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Acta Crystallographica. Section E,... Nov 2015The title compounds, (N-methyl-N-phenyl-amino)(N-methyl-N-phenyl-car-bam-oyl)sulfide, C15H16N2OS, (I), and...
The title compounds, (N-methyl-N-phenyl-amino)(N-methyl-N-phenyl-car-bam-oyl)sulfide, C15H16N2OS, (I), and (N-methyl-N-phenyl-amino)-(N-methyl-N-phenyl-carbamo-yl)disulfane, C15H16N2OS2, (II), are stable derivatives of (chloro-carbon-yl)sulfenyl chloride and (chloro-carbon-yl)disulfanyl chloride, respectively. The torsion angle about the S-S bond in (II) is -92.62 (6)°, which is close to the theoretical value of 90°. In the crystal of (II), non-classical inter-molecular C-H⋯O hydrogen bonds form centrosymmetric cyclic dimers [graph set R 2 (2)(10)], while inter-dimer C-H⋯S inter-actions generate chains extending along the b axis.
PubMed: 26594513
DOI: 10.1107/S2056989015018289 -
Acta Crystallographica. Section E,... Feb 2011In the crystal structure of the title compound, C(12)H(20)N(3) (+)·Cl(-), the protonated (1R,2R)-(pyridin-4-ylmeth-yl)cyclo-hexane-1,2-diamine cations and chloride...
In the crystal structure of the title compound, C(12)H(20)N(3) (+)·Cl(-), the protonated (1R,2R)-(pyridin-4-ylmeth-yl)cyclo-hexane-1,2-diamine cations and chloride anions are linked via N-H⋯N and N-H⋯Cl hydrogen bonds into a three-dimensional network.
PubMed: 21522424
DOI: 10.1107/S1600536811005526 -
British Medical Journal Dec 1954
Topics: Humans; Methyl Chloride; Poisoning; Refrigeration
PubMed: 13209119
DOI: 10.1136/bmj.2.4900.1353 -
Acta Crystallographica. Section E,... Mar 2018The crystal structure of complexes of 3,4,5-tri-methyl-1-pyrazole with CuCl·2HO and Cu(NO)·2.5HO are presented, namely...
The crystal structure of complexes of 3,4,5-tri-methyl-1-pyrazole with CuCl·2HO and Cu(NO)·2.5HO are presented, namely di-μ-chlorido-bis[chloridobis(3,4,5-trimethyl-1-pyrazole-κ)copper(II)], [CuCl(CHN)] () and aquatetrakis(3,4,5-trimethyl-1-pyrazole-κ)copper(II) dinitrate, [Cu(CHN)(HO)](NO) (), and compared to the previously determined structures for 3-methyl-1-pyrazole and 3,5-di-methyl-1-pyrazole. CuCl forms a 2:1 ligand-to-metal chloride-bridged complex with 3,4,5-tri-methyl-1-pyrazole, with a square-pyramidal coordination geometry about each copper(II) center. Similarly to the previously obtained 3,5-di-methyl-1-pyrazole complex with CuCl, the pyrazole ligands are to each other, with two chloride ions bridging the two copper(II) centers, and a terminal chloride ion occupying the axial position. Cu(NO) forms a 4:1 ligand-to-metal complex with 3,4,5-tri-methyl-1-pyrazole that is also arranged in a square-pyramidal geometry about Cu. The newly obtained copper(II) complex has the same coordination geometry as the 3,5-di-methyl-1-pyrazole complex, including an axial water mol-ecule, two nitrate ions hydrogen-bonded to the water mol-ecule, and four pyrazole ligands in the equatorial plane, suggesting that similar steric forces are at play in the formation of these complexes.
PubMed: 29765723
DOI: 10.1107/S2056989018002359 -
Biological Trace Element Research May 2016The objective of this study is to investigate the impacts of Methyl Mercury Chloride (MMC) on cognitive functions and ultrastructural changes of hippocampus in Sprague...
The objective of this study is to investigate the impacts of Methyl Mercury Chloride (MMC) on cognitive functions and ultrastructural changes of hippocampus in Sprague Dawley (SD) rats. Thirty healthy 20-day-old male SD rats weighing 30-40 g were randomly divided into three groups to receive daily injections. Two different dose levels were used: 4 mg/kg as high dose (H-MMC) and 2 mg/kg as low dose (L-MMC).The control group received 4 mg/kg saline solution (N-NaCl). After daily subcutaneous injection for 50 days, 6-day Morris water maze tests were used to assess the learning and memory functions of the rats. After a 5-day continuous training, spatial probe tests were conducted of times and paths crossing to the target quadrant on the 6th day. After the rats were euthanized, their hippocampus sections were stained with hematoxylin and eosin and analyzed under bothoptical microscope and electron microscope. The time H-MMC group spent in finding platform was significantly longer as compared toN-NaCl group on day 2 to day 5 and L-MMC group on day 4 to day 5. The number of crossing times of H-MMC group to the target quadrant was 0.63 ± 0.74, which is much lower than C-NaCl group (3.13 ± 1.56) with P value <0.05. No statistically significant difference in crossing times was found between L-MMC and C-NaCl groups. For H-MMC group, decreasing number of neurons and disorganized nerve cells were examined under light microscope. Swelling and dissolution of Golgi complex were examined under electron microscope, along with endoplasmic reticulum expansion and cytoplasmic edema. Mild cytoplasmic edema was found in L-MMC group. MMC can cause cognitive impairment in terms of learning and memory in SD rats. Additionally, it can also cause changes in the ultrastructure of neurons and morphological changes in the hippocampus, causing significant damage.
