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Scientific Reports Sep 2023Food packaging reinforced with Zn-doped TiO nanoparticles with enhanced prerequisite film-forming and biodegradable traits was prepared to augment fresh food storage....
Food packaging reinforced with Zn-doped TiO nanoparticles with enhanced prerequisite film-forming and biodegradable traits was prepared to augment fresh food storage. Pure and tailored metal (Zinc, Copper, and Selenium) doped TiO nanoparticles were synthesized and analyzed through multiple characterization techniques (optical spectra, XRD patterns (X-Ray Diffraction), Dynamic Light Scattering, and Scanning Electron Microscopy). The synthesized nanoparticles were tested for their Minimum Inhibitory Concentrations, antimicrobial potential against common lethal food pathogens, and cytotoxicity. Compared to Cu- and Se-doped nanoparticles, Zn-doped TiO nanoparticles displayed the most potent antimicrobial activity with insignificant cytotoxicity and were incorporated into the food packaging materials. The developed nano-reinforced food packaging efficaciously augmented the freshness of plums (Oemleria cerasiformis) for 16 days (42 ± 2 °C). The physicomechanical characterization of the nano-reinforced packaging establishes its utility in food packaging applications. The developed biodegradable packaging undergoes complete decomposition within 12 days of storage in natural soil.
Topics: Prunus domestica; Drug Packaging; Rosaceae; Food Packaging
PubMed: 37666921
DOI: 10.1038/s41598-023-41640-1 -
STAR Protocols Sep 2022The cost of supply cylinders can be expensive for smaller gnotobiotic facilities on strict budgets. Here, we present an alternative approach to enter supplies into...
The cost of supply cylinders can be expensive for smaller gnotobiotic facilities on strict budgets. Here, we present an alternative approach to enter supplies into germ-free isolators that does not require large cylinder drums (supply cylinders). We describe procedures for autoclaving double-bagged packs of supplies, sealing the packs aseptically into zip lock bags in biosafety cabinet, and entering supply packages into isolators. Our gnotobiotic facility has been using this protocol since 2018 and has been effective in maintaining germ-free status.
Topics: Animals; Bandages; Drug Packaging; Germ-Free Life; Quarantine; Rodentia
PubMed: 35776636
DOI: 10.1016/j.xpro.2022.101511 -
Canadian Association of Radiologists... Nov 2012
Review
Topics: Diagnostic Imaging; Drug Packaging; Foreign Bodies; Humans; Illicit Drugs
PubMed: 22280790
DOI: 10.1016/j.carj.2011.06.007 -
British Journal of Anaesthesia Jun 2019
Topics: Anesthesia; Anesthesiology; Drug Packaging
PubMed: 30961916
DOI: 10.1016/j.bja.2019.03.007 -
European Journal of Pharmaceutics and... Sep 2022During the filling process of a biopharmaceutical drug product (DP), a liquid DP film might creep up the inner vial wall which is barely discernible, appears as...
During the filling process of a biopharmaceutical drug product (DP), a liquid DP film might creep up the inner vial wall which is barely discernible, appears as milky-white haze after lyophilisation and is known as fogging. Creeping and fogging are mainly dependent on the primary packaging material surface and its hydration, vial preparation process as well as DP composition. The occurrence of both can impede visual inspection and might lead to DP rejection. Hence, our studies focused on the early detection of liquid solution and glass vial surface interaction directly after filling. For a fast and highly sensitive evaluation a novel video-based analysis was used. To our knowledge, this is the first time a MATLAB®-algorithm-based video analysis was applied to quantitatively determine creeping time-resolved. Furthermore, creeping in dependence of vial processing sites, surfactant type and concentration, filling temperature, and vial format were investigated. The results were verified using orthogonal conventional methods such as surface tension, wetting behaviour, and contact angle measurements, as well as ToF-SIMS, ICP-MS, and SEM. Additionally, the methods applied were assessed regarding their cross-validation capability. The observations indicate that the vial preparation process can have a pronounced impact on alteration of the glass vial surface and related creeping behaviour of the filled solution.
Topics: Algorithms; Drug Packaging; Freeze Drying; Glass; Pharmaceutical Preparations
PubMed: 35961565
DOI: 10.1016/j.ejpb.2022.08.003 -
Journal of Biomedical Semantics Sep 2017Drug Package Leaflets (DPLs) provide information for patients on how to safely use medicines. Pharmaceutical companies are responsible for producing these documents....
BACKGROUND
Drug Package Leaflets (DPLs) provide information for patients on how to safely use medicines. Pharmaceutical companies are responsible for producing these documents. However, several studies have shown that patients usually have problems in understanding sections describing posology (dosage quantity and prescription), contraindications and adverse drug reactions. An ultimate goal of this work is to provide an automatic approach that helps these companies to write drug package leaflets in an easy-to-understand language. Natural language processing has become a powerful tool for improving patient care and advancing medicine because it leads to automatically process the large amount of unstructured information needed for patient care. However, to the best of our knowledge, no research has been done on the automatic simplification of drug package leaflets. In a previous work, we proposed to use domain terminological resources for gathering a set of synonyms for a given target term. A potential drawback of this approach is that it depends heavily on the existence of dictionaries, however these are not always available for any domain and language or if they exist, their coverage is very scarce. To overcome this limitation, we propose the use of word embeddings to identify the simplest synonym for a given term. Word embedding models represent each word in a corpus with a vector in a semantic space. Our approach is based on assumption that synonyms should have close vectors because they occur in similar contexts.
RESULTS
In our evaluation, we used the corpus EasyDPL (Easy Drug Package Leaflets), a collection of 306 leaflets written in Spanish and manually annotated with 1400 adverse drug effects and their simplest synonyms. We focus on leaflets written in Spanish because it is the second most widely spoken language on the world, but as for the existence of terminological resources, the Spanish language is usually less prolific than the English language. Our experiments show an accuracy of 38.5% using word embeddings.
