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Acta Dermato-venereologica Jun 2023Atopic dermatitis is a chronic, relapsing and inflammatory skin disease. The impact of atopic dermatitis on the partners living with patients has been poorly...
Atopic dermatitis is a chronic, relapsing and inflammatory skin disease. The impact of atopic dermatitis on the partners living with patients has been poorly investigated. The objective of this study was to evaluate the impact of atopic dermatitis in the daily lives of adult patients and to assess the burden of the disease on their partners. A population-based study was conducted on a representative sample of the general population of French adults aged 18 years of age using stratified, proportional sampling with a replacement design. Data were collected on 1,266 atopic dermatitis patient-partner dyads (mean age of patients 41.6 years, 723 (57.1%) women). The mean age of partners was 41.8 years. Patient burden, measured by the Atopic Dermatitis Burden Scale for Adults (ABS-A) score, was closely related to the objective atopic dermatitis severity: the mean score in the mild group (29.5) was significantly lower than in the moderate (43.9) and severe groups (48.6) (p < 0.0001). Partner burden, measured by the EczemaPartner score, was highly related to atopic dermatitis severity (p < 0.0001). Daytime sleepiness, measured by the Epworth Sleepiness Scale, showed a mean score of 9.24 in patients and 9.01 in their partners, indicating impaired sleep. Atopic dermatitis was found to decrease sexual desire in 39% and 26% of partners and patients respectively.
Topics: Adult; Humans; Female; Adolescent; Male; Dermatitis, Atopic; Quality of Life; Severity of Illness Index; Libido; Patients
PubMed: 37358393
DOI: 10.2340/actadv.v103.5285 -
Archives of Endocrinology and Metabolism Jul 2019
Topics: Brazil; Endocrinology; Female; Humans; Libido; Testosterone
PubMed: 31340239
DOI: 10.20945/2359-3997000000153 -
Oncology 2018The aim of this study was to evaluate the prevalence of menopausal symptoms in young cancer survivors immediately following the completion of chemotherapy.
PURPOSE
The aim of this study was to evaluate the prevalence of menopausal symptoms in young cancer survivors immediately following the completion of chemotherapy.
METHODS
This prospective cohort study followed 124 young females with a new diagnosis of cancer requiring chemotherapy to assess symptoms of menopause before treatment and immediately following chemotherapy. Symptoms were compared before and after treatment using the McNemar test and between cancer patients and 133 similar-aged healthy controls using Pearson χ2 and Fisher's exact tests.
RESULTS
Participants undergoing cancer therapy reported more menopausal symptoms compared to controls prior to the initiation of any treatment (hot flashes or night sweats 33 vs. 7%, p < 0.01, trouble sleeping 57 vs. 31%, p < 0.01, headaches 50 vs. 35%, p = 0.02, and decreased libido 36 vs. 16%, p < 0.01) and also reported a greater prevalence of symptoms immediately after cancer therapy compared to pretreatment prevalence (vasomotor symptoms, p < 0.01, vaginal dryness, p < 0.01, decreased concentration, p < 0.01, and body aches, p = 0.01). Cancer patients with lower anti-Müllerian hormone (AMH) levels after treatment (<0.10 ng/mL) had an increased risk of vasomotor symptoms (OR 2.2, p = 0.04), mood swings (OR 2.4, p = 0.03), feeling sad (OR 2.2, p = 0.04), trouble sleeping (OR 2.7, p = 0.02), and decreased libido (OR 3.0, p = 0.03) when controlled for age and cancer type, and the incidence of these symptoms was not affected by the use of systemic hormones or psychiatric medications. Treatment length, use of alkylating agents, pelvic radiation, and marital status were also not associated with the prevalence of menopausal symptoms.
CONCLUSIONS
Premenopausal women with a new cancer diagnosis have more menopausal symptoms than females of similar age before and after cancer treatment, the effects of which are not mitigated by systemic hormone use. Decreased AMH levels were associated with an increased likelihood of reporting physiologic symptoms after therapy.
