cell Transplantation
PubMed: 36401464
DOI: 10.1097/MD.0000000000031874