-
Pediatrics and Neonatology Aug 2014
Topics: Contrast Media; Diatrizoate Meglumine; Enema; Humans; Infant; Infant, Newborn; Intestinal Diseases; Radiography; Renal Elimination
PubMed: 24861535
DOI: 10.1016/j.pedneo.2014.04.004 -
Arquivos Brasileiros de Cirurgia... 2023Adhesive small bowel obstruction is one of the most common causes of surgical emergencies, representing about 15% of hospital admissions. Defining the need and timing of...
BACKGROUND
Adhesive small bowel obstruction is one of the most common causes of surgical emergencies, representing about 15% of hospital admissions. Defining the need and timing of surgical intervention still remains a challenge.
AIMS
To report the experience of using meglumine-based water-soluble contrast in a tertiary hospital in southern Brazil, comparing with the world literature.
METHODS
Patients suspected of having adhesive small bowel obstruction, according to their clinical conditions, underwent an established protocol, consisting of the administration of water-soluble contrast, followed by plain abdominal radiograph within 12 hours and by a new clinical evaluation. The protocol was initiated after starting conservative management, including fasting and placement of a nasogastric tube, as well as intravenous fluid reposition.
RESULTS
A total of 126 patients were submitted to the protocol. The water-soluble contrast test sensitivity and specificity after the first radiograph were 94.6 and 91.0%, respectively; after the second radiograph, these values were 92.3 and 100%. The general test values for sensitivity and specificity were 91.9 and 100%, respectively.
CONCLUSIONS
The measure parameters evaluated in this study were similar to those found in the literature, contributing to endorse the importance of this test in the evaluation of patients with adhesive small bowel obstruction. The particular relevance of this study was the similar results that were found using a different type of meglumine-based contrast, which is available in Brazil.
Topics: Humans; Diatrizoate Meglumine; Tissue Adhesions; Contrast Media; Intestinal Obstruction; Meglumine; Water
PubMed: 38088723
DOI: 10.1590/0102-672020230059e1777 -
The Journal of International Medical... Jun 2021The post-operative complication of chylous leakage after breast cancer is relatively rare, and few clinical studies have been published. We report a 64-year-old woman...
The post-operative complication of chylous leakage after breast cancer is relatively rare, and few clinical studies have been published. We report a 64-year-old woman with chylous leakage following modified radical mastectomy. We describe the patient's diagnostic and treatment process in detail. The patient was diagnosed with grade II (left) breast invasive ductal carcinoma. Post-operatively, the patient's chest wall and axilla were pressurized, and negative pressure drainage was initiated. On the fifth post-operative day, the drainage from the chest wall and axilla increased significantly, and the patient developed chylous leakage on the eighth postoperative day. We injected meglumine diatrizoate (100 mL) and elemene (10 mL) into the patient's axilla, and the chylous leakage gradually resolved 18 days post-operatively. In this report, we focus on managing a case of chylous leakage after modified radical mastectomy for breast cancer. Meglumine diatrizoate combined with elemene is a possible treatment for the management of this rare complication.
Topics: Axilla; Breast Neoplasms; Female; Humans; Lymph Node Excision; Mastectomy; Mastectomy, Modified Radical; Middle Aged
PubMed: 34130539
DOI: 10.1177/03000605211021375 -
AJNR. American Journal of Neuroradiology 1983Iohexol is a nonionic water-soluble iodinated contrast medium with chemical and physical properties similar to those of metrizamide. A randomized double-blind study was... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
Iohexol is a nonionic water-soluble iodinated contrast medium with chemical and physical properties similar to those of metrizamide. A randomized double-blind study was performed in 40 patients undergoing intravenous digital subtraction angiography for suspected carotid and vertebral disease to compare the radiographic imaging quality and side effects of iohexol with those of Renografin-76 (diatrizoate meglumine and diatrizoate sodium). The use of iohexol yielded a higher percentage of "excellent" images with a lesser incidence of image degradation due to swallowing and motion. Iohexol was also associated with milder and less frequent patient discomfort. No clinically significant changes in laboratory data parameters were observed with either contrast medium.
Topics: Adult; Aged; Cerebral Angiography; Cerebrovascular Disorders; Computers; Contrast Media; Diatrizoate; Diatrizoate Meglumine; Double-Blind Method; Drug Combinations; Female; Humans; Iodobenzoates; Iohexol; Male; Middle Aged; Triiodobenzoic Acids
PubMed: 6410736
DOI: No ID Found -
Annals of Surgery Jul 2002
Topics: Barium; Contrast Media; Diatrizoate Meglumine; Humans; Intestinal Obstruction; Tomography, X-Ray Computed; Treatment Outcome
PubMed: 12131079
DOI: 10.1097/00000658-200207000-00003 -
World Journal of Gastroenterology Feb 2015To determine the efficacy and safety benefits of performing intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC) to treat symptomatic... (Randomized Controlled Trial)
Randomized Controlled Trial
AIM
To determine the efficacy and safety benefits of performing intraoperative cholangiography (IOC) during laparoscopic cholecystectomy (LC) to treat symptomatic cholelithiasis.
