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Proceedings of the Royal Society of... Apr 1954
Topics: Addison Disease; Adrenal Insufficiency; Goiter; Humans; Hypoadrenocorticism, Familial
PubMed: 13155529
DOI: No ID Found -
Journal of Veterinary Internal Medicine Mar 2023Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse.
BACKGROUND
Primary hypoadrenocorticism (PH) is rare in cats and knowledge about treatment is sparse.
OBJECTIVE
To describe cats with PH with a focus on long-term treatment.
ANIMALS
Eleven cats with naturally occurring PH.
METHODS
Descriptive case series with data on signalment, clinicopathological findings, adrenal width, and doses of desoxycorticosterone pivalate (DOCP) and prednisolone during a follow-up period of >12 months.
RESULTS
Cats ranged from 2 to 10 years (median 6.5); 6 cats were British Shorthair. Most common signs were reduced general condition and lethargy, anorexia, dehydration, obstipation, weakness, weight loss, and hypothermia. Adrenal glands on ultrasonography were judged small in 6. Eight cats could be followed for 14 to 70 months (median: 28). Two were started on DOCP doses ≥2.2 mg/kg (2.2; 2.5) and 6 < 2.2 mg/kg (1.5-2.0 mg/kg, median 1.8) q28 days. Both high-dose cats and 4 low-dose cats needed a dose increase. Desoxycorticosterone pivalate and prednisolone doses at the end of the follow-up period were 1.3 to 3.0 mg/kg (median: 2.3) and 0.08 to 0.5 mg/kg/day (median: 0.3), respectively.
CONCLUSIONS AND CLINICAL IMPORTANCE
Desoxycorticosterone pivalate and prednisolone requirements in cats were higher than what is currently used in dogs; thus, a DOCP starting dose of 2.2 mg/kg q28 days and a prednisolone maintenance dose of 0.3 mg/kg/day titrated to the individual need seems warranted. Small adrenal glands (width < 2.7 mm) on ultrasonography in a cat suspected of hypoadrenocorticism can be suggestive of the disease. The apparent predilection of British Shorthaired cats for PH should be further evaluated.
Topics: Cats; Animals; Dogs; Prednisolone; Dog Diseases; Adrenal Insufficiency; Desoxycorticosterone; Addison Disease; Cat Diseases
PubMed: 36809682
DOI: 10.1111/jvim.16658 -
Cleveland Clinic Journal of Medicine Sep 2022
Topics: Humans; Addison Disease; Hyperpigmentation
PubMed: 37907439
DOI: 10.3949/ccjm.89a.21082 -
British Medical Journal Apr 1953
Topics: Addison Disease; Adrenal Insufficiency; Cortisone; Desoxycorticosterone; Hypoadrenocorticism, Familial
PubMed: 13032539
DOI: No ID Found -
Postgraduate Medical Journal Apr 1953
Topics: Addison Disease; Adrenal Insufficiency; Adrenocorticotropic Hormone; Cortisone; Desoxycorticosterone; Humans; Hypoadrenocorticism, Familial
PubMed: 13055541
DOI: 10.1136/pgmj.29.330.200 -
British Medical Journal Nov 1950
Topics: Addison Disease; Adrenal Insufficiency; Humans; Hypoadrenocorticism, Familial
PubMed: 14777902
DOI: 10.1136/bmj.2.4689.1164 -
Proceedings of the Royal Society of... Apr 1949
Topics: Addison Disease; Adrenal Insufficiency; Humans; Hypoadrenocorticism, Familial
PubMed: 18127915
DOI: No ID Found -
Proceedings of the Royal Society of... Jun 1974
Review
Topics: Addison Disease; Amenorrhea; Anemia, Pernicious; Animals; Antibodies; Antigen-Antibody Complex; Autoimmune Diseases; B-Lymphocytes; Complement System Proteins; Diabetes Mellitus; Endocrine System Diseases; Female; Humans; Hypersensitivity, Immediate; Hypoparathyroidism; Male; Middle Aged; T-Lymphocytes; Thyroid Diseases
PubMed: 4604200
DOI: No ID Found -
Postgraduate Medical Journal May 1970Vitiligo, a common skin condition, has been reported in association with thyroid disease, pernicious anaemia, carcinoma of the stomach, Addison's disease and diabetes...
Vitiligo, a common skin condition, has been reported in association with thyroid disease, pernicious anaemia, carcinoma of the stomach, Addison's disease and diabetes mellitus. Some subjects with vitiligo can be shown to possess circulating antibodies to thyroid gland, thyroglobulin, gastric parietal cells and adrenal gland, even in the absence of disease. Vitiligo is evidently another ‘skin-marker of internal disease’.
Topics: Addison Disease; Anemia, Pernicious; Diabetes Complications; Humans; Stomach Neoplasms; Thyroid Diseases; Vitiligo
PubMed: 5448375
DOI: 10.1136/pgmj.46.535.276 -
Annales de Biologie Clinique Aug 2018Salivary cortisol assay, described for the first time almost forty years ago, has not been expanding until the last decade. Its simplicity, non-invasiveness and the easy... (Review)
Review
Salivary cortisol assay, described for the first time almost forty years ago, has not been expanding until the last decade. Its simplicity, non-invasiveness and the easy repetition of sampling make it an analytical matrix of interest. Since the publication of the recommendations of the American endocrinology society in 2008, salivary cortisol is recognized as one of the three main tests to screen for Cushing's syndrome. In addition, salivary cortisone, the major metabolite of salivary cortisol, still represents a severe potential interferent but could also be a complementary analyte for indications where evaluation of cortisol secretion is sought. Moreover, in the current context of practices and methods harmonization, the problem of lack of standardization presents also for salivary cortisol. This review briefly develops the three main tests of Cushing's syndrome screening to explain the reasons for integrating the saliva test into this screening. Then we will develop the variables that can influence salivary cortisol from a pre-analytic, physiopathological and finally analytical point of view.
Topics: Addison Disease; Circadian Rhythm; Cushing Syndrome; Humans; Hydrocortisone; Pre-Analytical Phase; Saliva; Specimen Handling
PubMed: 29952304
DOI: 10.1684/abc.2018.1355