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Frontiers in Public Health 2022This umbrella review aimed to summarize the available evidence on the association between dry eye disease and depression.
PURPOSE
This umbrella review aimed to summarize the available evidence on the association between dry eye disease and depression.
METHODS
We searched the Pubmed, Embase, and Cochrane databases using the search string "(Dry eye syndrome OR Keratoconjunctivitis sicca OR KCS OR Aqueous tear deficiency OR Sjogren syndrome) AND (depression OR depressive symptoms) AND (meta-analysis OR systematic review)" from inception to 20 July 2022. We considered all meta-analyses investigating the association between dry eye disease and depression.
RESULTS
After summarizing the included meta-analyses, it was concluded that dry eye disease is associated with depression. The symptoms of dry eye disease affect the daily lives of patients, thus affecting their mood. However, further evidence is required to confirm this association.
CONCLUSION
This finding highlights the importance of psychological support for patients with dry eye disease. Future clinical studies should investigate the mechanism underlying the association between dry eye disease and depression.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42022320619.
Topics: Humans; Affect; Databases, Factual; Depression; Dry Eye Syndromes
PubMed: 36466469
DOI: 10.3389/fpubh.2022.910608 -
Investigative Ophthalmology & Visual... Jul 2014To evaluate the relationship between androgen levels and subjective and objective measures of dry eye syndrome (DES).
PURPOSE
To evaluate the relationship between androgen levels and subjective and objective measures of dry eye syndrome (DES).
METHODS
A total of 263 male patients from the Miami Veterans Affairs Medical Center eye clinic aged ≥50 were recruited for this prospective cross-sectional study. Patients completed Dry Eye Questionnaire 5, underwent tear film evaluation, and had serum androgen levels measured. The correlations between androgen levels, DES composite scores, DES symptoms, and global, lipid, and aqueous tear film parameters were evaluated.
RESULTS
Two hundred sixty-three patients with a mean age of 69 (50-95) were examined. There was no linear association between composite DES scores (generated using latent class analysis) and androgen levels. However, eyes with high DES scores (0.95-1.0) had higher levels of sex hormone-binding globulin (P = 0.03) and lower levels of dehydroepiandrosterone sulfate (DHEAS) (P = 0.02), androstenedione (A) (P = 0.02), and androstane-3α,17β-diol glucuronide (P = 0.03) compared to eyes with intermediate (0.05-0.95) or low (0-0.05) scores. There were no strong correlations between tear film measures and androgen levels. Regarding global parameters, a weak inverse correlation was found between corneal staining and A (r = -0.17, P = 0.009). For lipid parameters, a weak correlation existed between tear breakup time (TBUT) and A (r = 0.15, P = 0.02). When considering aqueous and lipid deficiency independently, the association between TBUT and A existed only with aqueous tear deficiency (r = 0.66, P = 0.002). Regarding aqueous parameters, a weak correlation existed between Schirmer test and DHEAS (r = 0.13, P = 0.047) and A (r = 0.21, P = 0.001).
CONCLUSIONS
There was a weak correlation between higher levels of androstenedione and healthier global, lipid, and aqueous tear film parameters.
Topics: Aged; Aged, 80 and over; Aging; Androgens; Biomarkers; Cross-Sectional Studies; Dry Eye Syndromes; Follow-Up Studies; Humans; Male; Meibomian Glands; Middle Aged; Prospective Studies; Tears
PubMed: 24994872
DOI: 10.1167/iovs.14-14689 -
Revista Brasileira de Enfermagem May 2018To analyse the concept of Dry Eye Syndrome in patients admitted to Intensive Care Units (ICU). (Review)
Review
PURPOSE
To analyse the concept of Dry Eye Syndrome in patients admitted to Intensive Care Units (ICU).
METHOD
This is a concept analysis, according to Walker's and Avant's method, conducted using an integrative review, through search in the database. Science Direct, Scopus, Cinahl, Pubmed, Lilacs, Cochrane and Web of Science. The following keywords were used: "Keratoconjuntivite Sicca", "Risk Factors", "Dry eye Syndromes" and "Intensive Care Units". After selection, 85 articles have been kept.
RESULTS
Antecedents found: age, lagophthalmos, environmental factors, use of medications, systemic diseases, mechanical ventilation and eye surgeries. Attributes: Tear Break-up Time < 10 s, Schirmer's test I < 10 mm, Schirmer's test II < 5 mm and signs and symptoms. Consequents: eye damage and discomfort; unstable vision. The Model Case and the Contrary Case were used to illustrate it.
