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Infectious Disease Reports Nov 2018is a well-known endocarditis pathogen, however it has never been described as a cause of primary aortitis. Here we describe the first published case of thoracic...
is a well-known endocarditis pathogen, however it has never been described as a cause of primary aortitis. Here we describe the first published case of thoracic aortitis and an unusual case of aortic graft infection due to , which were both managed conservatively.
PubMed: 30662691
DOI: 10.4081/idr.2018.7746 -
Journal of Laboratory Physicians Dec 2020We present a case of in a prosthetic knee infection following total knee replacement for the first time. A 69-year-old female was prediagnosed with prosthetic knee...
We present a case of in a prosthetic knee infection following total knee replacement for the first time. A 69-year-old female was prediagnosed with prosthetic knee infection, and a two-stage revision arthroplasty was applied. was cultured by matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from the synovial fluid aspirates. Penicillin G and gentamicin had been administered. One year postoperatively, a scintigraphy showed no recurrence. may be missed in culture negative patients with knee or hip arthroplasty. They should be carefully evaluated if they have undergone recent dental procedures.
PubMed: 33268940
DOI: 10.1055/s-0040-1720942 -
Access Microbiology 2020is a fastidious organism that has been implicated in severe infections such as endocarditis in immunocompetent patients. Modern tools are available to aid...
INTRODUCTION
is a fastidious organism that has been implicated in severe infections such as endocarditis in immunocompetent patients. Modern tools are available to aid identification, but the main challenge remains clinical suspicion of .
CASE PRESENTATION
An otherwise fit and well 65-year-old female presented with reduced vision, red eye and discomfort 2 days following routine left cataract surgery. She had visual acuity of light perception only, significant anterior chamber inflammation (including hypopyon) and limited fundal view. She was diagnosed with post-operative endophthalmitis and 0.1 ml of ceftazidime (2 mg/0.1 ml) and 0.1 ml vancomycin (2 mg/0.1 ml) were injected intravitreally after vitreous aspiration. Subconjunctival cefuroxime was also injected. A repeat injection was performed on day three of admission. Gram staining revealed Gram-positive long-chain cocci, which were identified as . The patient was discharged on oral ciprofloxacin 500 mg twice a day with oral prednisolone 60 mg once a day; this was tapered and stopped at 8 weeks post-discharge. The left eye received dexamethasone 0.1 % 6 times a day (again, tapered over 8 weeks), moxifloxacin 5 % 6 times a day and atropine 1 % twice a day. Vision improved to 6/12 unaided (6/9.5 with pinhole) at 9 weeks post-operatively, with a clear fundal view.
CONCLUSION
We present a case of endophthalmitis following routine cataract surgery. To our knowledge, this is the first reported case in the UK and the fourth globally, which with prompt treatment ended with a good visual outcome.
PubMed: 32974588
DOI: 10.1099/acmi.0.000124 -
Journal of Clinical Microbiology Aug 2016The Etest on chocolate Mueller-Hinton agar was compared to broth microdilution (BMD) for 125 isolates of nutritionally variant streptococci. Vancomycin Etests yielded... (Comparative Study)
Comparative Study
The Etest on chocolate Mueller-Hinton agar was compared to broth microdilution (BMD) for 125 isolates of nutritionally variant streptococci. Vancomycin Etests yielded 31.1% essential agreement (EA) and 20.0% categorical agreement (CA). Penicillin Etests yielded 86.0% EA and 85.6% CA, whereas ceftriaxone Etests yielded 73.6% EA and 68.0% CA.
Topics: Abiotrophia; Anti-Bacterial Agents; Carnobacteriaceae; Culture Media; Disk Diffusion Antimicrobial Tests; Humans
PubMed: 27280419
DOI: 10.1128/JCM.00822-16 -
Journal of Medical Case Reports Sep 2011Abiotrophia species have rarely been implicated in osteoarticular infections. We report one case of an A. defectiva knee prosthesis infection.
BACKGROUND
Abiotrophia species have rarely been implicated in osteoarticular infections. We report one case of an A. defectiva knee prosthesis infection.
CASE PRESENTATION
A 71-year-old man of Italian origin presented with pain and swelling of the knee four years after the implantation of a total knee replacement prosthesis. While standard culturing of the synovial fluid resulted in no isolation of microorganisms, the direct inoculation of the synovial fluid into a rich culture medium resulted in the identification of A. defectiva by polymerase chain reaction sequencing. Repeated attempts of culturing microorganisms from blood were negative, and echocardiograms and colonoscopies were unremarkable. High-dose amoxicillin for nine months and a two-stage replacement of the knee prosthesis led to full patient recovery by the time of the 12-month follow-up examination.
CONCLUSIONS
Because Abiotrophia spp. are fastidious microorganisms, it is likely that cases of Abiotrophia orthopedic infection are misdiagnosed as culture-negative infections. Direct inoculation of synovial fluids into rich broth medium and further polymerase chain reaction-based detection of culture-negative synovial fluids are key tests for accurate documentation and detection of these infections.
