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The Journal of Clinical Pediatric... 2014Methods of systematic review and meta analysis were employed to compare the success rate of pulpotomy of primary molars using mineral trioxide aggregate (MTA) and ferric... (Comparative Study)
Comparative Study Meta-Analysis Review
OBJECTIVE
Methods of systematic review and meta analysis were employed to compare the success rate of pulpotomy of primary molars using mineral trioxide aggregate (MTA) and ferric sulfate (FS) as two regenerative and preservative agents, respectively.
STUDY DESIGN
After raising a PICO question (In pulpotomy of vital carious-exposed primary molars, how does MTA compare to FS in terms of clinical and radiographic outcomes?) and determining the search strategy, MeSH-matching keywords were searched in four electronic databases and retrieved papers were examined in titles, and if necessary abstracts and full texts, to be relevant. Randomized clinical trials (RCTs) evaluating pulpotomy of vital primary molars after carious/traumatic exposure conducted with either FS or MTA, with at least a 6-month recall, tooth restorability, and those considering clinical and radiographic signs/symptoms, were included. The nonrandomized allocation and absence of comparison between the treatment groups caused the exclusion of the article. The quality of the RCTs and also their risk of bias (low, moderate, high), were assessed using a modification of van Tulder list; for meta-analysis of the matching studies, the extracted data were analyzed by Mantel Hanszel analysis.
RESULTS
A total number of 620 articles were found. After exclusion of the common titles and application of the eligibility criteria, 4 RCTs [12-month follow-up: n=3, 24-month follow-up: n=4, in total: 264 teeth) comparing MTA and FS, were selected. It was showed that the 12-month outcome of both materials were similar [RR= 0.642 (CI 95%: 0.225-1.833, P=0.407)], while the two-year follow-up results revealed significant differences in treatment outcome, in favor of MTA [RR was 0.300 (CI 95%: 0.132-0.683, P=0.004)].
CONCLUSION
MTA demonstrated superior long-term treatment outcomes in pulpotomy of primary molars than FS.
Topics: Aluminum Compounds; Calcium Compounds; Dental Pulp Exposure; Drug Combinations; Ferric Compounds; Humans; Molar; Oxides; Pulp Capping and Pulpectomy Agents; Pulpotomy; Randomized Controlled Trials as Topic; Silicates; Tooth, Deciduous; Treatment Outcome
PubMed: 25631717
DOI: 10.17796/jcpd.39.1.b454r616m2582373 -
Journal of Applied Oral Science :... 2023Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as... (Meta-Analysis)
Meta-Analysis
BACKGROUND
Osteogenesis imperfecta (OI) is a rare genetic disorder primarily caused by mutations in the genes involved in the production of type 1 collagen. OI is also known as brittle bone disease.
OBJECTIVE
This study aims to describe the prevalence of dental anomalies (except dentinogenesis imperfecta) in individuals with OI, and compare the prevalence of dental anomalies between individuals with and without OI and between individuals with different types of OI.
SEARCH METHODS
Searches in PubMed, Web of Science, Scopus, Ovid, and gray literature were performed in October 2022.
SELECTION CRITERIA
Observational studies (with or without a comparison group) that evaluated the prevalence of dental anomalies in individuals with OI. Data collection and analysis: Data items were extracted by two authors. Quality assessment employing the Joanna Briggs Institute checklists and meta-analyses was conducted. Results were provided in prevalence values and odds ratio (OR) / 95% confidence interval (CI). Strength of evidence was determined.
RESULTS
Eighteen studies were included. Most prevalent dental anomalies in individuals with OI included pulp obliteration (46.4%), dental impaction (33.5%), dental impaction of second molars (27%), and tooth agenesis (23.9%). Individuals with OI type III/IV had 20.16-fold greater chance of exhibiting tooth discoloration in comparison with individuals with OI type I (CI: 1.10-370.98). In comparison with the group without OI, the individuals with OI had 6.90-fold greater chance of exhibiting dental impaction (CI: 1.54-31.00). High methodological quality was found in 47% of the studies. Strength of evidence was low or very low.
CONCLUSIONS
Pulp obliteration, dental impaction, and tooth agenesis were the most prevalent dental anomalies in the OI group. Individuals with OI were more likely to have dental impaction than individuals without OI. Individuals with OI type III/IV (severe-moderate) are more likely to have tooth discoloration than individuals with OI type I (mild).
