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Medical Ultrasonography May 2022Contrast-enhanced ultrasound (CEUS) appears to be a promising application for the diagnosis of parotid gland tumours. We aimed to systematically review and meta-analyse... (Meta-Analysis)
Meta-Analysis Review
AIM
Contrast-enhanced ultrasound (CEUS) appears to be a promising application for the diagnosis of parotid gland tumours. We aimed to systematically review and meta-analyse the ability of CEUS in distinguishing benign from malignant parotid gland tumours.
MATERIAL AND METHODS
PubMed was searched for relevant studies. Data on area under time intensity curve (AUC) in arbitrary unit (AU), and mean transit time (MTT) in seconds (sec) were analysed using the Cochrane Review Manager Software.
RESULTS
Nine studies met the eligibility criteria comprising a total number of 498 parotid gland tumours (benign, number (n)=423; malignant, n=75). Descriptive evaluation of parotid gland tumours following CEUS administration showed overlap characteristics in benign and malignancies. Two publications assessed AUC and MTT in 72 and 60 parotid gland tumours, respectively. AUC was significantly lower in benign compared to malignant tumours following contrast administration (AUC, mean difference (MD) -266.77 AU, 95% confidence intervals (CI) -433.22, -100.33, p=0.002). No significant different in MTT between benign and malignant tumours (p=0.12). Heterogeneity was statistically significant in AUC (p=0.04) and MTT (p<0.00001).
CONCLUSION
Descriptive evaluation of parotid gland tumours showed overlap CEUS characteristics. Perfusion related CEUS parameters analysis is promising in differentiating benign parotid tumours from malignancies.
Topics: Contrast Media; Diagnosis, Differential; Humans; Parotid Gland; Parotid Neoplasms; Perfusion; Ultrasonography
PubMed: 34216453
DOI: 10.11152/mu-3119 -
Frontiers in Physiology 2022The aim of this study was to evaluate whether pain stimuli can be measured validly and reliably by the eEgg (electronic Egg), a new device to measure pain intensity, in...
The aim of this study was to evaluate whether pain stimuli can be measured validly and reliably by the eEgg (electronic Egg), a new device to measure pain intensity, in comparison to the hand dynamometer. This study consists of screening and diagnostic tests conforming to the standard criterion of handgrip strength measurement. Fifty healthy participants (25 women, 25 men; age, 39.1 ± 13.7 years) participated in this study. The approach of intermodal comparison was used to transfer different degrees of pain sensations into measurable handgrip strength values. This included an intensity comparison of 10-100% of the subjective maximum handgrip strength and an application of thermal stimuli of 34-48°C. The eEgg was compared to the numeric rating scale (NRS) as a categorization method regarding the subjective assessment of pain. An online questionnaire was distributed to test the evaluation of the product's features. Regarding the experiment's validity, the handgrip strength values showed significant ( < 0.05) positive correlations between the eEgg and the hand dynamometer (intensities: r=0.328 to r=0.550; thermal stimuli: r=0.353 to r=0.614). The reliability results showed good to very good correlations ( < 0.05) in the calculated ICC (intraclass correlation coefficient) values between the individual measurement devices: eEgg intensities: ICC=0.621 to 0.851; thermal stimuli: ICC=0.487 to 0.776 and hand dynamometer intensities: ICC= 0.789 to 0.974; thermal stimuli: ICC=0.716 to 0.910. The new eEgg device shows strong correlations with the hand dynamometer. The central limitation focuses on the obligatory use of an arbitrary unit (AU) for the eEgg. The results of the study indicate that this device can be used in medical and therapeutic practice in the future.
PubMed: 35418877
DOI: 10.3389/fphys.2022.832172 -
Optics Express Apr 2022The application of the inverse design method and free-form geometrical optimization in photonic devices endows them with highly tunable functionality and an...
