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Journal of Neurology, Neurosurgery, and... Aug 2000
Topics: Deafness; Disease Management; Evoked Potentials, Auditory, Brain Stem; Health Services Accessibility; Hearing Tests; Humans; Neuroma, Acoustic; Patient Care Team
PubMed: 10896683
DOI: 10.1136/jnnp.69.2.147 -
PloS One 2021Many studies have investigated the surgical outcome and predictive factors of acoustic neuroma using different approaches. The present study focused on large tumors due... (Clinical Trial)
Clinical Trial
OBJECTIVES
Many studies have investigated the surgical outcome and predictive factors of acoustic neuroma using different approaches. The present study focused on large tumors due to the greater likelihood of internal acoustic meatus involvement and the greater application of surgical intervention than radiosurgery. There have been no previous reports on outcomes of internal acoustic meatus tumor removal. We investigated the impact of the extent of internal acoustic meatus tumor removal using a translabyrinthine approach for large acoustic neuroma surgery and predictive factors of tumor control.
METHODS
This retrospective study reviewed 104 patients with large cerebellopontine angle tumor >3 cm treated by translabyrinthine approach microsurgery. Predictive factors of postoperative facial palsy, tumor control, and extent of internal acoustic meatus tumor removal were assessed.
RESULTS
The mean tumor size was 38.95 ± 6.83 mm. Postoperative facial function showed 76.9% acceptable function (House-Brackmann grade 1 or 2) six months after surgery. The extent of internal acoustic meatus tumor removal was a statistically significant predictor factor of poor postoperative facial function. Younger age, larger tumor size needing radiosurgery, and more extensive removal of tumor were associated with better tumor control.
CONCLUSION
More extensive internal acoustic meatus tumor removal was associated with poor postoperative facial function and better tumor control.
Topics: Adult; Age Factors; Face; Female; Humans; Male; Middle Aged; Neuroma, Acoustic; Recovery of Function; Retrospective Studies
PubMed: 34351928
DOI: 10.1371/journal.pone.0253338 -
Occupational and Environmental Medicine Sep 2014To look for an association between acoustic neuroma (AN) and participation in a hearing conservation programme (HCP) and also for an association between AN and possible...
OBJECTIVES
To look for an association between acoustic neuroma (AN) and participation in a hearing conservation programme (HCP) and also for an association between AN and possible occupational risk factors in the aluminium industry.
METHODS
We conducted a case-control analysis of a population of US aluminium production workers in 8 smelters and 43 other plants. Using insurance claims data, 97 cases of AN were identified between 1996 and 2009. Each was matched with four controls. Covariates included participation in a HCP, working in an aluminium smelter, working in an electrical job and hearing loss.
RESULTS
In the bivariate analyses, covariates associated with AN were participation in the HCP (OR=1.72; 95% CI 1.09 to 2.69) and smelter work (OR=1.88; 95% CI 1.06 to 3.36). Electrical work was not significant (OR=1.60; 95% CI 0.65 to 3.94). Owing to high participation in the HCP in smelters, multivariate subanalyses were required. In the multivariate analyses, participation in the HCP was the only statistically significant risk factor for AN. In the multivariate analysis restricted to employees not working in a smelter, the OR was 1.81 (95% CI 1.04 to 3.17). Hearing loss, an indirect measure of in-ear noise dose, was not predictive of AN.
CONCLUSIONS
Our results suggest the incidental detection of previously undiagnosed tumours in workers who participated in the company-sponsored HCP. The increased medical surveillance among this population of workers most likely introduced detection bias, leading to the identification of AN cases that would have otherwise remained undetected.
Topics: Adult; Aluminum; Analysis of Variance; Case-Control Studies; Female; Hearing Loss, Noise-Induced; Humans; Male; Manufacturing Industry; Middle Aged; Neuroma, Acoustic; Occupational Exposure; Risk Factors; United States
PubMed: 25015928
DOI: 10.1136/oemed-2014-102094 -
Lin Chuang Er Bi Yan Hou Tou Jing Wai... Dec 2022At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective... (Review)
Review
At present, the main treatment for vestibular schwannomas is surgery. Considering the risk of multiple complications from surgery and the subjective and objective conditions of patients, a non-surgical treatment modality, namely stereotactic radiotherapy, has gradually been included in the treatment of vestibular schwannomas. Studies have shown that Gamma Knife therapy has a more prominent therapeutic effect on smaller tumors and can alleviate facial nerve disorders caused by space occupying of tumor mass. Cyberknife not only has a better effect on tumor control, but also has an ideal retention rate for patients' auditory function. Proton beam therapy has also been gradually applied to the treatment of vestibular schwannomas, but the effect of treatment remains to be further studied. Drug therapy includes a variety of target inhibitors and anti-angiogenic drugs. At present, drug treatment focuses more on preclinical research. This article reviews the clinical research of various radiotherapy and the progress of drug treatment.