Topics: Humans; Osteogenesis Imperfecta; Prevalence; Tooth Discoloration
PubMed: 37672427
DOI: 10.1590/1678-7757-2023-0040 -
Oral Health & Preventive Dentistry Nov 2022To identify and assess any changes in the pulp tissue complex following orthodontic force application. (Meta-Analysis)
Meta-Analysis
Changes in the Pulp Tissue Complex Induced by Orthodontic Forces: Is There a Need for Concern? A Systematic Review and Meta-Analysis of RCTs and Prospective Clinical Trials.
PURPOSE
To identify and assess any changes in the pulp tissue complex following orthodontic force application.
MATERIALS AND METHODS
Published and unpublished literature was searched in seven databases until 9 August 2022 for randomised controlled trials (RCTs) and prospective trials (nR-PCT). Representative key words included 'pulp response', 'pulp tissue', 'orthodontic force', and 'tooth movement'. Study selection, data extraction, risk of bias and certainty of evidence assessment were conducted independently by two reviewers. Random effects meta-analyses with respective confidence intervals (95%CIs) were conducted where applicable.
RESULTS
A total of 363 records were screened, a final number of 24 articles were eligible for qualitative synthesis, while 8 of those contributed to meta-analyses. There was evidence that pulpal blood flow (PBF) decreased after 3 weeks of tooth movement compared to no force application (4 studies, mean difference: -1.68; 95% CI: -3.21, -0.15; p = 0.03). However, this was not the case after 6 months of treatment (p = 0.68). A rise in the activity of aspartate aminotransferase (AST) was detected after 7 days of treatment, but combining 2 studies, this was not statistically significant (p = 0.25). Other outcomes were assessed through single studies. Risk of bias was within the range of 'some concerns/moderate to high/critical overall', while certainty of evidence was low to very low according to GRADE.
CONCLUSIONS
As a short-term effect, PBF decreased upon initiation of orthodontic force application, while enzymatic and peptide activity within the pulp was transiently affected. Further long-term evidence of improved quality and certainty is needed.
Topics: Humans; Dental Pulp; Tooth Movement Techniques
PubMed: 36346338
DOI: 10.3290/j.ohpd.b3556039 -
Stomatologija 2018The objective of this article was to conduct a systematic literature review about the consequences and recovery of dental roots' and surrounding structures' after...
The objective of this article was to conduct a systematic literature review about the consequences and recovery of dental roots' and surrounding structures' after iatrogenic mini implant (MI) contact based on peer reviewed publications of 2008-2017 January. The Cochrane and PRISMA references were used while searching for scientific literature in six data bases. The inclusion criteria to select articles were: 1) root contact evaluation associated with the use of orthodontic MI, 2) the diameter of MI was ≤2.5 mm, 3) the research sample was ≥20 MI, 4) the extent of dental root or surrounding structures damage, the regeneration/degeneration and their progress was described, 5) the condition of dental roots and surrounding structures should be evaluated immediately after damage with MI, after longer contact with MI and after a certain period of time, 6) articles published in 2008-2017 January. Two authors independently reviewed and extracted data from the selected studies and a methodological quality assessment process was used to rank the studies classifying them as low, moderate or high quality. 13 articles met the selection criteria of the research. The success of damaged dental root or surrounding structure regeneration was influenced by the damage extent: the cementum, dentin or periodontal ligament may regenerate; the regeneration of damaged pulp is uncertain. The loss of pulp vitality, root resorption, root fracture, ankylosis or osteosclerosis are rare complications. Dental roots may resorb due to contact with MI, but the regeneration is possible after cause removal.
Topics: Animals; Dental Implants; Humans; Orthodontic Anchorage Procedures; Orthodontic Appliance Design; Tooth Root
PubMed: 30531161
DOI: No ID Found -
The Cochrane Database of Systematic... Mar 2016Dental caries (tooth decay) is one of the commonest diseases which afflicts mankind, and has been estimated to affect up to 80% of people in high-income countries.... (Review)
Review
BACKGROUND
Dental caries (tooth decay) is one of the commonest diseases which afflicts mankind, and has been estimated to affect up to 80% of people in high-income countries. Caries adversely affects and progressively destroys the tissues of the tooth, including the dental pulp (nerve), leaving teeth unsightly, weakened and with impaired function. The treatment of lesions of dental caries, which are progressing through dentine and have caused the formation of a cavity, involves the provision of dental restorations (fillings). This review updates the previous version published in 2009.
OBJECTIVES
To assess the effects of adhesive bonding on the in-service performance and longevity of dental amalgam restorations.
SEARCH METHODS
We searched the Cochrane Oral Health Group Trials Register (to 21 January 2016), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2015, Issue 12), MEDLINE via Ovid (1946 to 21 January 2016) and EMBASE via Ovid (1980 to 21 January 2016). We also searched the US National Institutes of Health Trials Registry (http://clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (www.who.int/ictrp/search/en) (both to 21 January 2016) for ongoing trials. No restrictions were placed on the language or date of publication when searching the electronic databases.