The application of the inverse design method and free-form geometrical optimization in photonic devices endows them with highly tunable functionality and an ultra-compact footprint. In this paper, we implemented this platform to silicon photonic guided-mode manipulation and demonstrated a guided mode-based signal switching architecture. The passive signal switching mechanism is utilized so that no power consumption is needed for routing state maintenance. To solve the explosive increasing design cost in such mechanism when the switching scale is expanded, we illustrate that only a small number of mode switching devices need to be designed as the switching basis. In theory, arbitrary signal routing states can be constructed by cascading some selected basis. The required switching devices can be decreased from factorial N to N - 1 for the N channels switching. For proof of concept, we design and experimentally demonstrate the three-mode cases and the cascade method to combine any three mode-based switching devices. Experiments show that the insertion losses of TE - TE mode switching unit (U1), TE - TE mode switching units (U2), and TE - TE mode switching unit (U3) are less than 2.8 dB, 3.1 dB, and 2.3 dB, respectively. The demonstrated architecture has both arbitrary signal switching capability and ultra-compact footprint, which is promising in the application of mode-division multiplexing communication systems.
PubMed: 35473264
DOI: 10.1364/OE.457842 -
Proceedings of the National Academy of... Mar 2019Humans' ability to create and manipulate symbolic structures far exceeds that of other animals. We hypothesized that this ability rests on an early capacity to use...
Humans' ability to create and manipulate symbolic structures far exceeds that of other animals. We hypothesized that this ability rests on an early capacity to use arbitrary signs to represent any mental representation, even as abstract as an algebraic rule. In three experiments, we collected high-density EEG recordings while 150 5-month-old infants were presented with speech triplets characterized by their abstract syllabic structure-the location of syllable repetition-which predicted a following arbitrary label (e.g., ABA words were followed by a fish picture, AAB words by a lion). After a brief learning phase, EEG responses to novel words revealed that infants built expectations about the upcoming label based on the triplet structure and were surprised when it happened to be incongruent. Preverbal infants were thus able to recode the incoming triplets into abstract mental variables to which arbitrary labels were flexibly assigned. Importantly, infants also generalized to novel trials in which the pairing order was reversed (with the label preceding the auditory structure). Beyond conditioned associations, infants instantly inferred a bidirectional mapping between the abstract structures and the following label, a foundational operation for any symbolic system.
Topics: Acoustic Stimulation; Electroencephalography; Female; Humans; Infant; Language; Language Development; Learning; Male; Speech; Speech Perception
PubMed: 30837317
DOI: 10.1073/pnas.1809144116 -
The Journal of Allergy and Clinical... May 2022There is limited evidence on the long-term impact of mild-to-moderate coronavirus disease 2019 (COVID-19) on lung function among young adults.
BACKGROUND
There is limited evidence on the long-term impact of mild-to-moderate coronavirus disease 2019 (COVID-19) on lung function among young adults.
OBJECTIVES
We aimed to assess whether COVID-19 has a negative impact on lung function in young adults and whether asthma, allergic sensitization, or use of inhaled corticosteroids (ICSs) modifies a potential association.
METHODS
Participants from the population-based BAMSE (Barn, Allergi, Miljö, Stockholm, Epidemiologi) cohort with spirometry assessed before (2016-2019) and after onset of the COVID-19 pandemic (2020-2021) were included. Serum levels of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor-binding domain-specific IgG, IgM, and/or IgA (determined with ELISA) defined seropositivity. Mean change in lung function (ie, change in FEV, forced vital capacity [FVC], and FEV/FVC ratio expressed as percent of predicted [pp]) from before to after onset of the pandemic were compared between the seronegative and seropositive participants. In seropositive participants, change in lung function was assessed in relation to allergic sensitization and self-reported ICS use.
RESULTS
Of the 853 included participants, 29% (n = 243) were seropositive. There were no differences in change in lung function between the seronegative and seropositive participants (for mean change in FEV pp [SD], seropositivity = 0.87% [4.79%] and seronegativity = 1.03% (4.76%) [66] for difference using a test; FVC pp (SD), seropositivity = 1.34% (4.44%) and seronegativity = 1.29% (4.27%) [87]; and for FEV/FVC pp (SD), seropositivity = -0.25% (3.13%) and seronegativity = -0.13% (3.15%) [61]). Similar results were observed among participants with asthma (n = 147 [17%]). Among seropositive participants, allergic sensitization or ICS use did not influence lung function.
CONCLUSION
We found no evidence of mild-to-moderate COVID-19 affecting lung function long term in a population-based cohort of young adults. Moreover, neither asthma nor allergic sensitization nor ICS use affected the results.