METHODS
Patients admitted to the Minimally Invasive Surgery Center of Tianjin Nankai Hospital between January 2012 and January 2014 for management of symptomatic cholelithiasis were recruited for this prospective randomized trial. Study enrollment was offered to patients with clinical presentation of biliary colic symptoms, radiological findings suggestive of gallstones, and normal serum biochemistry results. Study participants were randomized to receive either routine LC treatment or LC+IOC treatment. The routine LC procedure was carried out using the standard four-port technique; the LC+IOC procedure was carried out with the addition of meglumine diatrizoate (1:1 dilution with normal saline) injection via a catheter introduced through a small incision in the cystic duct made by laparoscopic scissors. Operative data and postoperative outcomes, including operative time, retained common bile duct (CBD) stones, CBD injury, other complications and length of hospital stay, were recorded for comparative analysis. Inter-group differences were statistically assessed by the χ2 test (categorical variables) and Fisher's exact test (binary variables), with the threshold for statistical significance set at P<0.05.
RESULTS
A total of 371 patients were enrolled in the trial (late-adolescent to adult, age range: 16-70 years), with 185 assigned to the routine LC group and 186 to the LC+IOC group. The two treatment groups were similar in age, sex, body mass index, duration of symptomology, number and size of gallstones, and clinical symptoms. The two treatment groups also showed no significant differences in the rates of successful LC (98.38% vs 97.85%), CBD stone retainment (0.54% vs 0.00%), CBD injury (0.54% vs 0.53%) and other complications (2.16% vs 2.15%), as well as in duration of hospital stay (5.10±1.41 d vs 4.99±1.53 d). However, the LC+IOC treatment group showed significantly longer mean operative time (routine LC group: 43.00±4.15 min vs 52.86±4.47 min, P<0.01). There were no cases of fatal complications in either group. At the one-year follow-up assessment, one patient in the routine LC group reported experiencing diarrhea for three months after the LC and one patient in the LC+IOC group reported on-going intermittent epigastric discomfort, but radiological examination provided no abnormal findings.
CONCLUSION
IOC addition to the routine LC treatment of symptomatic cholelithiasis does not improve rates of CBD stone retainment or bile duct injury but lengthens operative time.
Topics: Adolescent; Adult; Aged; Chi-Square Distribution; China; Cholangiography; Cholecystectomy, Laparoscopic; Cholelithiasis; Female; Humans; Intraoperative Care; Length of Stay; Male; Middle Aged; Operative Time; Postoperative Complications; Predictive Value of Tests; Prospective Studies; Risk Factors; Time Factors; Treatment Outcome; Young Adult
PubMed: 25717250
DOI: 10.3748/wjg.v21.i7.2147 -
PloS One 2017Post-mortem computed tomography (PMCT) and PMCT angiography (PMCTA) are rapidly becoming effective and practical methods in forensic medicine. In this article, the...
Post-mortem computed tomography (PMCT) and PMCT angiography (PMCTA) are rapidly becoming effective and practical methods in forensic medicine. In this article, the authors introduce a whole-body PMCTA approach involving left ventricle cardiac puncture. This procedure was performed in 9 males and 3 females. PMCT was performed first. Then a biopsy core needle was used for a percutaneous puncture into the left ventricle through the intercostal area under CT guidance. 1000 mL of contrast media (diatrizoate meglumine and normal saline [0.9%] at 1:2 ratio) was injected at a rate of 50 mL/8 s, followed by CT scan. Visualization of systemic arteries was achieved in 11 cases, while only partial visualization was achieved in 1 case, which may have been related to incomplete thawing of the cadaver. PMCTA results revealed no vascular diseases and abnormalities in 10 victims. Among the 10 victims, 4 post-scan autopsies were performed and found no vascular abnormalities, consistent with the PMCTA results. Autopsy of the other 6 victims were refused by the relatives. PMCTA revealed signs of internal carotid artery aneurysm inside the sphenoid sinus in one victim, which was confirmed by autopsy. PMCTA results of another victim showed signs of stenosis and blockage of the distal part of the right vertebral artery and basilar artery. Thromboembolism of those arteries was found during autopsy. Compared with other existing PMCTA methods for examination of vascular injuries and diseases, this technique involves simple procedures, is less time consuming, has lower associated costs, does not require specialized equipment, provides adequate imaging quality, and is suitable for centres not equipped with cardiopulmonary bypass machines or other specialized equipment.
