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Current Opinion in Obstetrics &... Aug 2011Understanding the cause of tubal ectopic pregnancy (tEP) remains incomplete. We aim to summarize the latest advances in laboratory models of tEP that we believe will,... (Review)
Review
PURPOSE OF REVIEW
Understanding the cause of tubal ectopic pregnancy (tEP) remains incomplete. We aim to summarize the latest advances in laboratory models of tEP that we believe will, ultimately, contribute to improving the diagnosis and management of the condition.
RECENT FINDINGS
Progress in proteome prefractionation and multidimensional protein identification technology has proved particularly effective in identifying novel biomarkers of tEP. These, and related global proteomic and genomic approaches, have as yet to be fully exploited in this context but do have substantial potential to inform future hypothesis-driven studies. The majority of data generated since 2009 to explain the cause of tEP continues to derive from descriptive human ex-vivo studies. In-vitro models of fallopian tube ciliary and smooth muscle function have improved to a limited degree, on the back of continuing advances in imaging and data acquisition. We believe that the recent development of a primary human fallopian tube epithelium culture system represents the most significant recent advance in laboratory models for studying ectopic pregnancy. There remain no good animal models of tEP.
SUMMARY
The establishment of a viable animal model of tEP remains the key obstacle to a complete understanding of the cause of the condition.
Topics: Animals; Biomarkers; Fallopian Tubes; Female; Humans; Models, Biological; Pregnancy; Pregnancy, Tubal; Tissue Culture Techniques
PubMed: 21666470
DOI: 10.1097/GCO.0b013e3283481212 -
Advances in Anatomic Pathology May 2022Ovarian serous tumors and related lesions are one of the most common conditions of the female genital tract. While ovarian high-grade serous carcinoma carries high... (Review)
Review
Ovarian serous tumors and related lesions are one of the most common conditions of the female genital tract. While ovarian high-grade serous carcinoma carries high mortality and adverse prognosis, most other serous lesions have better clinical behavior. In recent years, significant progress has been made in understanding the nature and histogenesis of these lesions that has contributed to better and more precise clinical management. Most of the high-grade serous carcinomas involve the ovaries and/or peritoneum, although in most cases, their origin seems to be in the fallopian tube. This view is supported by the recognition of precursor lesions in the fallopian tube, such as p53 signature and serous tubular in situ carcinoma. This paper presents salient morphologic, immunohistochemical, and molecular data related to serous tumors and related lesions of the female pelvis and discusses the histogenetic interrelationship among these lesions in light of current knowledge.
Topics: Carcinoma; Fallopian Tube Neoplasms; Fallopian Tubes; Female; Humans; Ovarian Neoplasms; Pelvis
PubMed: 35180738
DOI: 10.1097/PAP.0000000000000334 -
Journal of Biophotonics Jun 2023Due to the lack of reliable early-diagnostic tools, most ovarian cancers are diagnosed at late stages. Although optical coherence tomography (OCT) has shown promise for...
Due to the lack of reliable early-diagnostic tools, most ovarian cancers are diagnosed at late stages. Although optical coherence tomography (OCT) has shown promise for identifying diseased ovaries and fallopian tubes at an earlier stage, previous studies either did not provide quantitative scattering mapping or simply used Beer's law to fit the scattering coefficients of each A-line. In this paper, we calculated the pixel-wise attenuation coefficients of ovaries and fallopian tubes in OCT images. Data from 73 freshly excised human ovaries and fallopian tubes from 36 patients have shown that statistical features are statistically different between cancerous ovaries, infundibula, and fimbriae and normal ones.
Topics: Female; Humans; Fallopian Tubes; Tomography, Optical Coherence; Ovarian Neoplasms
PubMed: 36916760
DOI: 10.1002/jbio.202300002 -
Scientific Reports Jul 2021Sustained adrenergic stimulation by norepinephrine (NE) contributes to ovarian carcinoma metastasis and impairment of chemotherapy response. Although the effect of...
Sustained adrenergic stimulation by norepinephrine (NE) contributes to ovarian carcinoma metastasis and impairment of chemotherapy response. Although the effect of sustained NE stimulation in cancer progression is well established, less is known about its role in cancer initiation. To determine the extent to which stress hormones influence ovarian cancer initiation, we conducted a long-term (> 3 months; > 40 population doublings) experiment in which normal immortalized fallopian tube secretory (iFTSEC283) and ovarian surface epithelial (iOSE11) cell lines and their isogenic pairs containing a p53 mutation (iFTSEC283; iOSE11), were continuously exposed to NE (100 nM, 1 μM, 10 μM). Fallopian tube cells displayed a p53-independent increase in proliferation and colony-forming ability in response to NE, while ovarian surface epithelial cells displayed a p53-independent decrease in both assays. Fallopian tube cells with mutant p53 showed a mild loss of chromosomes and TP53 status was also a defining factor in transcriptional response of fallopian tube cells to long-term NE treatment.