PubMed: 36647376
DOI: 10.1016/j.jacig.2022.03.001 -
Proceedings of the National Academy of... Aug 2022Geometric compatibility constraints dictate the mechanical response of soft systems that can be utilized for the design of mechanical metamaterials such as the negative...
Geometric compatibility constraints dictate the mechanical response of soft systems that can be utilized for the design of mechanical metamaterials such as the negative Poisson's ratio Miura-ori origami crease pattern. Here, we develop a formalism for linear compatibility that enables explicit investigation of the interplay between geometric symmetries and functionality in origami crease patterns. We apply this formalism to a particular class of periodic crease patterns with unit cells composed of four arbitrary parallelogram faces and establish that their mechanical response is characterized by an anticommuting symmetry. In particular, we show that the modes are eigenstates of this symmetry operator and that these modes are simultaneously diagonalizable with the symmetric strain operator and the antisymmetric curvature operator. This feature reveals that the anticommuting symmetry defines an equivalence class of crease pattern geometries that possess equal and opposite in-plane and out-of-plane Poisson's ratios. Finally, we show that such Poisson's ratios generically change sign as the crease pattern rigidly folds between degenerate ground states and we determine subfamilies that possess strictly negative in-plane or out-of-plane Poisson's ratios throughout all configurations.
PubMed: 35921444
DOI: 10.1073/pnas.2202777119 -
Critical Care (London, England) 2007Withdrawal and limitation of life support in the intensive care unit is common, although how this decision is reached can be varied and arbitrary. Inevitably, the... (Review)
Review
Withdrawal and limitation of life support in the intensive care unit is common, although how this decision is reached can be varied and arbitrary. Inevitably, the patient is unable to participate in this discussion because their capacity is limited by the nature of the illness and the effects of its treatment. Physicians often discuss these decisions with relatives in an attempt to respect the patient's wishes despite evidence suggesting that the relatives may not correctly reflect the patient's desires. Advance decisions, commonly known as 'living wills', have been proposed as a way of facilitating the maintenance of an individual's autonomy when they become incapacitated. Others have argued that legalising advance decisions is euthanasia by the back door. In October 2007 in England and Wales, advance decisions will become legally binding as part of the 2005 Mental Capacity Act. This has been the case in the USA for many years. The purpose of the present review is to examine the published literature regarding the effect of advance decisions in relation to the provision of adult critical care.
Topics: Advance Directives; Aged; Critical Care; Health Care Costs; Humans; Intensive Care Units; Quality of Life; Suicide, Assisted; Terminal Care; United States
PubMed: 17634087
DOI: 10.1186/cc5945 -
Biology of Sport Jul 2023The aims of this scoping review were (i) to characterize the main methodological approaches to assessing individualized running speed thresholds in team sports players;... (Review)
Review
The aims of this scoping review were (i) to characterize the main methodological approaches to assessing individualized running speed thresholds in team sports players; (ii) to assess the use of traditional arbitrary (absolute) thresholds compared to individualized running speed thresholds in team sports players; (iii) to provide an evidence gap map (EGM) about the approaches and study designs employed in investigations in team sports and (iv) to provide directions for future research and practical applications for the strength and conditioning field. Methods studies were searched for in the following databases: (i) PubMed; (ii) Scopus; (iii) SPORTDiscus and (iv) Web of Science. The search was conducted on 15/07/2022. Risk of bias was assessed using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS). From 3,195 potentially relevant articles, 36 were eligible for inclusion in this review. Of the 36 included articles, 27 (75%) focused on the use of arbitrary and individualized running speed thresholds to describe the locomotor demands (e.g., high intensity running) of players. Thirty-four articles used individualized speed running thresholds based on physical fitness assessments (e.g., 40-m linear sprint) or physical performance (e.g., maximal acceleration). This scoping review supported the need for a greater focus to be placed on improving the methodological aspects of using individualized speed running thresholds in team sports. More than just creating alternatives to arbitrary thresholds, it is essential to increase the replicability of methodological conditions whilst ensuring that research comparing the most adequate measures and approaches to individualization takes into consideration the population and context of each study.
