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Bulletin Du Cancer Sep 1997Hormonotherapy in metastatic breast cancer is actually performed using 3 therapeutic classes: antiestrogen as tamoxifen (TAM), progestins, megestrol acetate (MA) and... (Comparative Study)
Comparative Study Meta-Analysis
Hormonotherapy in metastatic breast cancer is actually performed using 3 therapeutic classes: antiestrogen as tamoxifen (TAM), progestins, megestrol acetate (MA) and medroxyprogesterone acetate (MPA), aromatase-inhibitors as aminoglutethimide (AG). We investigated therapeutic efficacy of progestins compared to other hormonotherapies in case of breast cancer with bone metastasis. In a literature review, we found ten randomized trials comparing: MPA versus AG, MPA versus MA, MPA versus TAM, MA versus AG versus TAM. The results show an advantage on the response rate using MPA; the usual dose was 900-2,000 mg daily. MPA mode of action can explain these results since they combine gestagenic, androgenics and glucocorticoid effects.
Topics: Aminoglutethimide; Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Dose-Response Relationship, Drug; Female; Humans; Medroxyprogesterone; Melengestrol Acetate; Survival Analysis; Tamoxifen
PubMed: 9435812
DOI: No ID Found -
Journal of Dairy Science Nov 1975Subcutaneous administration of progesterone (.25 mg/kg body weight per day) to mature cows from 14 days before projected parturition until parturition increased feed...
Subcutaneous administration of progesterone (.25 mg/kg body weight per day) to mature cows from 14 days before projected parturition until parturition increased feed intake over control cows. Incidence of milk fever and plasma calcium, phosphorus, magnesium, and hydroxyproline were not significantly different between treated and control cows. Subcutaneous administration of estradiol-17beta (.05 mg/kg body weight per day) or oral administration of melengestrol acetate (1 mg/day) from 7 days before projected parturition date until parturition decreased feed intake over control cows. Milk fever incidence and absorption of calcium, phosphorus, and magnesium were not significantly different between treatment groups. Plasma calcium was not significantly different between treatment groups during either the prepartum or postpartal periods but tended to be higher postpartum in cows treated with estrogen.
Topics: Animals; Calcium; Cattle; Cattle Diseases; Diet; Estradiol; Estrogens; Female; Labor, Obstetric; Magnesium; Melengestrol Acetate; Minerals; Parturient Paresis; Phosphorus; Pregnancy; Progesterone; Time Factors
PubMed: 1194470
DOI: 10.3168/jds.S0022-0302(75)84771-0 -
Journal of Dairy Science Dec 1971
Topics: Animals; Birth Weight; Body Weight; Cattle; Depression, Chemical; Estrus; Female; Fertilization; Ketosteroids; Lactation; Lipid Metabolism; Male; Milk; Pregnancy; Pregnanes; Progestins; Reproduction; Time Factors
PubMed: 5132684
DOI: 10.3168/jds.S0022-0302(71)86125-8