PubMed: 21896178
DOI: 10.1186/1752-1947-5-438 -
Clinics and Practice Mar 2021is a rare agent of endocarditis and subacute presentation may delay the diagnosis. We present the case of a 41-year-old male who was admitted to the hospital for...
is a rare agent of endocarditis and subacute presentation may delay the diagnosis. We present the case of a 41-year-old male who was admitted to the hospital for further investigation regarding a consumptive syndrome with microcytic anaemia. Past medical history included new-onset mitral insufficiency followed by an ischaemic stroke due to small vessel disease. Thoraco-abdominal computed tomography revealed a splenic infarction. In the presence of two ischaemic events associated with mitral valve disease of unknown aetiology, we considered the possibility of subacute endocarditis. Blood cultures were positive for , and transoesophageal echocardiography confirmed the diagnosis. As a subacute presentation of endocarditis, the paucity of symptoms caused a five-month delay in diagnosis. New-onset valvular disease and a stroke in an otherwise healthy young patient should always prompt proper investigation. This case highlights several complications caused by septic emboli of undiagnosed and untreated endocarditis.
PubMed: 33801364
DOI: 10.3390/clinpract11010022 -
Internal Medicine (Tokyo, Japan) Oct 2004A 74-year-old woman with recurrent fever and multiple joint pain was admitted to Hokkaido University Hospital. Trans-esophageal echocardiogram revealed bacterial... (Review)
Review
A 74-year-old woman with recurrent fever and multiple joint pain was admitted to Hokkaido University Hospital. Trans-esophageal echocardiogram revealed bacterial vegetation and destruction of the aortic valve. Although few bacteria grew in regular blood agar, Gram-positive coccobacillus was specifically grown in chocolate blood agar and Brucella agar, and it was identified to be Abiotrophia defectiva. Infectious endocarditis caused by Abiotrophia defectiva was diagnosed, she was treated with diuretics, penicillin G and gentamicin, and she immediately improved. Infectious diseases caused by Abiotrophia defectiva are extremely rare, and identification of this pathogen is important, as its bacterial characteristics require proper attention.
Topics: Aged; Anti-Bacterial Agents; Antihypertensive Agents; Endocarditis, Bacterial; Female; Fever; Gentamicins; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Hypertension; Penicillins; Sulfonamides; Torsemide; Treatment Outcome
PubMed: 15575256
DOI: 10.2169/internalmedicine.43.1000 -
Journal of Personalized Medicine Jul 2021A 57-year female patient diagnosed with Behçet's disease, on azathioprine, was noticed to have at a routine examination antinuclear and antiphospholipid antibodies. An...
A 57-year female patient diagnosed with Behçet's disease, on azathioprine, was noticed to have at a routine examination antinuclear and antiphospholipid antibodies. An overlapping lupus-like syndrome was diagnosed; hydroxychloroquine and aspirin were added. Three years later, the patient presented with dyspnea and sweating, with no fever. A cardiac bruit was noted; a giant vegetation was detected by echocardiography. Laboratory revealed severe thrombocytopenia, antiphospholipid antibodies and low complement. Blood cultures were positive for serology and also revealed a chronic infection. Antibiotic therapy, low-dose anticoagulation and control of the underlying disease mildly improved the platelet count, which fully recovered only after cardiac valve replacement. However, the Behçet's disease, initially quiescent, flared after the therapy of infections. We discuss potential links between Behçet's disease and the occurrence of antinuclear and antiphospholipid antibodies and endocarditis in this setting. We also highlight the differences between the endocarditis in Behçet's disease, antiphospholipid syndrome, and infection, respectively. Intracellular infections may modify the presentation of autoimmune diseases. Confounding clinical features of persistent infection and non-bacterial thrombotic endocarditis in Behçet's disease warrant further insight.
PubMed: 34442371
DOI: 10.3390/jpm11080728 -
Clinical Practice and Cases in... Aug 2017Subacute endocarditis often presents with an indolent course. A potentially lethal form generated by infection with may be easily overlooked early in its presentation....
Subacute endocarditis often presents with an indolent course. A potentially lethal form generated by infection with may be easily overlooked early in its presentation. This report discusses the case of an 18-year-old male discovered to have severe endocarditis after presenting to the emergency department with the chief complaint of foot pain.
PubMed: 29849317
DOI: 10.5811/cpcem.2017.3.33126 -
Cureus Dec 2019Infective endocarditis (IE) refers to an infection involving the endocardial surface of the heart. Most of the cases of IE are known to occur due to infection by...
Infective endocarditis (IE) refers to an infection involving the endocardial surface of the heart. Most of the cases of IE are known to occur due to infection by viridans Streptococci or Staphylococci species. Abiotrophia defectiva is known to cause less than 1% of cases of IE. Though rare, this organism can cause life-threatening complications such as septic embolization, destruction of heart valves, and heart failure if not detected and treated timely. Here we discuss a case of a 44-year-old female who presented to our tertiary care centre with complaints of fever and easy fatiguability for two weeks. After further investigations, she was finally diagnosed to have IE due to Abiotrophia defectiva. Imaging demonstrated the presence of embolic and valvular complications as well. Through this case, we highlight the importance of early detection and timely management of this condition in order to decrease the occurrence of fatal complications and mortality.
PubMed: 32025414
DOI: 10.7759/cureus.6492