Topics: Humans; Neuroma, Acoustic; Treatment Outcome; Hearing; Facial Nerve Diseases; Radiosurgery; Retrospective Studies
PubMed: 36543410
DOI: 10.13201/j.issn.2096-7993.2022.12.017 -
Lin Chuang Er Bi Yan Hou Tou Jing Wai... Dec 2022To analyze the clinical characteristics of unilateral acoustic neuroma(AN) with normal hearing, so as to provide evidence for early identification AN. Clinical datas...
To analyze the clinical characteristics of unilateral acoustic neuroma(AN) with normal hearing, so as to provide evidence for early identification AN. Clinical datas from 73 patients of unilateral AN with normal hearing of Otorhinolaryngology Head and Neck Surgery of Beijing Tiantan Hospital affiliated of Capital Medical University from August 2019 to April 2022 admitted to department were retrospectively analyzed. All patients underwent pure tone audiometry(PTA), speech discrimination score(SDS), auditory brainstem response(ABR), distortion product otoacoustic emission(DPOAE) and head enhanced MRI. The incidence of normal hearing among patients with AN was 10.7%. Male∶female=1∶2.2; the mean age of the patients was(37.3±9.4) years; the mean tumor size was(24.2±11.2) mm. Tinnitus was the most common reason for visit; the patients who had headache and dizziness had larger tumors. Surgery was the main treatment, and the patients who underwent surgery had larger tumors than those of follow-up. Heterogeneous tumors were the most common type of MRI, homogeneous tumors were smaller than heterogeneous and cystic tumors. The sensitivity of ABR in the diagnosis of AN with normal hearing was 95.9%, and that of ≥20 mm tumors was 100%; prolonged Ⅴ-waves were the most common, patients with Ⅴ-wave deletion had larger tumors than those with normal or prolonged Ⅴ-waves. Patients who had the longer the Ⅴ-wave and the longer difference between Ⅰ-Ⅴ wave had larger tumors. DPOAE was not elicited at full frequency in 11 patients. There was no statistically significant difference in age among patients with different symptoms, treatments, types of MRI, ABR and DPOAE. AN of normal hearing was most common in 30-39 years old women. Patients had different symptoms, phenotypes of MRI and ABR. Patients with normal hearing who had tinnitus, dizziness, headache, facial paraesthesia, and recovery after sudden haring loss can be further examination of ABR and DPOAE for early identification AN. The sensitivity of ABR in diagnosis of hearing normal AN was 95.9%, and the abnormal type of Ⅴ-wave is related to tumor size.
Topics: Female; Humans; Tinnitus; Neuroma, Acoustic; Retrospective Studies; Dizziness; Auditory Threshold; Hearing; Evoked Potentials, Auditory, Brain Stem; Vertigo; Audiometry, Pure-Tone
PubMed: 36543395
DOI: 10.13201/j.issn.2096-7993.2022.12.002 -
Science Advances Nov 2023Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing...
Vestibular schwannoma (VS) is an intracranial tumor arising from neoplastic Schwann cells and typically presenting with hearing loss. The traditional belief that hearing deficit is caused by physical expansion of the VS, compressing the auditory nerve, does not explain the common clinical finding that patients with small tumors can have profound hearing loss, suggesting that tumor-secreted factors could influence hearing ability in VS patients. We conducted profiling of patients' plasma for 66 immune-related factors in patients with sporadic VS ( > 170) and identified and validated candidate biomarkers associated with tumor size (S100B) and hearing (MCP-3). We further identified a nine-biomarker panel (TNR-R2, MIF, CD30, MCP-3, IL-2R, BLC, TWEAK, eotaxin, and S100B) with outstanding discriminatory ability for VS. These findings revealed possible therapeutic targets for VS, providing a unique diagnostic tool that may predict hearing change and tumor growth in VS patients, and may inform the timing of tumor resection to preserve hearing.
Topics: Humans; Neuroma, Acoustic; Hearing Loss; Hearing; Biomarkers; Deafness
PubMed: 37948527
DOI: 10.1126/sciadv.adf7295 -
The Journal of International Advanced... Apr 2018The wait and scan policy is being increasingly used as the first measure after the diagnosis of a vestibular schwannoma (VS) using magnetic resonance imaging (MRI). As... (Review)
Review
The wait and scan policy is being increasingly used as the first measure after the diagnosis of a vestibular schwannoma (VS) using magnetic resonance imaging (MRI). As part of the European Academy of Otology and Neuro-Otology (EAONO) position statement on VS, the frequency of imaging has been studied in the literature. Among 163 studies, 29 fulfilled the inclusion criteria and were scored using the Grading of Recommendations, Assessment, Development, and Evaluation system. Because tumor growth rate during the first 5 years of follow-up is predictive of further growth during the upcoming years, a protocol for wait and scan is useful for centers dealing with this condition. The EAONO proposal is that after the initial diagnosis by MRI, a first new MRI would take place after 6 months, annually for 5 years, and then every other year for 4 years, followed by a lifelong MRI follow-up every 5 years. The first early MRI is to screen for fast-growing tumors, and the lifelong follow-up with tapered intervals is to detect late repeated growth.