SELECTION CRITERIA
Randomised controlled trials comparing adhesively bonded versus traditional non-bonded amalgam restorations in conventional preparations utilising deliberate retention, in adults with permanent molar and premolar teeth suitable for Class I and II amalgam restorations only.
DATA COLLECTION AND ANALYSIS
Two review authors independently screened papers, extracted trial details and assessed the risk of bias in the included study.
MAIN RESULTS
One trial with 31 patients who received 113 restorations was included. At two years, 50 out of 53 restorations in the non-bonded group survived, and 55 of 60 bonded restorations survived with five unaccounted for at follow-up. Post-insertion sensitivity was not significantly different (P > 0.05) at baseline or two-year follow-up. No fractures of tooth tissue were reported and there was no significant difference between the groups or matched pairs of restorations in their marginal adaptation (P > 0.05).
AUTHORS' CONCLUSIONS
There is no evidence to either claim or refute a difference in survival between bonded and non-bonded amalgam restorations. This review only found one under-reported trial. This trial did not find any significant difference in the in-service performance of moderately sized adhesively bonded amalgam restorations, in terms of their survival rate and marginal integrity, in comparison to non-bonded amalgam restorations over a two-year period. In view of the lack of evidence on the additional benefit of adhesively bonding amalgam in comparison with non-bonded amalgam, it is important that clinicians are mindful of the additional costs that may be incurred.
Topics: Adult; Dental Amalgam; Dental Bonding; Dental Caries; Dental Restoration Failure; Dental Restoration, Permanent; Humans
PubMed: 26954446
DOI: 10.1002/14651858.CD007517.pub3 -
International Journal of Clinical and... 2015Direct pulp capping is one of the most common dental practices in endodontic therapy. This systematic review and meta-analysis aim to determine whether the effect of... (Review)
Review
Direct pulp capping is one of the most common dental practices in endodontic therapy. This systematic review and meta-analysis aim to determine whether the effect of mineral trioxide aggregate (MTA) and calcium hydroxide for direct pulp capping is different, as measured by the clinical and radiographic analysis. The study list was obtained by searching PubMed, Springer Link, Scopus and Cochrane Database. Only those papers that met the inclusion criteria were analyzed. The results indicated that four studies met the inclusion criteria. Statistically significant difference was found between the success rates of MTA and calcium hydroxide treated teeth that needed direct pulp capping (P=0.002). Clinical assessments of the MTA versus calcium hydroxide for direct pulp capping suggested that MTA was superior to calcium hydroxide in direct pulp capping resulting in a lower failure rate (risk difference 0.1 [95% CI 0.04 to 0.16]). In conclusion, MTA has a higher clinical success rate for direct pulp capping comparing to calcium hydroxide, and might be a suitable replacement for calcium hydroxide.
PubMed: 26770296
DOI: No ID Found -
International Journal of Clinical... 2023The purpose of this systematic review is to describe developments in three-dimensional (3D) cell printing in the formation of dental pulp tissue using polyester as a... (Review)
Review
OBJECTIVE
The purpose of this systematic review is to describe developments in three-dimensional (3D) cell printing in the formation of dental pulp tissue using polyester as a scaffold to revitalize the damaged dental pulp tissue.
MATERIALS AND METHODS
A literature search for all the data published in PubMed and Google Scholar from January 2000 to April 2022 was conducted. Articles with the keywords 3D cell printing, scaffolds, polyester, dental pulp, and dentistry were used. Inclusion criteria consisted of any publication in electronic or print media directly studying or commenting on the use of polyester scaffolds in 3D cell printing technology in the regeneration of dental pulp. A total of 528 articles were selected, of which 27 duplicates and 286 irrelevant articles were discarded. A total of 215 articles were finally included in the systematic review.
RESULT AND CONCLUSION
For dental pulp regeneration, several scaffolds have been discovered to be appealing. Polylactic acid (PLA), polyglycolic acid (PGA), and their copolymers are nontoxic and biocompatible synthetic polyesters that degrade by hydrolysis and have received Food and Drug Administration (FDA) approval for a variety of applications. This review paper is intended to spark new ideas for using a certain scaffold in a specific regenerative approach to produce the desired pulp-dentin complex.
PubMed: 37496946
DOI: 10.5005/jp-journals-10005-2609 -
International Journal of Clinical... 2019To extract and systematically identify the existing literature on the "Clinical and radiographic outcome of calcium hydroxide vs other agents in indirect pulp capping of... (Review)
Review
AIM
To extract and systematically identify the existing literature on the "Clinical and radiographic outcome of calcium hydroxide vs other agents in indirect pulp capping of primary teeth".