Topics: Fallopian Tubes; Female; Gene Expression Regulation, Neoplastic; Humans; Norepinephrine; Ovarian Neoplasms
PubMed: 34253763
DOI: 10.1038/s41598-021-93506-z -
The Oncologist Nov 2015Both the American College of Obstetricians and Gynecologists (ACOG) and the American Cancer Society have recommended that surgeons should discuss the potential benefits...
Both the American College of Obstetricians and Gynecologists (ACOG) and the American Cancer Society have recommended that surgeons should discuss the potential benefits of the prophylactic removal of the Fallopian tubes for permanent contraception or during surgeries for benign pathologies with every woman at risk for ovarian cancer. With the release of the ACOG Committee on Gynecologic Practice, the time has finally come to extend this information from specialist colleges to the entire medical community.
Topics: Fallopian Tube Neoplasms; Fallopian Tubes; Female; Humans; Ovarian Neoplasms
PubMed: 26382741
DOI: 10.1634/theoncologist.2015-0172 -
PloS One 2013Prolapse of the fallopian tube into the vaginal vault is a rarely reported complication that may occur after hysterectomy. Clinicians can miss the diagnosis of this... (Review)
Review
BACKGROUND
Prolapse of the fallopian tube into the vaginal vault is a rarely reported complication that may occur after hysterectomy. Clinicians can miss the diagnosis of this disregarded complication when dealing with post-hysterectomy vaginal bleeding.
OBJECTIVES
We performed a systematic review in order to describe the clinical presentation, therapeutic management and outcome of fallopian tube prolapse occurring after hysterectomy.
SEARCH STRATEGY
A systematic search of MEDLINE and EMBASE references from January 1980 to December 2010 was performed. We included articles that reported cases of fallopian tube prolapse after hysterectomy. Data from eligible studies were independently extracted onto standardized forms by two reviewers.
RESULTS
Twenty-eight articles including 51 cases of fallopian tube prolapse after hysterectomy were included in this systematic review. Clinical presentations included abdominal pain, dyspareunia, post- coital bleeding, and/or vaginal discharge. Two cases were asymptomatic and diagnosed at routine checkup. The surgical management reported comprised partial or total salpingectomy, with vaginal repair in some cases combined with oophorectomy using different approaches (vaginal approach, combined vaginal-laparoscopic approach, laparoscopic approach, or laparotomy). Six patients were initially treated by silver nitrate application without success.
CONCLUSIONS
This systematic review provided a precise summary of the clinical characteristics and treatment of patients presenting with fallopian tube prolapse following hysterectomy published in the past 30 years. We anticipate that these results will help inform current investigations and treatment.
Topics: Abdominal Pain; Dyspareunia; Fallopian Tube Diseases; Fallopian Tubes; Female; Humans; Hysterectomy; Postoperative Complications; Prolapse
PubMed: 24116117
DOI: 10.1371/journal.pone.0076543 -
Taiwanese Journal of Obstetrics &... Jun 2018Leiomyosarcoma of the fallopian tube is a rare malignant gynecologic neoplasm with poor prognosis. It is important to share experience and to collect more cases to... (Review)
Review
OBJECTIVE
Leiomyosarcoma of the fallopian tube is a rare malignant gynecologic neoplasm with poor prognosis. It is important to share experience and to collect more cases to improve the understanding of the disease.
CASE REPORT
We reported three patients with leiomyosarcoma of the fallopian tube who were treated in Fudan University Shanghai Cancer Center (Shanghai, China) from 2012 to 2016. Although the three cases shared the same diagnosis, they varied in the presentations, treatments, and outcomes.
CONCLUSION
Leiomyosarcoma of the fallopian tube seems to have some particularities in imaging manifestations and immunohistochemical results. It has a progressive course with limited therapeutic options such as surgery, chemotherapy or radiotherapy.
Topics: Biomarkers, Tumor; Combined Modality Therapy; Fallopian Tube Neoplasms; Fallopian Tubes; Female; Humans; Hysterectomy; Leiomyosarcoma; Magnetic Resonance Imaging; Middle Aged; Neoplasm Staging; Tomography, X-Ray Computed
PubMed: 29880185
DOI: 10.1016/j.tjog.2018.04.024 -
Journal of Medicine and Life 2015Around 30% of the infertile women worldwide have associated Fallopian tubes pathology. Unfortunately, for a long time, this aspect of infertility has been neglected due... (Meta-Analysis)
Meta-Analysis Review
RATIONALE
Around 30% of the infertile women worldwide have associated Fallopian tubes pathology. Unfortunately, for a long time, this aspect of infertility has been neglected due to the possibility of bypassing this deadlock through IVF.
