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Journal of Nuclear Cardiology :... Apr 2014Imaging cellular and molecular processes associated with aneurysm expansion, dissection, and rupture can potentially transform the management of patients with thoracic... (Review)
Review
Imaging cellular and molecular processes associated with aneurysm expansion, dissection, and rupture can potentially transform the management of patients with thoracic and abdominal aortic aneurysm. Here, we review recent advances in molecular imaging of aortic aneurysm, focusing on imaging modalities with the greatest potential for clinical translation and application, PET, SPECT, and MRI. Inflammation (e.g., with (18)F-FDG, nanoparticles) and matrix remodeling (e.g., with matrix metalloproteinase-targeted tracers) are highlighted as promising targets for molecular imaging of aneurysm. Potential alternative or complementary approaches to molecular imaging for aneurysm risk stratification are briefly discussed.
Topics: Aortic Aneurysm; Biomarkers; Cytokines; Humans; Immunologic Factors; Molecular Imaging; Risk Assessment
PubMed: 24381115
DOI: 10.1007/s12350-013-9845-5 -
Brazilian Journal of Cardiovascular... Feb 2021Although aortic valve replacement remains the gold standard treatment for aortic valve diseases like stenosis (AS) or insufficiency, new surgical methods have been...
Although aortic valve replacement remains the gold standard treatment for aortic valve diseases like stenosis (AS) or insufficiency, new surgical methods have been developed with a focus in the reconstruction of the aortic valve rather than replacing it. The Ozaki procedure involves a tailored replacement of each individual valvular leaflet with glutaraldehyde-treated autologous pericardium and aims to reproduce the normal anatomy of the aortic valve. Cases of patients with unicuspid aortic valve treated with the Ozaki procedure are uncommon in the litrature and become even more rare when it comes to concomitant diseases like AS and ascending aorta aneurysm. We present the case of a 21-year-old, fit and asymptomatic male, with unicuspid aortic valve with severe stenosis and ascending aorta dilatation, surgically treated with tricuspidization of the aortic valve with glutaraldehyde-treated autologous pericardium and replacement of the ascending aorta with a straight synthetic graft. Postoperative studies showed a fully functional, neo-tailored tricuspid aortic valve with trivial regurgitation. The patient had an uncomplicated recovery, stayed in the intensive care unit for 2 days and was discharged on the 7th postoperative day.
Topics: Adult; Aorta; Aortic Aneurysm; Aortic Valve; Heart Valve Diseases; Humans; Male; Young Adult
PubMed: 33355794
DOI: 10.21470/1678-9741-2020-0150 -
Current Problems in Surgery Mar 2017
Review
Topics: Aortic Dissection; Aorta; Aortic Aneurysm; Genetic Predisposition to Disease; Humans; Risk Factors
PubMed: 28521856
DOI: 10.1067/j.cpsurg.2017.01.001 -
Current Vascular Pharmacology Nov 2010Abdominal Aortic Aneurysm (AAA) is a common, progressive, and potentially lethal vascular disease. A major obstacle in AAA research, as well as patient care, is the lack... (Review)
Review
Abdominal Aortic Aneurysm (AAA) is a common, progressive, and potentially lethal vascular disease. A major obstacle in AAA research, as well as patient care, is the lack of technology that enables non-invasive acquisition of molecular/cellular information in the developing AAA. In this review we will briefly summarize the current techniques (e.g. ultrasound, computed tomography, and magnetic resonance imaging) for anatomical imaging of AAA. We also discuss the various functional imaging techniques that have been explored for AAA imaging. In many cases, these anatomical and functional imaging techniques are not sufficient for providing surgeons/clinicians enough information about each individual AAA (e.g. rupture risk) to optimize patient management. Recently, molecular imaging techniques (e.g. optical and radionuclide-based) have been employed to visualize the molecular alterations associated with AAA, which are discussed in this review. Lastly, we try to provide a glance into the future and point out the challenges for AAA imaging. We believe that the future of AAA imaging lies in the combination of anatomical and molecular imaging techniques, which are largely complementary rather than competitive. Ultimately, with the right molecular imaging probe, clinicians will be able to monitor AAA growth and evaluate the risk of rupture accurately, so that the life-saving surgery can be provided to the right patients at the right time. Equally important, the right imaging probe will also allow scientists/clinicians to acquire critical data during AAA development and to more accurately evaluate the efficacy of potential treatments.
Topics: Animals; Aortic Aneurysm, Abdominal; Aortic Rupture; Diagnostic Imaging; Female; Humans; Magnetic Resonance Imaging; Male; Molecular Imaging; Positron-Emission Tomography; Tomography, Emission-Computed, Single-Photon
PubMed: 20180767
DOI: 10.2174/157016110793563898 -
Clinical Cardiology Nov 2020The association between psoriasis and the risk of aortic aneurysm is still unclear. (Meta-Analysis)
Meta-Analysis
BACKGROUND
The association between psoriasis and the risk of aortic aneurysm is still unclear.
HYPOTHESIS
Patients with psoriasis have a higher risk of aortic aneurysm than healthy individuals.
METHODS
PubMed, Embase, and Scopus from inception to 20 July 2019 were searched. We included cohort studies if they reported estimate effects on the risk of aortic aneurysm in patient with psoriasis. We used Newcastle-Ottawa Scale to evaluate methodology quality of eligible studies. Random-effect meta-analyses were used to estimate the overall risk. Subgroup analyses were conducted for analysis of influencing factors.
