-
Editorial: mucosal healing and adherence to the gluten-free diet in coeliac disease--authors' reply.Alimentary Pharmacology & Therapeutics Nov 2014
Topics: Celiac Disease; Diet, Gluten-Free; Duodenum; Female; Humans; Male
PubMed: 25303375
DOI: 10.1111/apt.12975 -
American Family Physician Jul 2017
Review
Topics: Clinical Trials as Topic; Diet, Gluten-Free; Evidence-Based Medicine; Humans; Irritable Bowel Syndrome; Treatment Outcome
PubMed: 28671373
DOI: No ID Found -
The American Journal of Clinical... Mar 2013
Topics: Blood Glucose; Diabetes Mellitus, Type 2; Diet, Carbohydrate-Restricted; Diet, Fat-Restricted; Diet, Mediterranean; Diet, Vegetarian; Glycemic Index; Humans
PubMed: 23364020
DOI: 10.3945/ajcn.112.057547 -
Journal of Child Neurology Jan 2024The ketogenic diet may be difficult for some patients and their families to implement and can impact physical, emotional, and social well-being.
BACKGROUND
The ketogenic diet may be difficult for some patients and their families to implement and can impact physical, emotional, and social well-being.
METHODS
Through principles of fundamental qualitative description, we completed an exploratory study on parents' experiences and expectations on the use and efficacy of the ketogenic diet for children with medically refractory epilepsy.
RESULTS
Seventeen parents (10 mothers and 7 fathers) of 12 children with epilepsy participated. At the time of the interview, parents had experienced an average of 25 months of ketogenic diet treatment for their child (range 2 months to 98 months). Half of the caregivers learned about the ketogenic diet from their neurologist, whereas the remainder had heard about it from another source (ie, the internet). Most caregivers' (n = 13) diet expectations were related to seizure control. However, child development (n = 5) and quality of life (n = 5) were also crucial to some. Physical impacts of the diet were most commonly gastrointestinal for children (n = 9). Social and emotional effects were noted in some older children with typical development. Most caregivers described negative impacts on finances (n = 15), relationships (n = 14), and emotional well-being (ie, stress) (n = 12). Caregivers benefited from the ketogenic diet team's regular communication, close follow-up, and family-centered care.
CONCLUSIONS
Despite the impacts that the ketogenic diet may have on caregivers' emotional and social well-being, the positive impacts of the diet were felt to outweigh any perceived risks. Effects (both positive and negative) on quality of life and child development (eg, social, emotional, cognitive) are essential for caregivers and require additional investigation.
Topics: Humans; Diet, Ketogenic; Female; Male; Child; Child, Preschool; Parents; Quality of Life; Adult; Infant; Adolescent; Drug Resistant Epilepsy; Caregivers
PubMed: 38314711
DOI: 10.1177/08830738241227066 -
Revista de Gastroenterologia de Mexico... 2020
Topics: Celiac Disease; Diet, Gluten-Free; Glutens; Humans; Malabsorption Syndromes
PubMed: 32115289
DOI: 10.1016/j.rgmx.2020.01.001 -
Epilepsy Research Jul 2012Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating... (Review)
Review
Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy's mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).