IMPLICATIONS FOR CANCER SURVIVORS
This information is imperative for counseling; ultimately, improved symptom management during and after cancer therapies will improve quality of life in young cancer survivors.
Topics: Adolescent; Adult; Anti-Mullerian Hormone; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Female; Headache; Hot Flashes; Humans; Libido; Mood Disorders; Neoplasms; Premenopause; Prevalence; Prospective Studies; Risk Factors; Sleep Wake Disorders; Sweating; Young Adult
PubMed: 29393227
DOI: 10.1159/000485917 -
Journal of Sex Research Jan 2022We used the developmental systems model to deduce a definition of female early adolescent sexual desire. We evaluated a measure of this phenomenon with a secondary... (Randomized Controlled Trial)
Randomized Controlled Trial
We used the developmental systems model to deduce a definition of female early adolescent sexual desire. We evaluated a measure of this phenomenon with a secondary analysis of data from a randomized group sexual health intervention trial involving low-income, English-speaking, seventh grade Latinas enrolled in a Miami-Dade County public school (542). As part of this study, girls completed a four-item early adolescent sexual desire (EASD) measure. Study findings supported internal consistency (Cronbach's alpha = .81 to .82) and stability over a 1-month period ( = .74). Developmental sensitivity was supported by a decline in stability over 12- ( = .66) and 24-month periods ( = .56). Validity was supported by correlations with puberty changes, sexual intentions, sexting, and sexual behavior, and hypothesized mean differences associated with dating and preference for shoes culturally associated with female sexual attractiveness ( < .01). Research implications include validation work with other ethnic/racial groups and using the EASD as a starting point for a measurement continuum tracking development of sexual desire across adolescence and into adulthood. Directions for future research also include measuring the development of sexual desire in boys and transgendered youth across adolescence and into adulthood.
Topics: Adolescent; Adolescent Behavior; Adult; Female; Hispanic or Latino; Humans; Libido; Male; Schools; Sexual Behavior
PubMed: 33739211
DOI: 10.1080/00224499.2021.1891190 -
Journal of Neurology, Neurosurgery, and... Jul 1975Forty men, mainly alcoholics, were administered either the dopamine receptor agonist, apomorphine HCl (1 mg), or distilled water subcutaneously three times a day for 14... (Clinical Trial)
Clinical Trial
Forty men, mainly alcoholics, were administered either the dopamine receptor agonist, apomorphine HCl (1 mg), or distilled water subcutaneously three times a day for 14 days in a double blind study. None of the subjects developed an endogenous depression or schizophrenic symptoms. Scores on the Hamilton Rating Scale, Zung Self Rating Scale, and Brief Psychiatric Rating Scale showed improvement with both apomorphine and placebo. There were no significant differences between the two treatments on these rating scales. A significant incidence of spontaneous penile erections occurred after apomorphine treatment compared with placebo. Both treatments eliminated subjective craving for alcohol. Acute administration of apomorphine had no effect on psychomotor retardation or depressed mood in two patients with endogenous depression.
Topics: Alcoholism; Antidepressive Agents; Apomorphine; Bipolar Disorder; Clinical Trials as Topic; Depression; Humans; Libido; Male; Middle Aged; Penis; Placebos; Psychiatric Status Rating Scales; Psychomotor Disorders; Psychoses, Substance-Induced; Schizophrenia
PubMed: 1099172
DOI: 10.1136/jnnp.38.7.722 -
The British Journal of Surgery Feb 2019The impact of radiotherapy (RT) for rectal cancer on ovarian androgen production is unknown. The aim was to examine the effect of RT for rectal cancer on androgen levels... (Comparative Study)
Comparative Study Randomized Controlled Trial
BACKGROUND
The impact of radiotherapy (RT) for rectal cancer on ovarian androgen production is unknown. The aim was to examine the effect of RT for rectal cancer on androgen levels in non-oophorectomised women and the association with female sexual desire.
