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Asian Pacific Journal of Cancer... Jun 2021Although cervical cancer screening has been performed as a national program since 1983 in Japan, the participation rate has remained below 20%. Equity of access is a... (Review)
Review
BACKGROUND
Although cervical cancer screening has been performed as a national program since 1983 in Japan, the participation rate has remained below 20%. Equity of access is a basic requirement for cancer screening. However, taking smears from the cervix has been limited to gynecologists or obstetricians in Japan and it might be a barrier for accessibility. We examined the current access and its available human resources for cervical cancer screening in Japan.
METHODS
We analyzed the number of gynecologists and obstetricians among 47 prefectures based on a national survey. A systematic review was performed to clarify disparity and use of human resources in cervical cancer screening, diagnosis, and treatment for cervical cancers in Japan. Candidate literature was searched using Ovid-MEDLINE and Ichushi-Web until the end of January 2020. Then, a systematic review regarding accessibility to cervical cancer screening was performed. The results of the selected articles were summarized in the tables.
RESULTS
Although the total number of all physicians in Japan increased from 1996 to 2016, the proportion of gynecologists and obstetricians has remained at approximately 5% over the last 2 decades. 43.6% of municipalities have no gynecologists and obstetricians in 2016. Through a systematic review, 4 English articles and 1 Japanese article were selected. From these 5 articles, the association between human resources and participation rates in cervical cancer screening was examined in 2 articles.
CONCLUSIONS
The human resources for taking smears for cervical cancer screening has remained insufficient with a huge disparity among municipalities in Japan. To improve accessibility for cervical cancer screening another option which may be considered could be involving general physicians as potential smear takers.
Topics: Data Analysis; Female; Health Services Accessibility; Humans; Japan; Mass Screening; Uterine Cervical Neoplasms; Vaginal Smears; Workforce
PubMed: 34181323
DOI: 10.31557/APJCP.2021.22.6.1695 -
British Journal of Clinical Pharmacology Sep 2022Linezolid is often used for the infections caused by drug-resistant Gram-positive bacteria. Recent studies suggest that large between-subject variability (BSV) and... (Review)
Review
AIMS
Linezolid is often used for the infections caused by drug-resistant Gram-positive bacteria. Recent studies suggest that large between-subject variability (BSV) and within-subject variability could alter drug pharmacokinetics (PK) during linezolid therapy due to pathophysiological changes. This review synthesized information on linezolid population PK studies and summarized the significant covariates that influence linezolid PK.
METHODS
A literature search was performed using PubMed, Web of Science and Embase from their inception to 30 September 2021. Published studies were included if they contained data analysing linezolid PK parameters in humans using a population approach with a nonlinear mixed-effects model.
RESULTS
Twenty-five studies conducted in adults and five in paediatrics were included. One- and two-compartment models were the commonly used structural models for linezolid. Body size (weight, lean body weight and body surface area), creatinine clearance (CLcr) and age significantly influenced linezolid PK. The median clearance (CL) values (ranges) in infants (0.128 L/h/kg [0.121-0.135]] and children (0.107 L/h/kg [0.088-0.151]] were higher than in adults (0.098 L/h/kg [0.044-0.237]]. For patients with severe renal impairment (CLcr ≤ 30 mL/min), the CL was 37.2% (15.2-55.3%) lower than in patients with normal renal function.
CONCLUSION
The optimal linezolid dosage should be adjusted based on the patient's body size, renal function and age. More studies are needed to explore the exact mechanism of linezolid elimination and evaluate the PK characteristics in paediatric patients.
Topics: Adult; Anti-Bacterial Agents; Child; Humans; Linezolid; Models, Biological; Nonlinear Dynamics; Renal Insufficiency
PubMed: 35484096
DOI: 10.1111/bcp.15368 -
BMC Cancer May 2015Optimising population-based cervical screening policies is becoming more complex due to the expanding range of screening technologies available and the interplay with... (Review)
Review
BACKGROUND
Optimising population-based cervical screening policies is becoming more complex due to the expanding range of screening technologies available and the interplay with vaccine-induced changes in epidemiology. Mathematical models are increasingly being applied to assess the impact of cervical cancer screening strategies.
METHODS
We systematically reviewed MEDLINE®, Embase, Web of Science®, EconLit, Health Economic Evaluation Database, and The Cochrane Library databases in order to identify the mathematical models of human papillomavirus (HPV) infection and cervical cancer progression used to assess the effectiveness and/or cost-effectiveness of cervical cancer screening strategies. Key model features and conclusions relevant to decision-making were extracted.