CONCLUSION
The research provided clarification of the concept and consequent understanding of the Dry Eye Syndrome, which is preventable especially in ICU.
Topics: Age Factors; Dry Eye Syndromes; Eye Diseases; Humans; Intensive Care Units; Respiration, Artificial; Risk Factors
PubMed: 29924155
DOI: 10.1590/0034-7167-2016-0582 -
Indian Journal of Ophthalmology Apr 2023
Topics: Humans; Tears; Dry Eye Syndromes
PubMed: 37026232
DOI: 10.4103/IJO.IJO_642_23 -
Vestnik Oftalmologii 2018The article reviews the particularities of development and pathogenesis of secondary dry eye syndrome (DES) after refractive surgeries including a complex of problems... (Review)
Review
The article reviews the particularities of development and pathogenesis of secondary dry eye syndrome (DES) after refractive surgeries including a complex of problems related to changes in tear film content, damage of eye surface and neurotrophic epitheliopathy. Additionally, modern algorithms of treatment and prevention of secondary DES in patients after refractive surgeries are described. Despite the transient nature of the changes, excimer-laser surgery can lead to lasting deficiencies of eye surface in some patients. Therefore, intensive and early treatment of secondary DES during the early follow-up period after refractive surgery may significantly reduce risks of tear dysfunction and neurotrophic epitheliopathy development in the long term.
Topics: Dry Eye Syndromes; Humans; Lasers, Excimer; Refractive Surgical Procedures; Tears
PubMed: 30499532
DOI: 10.17116/oftalma2018134051294 -
Medicina (Kaunas, Lithuania) Jun 2022It is estimated that a wide proportion of the world's population (5% to 50%) may suffer from dry eye disease to a various extent [...].
It is estimated that a wide proportion of the world's population (5% to 50%) may suffer from dry eye disease to a various extent [...].
Topics: Dry Eye Syndromes; Humans; Inflammation; Tears
PubMed: 35744027
DOI: 10.3390/medicina58060764 -
International Journal of Molecular... Apr 2021Choline is essential for maintaining the structure and function of cells in humans. Choline plays an important role in eye health and disease. It is a precursor of... (Review)
Review
Choline is essential for maintaining the structure and function of cells in humans. Choline plays an important role in eye health and disease. It is a precursor of acetylcholine, a neurotransmitter of the parasympathetic nervous system, and it is involved in the production and secretion of tears by the lacrimal glands. It also contributes to the stability of the cells and tears on the ocular surface and is involved in retinal development and differentiation. Choline deficiency is associated with retinal hemorrhage, glaucoma, and dry eye syndrome. Choline supplementation may be effective for treating these diseases.
Topics: Acetylcholine; Animals; Choline; Choline Deficiency; Diabetic Retinopathy; Dry Eye Syndromes; Eye Diseases; Eye Pain; Glaucoma; Glycerylphosphorylcholine; Humans; Lacrimal Apparatus; Lens, Crystalline; Nociception; Optic Nerve; Parasympathetic Nervous System; Phosphatidylcholines; Phospholipids; Receptors, Nicotinic; Retina; Retinal Vessels; Tears
PubMed: 33946979
DOI: 10.3390/ijms22094733 -
Scientific Reports Jul 2022We aimed to investigate the density and morphology of corneal dendritic cells (DCs) in dry eye (DE) patients with or without Sjogren's syndrome (SS). This study included...
We aimed to investigate the density and morphology of corneal dendritic cells (DCs) in dry eye (DE) patients with or without Sjogren's syndrome (SS). This study included 28 patients with Sjogren's syndrome dry eye (SSDE), 33 patients with non-Sjogren's syndrome dry eye (NSSDE), and 30 age and sex matched healthy volunteers. In vivo confocal microscopy (IVCM) was used to investigate density and morphology (size, dendrites, and field) of DC. Compared with NSSDE and healthy group, SSDE showed significantly higher DC density, larger DC size, more DC dendrites with larger DC field (all P < 0.001). Comparison between NSSDE and healthy group demonstrated that DC density, dendrites and field were significantly higher in NSSDE. However, there was no significant difference in DC size (P = 0.076). DC density and morphological parameters showed significant associations with the systemic severity (salivary gland biopsy and serum antibodies) and ocular surface damage. The corneal epithelium DC density and morphological alterations were obvious in SSDE, which reflected higher level of immune activation and inflammatory response in SS. Marked correlations were found between DC density/morphology and systemic/ocular severity. Dynamic assessment of corneal DC may facilitate to clarify pathogenesis, stratify patient, and tailor treatment in SS patients.