Topics: Aftercare; Disease Progression; Humans; Magnetic Resonance Imaging; Meta-Analysis as Topic; Neoplasm Grading; Neurofibromatosis 2; Neuroma, Acoustic; Practice Guidelines as Topic; Prospective Studies; Retrospective Studies; Watchful Waiting
PubMed: 29764780
DOI: 10.5152/iao.2018.5348 -
Mathematical Biosciences and... Apr 2023Prior to the surgical removal of an acoustic neuroma, the majority of patients anticipate that their hearing will be preserved to the greatest possible extent following...
Prior to the surgical removal of an acoustic neuroma, the majority of patients anticipate that their hearing will be preserved to the greatest possible extent following surgery. This paper proposes a postoperative hearing preservation prediction model for the characteristics of class-imbalanced hospital real data based on the extreme gradient boost tree (XGBoost). In order to eliminate sample imbalance, the synthetic minority oversampling technique (SMOTE) is applied to increase the number of underclass samples in the data. Multiple machine learning models are also used for the accurate prediction of surgical hearing preservation in acoustic neuroma patients. In comparison to research results from existing literature, the experimental results found the model proposed in this paper to be superior. In summary, the method this paper proposes can make a significant contribution to the development of personalized preoperative diagnosis and treatment plans for patients, leading to effective judgment for the hearing retention of patients with acoustic neuroma following surgery, a simplified long medical treatment process and saved medical resources.
Topics: Humans; Neuroma, Acoustic; Retrospective Studies; Hearing
PubMed: 37322959
DOI: 10.3934/mbe.2023477 -
Lin Chuang Er Bi Yan Hou Tou Jing Wai... Aug 2022To explore the application value of video head impulse test(vHIT), caloric test(CT) and the dizziness handicap inventory(DHI) in the diagnosis of acoustic...
To explore the application value of video head impulse test(vHIT), caloric test(CT) and the dizziness handicap inventory(DHI) in the diagnosis of acoustic neuroma(AN), to analyze the correlation between vHIT and CT, and to determine the correlationsof tumor size, vHIT, CT and DHI score. The clinical data of 24 patients with AN who underwent surgery in our department from January 2019 to January 2022 were analyzed retrospectively, including craniocerebral MRI, vHIT, caloric test and DHI score. All the data were statistically analyzed by GraphPadPrism9.0. There was a significant negative correlation between the UW value of CT and the vestibular eye reflex gain of vHIT(<0.01, =-0.62). The tumor size was significantly correlated with the increase of UW value of CT(<0.01, =0.69), and with the decrease of vestibulo-ocular reflex gain of vHIT(<0.01, =-0.53). The average Dizziness Handicap Inventory score was 8.9±16.2, which was not correlated with tumor size(>0.05). Both vHIT and CT can effectively evaluate the vestibular function of patients with AN(and they are complementary), and they are related to the size of the tumor and have certain value in the diagnosis of acoustic neuroma.
Topics: Caloric Tests; Dizziness; Head Impulse Test; Humans; Neuroma, Acoustic; Reflex, Vestibulo-Ocular; Retrospective Studies; Vertigo
PubMed: 35959580
DOI: 10.13201/j.issn.2096-7993.2022.08.009 -
Occupational and Environmental Medicine Dec 2006The rapid increase of mobile phone use has increased public concern about its possible health effects in Japan, where the mobile phone system is unique in the...
OBJECTIVES
The rapid increase of mobile phone use has increased public concern about its possible health effects in Japan, where the mobile phone system is unique in the characteristics of its signal transmission. To examine the relation between mobile phone use and acoustic neuroma, a case-control study was initiated.
METHODS
The study followed the common, core protocol of the international collaborative study, INTERPHONE. A prospective case recruitment was done in Japan for 2000-04. One hundred and one acoustic neuroma cases, who were 30-69 years of age and resided in the Tokyo area, and 339 age, sex, and residency matched controls were interviewed using a common computer assisted personal interview system. Education and marital status adjusted odds ratio was calculated with a conditional logistic regression analysis.
RESULTS
Fifty one cases (52.6%) and 192 controls (58.2%) were regular mobile phone users on the reference date, which was set as one year before the diagnosis, and no significant increase of acoustic neuroma risk was observed, with the odds ratio (OR) being 0.73 (95% CI 0.43 to 1.23). No exposure related increase in the risk of acoustic neuroma was observed when the cumulative length of use (<4 years, 4-8 years, >8 years) or cumulative call time (<300 hours, 300-900 hours, >900 hours) was used as an exposure index. The OR was 1.09 (95% CI 0.58 to 2.06) when the reference date was set as five years before the diagnosis. Further, laterality of mobile phone use was not associated with tumours.
CONCLUSIONS
These results suggest that there is no significant increase in the risk of acoustic neuroma in association with mobile phone use in Japan.
Topics: Adult; Age Distribution; Aged; Case-Control Studies; Cell Phone; Female; Humans; Japan; Male; Middle Aged; Neoplasms, Radiation-Induced; Neuroma, Acoustic; Risk Assessment; Time Factors
PubMed: 16912083
DOI: 10.1136/oem.2006.028308