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European Journal of Hospital Pharmacy :... Sep 2020
Topics: Clinical Competence; High-Throughput Nucleotide Sequencing; Humans; Medical Oncology; Molecular Medicine; Neoplasms; Workforce
PubMed: 32839254
DOI: 10.1136/ejhpharm-2019-002134 -
Neurochemical Research Sep 2022Ischemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke... (Review)
Review
Ischemic stroke leads to acute neuron death and forms an injured core, triggering delayed cell death at the penumbra. The impaired brain functions after ischemic stroke are hardly recovered because of the limited regenerative properties. However, recent rodent intervention studies manipulating the extracellular environments at the subacute phase shed new light on the regenerative potency of the injured brain. This review introduces the rational design of artificial extracellular matrix (ECM) mimics using supramolecular peptidic scaffolds, which self-assemble via non-covalent bonds and form hydrogels. The facile customizability of the peptide structures allows tuning the hydrogels' physical and biochemical properties, such as charge states, hydrophobicity, cell adhesiveness, stiffness, and stimuli responses. Supramolecular peptidic materials can create safer and more economical drugs than polymer materials and cell transplantation. We also discuss the importance of activating developmental programs for the recovery at the subacute phase of ischemic stroke. Self-assembling molecular medicine mimicking the ECMs and activating developmental programs may stand as a new drug modality of regenerative medicine in various tissues.
Topics: Extracellular Matrix; Humans; Hydrogels; Ischemic Stroke; Molecular Medicine; Peptides; Regenerative Medicine; Tissue Engineering
PubMed: 35666393
DOI: 10.1007/s11064-022-03638-5 -
Sovremennye Tekhnologii V Meditsine 2022The development of high-throughput technologies has sharply increased the opportunities to research the human body at the molecular, cellular, and organismal levels in... (Review)
Review
The development of high-throughput technologies has sharply increased the opportunities to research the human body at the molecular, cellular, and organismal levels in the last decade. Rapid progress in biotechnology has caused a paradigm shift in population-based studies. Advances in modern biomedical sciences, including genomic, genome-wide, post-genomic research and bioinformatics, have contributed to the emergence of molecular epidemiology focused on the study of the personalized molecular mechanism of disease development and its extrapolation to the population level. The work of research teams at the intersection of information technology and medicine has become the basis for highlighting digital epidemiology, the important tools of which are machine learning, the ability to work with real world data, and accumulated big data. The developed approaches accelerate the process of collecting and processing biomedical data, testing new scientific hypotheses. However, new methods are still in their infancy, they require testing of application under various conditions, as well as standardization. This review highlights the role of omics and digital technologies in population-based studies.
Topics: Humans; Computational Biology; Genomics; Molecular Epidemiology; Machine Learning; Research
PubMed: 37179982
DOI: 10.17691/stm2022.14.4.07 -
Haematologica Sep 2022
Topics: Humans; Molecular Medicine
PubMed: 36047317
DOI: 10.3324/haematol.2022.281711 -
European Journal of Epidemiology Oct 2011
Topics: Biomarkers; Epidemiologic Research Design; Epidemiologic Studies; Guidelines as Topic; Humans; Molecular Epidemiology
PubMed: 22076058
DOI: 10.1007/s10654-011-9628-8 -
Frontiers in Cellular and Infection... 2022
Topics: Drug Resistance, Fungal; Humans; Molecular Epidemiology; Mycoses
PubMed: 35711661
DOI: 10.3389/fcimb.2022.939140 -
Advanced Drug Delivery Reviews Oct 2023Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a... (Review)
Review
Ocular surface neovascularization and its resulting pathological changes significantly alter corneal refraction and obstruct the light path to the retina, and hence is a major cause of vision loss. Various factors such as infection, irritation, trauma, dry eye, and ocular surface surgery trigger neovascularization via angiogenesis and lymphangiogenesis dependent on VEGF-related and alternative mechanisms. Recent advances in antiangiogenic drugs, nanotechnology, gene therapy, surgical equipment and techniques, animal models, and drug delivery strategies have provided a range of novel therapeutic options for the treatment of ocular surface neovascularization. In this review article, we comprehensively discuss the etiology and mechanisms of corneal neovascularization and other types of ocular surface neovascularization, as well as emerging animal models and drug delivery strategies that facilitate its management.
Topics: Animals; Molecular Medicine; Neovascularization, Pathologic; Corneal Neovascularization; Retina; Angiogenesis Inhibitors
PubMed: 37689278
DOI: 10.1016/j.addr.2023.115084 -
Clinical and Translational Medicine Mar 2021
Topics: Diagnostic Imaging; Humans; Molecular Imaging; Molecular Medicine; Spatio-Temporal Analysis
PubMed: 33784006
DOI: 10.1002/ctm2.347 -
Annals of Global Health 2014Genetic and molecular factors can play an important role in an individual's cancer susceptibility and response to carcinogen exposure. Cancer susceptibility and response... (Review)
Review
BACKGROUND
Genetic and molecular factors can play an important role in an individual's cancer susceptibility and response to carcinogen exposure. Cancer susceptibility and response to carcinogen exposure can be either through inheritance of high penetrance but rare germline mutations that constitute heritable cancer syndromes, or it can be inherited as common genetic variations or polymorphisms that are associated with low to moderate risk for development of cancer. These polymorphisms can interact with environmental exposures and can influence an individual's cancer risk through multiple pathways, including affecting the rate of metabolism of carcinogens or the immune response to these toxins. Thus, these genetic polymorphisms can account for some of the geographical differences seen in cancer prevalence between different populations.
OBJECTIVES
This review explores the role of molecular epidemiology in the field of cancer prevention and control in low- and medium-income countries.
FINDINGS
Using data from Human Genome Project and HapMap Project, genome-wide association studies have been able to identify multiple susceptibility loci for different cancers. The field of genetic and molecular epidemiology has been further revolutionized by the discovery of newer, faster, and more efficient DNA-sequencing technologies including next-generation sequencing.
CONCLUSIONS
The new DNA-sequencing technologies can play an important role in planning and implementation of cancer prevention and screening strategies. More research is needed in this area, especially in investigating new biomarkers and measuring gene-environment interactions.
Topics: Developing Countries; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Molecular Epidemiology; Neoplasms; Neoplastic Syndromes, Hereditary; Polymorphism, Genetic
PubMed: 25512157
DOI: 10.1016/j.aogh.2014.09.011 -
The Journal of Molecular Diagnostics :... Jan 2023
Topics: Humans; Pathology, Molecular
PubMed: 36517203
DOI: 10.1016/j.jmoldx.2022.11.001