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Journal of the American College of... Feb 2023
Topics: Humans; Mitral Valve Insufficiency; Mitral Valve; Benchmarking; Cardiac Surgical Procedures; Heart Valve Prosthesis Implantation; Treatment Outcome; Cardiac Catheterization
PubMed: 36792279
DOI: 10.1016/j.jacc.2023.01.001 -
Annals of Biomedical Engineering Jun 2015The mitral valve (MV) apparatus consists of the two asymmetric leaflets, the saddle-shaped annulus, the chordae tendineae, and the papillary muscles. MV function over... (Review)
Review
The mitral valve (MV) apparatus consists of the two asymmetric leaflets, the saddle-shaped annulus, the chordae tendineae, and the papillary muscles. MV function over the cardiac cycle involves complex interaction between the MV apparatus components for efficient blood circulation. Common diseases of the MV include valvular stenosis, regurgitation, and prolapse. MV repair is the most popular and most reliable surgical treatment for early MV pathology. One of the unsolved problems in MV repair is to predict the optimal repair strategy for each patient. Although experimental studies have provided valuable information to improve repair techniques, computational simulations are increasingly playing an important role in understanding the complex MV dynamics, particularly with the availability of patient-specific real-time imaging modalities. This work presents a review of computational simulation studies of MV function employing finite element structural analysis and fluid-structure interaction approach reported in the literature to date. More recent studies towards potential applications of computational simulation approaches in the assessment of valvular repair techniques and potential pre-surgical planning of repair strategies are also discussed. It is anticipated that further advancements in computational techniques combined with the next generations of clinical imaging modalities will enable physiologically more realistic simulations. Such advancement in imaging and computation will allow for patient-specific, disease-specific, and case-specific MV evaluation and virtual prediction of MV repair.
Topics: Computer Simulation; Humans; Mitral Valve; Mitral Valve Stenosis; Models, Cardiovascular
PubMed: 25134487
DOI: 10.1007/s10439-014-1094-5 -
JACC. Cardiovascular Imaging Feb 2022
Topics: Cardiomyopathies; Fibrosis; Humans; Mitral Valve; Mitral Valve Insufficiency; Predictive Value of Tests
PubMed: 34656464
DOI: 10.1016/j.jcmg.2021.07.025 -
Journal of Anatomy Aug 2020The mitral valve is a complex anatomical structure whose physiological functioning relies on the biomechanical properties and structural integrity of its components.... (Review)
Review
The mitral valve is a complex anatomical structure whose physiological functioning relies on the biomechanical properties and structural integrity of its components. Their compromise can lead to mitral valve dysfunction, associated with morbidity and mortality. Therefore, a review on the morphometry of the mitral valve is crucial, more specifically on the importance of valve dimensions and shape for its function. This review initially provides a brief background on the anatomy and physiology of the mitral valve, followed by an analysis of the morphological information available. A characterisation of mathematical descriptions of several parts of the valve is performed and the impact of different dimensions and shape changes in disease is then outlined. Finally, a section regarding future directions and recommendations for the use of morphometric information in clinical analysis of the mitral valve is presented.
Topics: Biomechanical Phenomena; Humans; Mitral Valve; Models, Anatomic
PubMed: 32242929
DOI: 10.1111/joa.13196 -
Journal of Biomechanical Engineering Feb 2016The mitral valve is a complex structure regulating forward flow of blood between the left atrium and left ventricle (LV). Multiple disease processes can affect its... (Review)
Review
The mitral valve is a complex structure regulating forward flow of blood between the left atrium and left ventricle (LV). Multiple disease processes can affect its proper function, and when these diseases cause severe mitral regurgitation (MR), optimal treatment is repair of the native valve. The mitral valve (MV) is a dynamic structure with multiple components that have complex interactions. Computational modeling through finite element (FE) analysis is a valuable tool to delineate the biomechanical properties of the mitral valve and understand its diseases and their repairs. In this review, we present an overview of relevant mitral valve diseases, and describe the evolution of FE models of surgical valve repair techniques.