METHOD
This prospective cohort study included women treated with surgery for rectal cancer with or without RT. Serum testosterone (T), free T, androstenedione and dehydroepiandrosterone sulfate (DHEA-S) were assessed at baseline, after RT and one year postoperatively. Sexual desire was assessed with the Female Sexual Function Index.
RESULTS
Twenty-seven participants had surgery alone (RT-) and 98 had preoperative RT and surgery (RT+). During the first year after surgery, median T and free T decreased from 0.6 (range 0.1–3.6) to 0.5 (0.1–2.3) nmol/L (p<0.001) and 9.1 (range 1.6–45.8) to 7.9 (1.4–22.7) pmol/L (p<0.001) respectively in the RT+ group and did not change in the RT- group. Longitudinal regression analysis confirmed a decrease in T and free T after RT. The adjusted change in androstenedione and DHEA-S was not significant in any group. The mean change in T (OR 2.74 (95% CI 1.06–7.11, p=0.038), free T (OR 1.08 (95% CI 1.02–1.15), p=0.011) and androstenedione (OR 1.52 (95% CI 1.07–2.16), p=0.019 was related to change in sexual desire.
CONCLUSION
Radiotherapy decreases androgens predominantly derived from the ovaries, while androgens of mainly adrenal origin remain unchanged. Reduction in ovarian derived androgens maybe associated with reduced sexual desire.
Topics: Aged; Aged, 80 and over; Androgens; Androstenedione; Dehydroepiandrosterone; Female; Gonadal Steroid Hormones; Humans; Libido; Middle Aged; Ovary; Prospective Studies; Rectal Neoplasms; Testosterone
PubMed: 30277569
DOI: 10.1002/bjs.10980 -
British Medical Journal Aug 1971Depression, headaches, and libido were rated in 272 women before starting a contraceptive method and at intervals during the first year of use-54 were fitted with an... (Clinical Trial)
Clinical Trial
Depression, headaches, and libido were rated in 272 women before starting a contraceptive method and at intervals during the first year of use-54 were fitted with an intrauterine device (I.U.D.) and 218 used one of three oral contraceptives. Side effects caused 25% of the oral contraceptive group and 13% of the I.U.D. group to stop the method. Depression, headaches, and loss of libido were the most common reasons for stopping oral contraceptives and breakthrough bleeding was the most common reason for stopping the I.U.D.The group of women who stopped or changed their oral contraceptives during the survey were compared with the group who remained on the same oral contraceptive throughout. The former had higher mean depression and neuroticism scores at the first clinic visit and contained more women with a history of premenstrual weepiness, depression during pregnancy, outpatient psychiatric treatment, and treatment with antidepressants. Changes in the depression, headache, and libido ratings throughout the survey are presented.
Topics: Adult; Antidepressive Agents; Contraceptives, Oral; Crying; Depression; Female; Headache; Hemorrhage; Humans; Intrauterine Devices; Libido; Menstruation; Personality Inventory; Pregnancy; Pregnancy Complications; Prospective Studies; Psychotherapy
PubMed: 5565516
DOI: 10.1136/bmj.3.5773.495 -
Archives of Sexual Behavior May 2023There is a lay assumption that women's sexual desire varies substantially over time, whereas men's is stable. This assumption is mirrored in prominent theories of...
There is a lay assumption that women's sexual desire varies substantially over time, whereas men's is stable. This assumption is mirrored in prominent theories of desire, which posit that women are more variable than men in the extent to which they desire sex, and that women's sexual desire is more contextually sensitive than men's. We tested this assumption across three longitudinal studies. Study 1 assessed desire at 3 time points spanning 13 years (N = 5562), and Studies 2 and 3 (N = 11,282) assessed desire moment-to-moment over 7 days. When desire was measured over years, women were more variable in their sexual desire than men (Study 1). However, we found a different pattern of results when desire was measured over the short term. In Studies 2 and 3, we found no significant differences in women's and men's desire variability. The extent to which desire varied as a function of affective states (e.g., happiness) and relationship-oriented states (e.g., partner closeness) was similar for women and men, with some exceptions; women's desire was more negatively associated with tiredness and anger in Study 2. These data qualify existing assumptions about sex differences in sexual desire variability.