RESULTS
We found 153 articles meeting our eligibility criteria published up to May 2013. Most studies (72/153) evaluated the introduction of a new screening technology, with particular focus on the comparison of HPV DNA testing and cytology (n = 58). Twenty-eight in forty of these analyses supported HPV DNA primary screening implementation. A few studies analysed more recent technologies - rapid HPV DNA testing (n = 3), HPV DNA self-sampling (n = 4), and genotyping (n = 1) - and were also supportive of their introduction. However, no study was found on emerging molecular markers and their potential utility in future screening programmes. Most evaluations (113/153) were based on models simulating aggregate groups of women at risk of cervical cancer over time without accounting for HPV infection transmission. Calibration to country-specific outcome data is becoming more common, but has not yet become standard practice.
CONCLUSIONS
Models of cervical screening are increasingly used, and allow extrapolation of trial data to project the population-level health and economic impact of different screening policy. However, post-vaccination analyses have rarely incorporated transmission dynamics. Model calibration to country-specific data is increasingly common in recent studies.
Topics: Cost-Benefit Analysis; Early Detection of Cancer; Female; Humans; Uterine Cervical Neoplasms
PubMed: 25924871
DOI: 10.1186/s12885-015-1332-8 -
Journal of General Internal Medicine Mar 2013Low health literacy is considered a potential barrier to improving health outcomes in people with diabetes and other chronic conditions, although the evidence has not... (Review)
Review
BACKGROUND
Low health literacy is considered a potential barrier to improving health outcomes in people with diabetes and other chronic conditions, although the evidence has not been previously systematically reviewed.
OBJECTIVE
To identify, appraise, and synthesize research evidence on the relationships between health literacy (functional, interactive, and critical) or numeracy and health outcomes (i.e., knowledge, behavioral and clinical) in people with diabetes.
METHODS
English-language articles that addressed the relationship between health literacy or numeracy and at least one health outcome in people with diabetes were identified by two reviewers through searching six scientific databases, and hand-searching journals and reference lists.
FINDINGS
Seven hundred twenty-three citations were identified and screened, 196 were considered, and 34 publications reporting data from 24 studies met the inclusion criteria and were included in this review. Consistent and sufficient evidence showed a positive association between health literacy and diabetes knowledge (eight studies). There was a lack of consistent evidence on the relationship between health literacy or numeracy and clinical outcomes, e.g., A1C (13 studies), self-reported complications (two studies), and achievement of clinical goals (one study); behavioral outcomes, e.g., self-monitoring of blood glucose (one study), self-efficacy (five studies); or patient-provider interactions (i.e., patient-physician communication, information exchange, decision-making, and trust), and other outcomes. The majority of the studies were from US primary care setting (87.5 %), and there were no randomized or other trials to improve health literacy.
CONCLUSIONS
Low health literacy is consistently associated with poorer diabetes knowledge. However, there is little sufficient or consistent evidence suggesting that it is independently associated with processes or outcomes of diabetes-related care. Based on these findings, it may be premature to routinely screen for low health literacy as a means for improving diabetes-related health-related outcomes.
Topics: Blood Glucose Self-Monitoring; Diabetes Mellitus; Evidence-Based Medicine; Health Knowledge, Attitudes, Practice; Health Literacy; Humans; Mathematics; Self Care; Treatment Outcome
PubMed: 23065575
DOI: 10.1007/s11606-012-2241-z -
International Journal of Environmental... Jul 2018Positive associations exist between physical activity, cognition, and academic performance in children and adolescents. Further research is required to examine which...
Positive associations exist between physical activity, cognition, and academic performance in children and adolescents. Further research is required to examine which factors underpin the relationships between physical activity and academic performance. This systematic review aimed to identify, critically appraise, and synthesize findings of studies examining relationships between motor proficiency and academic performance in mathematics and reading in typically developing school-aged children and adolescents. A systematic search of electronic databases was performed to identify relevant studies. Fifty-five eligible articles were critically appraised and key data was extracted and synthesized. Findings support associations between several components of motor proficiency and academic performance in mathematics and reading. There was evidence that fine motor proficiency was significantly and positively associated with academic performance in mathematics and reading, particularly during the early years of school. Significant positive associations were also evident between academic performance and components of gross motor proficiency, specifically speed and agility, upper-limb coordination, and total gross motor scores. Preliminary evidence from a small number of experimental studies suggests motor skill interventions in primary school settings may have a positive impact on academic performance in mathematics and/or reading. Future research should include more robust study designs to explore more extensively the impact of motor skill interventions on academic performance.