RESULTS
After a view of 2207 citations, we included three large cohort studies enrolling 5 706 525 participants in this systematic review. Psoriasis patients have an increased risk of development of aortic aneurysm (hazard ratio [HR]: 1.30, 95%confidence intervals [CI], 1.10-1.55, I = 53.1%). The risk is not statistically different between patients with severe psoriasis (HR, 1.51, 95%CI, 1.04-2.19, I = 40.2%) and patients with mild psoriasis (HR, 1.24, 95%CI, 1.08-1.42, I = 24.1%). The risk was not statistically increased in female patients (HR, 1.55, 95%CI, 0.65-3.72), patients ≥50 years old (HR, 4.05, 95%CI, 0.69-23.75, I = 97.3%), and patients with diabetes (HR, 0.97, 95%CI, 0.83-1.14).
CONCLUSIONS
Current evidence from observational studies suggests that psoriasis increases the risk of aortic aneurysm, and screening of aortic aneurysm might be considered among psoriasis patients.
Topics: Aortic Aneurysm; Endovascular Procedures; Global Health; Humans; Incidence; Psoriasis; Risk Assessment; Risk Factors
PubMed: 32757333
DOI: 10.1002/clc.23438 -
European Journal of Vascular and... Nov 2023
Topics: Humans; Renal Veins; Aortic Aneurysm; Aorta; Aortic Aneurysm, Abdominal
PubMed: 37562762
DOI: 10.1016/j.ejvs.2023.08.004 -
Texas Heart Institute Journal 2011Two hundred fifty years have passed since Frank Nicholls' history-making, accurate observations on the anatomic findings and cause of death of King George II were... (Review)
Review
Two hundred fifty years have passed since Frank Nicholls' history-making, accurate observations on the anatomic findings and cause of death of King George II were published. Several decades later, the disease was named, using--for the first time--the terms dissection and dissecting attached to an aortic disease process. Another century went by before effective surgical treatment was developed. In sharp contrast, the evolution of the last 20 years has been nothing short of amazing. Our understanding of AD, while not yet complete, has improved dramatically. In addition, the introduction of nonsurgical endovascular therapy has had a profoundly transformative impact--and we are just at the beginning! It would not be unreasonable to predict that stent-graft repair will likely replace (or nearly replace) open surgery in the treatment of complicated type B dissection in the near future, especially as technologies continue to improve and indication-specific designs are developed and tested in the clinical setting. Moreover, it is predictable that endovascular solutions for some patients with type A aortic dissection will become available in the years to come as surgical results continue to be suboptimal. Finally, and amidst this plethora of “good news,” it is appropriate to reflect on the formidable challenge that endovascular therapies face as they gear to “compete” with optimal medical therapy in the management of patients with acute uncomplicated type B dissection, because it will obviously be difficult (if not impossible) to improve on the already-achieved 30-day mortality rate of less than 10%. Long-term gains may well become the winning card when and if the late results of TEVAR can be shown to improve on the rather compromised outlook of medically treated dissection patients. Stay tuned.
Topics: Aortic Dissection; Aortic Aneurysm; Blood Vessel Prosthesis Implantation; Endovascular Procedures; History, 18th Century; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Vascular Surgical Procedures
PubMed: 22199439
DOI: No ID Found -
Circulation Journal : Official Journal... 2014
Topics: Angioplasty; Aortic Aneurysm, Abdominal; Aortic Aneurysm, Thoracic; Female; Humans; Male; Vascular Stiffness; Ventricular Function, Left
PubMed: 24389595
DOI: 10.1253/circj.cj-13-1520 -
The Medical Journal of Malaysia Feb 2019Aortic disease includes conditions such as chronic aortic aneurysms, acute aortic syndromes and congenital aortic abnormalities, amongst others. This paper reviews all... (Review)
Review
INTRODUCTION
Aortic disease includes conditions such as chronic aortic aneurysms, acute aortic syndromes and congenital aortic abnormalities, amongst others. This paper reviews all research on aortic disease performed in Malaysia and published between 2000-2016.
METHODS
A literature search was conducted in PubMed, Scopus, MyJurnal and the UKM Journal Repository. The search process was based on a previously published methodology. The medical subject headings (MeSH) search terms used were "aortic", "aorta" and "Malaysia".
RESULTS
Two-hundred-thirteen papers were identified, of which 60 papers were selected and reviewed on the basis of their relevance. The epidemiology, pathophysiology, clinical presentations, case reports, investigations, treatment and outcomes of aortic disease in Malaysia were reviewed and summarised. The clinical relevance of the studies performed are discussed.
CONCLUSION
The review provided an insight into the pathophysiology, prevalence and epidemiology of aortic diseases in Malaysia, how the condition is managed, and the outcomes of treatment. Limitations of the research performed in Malaysia to date were identified and recommendations for further research and improvement in clinical practice were recommended.
Topics: Aortic Dissection; Aortic Aneurysm; Aortic Diseases; Biomedical Research; Humans; Malaysia
PubMed: 30846666
DOI: No ID Found -
Anatolian Journal of Cardiology Feb 2019
Topics: Aorta; Aortic Aneurysm; Aortic Valve Insufficiency; Humans; Video Recording
PubMed: 30694811
DOI: 10.14744/AnatolJCardiol.2018.92597