Topics: Humans; Female; Male; Men; Libido; Sex Characteristics; Emotions; Happiness; Sexual Behavior; Sexual Partners
PubMed: 36695962
DOI: 10.1007/s10508-022-02525-y -
Archives of Sexual Behavior Nov 2022While most studies on sexuality in later life report that sexual desire declines with age, little is known about the exact nature of age effects on sexual desire. Using...
While most studies on sexuality in later life report that sexual desire declines with age, little is known about the exact nature of age effects on sexual desire. Using self-reported dyadic sexual desire relating to a partner, dyadic sexual desire relating to an attractive person, and solitary sexual desire from a large (N > 8000) and age diverse (14.6-80.2 years) online sample, the current study had three goals: First, we investigated relationships between men and women's sexual desire and age. Second, we examined whether individual differences such as gender/sex, sexual orientation, self-rated masculinity, relationship status, self-rated attractiveness, and self-rated health predict sexual desire. Third, we examined how these associations differed across sexual desire facets. On average, the associations between age and both men and women's sexual desire followed nonlinear trends and differed between genders/sexes and types of sexual desire. Average levels of all types of sexual desire were generally higher in men. Dyadic sexual desire related positively to self-rated masculinity and having a romantic partner and solitary desire was higher in people with same-sex attraction. We discuss the results in the context of the evolutionary hypothesis that predict an increase of sexual desire and female reproductive effort prior to declining fertility. Our findings both support and challenge beliefs about gender/sex specificity of age effects on sexual desire and highlight the importance of differentiating between desire types.
Topics: Female; Humans; Male; Adolescent; Young Adult; Adult; Middle Aged; Aged; Aged, 80 and over; Libido; Sexual Behavior; Men; Masculinity; Sexuality; Sexual Partners
PubMed: 35916987
DOI: 10.1007/s10508-022-02375-8 -
Medical Science Monitor : International... Jan 2020BACKGROUND The aim of this study was to investigate factors affecting the sex lives of middle-aged women, and whether surgical menopause affects sexual function...
BACKGROUND The aim of this study was to investigate factors affecting the sex lives of middle-aged women, and whether surgical menopause affects sexual function differently from natural menopause, by comparing effects on sexual performance of women with similar demographic features. MATERIAL AND METHODS The study included 151 women with surgical menopause (SM), 357 women with natural menopause (NM), and 186 perimenopausal women (PM). The women were asked to complete a 6-question survey of sexual performance parameters. The relationship between the demographic and clinical features and hormone levels of the groups and sexual function parameters were evaluated. We also compared these parameters between the 3 study groups, and paired comparisons were made between the SM group and the NM group. RESULTS Demographic features, serum DHEA-S, total testosterone, and FSH levels were found to have statistically significant effects on sexual performance of women (p<0.05). The sexual function scores for the frequency of sexual desire, coitus, and orgasm were significantly higher in the PM group, whereas vaginal lubrication scores were lower compared to the NM and SM group (p<0.05). In paired comparison of NM and SM, the scores for the frequency of coitus, orgasm, and vaginal lubrication were significantly higher in the SM group, while sexual desire frequency scores were higher in the NM group (p<0.05). CONCLUSIONS Our study approached to this topic in an extended manner and found significant relationships between several demographic-clinical and hormonal factors. SM was found to not affect female sexual performance, except for sexual desire, more than NM.
Topics: Adult; Coitus; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Humans; Libido; Menopause; Menopause, Premature; Middle Aged; Orgasm; Perimenopause; Sexual Behavior; Surveys and Questionnaires; Testosterone
PubMed: 31907344
DOI: 10.12659/MSM.921811