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European Journal of Rheumatology Jul 2023
PubMed: 37681258
DOI: 10.5152/eurjrheum.2023.23038 -
JAAD Case Reports Aug 2021
PubMed: 34337118
DOI: 10.1016/j.jdcr.2021.06.007 -
The Australasian Journal of Dermatology Nov 2022We describe a strikingly robust presentation of trimethoprim-sulfamethoxazole (TMP-SMX)-induced pustular Sweet syndrome and discuss how to distinguish it from iododerma... (Review)
Review
We describe a strikingly robust presentation of trimethoprim-sulfamethoxazole (TMP-SMX)-induced pustular Sweet syndrome and discuss how to distinguish it from iododerma and other neutrophil-rich conditions. A review of the literature indicates that TMP-SMX-induced Sweet syndrome (SS) may have higher rates of neutrophilia and greater ocular, mucosal, and musculoskeletal involvement compared to SS from other drugs. Recognizing these features and identifying the offending agent are critical for correctly diagnosing TMP-SMX-induced SS in a timely manner.
Topics: Humans; Trimethoprim, Sulfamethoxazole Drug Combination; Sweet Syndrome
PubMed: 35866718
DOI: 10.1111/ajd.13897 -
Internal Medicine (Tokyo, Japan) Feb 2022Behçet disease and its related disorder, Sweet disease, are multifactorial disorders whose susceptibility loci have been identified in the genes of various...
Behçet disease and its related disorder, Sweet disease, are multifactorial disorders whose susceptibility loci have been identified in the genes of various immunological factors aside from human leukocyte antigens. The neurological involvement of these diseases, including encephalitis, myelitis, and meningitis, referred to as neuro-Behçet disease (NBD) and neuro-Sweet disease (NSD) respectively, is sometimes difficult to diagnose, especially when the characteristic mucocutaneous symptoms do not precede neurological symptoms or when characteristics of both diseases are present in a single patient. NBD and NSD constitute a spectrum of diseases that are differentiated according to the combination of risk factors, including the genetic background. Encephalitis, myelitis, and meningitis similar to NBD or NSD can be diagnosed as spectrum disorders, even if the characteristic mucocutaneous symptoms fail to be detected. Understanding these conditions as a disease spectrum may help elucidate the disease pathogenesis and assist in the development of therapeutic agents.
Topics: Behcet Syndrome; Diagnosis, Differential; Encephalitis; Humans; Meningitis; Sweet Syndrome
PubMed: 34615825
DOI: 10.2169/internalmedicine.8227-21 -
Cell Death Discovery Jan 2024Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative... (Review)
Review
Neutrophils have both antimicrobial ability and pathogenic effect in the immune system, neutrophil extracellular traps (NETs) formation is one of the representative behaviors of their dual role. NETs formation was triggered by pathogen-related components and pathogen non-related proteins as cytokines to exert its effector functions. Recent studies indicate that the pathogenicity of NETs contributed to several skin diseases such as psoriasis, Stevens-Johnson syndrome, toxic epidermal necrolysis, and neutrophilic dermatosis. Especially in neutrophilic dermatosis, a heterogeneous group of inflammatory skin disorders characterized with sterile neutrophilic infiltrate on dermis, NETs formation was reported as the way of participation of neutrophils in the pathogenesis of these diseases. In this review, we describe the different processes of NETs formation, then summarized the most recent updates about the pathogenesis of neutrophilic dermatosis and the participation of NETs, including pyoderma gangrenosum and PAPA syndrome, Behçet syndrome, hidradenitis suppurativa, Sweet Syndrome, pustular dermatosis and other neutrophilic dermatosis. Furthermore, we discuss the link between NETs formation and the development of neutrophilic dermatosis.
PubMed: 38195543
DOI: 10.1038/s41420-023-01787-2 -
Case Reports in Dermatology 2021Syphilis has received its classical designation as one of "the great imitators," reflecting a wide variety of symptoms and presentations, which can cause difficulties in...