Topics: Academic Performance; Adolescent; Child; Female; Humans; Male; Mathematics; Motor Skills; Reading
PubMed: 30060590
DOI: 10.3390/ijerph15081603 -
Heliyon Aug 2022The development of science, technology, engineering, and mathematics (STEM) requires more qualified professionals in these fields. However, gender segregation in higher... (Review)
Review
The development of science, technology, engineering, and mathematics (STEM) requires more qualified professionals in these fields. However, gender segregation in higher education in this sector is creating a gender gap that means that for some disciplines female representation does not even reach 30% of the total. In order to propose measures to address the phenomenon, it is necessary to understand the possible causes of this issue. A systematic literature review and mapping were carried out for the study, following the PRISMA guidelines and flowchart. The research questions to be answered were (RQ1) What studies exist on the gender gap in relation to the choice of higher education in the STEM field; and (RQ2) How do gender roles and stereotypes influence decision-making related to higher education? The review of peer-reviewed scientific articles, conferences texts, books and book chapters on the European education area was applied. A total of 4571 initial results were obtained and, after the process marked by the PRISMA flowchart, the final results were reduced to 26. The results revealed that gender stereotypes are strong drivers of the gender gap in general, and the Leaky Pipeline and Stereotype Threat in particular. To narrow the gender gap, it is necessary to focus on influences from the family, the educational environment, and the peer group, as well as from the culture itself. Positive self-concept, self-efficacy, self-confidence, and self-perception need to be fostered, so that the individual chooses their studies according to their goals.
PubMed: 36090203
DOI: 10.1016/j.heliyon.2022.e10300 -
Entropy (Basel, Switzerland) Jun 2023Count time series are widely available in fields such as epidemiology, finance, meteorology, and sports, and thus there is a growing demand for both methodological and... (Review)
Review
Count time series are widely available in fields such as epidemiology, finance, meteorology, and sports, and thus there is a growing demand for both methodological and application-oriented research on such data. This paper reviews recent developments in integer-valued generalized autoregressive conditional heteroscedasticity (INGARCH) models over the past five years, focusing on data types including unbounded non-negative counts, bounded non-negative counts, Z-valued time series and multivariate counts. For each type of data, our review follows the three main lines of model innovation, methodological development, and expansion of application areas. We attempt to summarize the recent methodological developments of INGARCH models for each data type for the integration of the whole INGARCH modeling field and suggest some potential research topics.
PubMed: 37372266
DOI: 10.3390/e25060922 -
Acta Tropica May 2023Schistosoma japonicum remains endemic in China and the Philippines. Substantial progress has been made in the control of Japonicum in both China and the Philippines.... (Review)
Review
BACKGROUND
Schistosoma japonicum remains endemic in China and the Philippines. Substantial progress has been made in the control of Japonicum in both China and the Philippines. China is reaching elimination thanks to a concerted effort of control strategies. Mathematical modelling has been a key tool in the design of control strategies, in place of expensive randomised-controlled trials. We conducted a systematic review to investigate mathematical models of Japonicum control strategies in China and the Philippines.
METHODS
We conducted a systematic review on July 5, 2020, in four electronic bibliographic databases - PubMed, Web of Science, SCOPUS and Embase. Articles were screened for relevance and for meeting the inclusion criteria. Data extracted included authors, year of publication, year of data collection, setting and ecological context, objectives, control strategies, main findings, the form and content of the model including its background, type, representation of population dynamics, heterogeneity of hosts, simulation period, source of parameters, model validation and sensitivity analysis. Results After screening, 19 eligible papers were included in the systematic review. Seventeen considered control strategies in China and two in the Philippines. Two frameworks were identified; the mean-worm burden framework and the prevalence-based framework, the latter of which increasingly common. Most models considered human and bovine definitive hosts. There were mixed additional elements included in the models, such as alternative definitive hosts and the role of seasonality and weather. Models generally agreed upon the need for an integrated control strategy rather than reliance on mass drug administration alone to sustain reductions in prevalence.
CONCLUSIONS
Mathematical modelling of Japonicum has converged from multiple approaches to modelling using the prevalence-based framework with human and bovine definitive hosts and find integrated control strategies to be most effective. Further research could investigate the role of other definitive hosts and model the effect of seasonal fluctuations in transmission.
Topics: Animals; Cattle; Humans; Schistosoma japonicum; Schistosomiasis japonica; Models, Theoretical; Computer Simulation; China
PubMed: 36907291
DOI: 10.1016/j.actatropica.2023.106873 -
JAMA Psychiatry Oct 2020Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent... (Comparative Study)
Comparative Study Meta-Analysis
IMPORTANCE
Recent estimates suggest that more than 50% of all deaths worldwide are currently attributable to inflammation-related diseases. Psychosocial interventions may represent a potentially useful strategy for addressing this global public health problem, but which types of interventions reliably improve immune system function, under what conditions, and for whom are unknown.
OBJECTIVE
To address this issue, we conducted a systematic review and meta-analysis of randomized clinical trials (RCTs) in which we estimated associations between 8 different psychosocial interventions and 7 markers of immune system function, and examined 9 potential moderating factors.
