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Perspective Infirmiere : Revue... 2015
Topics: Humans; Spondylitis, Ankylosing
PubMed: 26727802
DOI: No ID Found -
Clinical Calcium Dec 2008Ankylosing Spondylitis (AS) is one of the rheumatoid diseases, however its clinical features are different. The diagnosis of AS and clinical features are shown,... (Review)
Review
Ankylosing Spondylitis (AS) is one of the rheumatoid diseases, however its clinical features are different. The diagnosis of AS and clinical features are shown, especially the diagnosis is very important. The new modified criteria for diagnosis is detailed here. In addition, the differential diagnosis is exhibited which is significantly useful for the diagnosis of AS. Recently As has been included in the group of seronegative spondylarthropathy (SPA). Now AS is thought to be the central position among SPA which has a lot of similar symptoms. The characteristic symptoms of SPA or AS are spinal, eye, skin, sytemic lesions and enthesopathy. These clinical features are also critical in the diagnosis of AS as well. Finally, what is the most important factor in AS? The answer is an early treatment by a correct diagnosis.
Topics: Adolescent; Adult; Age Factors; Biomarkers; Child; Diagnosis, Differential; Diagnostic Imaging; Female; HLA-B27 Antigen; Humans; Male; Reference Standards; Rheumatoid Factor; Sex Factors; Spondylitis, Ankylosing; Young Adult
PubMed: 19043193
DOI: No ID Found -
Arthritis Research & Therapy Oct 2019Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a...
BACKGROUND
Patients with ankylosing spondylitis (AS) have a higher prevalence of depression compared to the general population. Comorbid depression in AS likely has a multifactorial origin. While several disease-related and contextual factors have been associated with depressive symptoms in AS, a comprehensive model of their interrelations is currently lacking. Such a model could help understand the mechanisms leading to, or maintaining, depression in AS. The objectives of the current study were to determine which factors are associated with depressive symptoms in AS and to understand their underlying relationships.
METHODS
Data from a cross-sectional survey-based multicentre study were used. Potential determinants included both contextual and disease-related factors. Depressive symptoms were assessed by the Hospital Anxiety and Depression Subscale (HADS-D). Direct and indirect associations between risk factors and the latent depressive symptom outcome were explored using structural equation modelling. A final model was selected based on model fit criteria and clinical plausibility.
RESULTS
Among 245 patients, median HADS-D score was 3 (interquartile range 1-6), and 44 patients (18%) had a HADS-D score ≥ 8, indicating possible depression. In the final model, contextual factors significantly associated with depressive symptoms were male gender, being employed, lower income, lower mastery and worse satisfaction with social role participation. Bath AS Disease Activity Index (BASDAI) was the only disease-related factor that was associated with depressive symptoms, acted only indirectly via mastery, and its standardized total effect on depressive symptoms was smaller than that of several contextual factors. Mastery had a central role in the path diagram and mediated the effects of BASDAI, income and satisfaction with social role participation on depressive symptoms. The final model explained 64% of the variance in the depression outcome.
CONCLUSIONS
Both contextual and disease-related factors are associated with depressive symptoms in AS. Mastery, the extent to which one feels in control over life and disease, has a key role in this process. Results support a relevance of self-efficacy in disease management and patient education. In order to improve patients' mental health, research is warranted whether mastery and its relation with depression can be modified.
