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Kidney International Nov 2001
Topics: Glomerulonephritis, IGA; Humans; Kidney Transplantation
PubMed: 11703625
DOI: 10.1046/j.1523-1755.2001.00021.x -
Journal of Neurovirology Aug 2013
Topics: Antiviral Agents; Humans; JC Virus; Leukoencephalopathy, Progressive Multifocal
PubMed: 23913113
DOI: 10.1007/s13365-013-0191-9 -
BJOG : An International Journal of... Jan 2022
Topics: COVID-19; Civil Defense; Climate Change; Communicable Disease Control; Communicable Diseases, Emerging; Female; Health Services Needs and Demand; Humans; Infectious Disease Transmission, Vertical; Pandemics; Pregnancy; Pregnancy Complications, Infectious; Public Health; SARS-CoV-2; Travel; Travel-Related Illness
PubMed: 34379870
DOI: 10.1111/1471-0528.16859 -
Tumour Biology : the Journal of the... Jun 2017From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer... (Review)
Review
From the application of Coley's toxin in the early 1900s to the present clinical trials using immune checkpoint regulatory inhibitors, the history of cancer immunotherapy has consisted of extremely high levels of enthusiasm after anecdotal case reports of enormous success, followed by decreasing levels of enthusiasm as the results of controlled clinical trials are available. In this review, this pattern will be documented for the various immunotherapeutic approaches over the years. The sole exception being vaccination against cancer causing viruses, which have already prevented thousands of cancers. We can only hope that the present high level of enthusiasm for the use of immune stimulation by removal of blocks to cancer immunity will be more productive than the incremental improvements using previous immunotherapies.
Topics: Cancer Vaccines; Genes, cdc; Humans; Immunotherapy; Neoplasms
PubMed: 28639883
DOI: 10.1177/1010428317707764 -
Fertility and Sterility Dec 2019
Topics: Aneuploidy; Embryo Transfer; Genetic Testing; Humans; Patient Selection; Prognosis
PubMed: 31843076
DOI: 10.1016/j.fertnstert.2019.08.102 -
Translational Psychiatry Oct 2021Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT receptor is a promising potential treatment...
Cognitive deficits commonly accompany psychiatric disorders but are often underrecognised, and difficult to treat. The 5-HT receptor is a promising potential treatment target for cognitive impairment because in animal studies 5-HT receptor agonists enhance hippocampal-dependent memory processes. To date, there has been little work translating these effects to humans. We tested whether short-term administration of the 5-HT partial agonist, prucalopride, modified behavioural and neural (fMRI) memory processing in 44 healthy human volunteers using an experimental medicine model. We found that participants who had received six days of prucalopride treatment were significantly better at recalling previously seen neutral images and distinguishing them from new images. At a neural level, prucalopride bilaterally increased hippocampal activity and activity in the right angular gyrus compared with placebo. Taken together, these findings demonstrate the potential of 5-HT-receptor activation for cognitive enhancement in humans, and support the potential of this receptor as a treatment target for cognitive impairment.
Topics: Benzofurans; Hippocampus; Humans; Receptors, Serotonin, 5-HT4; Serotonin; Serotonin 5-HT4 Receptor Agonists
PubMed: 34602607
DOI: 10.1038/s41398-021-01568-4 -
Journal of Applied Physiology... Apr 2013
Topics: Asthma; Humans; Lung; Models, Biological; Muscle, Smooth
PubMed: 23329822
DOI: 10.1152/japplphysiol.00028.2013 -
Andes Pediatrica : Revista Chilena de... Feb 2022The birth of intensive care was a process that took place in Copenhagen, Denmark, during and after the polio epidemic of 1952-1953. The fact that marks its beginning was...