CONCLUSIONS
This work provides a promising approach to simplify DPLs without using terminological resources or parallel corpora. Moreover, it could be easily adapted to different domains and languages. However, more research efforts are needed to improve our approach based on word embedding because it does not overcome our previous work using dictionaries yet.
Topics: Algorithms; Comprehension; Drug Packaging; Humans; Language; Patient Care; Semantics; Spain; Writing
PubMed: 28962645
DOI: 10.1186/s13326-017-0156-7 -
Anesthesiology Jul 2017
Topics: Academic Medical Centers; Art; Drug Packaging; Humans; Recycling; Wisconsin
PubMed: 28632631
DOI: 10.1097/ALN.0000000000001684 -
Einstein (Sao Paulo, Brazil) May 2016To compare sterility and microbial (bacteria and fungi) load in the outer part of hyperbaric bupivacaine (Neocaína®) in ampoule and bupivacaine in vial, in... (Comparative Study)
Comparative Study
OBJECTIVE
To compare sterility and microbial (bacteria and fungi) load in the outer part of hyperbaric bupivacaine (Neocaína®) in ampoule and bupivacaine in vial, in conventional and sterile pack formulations.
METHODS
The sterile packs were divided into two groups: G1 (n=16) with ampoules and G2 (n=16) with vials. Conventional formulations were divided into two groups, being G3 (n=16) with ampoules and G4 (n=16) with vials. The ampoules and vials were opened and had their content drawn. The empty bottles were then placed in sterile plastic bags and sent for analysis of microbial load (bacteria and fungi) and sterility testing. Data were analyzed using the χ2 test with Yates correction, and 95% confidence interval.
RESULTS
G1 and G2 showed no bacterial growth when compared to conventional groups (p<0.001). The most common agent in conventional microbiological samples was Staphylococcus aureus. There was no fungal growth in both groups.
CONCLUSION
The use of (sterile pack) reduces the microbial load of bottles, and would decrease the chance of exposure to potential contamination of the anesthetic solution.
OBJETIVO
Comparar a esterilidade e a carga microbiana (bactérias e fungos) da parte externa dos frascos de envasamento de bupivacaína hiperbárica (Neocaína®) em ampola e bupivacaína em frasco-ampola das apresentações convencional e estéril (sterile pack).
MÉTODOS
As apresentações estéreis (sterile pack) foram distribuídas em dois grupos, sendo que o G1 (n=16) continha as ampolas e o G2 (n=16), os frascos-ampola. As apresentações convencionais foram distribuídas em dois grupos, a saber G3 (n=16) com as ampolas e G4 (n=16) com os frascos-ampola. As ampolas e os frascos-ampolas eram abertos e tinham seu conteúdo aspirado. Os frascos vazios eram, então, acondicionados em sacos plásticos estéreis e enviados para análise quanto à carga microbiana (bactérias e fungos), bem como para o teste de esterilidade. Os dados foram analisados por meio do teste χ2 com correção Yates com intervalo de confiança de 95%.
RESULTADOS
Os grupos G1 e G2 não apresentaram crescimento bacteriano quando comparado aos grupos convencionais (p<0,001). O microbiano mais comum nas amostras convencionais foi o Staphylococcus aureus. Não houve crescimento de fungos em nenhum dos grupos.
CONCLUSÃO
O uso de embalagens estéreis (sterile pack) diminui a carga microbiana dos frascos de envasamentos, o que diminuiria a chance de exposição a uma potencial contaminação da solução anestésica.
Topics: Anesthetics, Local; Bacillus; Bupivacaine; Colony Count, Microbial; Drug Contamination; Drug Packaging; Equipment Contamination; Equipment and Supplies; Micrococcus; Reproducibility of Results; Risk Factors; Staphylococcus aureus; Sterilization; Time Factors
PubMed: 27223307
DOI: 10.1590/S1679-45082016AO3484 -
Yakugaku Zasshi : Journal of the... Sep 2009The hazardous effects due to the insoluble microparticles generated in the injections have been pointed out. To our knowledge, however, there have been no reports about... (Review)
Review
The hazardous effects due to the insoluble microparticles generated in the injections have been pointed out. To our knowledge, however, there have been no reports about insoluble microparticulate contamination at ampoule opening. Therefore, we performed this study to evaluate the relationship between time and glass particulate sedimentation to examine the effect of swabbing the ampoule neck on particle generation to clarify the relationship between the inner-diameter size of an ampoule and the amount of glass particulate sedimentation to find out the effect of methods for ampule opening, and compare particle contamination in glass ampoule and that of plastic, after ampoule opening and assessed the contribution of material of ampoule to the particle generation. We observed that the glass particulate contamination of accumulation value at a size over 2 mum increased significantly after 60 seconds, the swabbing the neck of the ampoule prior to opening had a negative effect on prevention of glass particulate contamination, the glass particulate contamination was positively influenced by the inner-diameter size of the ampoule, but not by the thickness of the ampoule walls, the particulate contamination derived from glass significantly increased by general method as well as using ampoule open adaptor compared with our method, and the insoluble microparticulate contamination in plastic ampoule was significantly lower than that in glass ampoule. The present findings might provide an useful information to reduce glass particules after ampoule opening performed in clinical practice.
Topics: Dosage Forms; Drug Contamination; Drug Packaging; Glass; Injections; Particle Size; Plastics; Solubility; Time Factors
PubMed: 19721379
DOI: 10.1248/yakushi.129.1041 -
Anaesthesia Jul 2013
Topics: Drug Packaging; Humans; Needles; Needlestick Injuries
PubMed: 24044398
DOI: 10.1111/anae.12297