OBJECTIVE
Up to date free full text literature was reviewed, meaning 4 major textbooks and around 100 articles centered on tubal infertility, in order to raise the awareness on this subject.
METHODS AND RESULTS
The anatomy of the Fallopian tube is complex starting from its embryological development and continuing with its vascular supply and ciliated microstructure, that is the key to the process of egg transport to the site of fertilization. There are many strongly documented causes of tubal infertility: infections (Chlamydia Trachomatis, Gonorrhea, and genital tuberculosis), intrauterine contraceptive devices, endometriosis, and complications after abdominal surgery, etc.
DISCUSSIONS
Although there are still many controversies about the etiology of tubal sterility with the advent of molecular diagnosis of infections there has been cleared the pathway of infection through endometriosis or through ciliary immobility towards the tubal obstruction.
Topics: Fallopian Tubes; Female; Humans; Infertility, Female
PubMed: 25866566
DOI: No ID Found -
Drug Delivery and Translational Research Aug 2019To prospectively study the efficacy of different anti-adhesion agents for the prevention of tubal obstruction after recanalization, this trial was approved by our... (Randomized Controlled Trial)
Randomized Controlled Trial
To prospectively study the efficacy of different anti-adhesion agents for the prevention of tubal obstruction after recanalization, this trial was approved by our hospital ethics committee. Four hundred patients with fallopian tube obstruction were randomly assigned to four groups. The control group underwent recanalization alone, whereas the other groups were injected with chitosan, Dan-shen, or combined chitosan and Dan-shen after recanalization. The tubal patency rate in all four groups was recorded after 12 day, 3 months, and 12 months. The pregnancy rates were noted after 12 months. The recanalization rates after 1 day in the control, chitosan, Dan-shen, and combined chitosan and Dan-shen groups were 94.1, 97.1, 96.5, and 98.2%, respectively (p = 0.18, p > 0.05). The rates of tubal patency after 3 months were significantly higher in the combined chitosan and Dan-shen (96.5%), chitosan (88%), and Dan-shen (85.2%) groups compared with the control group (73.9%) (p = 0.0001, p < 0.05). The recanalization rate and intrauterine pregnancy rate after 12 months was significantly higher in the combined chitosan and Dan-shen group (93.8 and 63.9%, respectively) compared with the other groups (control 39 and 30.6%, chitosan 78.4 and 46.9%, and Dan-shen 77.3 and 43.3%) (p = 0.0029 and p = 0.0001, p < 0.05). Chitosan, Dan-shen, or a combination of the two compounds could be effective for preventing tubal obstruction after interventional recanalization, possibly increasing the rate of pregnancy in affected women. The combined chitosan and Dan-shen injection has unique advantages in the interventional recanalization of obstructed fallopian tubes.
Topics: Adult; Chitosan; Drug Therapy, Combination; Drugs, Chinese Herbal; Fallopian Tube Diseases; Fallopian Tubes; Female; Humans; Infertility; Injections; Middle Aged; Pregnancy; Salvia miltiorrhiza; Single-Blind Method; Young Adult
PubMed: 30610502
DOI: 10.1007/s13346-018-00611-0 -
Fertility and Sterility Jul 2011To present a case of unilateral tubal and ovarian absence, along with laparoscopic images. (Review)
Review
OBJECTIVE
To present a case of unilateral tubal and ovarian absence, along with laparoscopic images.
DESIGN
Case report.
SETTING
University hospital.
PATIENT(S)
A 21-year-old patient presented with primary infertility of 3 years' duration. Left adnexal structures were not visualized on transvaginal ultrasound and hysterosalpingography.
INTERVENTION(S)
Diagnostic laparoscopy and hysteroscopy.
MAIN OUTCOME MEASURE(S)
Complete absence of the left fallopian tube together with ovary was detected during laparoscopy. Subsequent karyotyping and urinary tract evaluation with intravenous pyelography were planned.
RESULT(S)
Ipsilateral absence of the fallopian tube and ovary without any other system anomalies were detected.
CONCLUSION(S)
Torsion or congenital defect might be the possible etiologic factors. However, vascular accident stands in the forefront of suggested etiologies. Laparoscopy is a feasible option as a diagnostic tool for these kinds of cases.
Topics: Fallopian Tubes; Female; Humans; Infertility, Female; Ovary; Ultrasonography; Young Adult
PubMed: 21561606
DOI: 10.1016/j.fertnstert.2011.04.027