Topics: Animals; Cognition Disorders; Dose-Response Relationship, Drug; Hippocampus; Injections, Subcutaneous; Male; Maze Learning; Methylmercury Compounds; Rats; Rats, Sprague-Dawley
PubMed: 26358766
DOI: 10.1007/s12011-015-0492-3 -
Acta Crystallographica. Section E,... Apr 2010The title salt, [Ni(2)(C(16)H(18)ClN(2)O(2))(2)(CH(3)COO)]Cl, features a dinuclear cation in which the Ni atoms are triply bridged by two phenolate O ligands and a...
The title salt, [Ni(2)(C(16)H(18)ClN(2)O(2))(2)(CH(3)COO)]Cl, features a dinuclear cation in which the Ni atoms are triply bridged by two phenolate O ligands and a bidentate acetate ligand with all of the bridging distances essentially symmetric. Each Ni atom is also coordinated by the amine N, pyridine N and hydr-oxy O atoms of the 2-{[(3-chloro-2-hydroxy-prop-yl)(2-pyridylmeth-yl)amino]meth-yl}phenolate ligand which is, therefore, penta-dentate. The resultant N(3)O(3) donor sets define octa-hedral coordination geometries. The chloride counter-anion is connected to the cation via two O(hydr-oxy)-H⋯Cl hydrogen bonds.
PubMed: 21579048
DOI: 10.1107/S160053681001442X -
Acta Crystallographica. Section E,... Dec 2009In the crystal structure of the title compound, C(22)H(26)N(+)·Cl(-), the piperidine ring is in a chair conformation and the two styryl groups are in axial and...
In the crystal structure of the title compound, C(22)H(26)N(+)·Cl(-), the piperidine ring is in a chair conformation and the two styryl groups are in axial and equatorial positions. The mol-ecule has a hydrogen bond between the NH group and the chloride anion.
PubMed: 21580177
DOI: 10.1107/S1600536809049587 -
Acta Crystallographica. Section E,... Apr 2009The title compound, C(13)H(17)N(5)OS, was obtained by cyclo-addition of 2-[2-(methyl-sulfan-yl)pyrimidin-4-yl]-3-oxo-propane-nitrile with...
The title compound, C(13)H(17)N(5)OS, was obtained by cyclo-addition of 2-[2-(methyl-sulfan-yl)pyrimidin-4-yl]-3-oxo-propane-nitrile with (tetra-hydro-furan-3-yl)hydrazine dihydro-chloride and subsequent N-methyl-ation of 4-[2-(methyl-sulfan-yl)-pyrimidin-4-yl]-1-(tetra-hydro-furan-2-yl)-1H-pyrazol-5-amine with methyl iodide. The two mol-ecules in the asymmetric unit have opposite absolute configurations and are related by a noncrystallographic inversion center. Both feature intra-mol-ecular N-H⋯N hydrogen bonds. The geometry of the mol-ecules is similar to that observed in the structure of a single enanti-omer of the title compound.
PubMed: 21583904
DOI: 10.1107/S1600536809014317 -
Acta Crystallographica. Section E,... Feb 2009The title compound, C(10)H(12)N(3)O(+)·Cl(-), is a derivative of o-phthaldehyde and methyl-thio-urea. The mol-ecules form dimers through intra- and inter-molecular...
The title compound, C(10)H(12)N(3)O(+)·Cl(-), is a derivative of o-phthaldehyde and methyl-thio-urea. The mol-ecules form dimers through intra- and inter-molecular N-H⋯O hydrogen bonds. The dimers are further linked into chains through one C-H⋯Cl and two N-H⋯Cl hydrogen bonds.
PubMed: 21582121
DOI: 10.1107/S1600536809003699 -
Molecules (Basel, Switzerland) Nov 2009Ionic liquids (ILs) are known to be non-volatile and thus to have low potential for atmospheric contamination or intoxication of humans by inhalation. However ILs have...
Ionic liquids (ILs) are known to be non-volatile and thus to have low potential for atmospheric contamination or intoxication of humans by inhalation. However ILs have the potential to contaminate soil and water as they might be water soluble and can be sorbed onto solids. The investigation of possible natural ways of reducing the concentration of ILs in the environment is of high importance, especially because the requirement for biodegradable chemicals increases, together with pressure for reduction of incineration and landfill waste. It was found that the upper concentration threshold for primary biodegradation of 1-methyl-3-octylimidazolium chloride is 0.2 mM. At higher concentrations the dehydrogenase activity of the cells dropped markedly, indicating that the IL inhibits cell activity. This concentration is in good agreement with the minimal inhibitory concentration of the same compound found for a series of bacteria and fungi by this research group. The sorption of 1-methyl-3-octylimidazolium chloride was found to be significant, and the sorption coefficient was determined to be 98.2 L kg(-1).
Topics: Biodegradation, Environmental; Ionic Liquids; Pyridinium Compounds; Sewage; Water Pollutants, Chemical
PubMed: 19924073
DOI: 10.3390/molecules14114396