PubMed: 37398971
DOI: 10.5114/biolsport.2023.122480 -
Frontiers in Physiology 2018There is undeniable evidence showing that bacteria have strongly influenced the evolution and biological functions of multicellular organisms. It has been hypothesized...
There is undeniable evidence showing that bacteria have strongly influenced the evolution and biological functions of multicellular organisms. It has been hypothesized that many host-microbial interactions have emerged so as to increase the adaptive fitness of the (the host plus its microbiota). Although this association has been corroborated for many specific cases, general mechanisms explaining the role of the microbiota in the evolution of the host are yet to be understood. Here we present an evolutionary model in which a network representing the host adapts in order to perform a predefined function. During its adaptation, the host network (HN) can interact with other networks representing its microbiota. We show that this interaction greatly accelerates and improves the adaptability of the HN without decreasing the adaptation of the microbial networks. Furthermore, the adaptation of the HN to perform several functions is possible only when it interacts with many different bacterial networks in a specialized way (each bacterial network participating in the adaptation of one function). Disrupting these interactions often leads to non-adaptive states, reminiscent of dysbiosis, where none of the networks the holobiont consists of can perform their respective functions. By considering the holobiont as a unit of selection and focusing on the adaptation of the host to predefined but arbitrary functions, our model predicts the need for specialized diversity in the microbiota. This structural and dynamical complexity in the holobiont facilitates its adaptation, whereas a homogeneous (non-specialized) microbiota is inconsequential or even detrimental to the holobiont's evolution. To our knowledge, this is the first model in which symbiotic interactions, diversity, specialization and dysbiosis in an ecosystem emerge as a result of coevolution. It also helps us understand the emergence of complex organisms, as they adapt more easily to perform multiple tasks than non-complex ones.
PubMed: 30618841
DOI: 10.3389/fphys.2018.01836 -
Journal of Neurophysiology May 2018We examined differences between normal weight (NW) and overweight (OW) children aged 8-10 yr in strength, muscle composition, and motor unit (MU) behavior of the first...
We examined differences between normal weight (NW) and overweight (OW) children aged 8-10 yr in strength, muscle composition, and motor unit (MU) behavior of the first dorsal interosseous. Ultrasonography was used to determine muscle cross-sectional area (CSA), subcutaneous fat (sFAT), and echo intensity (EI). MU behavior was assessed during isometric muscle actions at 20% and 50% of maximal voluntary contraction (MVC) by analyzing electromyography amplitude (EMG) and relationships between mean firing rates (MFR), recruitment thresholds (RT), and MU action potential amplitudes (MUAP) and durations (MUAP). The OW group had significantly greater EI than the NW group ( P = 0.002; NW, 47.99 ± 6.01 AU; OW, 58.90 ± 10.63 AU, where AU is arbitrary units) with no differences between groups for CSA ( P = 0.688) or MVC force ( P = 0.790). MUAP was larger for NW than OW in relation to RT ( P = 0.002) and for MUs expressing similar MFRs ( P = 0.011). There were no significant differences ( P = 0.279-0.969) between groups for slopes or y-intercepts from the MFR vs. RT relationships. MUAP was larger in OW ( P = 0.015) and EMG was attenuated in OW compared with NW ( P = 0.034); however, there were no significant correlations ( P = 0.133-0.164, r = 0.270-0.291) between sFAT and EMG. In a muscle that does not support body mass, the OW children had smaller MUAP as well as greater EI, although anatomical CSA was similar. This contradicts previous studies examining larger limb muscles. Despite evidence of smaller MUs, the OW children had similar isometric strength compared with NW children. NEW & NOTEWORTHY Ultrasound data and motor unit action potential sizes suggest that overweight children have poorer muscle composition and smaller motor units in the first dorsal interosseous than normal weight children. Evidence is presented that suggests differences in action potential size cannot be explained by differences in subcutaneous fat alone.
Topics: Action Potentials; Child; Electromyography; Female; Fingers; Humans; Male; Motor Neurons; Muscle Fibers, Skeletal; Muscle Strength; Muscle, Skeletal; Overweight; Pediatric Obesity; Subcutaneous Fat; Ultrasonography
PubMed: 29412774
DOI: 10.1152/jn.00675.2017