Syphilis has received its classical designation as one of "the great imitators," reflecting a wide variety of symptoms and presentations, which can cause difficulties in diagnosis. Here we report an unusual case of secondary syphilis in a person with acute necrotizing tonsillitis and Sweet syndrome. A 33-year-old female presented with fever, bilateral cervical lymphadenopathy, tonsillar enlargements with ulcerated pus-filled lesions on the right tonsil, and multiple pseudovesicular, mammillated, edematous plaques on her neck, face, and extremities. Syphilis serology was positive and a skin biopsy demonstrated a neutrophil-rich dermatitis characteristic of Sweet syndrome. The association of infection with Sweet syndrome may be a coincidence; nevertheless, our case serves as a reminder that secondary syphilis should remain in the differential diagnosis of the acute febrile neutrophilic dermatosis.
PubMed: 34054456
DOI: 10.1159/000509374 -
Indian Journal of Dermatology,... 2022
Topics: Humans; Photosensitivity Disorders; Sweet Syndrome
PubMed: 35593291
DOI: 10.25259/IJDVL_201_20 -
Journal of the European Academy of... Nov 2022
Topics: Antibodies, Viral; COVID-19; COVID-19 Vaccines; Humans; Neutralization Tests; SARS-CoV-2; Sweet Syndrome
PubMed: 35723896
DOI: 10.1111/jdv.18336 -
Journal of Family & Community Medicine 2023Despite the numerous reports of cutaneous manifestations associated with vaccines for coronavirus disease 2019 (COVID-19), the relationship between COVID-19 vaccines and... (Review)
Review
Despite the numerous reports of cutaneous manifestations associated with vaccines for coronavirus disease 2019 (COVID-19), the relationship between COVID-19 vaccines and cutaneous side effects remains unevaluated. In this review, we examine these manifestations and their management. Reported dermatoses included injection-site reaction (early and delayed), type I allergic reaction, morbilliform eruption, pityriasis rosea, Sweet syndrome, lichen planus, psoriasis, herpes zoster reactivation, erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis (TEN). The most common COVID-19 vaccination-related cutaneous manifestations are delayed local reactions, approximately 66% of which are associated with the Moderna vaccine, and 33% with the Pfizer vaccine. Aside from mild injection-site reactions, severe reactions include anaphylaxis and TEN. Most reactions, except for Stevens-Johnson syndrome and anaphylaxis, though unpredictable and unpreventable are mild and can be treated symptomatically. Findings from this review should allow primary care physicians and dermatologists to reach faster diagnosis and initiate prompt intervention.
PubMed: 37675215
DOI: 10.4103/jfcm.jfcm_3_23 -
Skin Health and Disease Jun 2021Sweet syndrome (SS) can be categorized as classical Sweet syndrome (CSS), malignancy-associated Sweet syndrome (MASS) or drug-induced Sweet syndrome (DISS). Appropriate...
BACKGROUND
Sweet syndrome (SS) can be categorized as classical Sweet syndrome (CSS), malignancy-associated Sweet syndrome (MASS) or drug-induced Sweet syndrome (DISS). Appropriate categorization of patients with SS and identification of the associated trigger are essential to direct subsequent investigations and follow-up, especially given that 21% of cases are malignancy-associated. However, no published guidelines exist to guide this.
OBJECTIVE
To analyse the categorization, management and outcomes of patients with SS in order to propose a structured approach for investigation and follow-up.
METHODS
Retrospective data collection from the electronic records of patients diagnosed with SS between 1 January 2005 and 31 December 2018. Categorized and non-categorized patients were compared, and the yield rate of investigations and duration of follow-up were analysed.
RESULTS
Sixty-four patients were included with CSS (77%), MASS (20%) and DISS (3%). Of these, 34 (53%) cases were not categorized by the assessing clinicians, three of which were subsequently diagnosed with a malignancy, up to 19 months later. There was no significant difference in investigations performed between categorized and non-categorized patients and the yield rates were modest overall. Follow-up averaged 10.5 (16.8) months; non-categorized patients were followed-up for significantly longer than categorized patients (15.0 (21.2) vs. 5.4 (6.8) months, < 0.05).
CONCLUSION
The lack of a structured way to approach patients with SS can lead to under- or over-investigation, diagnostic delays of underlying conditions and unnecessary follow-up. An algorithm is proposed to identify the likely trigger and manage patients accordingly. Larger prospective studies are required to confirm the optimal approach to investigate and follow-up patients with SS.
PubMed: 35664987
DOI: 10.1002/ski2.23