Topics: Alzheimer Disease; Animals; Caloric Restriction; Diet, Ketogenic; Humans; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease
PubMed: 21872441
DOI: 10.1016/j.eplepsyres.2011.04.016 -
Nutrients Nov 2020Irritable Bowel Syndrome (IBS) is a very common functional gastrointestinal disease. Its pathogenesis is multifactorial and not yet clearly defined, and hence, its... (Review)
Review
Irritable Bowel Syndrome (IBS) is a very common functional gastrointestinal disease. Its pathogenesis is multifactorial and not yet clearly defined, and hence, its therapy mainly relies on symptomatic treatments. Changes in lifestyle and dietary behavior are usually the first step, but unfortunately, there is little high-quality scientific evidence regarding a dietary approach. This is due to the difficulty in setting up randomized double-blind controlled trials which objectively evaluate efficacy without the risk of a placebo effect. However, a Low Fermentable Oligo-, Di- and Mono-saccharides And Polyols (FODMAP) Diet (LFD) and Gluten Free Diet (GFD) are among the most frequently suggested diets. This paper aims to evaluate their possible role in IBS management. A GFD is less restrictive and easier to implement in everyday life and can be suggested for patients who clearly recognize gluten as a trigger of their symptoms. An LFD, being more restrictive and less easy to learn and to follow, needs the close supervision of a skilled nutritionist and should be reserved for patients who recognize that the trigger of their symptoms is not, or not only, gluten. Even if the evidence is of very low-quality for both diets, the LFD is the most effective among the dietary interventions suggested for treating IBS, and it is included in the most updated guidelines.
Topics: Clinical Trials as Topic; Diet, Carbohydrate-Restricted; Diet, Gluten-Free; Disaccharides; Fermentation; Humans; Irritable Bowel Syndrome; Monosaccharides; Oligosaccharides; Polymers; Treatment Outcome
PubMed: 33139629
DOI: 10.3390/nu12113368 -
Neurobiology of Disease Dec 2019Metabolic interventions including special diets and supplements are commonly used in Autism Spectrum Disorder (ASD). Yet little is known about how these interventions,... (Review)
Review
Metabolic interventions including special diets and supplements are commonly used in Autism Spectrum Disorder (ASD). Yet little is known about how these interventions, typically initiated by caregivers, may affect metabolic function or the core symptoms of ASD. This review examines possible direct and indirect roles for metabolism in the core symptoms of ASD as well as evidence for metabolic dysfunction and nutritional deficiencies. We also discuss some of the most popular diets and supplements used in our patient population and suggest strategies for discussing the utility of these interventions with patients, families, and caregivers.
Topics: Autism Spectrum Disorder; Diet, Gluten-Free; Diet, Ketogenic; Dietary Supplements; Humans; Metabolic Diseases; Nutritional Status; Nutritional Support; Vitamins
PubMed: 31351171
DOI: 10.1016/j.nbd.2019.104544 -
Nutrients Jul 2021Metabolic acidosis is a severe complication of chronic kidney disease (CKD) which is associated with nefarious impairments such as bone demineralization, muscle wasting,... (Review)
Review
Metabolic acidosis is a severe complication of chronic kidney disease (CKD) which is associated with nefarious impairments such as bone demineralization, muscle wasting, and hormonal alterations, for example, insulin resistance. Whilst it is possible to control this condition with alkali treatment, consisting in the oral administration of sodium citrate or sodium bicarbonate, this type of intervention is not free from side effects. On the contrary, opting for the implementation of a targeted dietetic-nutritional treatment for the control of CKD metabolic acidosis also comes with a range of additional benefits such as lipid profile control, increased vitamins, and antioxidants intake. In our review, we evaluated the main dietary-nutritional regimens useful to counteract metabolic acidosis, such as the Mediterranean diet, the alkaline diet, the low-protein diet, and the vegan low-protein diet, analyzing the potentialities and limits of every dietary-nutritional treatment. Literature data suggest that the Mediterranean and alkaline diets represent a valid nutritional approach in the prevention and correction of metabolic acidosis in CKD early stages, while the low-protein diet and the vegan low-protein diet are more effective in CKD advanced stages. In conclusion, we propose that tailored nutritional approaches should represent a valid therapeutic alternative to counteract metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Diet; Diet, Mediterranean; Diet, Protein-Restricted; Diet, Vegan; Humans; Nutrition Therapy; Renal Insufficiency, Chronic
PubMed: 34444694
DOI: 10.3390/nu13082534 -
Science Progress 2015
Topics: Animals; Diet; Diet Therapy; History, 20th Century; Humans; Vitamins
PubMed: 26292365
DOI: 10.3184/003685015X14320243472767