The birth of intensive care was a process that took place in Copenhagen, Denmark, during and after the polio epidemic of 1952-1953. The fact that marks its beginning was that anesthesiologist Björn Ibsen was asked to help and "came out of the operating room", not without some controversy. Ib sen proposed and advocated the use of tracheostomy, suctioning and ventilation. Given the lack of positive pressure ventilators, this task was carried out by students who contributed 165,000 hours of manual ventilation. Few years later, in Gothenburg, Sweden, the anesthesiologist Göran Haglund, motivated by the case of a four years old boy with complicated appendicitis, created the first multi disciplinary pediatric intensive care unit in the world (1955). In Chile, during the 1950s, the concept of pediatric intensive care began to develop under the direction of physicians with a solid vision of the future. Given that the planet is experiencing a pandemic, it seems an appropriate moment to review the role of the polio epidemic in the development of positive pressure ventilation, the birth of intensive care medicine and intensive care units, in order to assess the role of the various tasks and innovations carried out.
Topics: Child; Child, Preschool; Critical Care; Humans; Intensive Care Units, Pediatric; Poliomyelitis; Respiration, Artificial; Ventilators, Mechanical
PubMed: 35506786
DOI: 10.32641/andespediatr.v93i1.3977 -
Journal of Occupational Health Jan 2020On 31 December 2019, the World Health Organization (WHO) received reports of pneumonia cases of unknown etiology in the city of Wuhan in Hubei Province, China. The agent...
On 31 December 2019, the World Health Organization (WHO) received reports of pneumonia cases of unknown etiology in the city of Wuhan in Hubei Province, China. The agent responsible was subsequently identified as a coronavirus-SARS-CoV-2. The WHO declared this disease as a Public Health Emergency of International Concern at the end of January 2020. This event evoked a sense of déjà vu, as it has many similarities to the outbreak of severe acute respiratory syndrome (SARS) of 2002-2003. Both illnesses were caused by a zoonotic novel coronavirus, both originated during winter in China and both spread rapidly all over the world. However, the case-fatality rate of SARS (9.6%) is higher than that of COVID-19 (<4%). Another zoonotic novel coronavirus, MERS-CoV, was responsible for the Middle East respiratory syndrome, which had a case-fatality rate of 34%. Our experiences in coping with the previous coronavirus outbreaks have better equipped us to face the challenges posed by COVID-19, especially in the health care setting. Among the insights gained from the past outbreaks were: outbreaks caused by viruses are hazardous to healthcare workers; the impact of the disease extends beyond the infection; general principles of prevention and control are effective in containing the disease; the disease poses both a public health as well as an occupational health threat; and emerging infectious diseases pose a continuing threat to the world. Given the perspectives gained and lessons learnt from these past events, we should be better prepared to face the current COVID-19 outbreak.
Topics: Betacoronavirus; COVID-19; China; Coronavirus Infections; Disease Outbreaks; Health Personnel; History, 21st Century; Humans; Occupational Diseases; Occupational Health; Pandemics; Pneumonia, Viral; SARS-CoV-2; Severe Acute Respiratory Syndrome; World Health Organization
PubMed: 32515882
DOI: 10.1002/1348-9585.12128 -
Epilepsy Research and Treatment 2012Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a...
Historically, déjà vu has been linked to seizure activity in temporal lobe epilepsy, and clinical reports suggest that many patients experience the phenomenon as a manifestation of simple partial seizures. We review studies on déjà vu in epilepsy with reference to recent advances in the understanding of déjà vu from a cognitive and neuropsychological standpoint. We propose a decoupled familiarity hypothesis, whereby déjà vu is produced by an erroneous feeling of familiarity which is not in keeping with current cognitive processing. Our hypothesis converges on a parahippocampal dysfunction as the locus of déjà vu experiences. However, several other temporal lobe structures feature in reports of déjà vu in epilepsy. We suggest that some of the inconsistency in the literature derives from a poor classification of the various types of déjà experiences. We propose déjà vu/déjà vécu as one way of understanding déjà experiences more fully. This distinction is based on current models of memory function, where déjà vu is caused by erroneous familiarity and déjà vécu by erroneous recollection. Priorities for future research and clinical issues are discussed.
PubMed: 22957231
DOI: 10.1155/2012/539567