OBJECTIVE
To compare the clinical and radiographic outcome of calcium hydroxide and other agents in indirect pulp capping of primary teeth.
SEARCH STRATEGY
The following databases were searched: PubMed Central, Cochrane Database of Systematic Reviews, Lilacs, Science Direct, Sigle. Bibliographies of clinical studies identified in the electronic search were analyzed for studies published outside the electronically searched journals.
SELECTION CRITERIA
Studies comparing the clinical and radiographic success rate of one or more indirect pulp capping agents with calcium hydroxide in primary molars were included.
RESULTS
The initial search revealed 243 of which only 9 met the inclusion criteria and 234 were excluded based on the exclusion criteria. All the 9 included studies analysed the clinical and radiographic outcome of calcium hydroxide in comparison with other agents in indirect pulp capping of primary teeth.
CONCLUSION
There is a very limited good quality studies estimating the clinical and radiographic outcome of calcium hydroxide in comparison with other agents in indirect pulp capping of primary teeth. The review identified the need for more studies on the clinical and radiographic outcome of calcium hydroxide in comparison with other agents in indirect pulp capping of primary teeth.
HOW TO CITE THIS ARTICLE
Nair M, Gurunathan D. Clinical and Radiographic Outcomes of Calcium Hydroxide vs Other Agents in Indirect Pulp Capping of Primary Teeth: A Systematic Review. Int J Clin Pediatr Dent 2019;12(5):437-444.
PubMed: 32440051
DOI: 10.5005/jp-journals-10005-1672 -
Journal of Oral Biology and... 2020Luxation injuries are one of the most prevalent type traumatic dental injuries in primary dentition. The impact of these injuries may not only be limited to the primary... (Review)
Review
OBJECTIVE
Luxation injuries are one of the most prevalent type traumatic dental injuries in primary dentition. The impact of these injuries may not only be limited to the primary teeth but may also have adverse effects on the developing succedaneous tooth bud resulting in various unfavorable consequences. This systematic review aims at compiling the evidence of available literature regarding luxation injuries to primary teeth, etiology, treatment modalities, outcomes and sequelae on permanent teeth.
METHODOLOGY
Search of PubMed, Google Scholar, Cochrane Database of Systematic Reviews, SCOPUS and LILACS virtual health library was conducted for the literature published from January 1, 2007 to December 31, 2017. Two authors separately reviewed the literature and extracted the data from the included studies.
RESULTS
After screening 224 articles, 13 articles fulfilled the inclusion criteria. Most common etiological factor for injury (up to 44.8%) is fall while walking or running. The unfavorable outcomes which are mostly associated with luxation injuries are pulp canal obliteration ranging from 8.6% to 43.3% and pulp necrosis 8.6% -78.9%. Sequelae on succedaneous teeth vary with a high incidence of white or yellow brown discoloration of enamel (78%) and enamel hypoplasia (7.8%-28.3%).
CONCLUSION
Fall is the most common cause and regular monitoring is recommended for most of the luxated teeth. Pulp canal obliteration, pulp necrosis and tooth loss due to trauma are prevalent complications observed following luxation. White or yellow brown discoloration of enamel and enamel hypoplasia are the most common undesirable sequelae to permanent teeth.
PubMed: 32489826
DOI: 10.1016/j.jobcr.2019.12.001 -
Journal of International Society of... 2021The aim of this study was to systematically review the applications of adipose tissue stem cells (ADSCs) in regenerative dentistry. (Review)
Review
AIM
The aim of this study was to systematically review the applications of adipose tissue stem cells (ADSCs) in regenerative dentistry.
MATERIALS AND METHODS
An electronic search was conducted in Medline (PubMed) and Scopus databases. The original research associated with the role of ADSCs in regeneration of alveolar bone, periodontal ligament (PDL), cementum as well as the dental pulp was evaluated. Among the included studies, three animal studies and one human study had low risk of bias.
RESULTS
A total of 33 relevant studies were included in the review. The animal models, human, and studies revealed that ADSCs had a significant osteogenic differentiation potential. Besides, they had potential to differentiate into PDL, cementum, and dental pulp tissue.
CONCLUSION
The ADSCs may be specifically applied for bone tissue engineering in the management of alveolar bone defects, specifically in dental implants and periodontal disease. However, their role in regeneration of PDL, cementum, and dental pulp requires further investigations. Overall, their applications in regenerative dentistry needs further verification through human clinical trials.
PubMed: 34268188
DOI: 10.4103/jispcd.JISPCD_43_21