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Frontiers in Endocrinology 2020
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Child; Female; Hirsutism; Humans; Male; Patient-Centered Care; Polycystic Ovary Syndrome; Prognosis; Treatment Outcome; Young Adult
PubMed: 32296393
DOI: 10.3389/fendo.2020.00170 -
British Medical Journal Feb 1980
Review
Topics: Androgens; Drug Therapy, Combination; Ethinyl Estradiol; Female; Hair Removal; Hirsutism; Humans; Polycystic Ovary Syndrome; Prednisolone; Virilism
PubMed: 6988040
DOI: 10.1136/bmj.280.6211.369 -
British Medical Journal May 1971
Topics: 17-Ketosteroids; Cushing Syndrome; Female; Hirsutism; Humans; Hyperplasia; Ovarian Cysts; Ovarian Neoplasms; Ovary; Ovulation; Testosterone; Virilism
PubMed: 5572389
DOI: 10.1136/bmj.2.5756.264 -
The Israel Medical Association Journal... Aug 2000
Topics: Algorithms; Hirsutism; Humans; Hyperandrogenism
PubMed: 10979363
DOI: No ID Found -
Skin Therapy LetterTwenty-two percent of women in North America have unwanted facial hair, which can cause embarrassment and result in a significant emotional burden. Treatment options... (Review)
Review
Twenty-two percent of women in North America have unwanted facial hair, which can cause embarrassment and result in a significant emotional burden. Treatment options include plucking, waxing (including the sugar forms), depilatories, bleaching, shaving, electrolysis, laser, intense pulsed light (IPL), and eflornithine 13.9% cream (Vaniqa, Barrier Therapeutics in Canada and Shire Pharmaceuticals elsewhere). Eflornithine 13.9% cream is a topical treatment that does not remove the hairs, but acts to reduce the rate of growth and appears to be effective for unwanted facial hair on the mustache and chin area. Eflornithine 13.9% cream can be used in combination with other treatments such as lasers and IPL to give the patient the best chance for successful hair removal.
Topics: Administration, Topical; Eflornithine; Enzyme Inhibitors; Face; Female; Hair Removal; Hirsutism; Humans; Polycystic Ovary Syndrome
PubMed: 16408139
DOI: No ID Found -
Hormone Research in Paediatrics 201017-β-Hydroxysteroid dehydrogenase type 3 (17βHSD-3) deficiency is a rare, but frequently misdiagnosed autosomal recessive cause of 46,XY disorder of sex development... (Review)
Review
17-β-Hydroxysteroid dehydrogenase type 3 (17βHSD-3) deficiency is a rare, but frequently misdiagnosed autosomal recessive cause of 46,XY disorder of sex development (DSD). 17βHSD-3 enzyme is present almost exclusively in the testes and converts Δ4-androstenedione (Δ4) to testosterone (T). The diagnosis can be easily missed in early childhood as the clinical presentation may be subtle. Any young girl with an inguinal hernia, mild clitoromegaly, single urethral opening or urogenital sinus should raise suspicion. If not diagnosed early, patients present with severe virilization and primary amenorrhea in adolescence and may undergo a change from a female to male gender role. A low T/Δ4 ratio on baseline or hCG (human chorionic gonadotropin)-stimulated testing is suggestive of 17βHSD-3 deficiency. The diagnosis can be confirmed with molecular genetic studies. This review summarizes the clinical presentations, reported mutations, diagnosis, treatment and clinical course of this disorder. The Arg80 site in exon 3 is the most common location of repeated mutations and can be considered a hot spot in certain Arab populations.
Topics: 17-Hydroxysteroid Dehydrogenases; Disorder of Sex Development, 46,XY; Female; Founder Effect; Genes, Recessive; Humans; Male; Sex Reassignment Procedures; Virilism
PubMed: 20689261
DOI: 10.1159/000318004 -
American Family Physician Jun 2003Hirsutism is a common disorder, often resulting from conditions that are not life-threatening. It may signal more serious clinical pathology, and clinical evaluation... (Review)
Review
Hirsutism is a common disorder, often resulting from conditions that are not life-threatening. It may signal more serious clinical pathology, and clinical evaluation should differentiate benign causes from tumors or other conditions such as polycystic ovary syndrome, late-onset adrenal hyperplasia, and Cushing's syndrome. Laboratory testing should be based on the patient's history and physical findings, but screening for levels of serum testosterone and 17alpha-hydroxyprogesterone is sufficient in most cases. Women with irregular menses and hirsutism should be screened for thyroid dysfunction and prolactin disorders. Pharmacologic and/or nonpharmacologic treatments may be used. Advances in laser hair removal methods and topical hair growth retardants offer new options. The use of insulin-sensitizing agents may be useful in women with polycystic ovary syndrome.
Topics: Algorithms; Female; Hirsutism; Humans; Physical Examination
PubMed: 12825846
DOI: No ID Found -
Acta Bio-medica : Atenei Parmensis Sep 2020Polycystic ovarian syndrome is a common endocrinologic condition diagnosed in women of childbearing age. It is primarily associated with androgen excess and ovarian... (Review)
Review
Polycystic ovarian syndrome is a common endocrinologic condition diagnosed in women of childbearing age. It is primarily associated with androgen excess and ovarian dysfunction, which contribute to menstrual irregularity, oligo-anovulation, infertility, hirsutism and acne. It is associated with several systemic conditions, including type 2 diabetes mellitus, cardiovascular disease, obesity and neuropsychological disorders. The exact pathophysiology and clinical features are highly variable and, thus, there is still controversy in defining the diagnostic criteria. In this review, we outline the main diagnostic criteria, discuss the mechanisms involved in the complex pathogenesis, and present the associated clinical manifestations and therapeutic management of the syndrome in adolescents.
Topics: Adolescent; Diabetes Mellitus, Type 2; Female; Hirsutism; Humans; Infertility; Obesity; Polycystic Ovary Syndrome
PubMed: 32921781
DOI: 10.23750/abm.v91i3.10162 -
Proceedings of the Royal Society of... Dec 1959
Topics: Adrenal Cortex Hormones; Adrenogenital Syndrome; Female; Humans; Medical Records; Virilism
PubMed: 13852146
DOI: No ID Found -
British Medical Journal Aug 1967
Topics: Aged; Female; Hirsutism; Humans; Hyperostosis Frontalis Interna; Hypertension; Obesity; Paranoid Disorders
PubMed: 6038327
DOI: 10.1136/bmj.3.5564.559-d