Topics: Adult; Cross-Sectional Studies; Depression; Female; Humans; Male; Middle Aged; Models, Theoretical; Spondylitis, Ankylosing; Surveys and Questionnaires
PubMed: 31639012
DOI: 10.1186/s13075-019-1995-7 -
British Medical Journal Sep 1978
Topics: Exercise Therapy; Humans; Spondylitis, Ankylosing
PubMed: 698694
DOI: No ID Found -
Rheumatology International Sep 2020Social media usage by back pain patients is a new and developing area. Analysing patterns of this online activity offers a new way to understand our patients' concerns... (Observational Study)
Observational Study
Social media usage by back pain patients is a new and developing area. Analysing patterns of this online activity offers a new way to understand our patients' concerns and behaviour around disease. Large volume data can be evaluated on a scale not feasible through alternative methods. A cross sectional review of specific terms relating to 'back pain' (BP) and 'ankylosing spondylitis' (AS) were tracked internationally on popular websites, blogs and boards over two 3 month periods, in 2016 and 2019. Relevant co-terms were also tracked in these discussions, such as 'exercise', 'medication' and 'doctor'. The size of the current online BP conversation is significant; there were over 100,000 mentions/month across each study period, particularly 'low-' BP. Discussions about AS increased threefold between 2016 and 2019. More discussions took place online at the start of the week, and in the afternoons. Pregnancy, baby and mens' health resources were the most popular sites for BP chats. People posting about AS were mainly female (80%) and predominantly had an established diagnosis, with health forums hosting more of these discussions than for BP. Exercise was more commonly mentioned in the context of BP, whereas medications were more common in the AS conversations. Analysing online discussions about BP and AS helps to identify themes amongst patients. Some are seeking a diagnosis, support, or treatment information. Understanding the massive scale of online conversations could help clinicians adopt targeted approaches to increase patient identification, meet patient concerns better, and optimise engagement.
Topics: Back Pain; Cross-Sectional Studies; Female; Humans; Information Seeking Behavior; Internet; Male; Social Media; Spondylitis, Ankylosing
PubMed: 32430806
DOI: 10.1007/s00296-020-04600-w -
Journal of Nanobiotechnology May 2023Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently...
Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal anti-inflammatory drugs (NSAIDs), disease-modifying anti-rheumatic drugs (DMARDs) and TNF inhibitors, are limited by side effects, high costs and unclear inhibitory effects on heterotopic ossification. Herein, we developed manganese ferrite nanoparticles modified by the aptamer CH6 (CH6-MF NPs) that can efficiently scavenge ROS and actively deliver siRNA into hMSCs and osteoblasts in vivo for effective AS treatment. CH6-MF NPs loaded with BMP2 siRNA (CH6-MF-Si NPs) effectively suppressed abnormal osteogenic differentiation under inflammatory conditions in vitro. During their circulation and passive accumulation in inflamed joints in the Zap70 mouse model, CH6-MF-Si NPs attenuated local inflammation and rescued heterotopic ossification in the entheses. Thus, CH6-MF NPs may be an effective inflammation reliever and osteoblast-specific delivery system, and CH6-MF-Si NPs have potential for the dual treatment of chronic inflammation and heterotopic ossification in AS.
Topics: Mice; Animals; Spondylitis, Ankylosing; Osteogenesis; Inflammation; Osteoblasts; RNA, Small Interfering; Ossification, Heterotopic
PubMed: 37231465
DOI: 10.1186/s12951-023-01906-2 -
Seminars in Arthritis and Rheumatism Aug 2020Axial spondyloarthritis (axSpA) is a chronic inflammatory immune-mediated disease resulting in inflammatory low back pain and other inflammatory manifestations in... (Review)
Review
Axial spondyloarthritis (axSpA) is a chronic inflammatory immune-mediated disease resulting in inflammatory low back pain and other inflammatory manifestations in peripheral joints and entheses. AxSpA encompasses both ankylosing spondylitis (AS), in which patients present with definitive sacroiliitis visible on radiographic imaging, as well as nonradiographic axSpA (nr-axSpA), in which such changes may not be discernable. Emerging evidence suggests that women and men experience axSpA differently. Although the prevalence of AS is approximately 2- to 3- fold higher in men than in women, nr-axSpA occurs with roughly equal frequency in women and men. The goal of this review is to increase awareness of sex differences in axSpA by exploring the distinct manifestations of disease and disease characteristics in women, the overall clinical burden, recommendations for diagnosis, and potential treatment options. We summarize and contextualize the results of recent studies that illuminate sex differences in nr-axSpA and AS, including differences in disease manifestation and progression. It is important that sex differences in axSpA are understood and considered when diagnosing and treating the spectrum of axSpA, including AS and nr-axSpA.