Topics: Animals; Computer Simulation; Finite Element Analysis; Heart Valve Diseases; Humans; Mechanical Phenomena; Mitral Valve; Stress, Mechanical
PubMed: 26632260
DOI: 10.1115/1.4032125 -
JACC. Cardiovascular Imaging Apr 2021
Topics: Humans; Mitral Valve; Mitral Valve Insufficiency; Predictive Value of Tests
PubMed: 33832662
DOI: 10.1016/j.jcmg.2021.03.002 -
JACC. Cardiovascular Imaging Nov 2021
Topics: Humans; Mitral Valve; Mitral Valve Prolapse; Predictive Value of Tests
PubMed: 34147448
DOI: 10.1016/j.jcmg.2021.05.014 -
The Surgical Clinics of North America Aug 2017Degenerative mitral valve disease causing mitral regurgitation is the most common organic valve pathology and is classified based on leaflet motion. The "French... (Comparative Study)
Comparative Study Review
Degenerative mitral valve disease causing mitral regurgitation is the most common organic valve pathology and is classified based on leaflet motion. The "French correction" mitral valve repair method restores normal valvular anatomy with extensive leaflet resection, chordal manipulation, and rigid annuloplasty. The American correction attempts to restore normal valve function through minimal leaflet resection, flexible annuloplasty, and use of artificial chordae. These differing methods of mitral valve repair reflect an evolution in principles, but both require understanding of the valve pathology and correction of leaflet prolapse and annular dilatation. Adhering to those unifying principles and ensuring that no patient leaves the operating room with significant persistent mitral regurgitation produces durable results and satisfactory patient outcomes.
Topics: Cardiac Surgical Procedures; France; Humans; Mitral Valve; Mitral Valve Annuloplasty; Mitral Valve Insufficiency; United States
PubMed: 28728720
DOI: 10.1016/j.suc.2017.03.009 -
JACC. Cardiovascular Imaging Apr 2021
Topics: Cardiac Surgical Procedures; Heart Valve Prosthesis Implantation; Humans; Mitral Valve; Mitral Valve Insufficiency; Predictive Value of Tests
PubMed: 33011126
DOI: 10.1016/j.jcmg.2020.07.038 -
Cardiology Journal 2012The purpose of this article is to document the clinical features of the unusual mitral valve myxoma based on the literature of recent years. (Review)
Review
BACKGROUND
The purpose of this article is to document the clinical features of the unusual mitral valve myxoma based on the literature of recent years.
METHODS
A literature retrieval of the mitral valve myxoma reported in recent years was made using the MEDLINE and EMBASE databases. The clinical information about this unusual disorder was collected and analyzed.
RESULTS
Mitral valve myxoma showed female predilection. Their major symptoms were cardiovascular or cerebrovascular, in addition to constitutional or embolic. The diagnosis was usually made based on two- and three-dimensional transthoracic and/or transesophageal echocardiography, as well as magnetic resonance imaging in the current era. Surgical resection with mitral valve defect repair was the commonest remedy for mitral valve myxoma when mitral valve function could be preserved, and the mitral valve should be replaced when necessary. Patients showed good response to surgical treatment during the follow-up of 17.0 ± 28.4 months after the operation.
CONCLUSIONS
Two- and three-dimensional echocardiography and magnetic resonance imaging are the major diagnostic tools for the diagnosis of a cardiac myxoma. After diagnosis, surgery should be performed urgently, in order to prevent complications such as embolic events or obstruction of the mitral orifice. Due to the fact that myxomas can recur, regular, postoperative cardiological control is mandatory.
Topics: Adolescent; Adult; Cardiac Surgical Procedures; Child; Diagnostic Imaging; Echocardiography, Three-Dimensional; Female; Heart Neoplasms; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Mitral Valve; Myxoma; Predictive Value of Tests; Treatment Outcome; Young Adult
PubMed: 22298179
DOI: 10.5603/cj.2012.0019