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The Israel Medical Association Journal... Nov 2021
Comment on: Efficacy and safety of enteral recombinant human insulin for reduction of time-to-full enteral feeding in preterm infants: a randomized, double-blind, placebo-controlled trial (IMAJ September 2021).
Topics: Double-Blind Method; Enteral Nutrition; Humans; Infant; Infant, Newborn; Infant, Premature; Insulins; Weight Gain
PubMed: 34811995
DOI: No ID Found -
Alternative Therapies in Health and... Sep 2021It's difficult to conduct experiments using a double-blind design in controlled clinical trials of acupuncture. To resolve this problem with blinding, we designed... (Randomized Controlled Trial)
Randomized Controlled Trial
CONTEXT
It's difficult to conduct experiments using a double-blind design in controlled clinical trials of acupuncture. To resolve this problem with blinding, we designed double-blind needles (DBNs) with stuffing to mimic the resistance felt during insertion of a regular acupuncture needle. Results of the past studies using 0.16 mm diameter DBNs found that the resistance felt by the acupuncturists during insertion successfully blinded them.
OBJECTIVE
The study intended to compare the effects on an acupuncturist's blinding when the practitioner used penetrating DBNs with 0.14, 0.16, 0.18, and 0.20 mm diameters.
DESIGN
We conducted a double-blind randomized trial.
SETTING
The study took place at the Japan School of Acupuncture, Moxibustion. and Physiotherapy in Tokyo, Japan.
PARTICIPANTS
The participant was one licensed acupuncturist who performed 320 needle insertions during acupuncture for 20 healthy students, who were familiar with acupuncture and who attended the Japan School of Acupuncture, Moxibustion, and Physiotherapy.
METHODS
The acupuncturist was informed she would administer a penetrating or non-penetrating needle; however, only penetrating needles were used. She inserted the four sizes of needles in both of each student's dorsal forearms using an alternating twirling technique. This procedure was repeated once more on another day, with at least one day between sessions.
PRIMARY OUTCOME MEASURES
After the acupuncturist removed each needle, we asked her to guess: (1) the type of needle inserted, (2) her level of confidence in the guess, and (3) the clues that contributed to her guess. A chi-squared test was used to determine whether the ratio of correctly or incorrectly identified needles met an expected probability of 0.5 for each needle diameter.
RESULTS
Of the 320 needle insertions, the acupuncturist correctly identified 54% of 0.14 mm, 45% of 0.16 mm, 46% of 0.18 mm, and 50% of 0.20 mm needle insertions. The correct and incorrect ratios of identified needles were fitted with a probability of 0.5, with no significant differences in the acupuncturist's confidence (P = .16). In 99% of the tests, the cue that contributed to the acupuncturist's guess was the feeling of the needle insertion.
CONCLUSION
These findings indicate that the differences in the diameters of DBNs from 0.14 to 0.20 mm didn't significantly affect the acupuncturist's blinding.
Topics: Acupuncture Therapy; Double-Blind Method; Female; Humans; Needles
PubMed: 33038081
DOI: No ID Found -
Anaesthesia Jun 2020
Topics: Anesthetics; Cross-Over Studies; Double-Blind Method; Neuromuscular Blockade; Sugammadex
PubMed: 32383511
DOI: 10.1111/anae.15002 -
Clinical and Translational... Jan 2022
Randomized Controlled Trial
Topics: Bias, Implicit; Double-Blind Method; Humans
PubMed: 35130182
DOI: 10.14309/ctg.0000000000000443 -
Gut Microbes Dec 2023
Randomized Controlled Trial
Topics: Humans; Adult; Synbiotics; Gastrointestinal Microbiome; Probiotics; Double-Blind Method
PubMed: 37766477
DOI: 10.1080/19490976.2023.2262618 -
Proceedings of the National Academy of... Feb 2018
Topics: Double-Blind Method; Peer Review; Peer Review, Research; Periodicals as Topic; Radiation Oncology
PubMed: 29434045
DOI: 10.1073/pnas.1721225115 -
Anaesthesia Jun 2021
Topics: Anesthesia, Obstetrical; Anesthesia, Spinal; Anesthetics, Local; Bupivacaine; Cesarean Section; Double-Blind Method; Female; Humans; Pregnancy; Prilocaine
PubMed: 33428235
DOI: 10.1111/anae.15341 -
Arquivos Brasileiros de Oftalmologia Aug 2019
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Single-Blind Method
PubMed: 31482964
DOI: 10.5935/0004-2749.20190085 -
British Journal of Anaesthesia Sep 2017
Topics: Blood Transfusion; Double-Blind Method; Female; Fibrinogen; Humans; Postpartum Hemorrhage; Postpartum Period; Pregnancy
PubMed: 28969322
DOI: 10.1093/bja/aex168 -
Indian Journal of Dermatology,... 2019
Topics: Double-Blind Method; Forecasting; Humans; Peer Review; Periodicals as Topic
PubMed: 30971533
DOI: 10.4103/ijdvl.IJDVL_296_19