Topics: Delayed Diagnosis; Disease Progression; Female; Humans; Male; Quality of Life; Sex Factors; Spondylitis, Ankylosing
PubMed: 32521322
DOI: 10.1016/j.semarthrit.2020.05.005 -
Frontiers in Immunology 2021Ankylosing spondylitis (AS) is a type of spondyloarthropathies, the diagnosis of which is often delayed. The lack of early diagnosis tools often delays the institution...
Ankylosing spondylitis (AS) is a type of spondyloarthropathies, the diagnosis of which is often delayed. The lack of early diagnosis tools often delays the institution of appropriate therapy. This study aimed to investigate the systemic metabolic shifts associated with AS and TNF inhibitors treatment. Additionally, we aimed to define reliable serum biomarkers for the diagnosis. We employed an untargeted technique, ultra-performance liquid chromatography-mass spectroscopy (LC-MS), to analyze the serum metabolome of 32 AS individuals before and after 24-week TNF inhibitors treatment, as well as 40 health controls (HCs). Multivariate and univariate statistical analyses were used to profile the differential metabolites associated with AS and TNF inhibitors. A diagnostic panel was established with the least absolute shrinkage and selection operator (LASSO). The pathway analysis was also conducted. A total of 55 significantly differential metabolites were detected. We generated a diagnostic panel comprising five metabolites (L-glutamate, arachidonic acid, L-phenylalanine, PC (18:1(9Z)/18:1(9Z)), 1-palmitoylglycerol), capable of distinguishing HCs from AS with a high AUC of 0.998, (95%CI: 0.992-1.000). TNF inhibitors treatment could restore the equilibrium of 21 metabolites. The most involved pathways in AS were amino acid biosynthesis, glycolysis, glutaminolysis, fatty acids biosynthesis and choline metabolism. This study characterized the serum metabolomics signatures of AS and TNF inhibitor therapy. We developed a five-metabolites-based panel serving as a diagnostic tool to separate patients from HCs. This serum metabolomics study yielded new knowledge about the AS pathogenesis and the systemic effects of TNF inhibitors.
Topics: Adult; Female; Humans; Male; Metabolomics; Spondylitis, Ankylosing; Tumor Necrosis Factor Inhibitors; Young Adult
PubMed: 33679777
DOI: 10.3389/fimmu.2021.630791 -
Dental and Medical Problems 2020There are no studies evaluating the possible association between ankylosing spondylitis (AS) and apical periodontitis (AP).
BACKGROUND
There are no studies evaluating the possible association between ankylosing spondylitis (AS) and apical periodontitis (AP).
OBJECTIVES
The aim of the present cross-sectional study was to investigate the possible association between AS and AP.
MATERIAL AND METHODS
Fifty patients diagnosed with AS, receiving treatment at the Rheumatology Clinic in Erzurum, Turkey, were included in the experimental group. Another 50 ageand gender-matched individuals without any history of systemic disease were included in the study as the control group. All patients were examined radiographically and clinically to diagnose the presence of AP. The following data was recorded for all patients: the smoking habit, the number of teeth present, the number of teeth with AP, the number of root canal-treated (RCT) teeth, and the number of RCT teeth with AP.
RESULTS
There were 1,283 teeth in the AS group and 1,305 in the control group. There was a significant association between teeth with AP and AS, as the prevalence of teeth with AP was significantly lower in the control group (1.3%) than in the AS group (2.9%) (OR (odds ratio) = 2.250; p = 0.005). There was no statistically significant difference between the groups in terms of the number of RCT teeth and RCT teeth with AP (p > 0.05).
CONCLUSIONS
Ankylosing spondylitis is significantly associated with an increased prevalence of AP. It can be concluded that patients with AS can be more prone to develop AP. However, AS does not reduce the success rate of endodontic treatment, because there was no significant difference between the AS and control groups in terms of RCT teeth with AP.
Topics: Cross-Sectional Studies; Humans; Periapical Periodontitis; Root Canal Therapy; Spondylitis, Ankylosing; Turkey
PubMed: 32104993
DOI: 10.17219/dmp/114463 -
British Medical Journal Nov 1958
Topics: Ankylosis; Humans; Spondylitis; Spondylitis, Ankylosing
PubMed: 13584855
DOI: 10.1136/bmj.2.5104.1082