DATA SOURCES
PubMed, Scopus, PsycInfo, and ClinicalTrials.gov databases were systematically searched from February 1, 2017, to December 31, 2018, for all relevant RCTs published through December 31, 2018.
STUDY SELECTION
Eligible RCTs included a psychosocial intervention, immune outcome, and preintervention and postintervention immunologic assessments. Studies were independently examined by 2 investigators. Of 4621 studies identified, 62 were eligible and 56 included.
DATA EXTRACTION AND SYNTHESIS
Data were extracted and analyzed from January 1, 2019, to July 29, 2019. The Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guideline was followed. Data were extracted by 2 investigators who were blind to study hypotheses and analyses, and were then analyzed using robust variance estimation. Analysis included 8 psychosocial interventions (behavior therapy, cognitive therapy, cognitive behavior therapy [CBT], CBT plus additive treatment or mode of delivery that augmented the CBT, bereavement or supportive therapy, multiple or combined interventions, other psychotherapy, and psychoeducation), 7 immune outcomes (proinflammatory cytokine or marker levels, anti-inflammatory cytokine levels, antibody levels, immune cell counts, natural killer cell activity, viral load, and other immune outcomes), and 9 moderating factors (intervention type, intervention format, intervention length, immune marker type, basal vs stimulated markers, immune marker measurement timing, disease state or reason for treatment, age, and sex).
MAIN OUTCOMES AND MEASURES
The primary a priori outcomes were pretest-posttest-control (ppc) group effect sizes (ppc g) for the 7 immunologic outcomes investigated.
RESULTS
Across 56 RCTs and 4060 participants, psychosocial interventions were associated with enhanced immune system function (ppc g = 0.30, 95% CI, 0.21-0.40; t50.9 = 6.22; P < .001). Overall, being randomly assigned to a psychosocial intervention condition vs a control condition was associated with a 14.7% (95% CI, 5.7%-23.8%) improvement in beneficial immune system function and an 18.0% (95% CI, 7.2%-28.8%) decrease in harmful immune system function over time. These associations persisted for at least 6 months following treatment and were robust across age, sex, and intervention duration. These associations were most reliable for CBT (ppc g = 0.33, 95% CI, 0.19-0.47; t27.2 = 4.82; P < .001) and multiple or combined interventions (ppc g = 0.52, 95% CI, 0.17-0.88; t5.7 = 3.63; P = .01), and for studies that assessed proinflammatory cytokines or markers (ppc g = 0.33, 95% CI, 0.19-0.48; t25.6 = 4.70; P < .001).
CONCLUSIONS AND RELEVANCE
These findings suggest that psychosocial interventions are reliably associated with enhanced immune system function and may therefore represent a viable strategy for improving immune-related health.
Topics: Biomarkers; Cognitive Behavioral Therapy; Combined Modality Therapy; Correlation of Data; Hospice Care; Immune System; Immune System Diseases; Patient Education as Topic; Psychosocial Intervention; Psychosocial Support Systems; Psychotherapy; Randomized Controlled Trials as Topic
PubMed: 32492090
DOI: 10.1001/jamapsychiatry.2020.0431 -
Circulation. Heart Failure Jul 2012There have been discrepant findings on the association between coffee consumption and risk of incident heart failure. (Meta-Analysis)
Meta-Analysis Review
BACKGROUND
There have been discrepant findings on the association between coffee consumption and risk of incident heart failure.
METHODS AND RESULTS
We conducted a systematic review and a dose-response meta-analysis of prospective studies that assessed the relationship between habitual coffee consumption and the risk of heart failure. We searched electronic databases (MEDLINE, Embase, and CINAHL) from January 1966 through December 2011, with the use of a standardized protocol. Eligible studies were prospective cohort studies that examined the association of coffee consumption with incident heart failure. Five independent prospective studies of coffee consumption and heart failure risk, including 6522 heart failure events and 140 220 participants, were included in the meta-analysis. We observed a statistically significant J-shaped relationship between coffee and heart failure. Compared with no consumption, the strongest inverse association was seen for 4 servings/day and a potentially higher risk at higher levels of consumption. There was no evidence that the relationship between coffee and heart failure risk varied by sex or by baseline history of myocardial infarction or diabetes.
CONCLUSIONS
Moderate coffee consumption is inversely associated with risk of heart failure, with the largest inverse association observed for consumption of 4 servings per day.
Topics: Caffeine; Central Nervous System Stimulants; Coffee; Dose-Response Relationship, Drug; Female; Heart Failure; Humans; Incidence; Male; Nonlinear Dynamics; Odds Ratio; Risk Assessment; Risk Factors
PubMed: 22740040
DOI: 10.1161/CIRCHEARTFAILURE.112.967299