Topics: Adult; Aged; Computed Tomography Angiography; Female; Heart Ventricles; Humans; Male; Middle Aged; Postmortem Changes
PubMed: 28827844
DOI: 10.1371/journal.pone.0183408 -
Scientific Reports Jun 2018Ehrlichia chaffeensis, a tick-transmitted rickettsial bacterium, is the causative agent of human monocytic ehrlichiosis. Biochemical characterization of this and other...
Ehrlichia chaffeensis, a tick-transmitted rickettsial bacterium, is the causative agent of human monocytic ehrlichiosis. Biochemical characterization of this and other related Rickettsiales remains a major challenge, as they require a host cell for their replication. We investigated the use of an axenic medium for E. chaffeensis growth, assessed by protein and DNA synthesis, in the absence of a host cell. E. chaffeensis organisms harvested from in vitro cultures grown in a vertebrate cell line were fractionated into infectious dense-core cells (DC) and the non-infectious replicating form, known as reticulate cells (RC) by renografin density gradient centrifugation and incubated in the axenic medium containing amino acids, nucleotides, and different energy sources. Bacterial protein and DNA synthesis were observed in RCs in response to glucose-6-phosphate, although adenosine triphosphate, alpha-ketoglutarate or sodium acetate supported protein synthesis. The biosynthetic activity could not be detected in DCs in the axenic medium. While the data demonstrate de novo protein and DNA synthesis under axenic conditions for E. chaffeensis RCs, additional modifications are required in order to establish conditions that support bacterial replication, and transition to DCs.
Topics: Axenic Culture; Carbon; Cell-Free System; DNA; Diatrizoate Meglumine; Ehrlichia chaffeensis; Hydrogen-Ion Concentration; Models, Biological; Protein Biosynthesis; RNA; RNA, Ribosomal, 16S
PubMed: 29915240
DOI: 10.1038/s41598-018-27574-z -
Iranian Red Crescent Medical Journal May 2014Myelograghy is a process of instilling contrast medium to the subarachnoid space for evaluating the spinal column by radiography. There are various contrast solutions...
INTRODUCTION
Myelograghy is a process of instilling contrast medium to the subarachnoid space for evaluating the spinal column by radiography. There are various contrast solutions for different radiographic studies but not all of them are suitable for spinal column evaluation.
CASE PRESENTATION
Our patient was a 60-year-old man who developed severe pain, tonic clonic convulsions and cardiopulmonary arrest after intrathecal injection of 14 mL of meglumine diatrizoate during an elective myelography procedure. Many of these cases would die or suffer from permanent sequelae if appropriate treatment is not received.
CONCLUSIONS
Our subject recovered completely without any sequelae after receiving appropriate treatment in a multidisciplinary intensive care unit.
PubMed: 25031869
DOI: 10.5812/ircmj.9661 -
Clinical Cardiology May 1982A new computer image enhancement technique was employed on cardiac images of 10 dogs and 7 patients to demonstrate the feasibility of an on-line automatic delineation of...
A new computer image enhancement technique was employed on cardiac images of 10 dogs and 7 patients to demonstrate the feasibility of an on-line automatic delineation of the left ventricular endocardial silhouette with a peripheral venous injection of contrast material while simultaneously reducing the x-ray dosage. This technique employs a very fast analog-to-digital conversion system capable of digitizing on-line video frames. By storing and continuously updating the first 30 video frames and then subtracting each incoming frame from this memory, most of the background is eliminated leaving only the contrast filled ventricle. Using calibrated densitometric measurements, we found that iodine concentrations in the human left ventricle following venous injection of 40 ml Renografin-76 (25 ml/s), peaked at 4.3 +/- 0.3 mg/ml (mean +/- SD) compared to 14.8 +/- 0.8 mg/ml following direct injection of 40 ml at 13 ml/s (p less than 0.001). The computer enhanced venous-injected images had an optical contrast 14 times greater than that of the unenhanced direct left ventriculogram. This increase in optical contrast provided unambiguous subjective definition of the endocardial borders. This technique is applicable to both central and peripheral contrast injection whereby high quality images can be obtained at approximately 98% reduction in radiation (5 mA, 65-85 kV), allowing performance of serial studies.
Topics: Angiocardiography; Animals; Body Weight; Cardiac Output; Computers; Diatrizoate; Diatrizoate Meglumine; Dogs; Drug Combinations; Female; Humans; Male; Radiation Dosage; Radiographic Image Enhancement; Time Factors
PubMed: 7094444
DOI: 10.1002/clc.4960050502