Topics: Cell Count; Dendritic Cells; Dry Eye Syndromes; Epithelium, Corneal; Humans; Microscopy, Confocal; Sjogren's Syndrome
PubMed: 35778532
DOI: 10.1038/s41598-022-15537-4 -
Scientific Reports Nov 2023We compared the efficacy and safety of autologous-serum (AS) and platelet-rich plasma (PRP) eye drops for dry eye (DE) treatment in primary Sjögren's syndrome (SS).... (Randomized Controlled Trial)
Randomized Controlled Trial
We compared the efficacy and safety of autologous-serum (AS) and platelet-rich plasma (PRP) eye drops for dry eye (DE) treatment in primary Sjögren's syndrome (SS). This prospective, randomized, double-blinded clinical study included patients diagnosed with primary SS DE. Thirty-eight participants were randomly assigned to the AS or PRP groups. Corneal and conjunctival staining scores, Schirmer I test, tear film break-up time (TBUT), and ocular surface disease index (OSDI) scores were evaluated at 4 and 12 weeks. Conjunctival impression cytology (CIC) metaplasia grade and goblet cell density grade at 12 weeks were compared with those at baseline. Corneal and conjunctival staining scores and TBUT significantly improved at 4 and 12 weeks in both groups (all p < 0.005). No significant difference between the AS and PRP groups was observed at 4 and 12 weeks. The Schirmer I values, OSDI scores, CIC metaplasia grade, and goblet cell density grade did not significantly change at 4 and 12 weeks in either group. Both AS and PRP eye drops are effective for primary SS DE without a significant difference. Considering that the preparation time of PRP is shorter than that of AS, PRP can be a good alternative treatment for primary SS DE.
Topics: Humans; Dry Eye Syndromes; Metaplasia; Ophthalmic Solutions; Platelet-Rich Plasma; Prospective Studies; Sjogren's Syndrome; Tears
PubMed: 37935760
DOI: 10.1038/s41598-023-46671-2 -
PloS One 2018Osteoporosis is a multifactorial disease associated with inflammation and hormone imbalance. It is noteworthy that dry eye syndrome shares a similar pathophysiology with...
OBJECTIVE
Osteoporosis is a multifactorial disease associated with inflammation and hormone imbalance. It is noteworthy that dry eye syndrome shares a similar pathophysiology with osteoporosis. Both diseases are more prevalent among the elderly and females. Dry eye syndrome can result in impaired vision, which increases the risk of fall and fracture when osteoporosis exists. In this study, we investigated whether osteoporosis is associated with an increased risk of developing dry eye syndrome.
METHODS
Claims data from the National Health Insurance Research Database (NHIRD) of Taiwan were used to conduct a retrospective population-based cohort study covering the period from January 1, 2000, to December 31, 2011. Multiple logistic regression was used to determine whether osteoporosis is an independent factor in the risk of developing dry eye syndrome, with risk estimates presented in the form of odds ratios (ORs).
RESULTS
The exclusion of patients with specific autoimmune diseases and those younger than 50 years old resulted in 42,365 patients in the osteoporosis group and 147,460 patients in the comparison group during the study period. The number of patients newly diagnosed with dry eye syndrome was 6,478 (15.29%) in the osteoporosis group and 15,396 (10.44%) in the comparison group. The crude OR of patients with osteoporosis developing dry eye syndrome was 1.55 and the 95% confidence interval (95% CI) was 1.50-1.60. After adjusting for patients' age, sex, and underlying comorbidities, the adjusted OR was 1.26 and the 95% CI was 1.22-1.30. Subgroup analysis revealed this association in each age group and among females but not among males.
CONCLUSIONS
Our results demonstrate that osteoporosis is a risk factor for the subsequent development of dry eye syndrome. Clinicians should be aware of the early symptoms of dry eye syndrome in osteoporotic patients in order to prevent further complications.
Topics: Accidental Falls; Aged; Aged, 80 and over; Databases, Factual; Dry Eye Syndromes; Female; Humans; Incidence; Logistic Models; Male; Middle Aged; Odds Ratio; Osteoporosis; Retrospective Studies; Risk; Taiwan
PubMed: 30395639
DOI: 10.1371/journal.pone.0207008