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Journal of Microbiology, Immunology,... Jun 2017
Topics: Anti-Bacterial Agents; Bacteremia; Drug Resistance, Multiple, Bacterial; Humans; Lung Neoplasms; Male; Microbial Sensitivity Tests; Molecular Diagnostic Techniques; Moraxella; Moraxellaceae Infections; Pneumonia, Bacterial; Radiography; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Taiwan; Treatment Outcome
PubMed: 26074282
DOI: 10.1016/j.jmii.2015.03.005 -
Case Reports in Cardiology 2018This is a case report of infective endocarditis due to . This study would be the fourth since the two latest episodes were described in 2015. The patient of this...
This is a case report of infective endocarditis due to . This study would be the fourth since the two latest episodes were described in 2015. The patient of this exposition is different from those previously described in the literature because it was a young adult, under 50 years of age, immunocompetent, with no comorbidities and no obvious focus of infection.
PubMed: 29977621
DOI: 10.1155/2018/4209094 -
The Journal of Veterinary Medical... Jun 2017A three-year-old spayed domestic short-haired cat presented for evaluation of weight loss, cardiomegaly and pleural effusion. Echocardiographic examination demonstrated...
A three-year-old spayed domestic short-haired cat presented for evaluation of weight loss, cardiomegaly and pleural effusion. Echocardiographic examination demonstrated a thickened pericardium with mild pericardial effusion and a large volume of pleural effusion characterized by exudate. Although the cat was treated with antibiotics, the clinical symptoms did not improve. The cat developed dyspnea and died on day 7. Necropsy revealed a large amount of modified transudates ascites, pleural effusion and markedly dilated pericardium. Histopathological examination revealed severe exudation of fibrin and granulation tissue in a thick layer of the epicardium. The cat was diagnosed with fibrinous pericarditis secondary to bacterial infection.
Topics: Animals; Cat Diseases; Cats; Echocardiography; Female; Fibrin; Moraxella; Moraxellaceae Infections; Pericarditis; Radiography
PubMed: 28484098
DOI: 10.1292/jvms.17-0051 -
World Journal of Gastrointestinal... Oct 2023Postpolypectomy syndrome (PPS) is a rare postoperative complication of colonic polypectomy. It presents with abdominal pain and fever accompanied by coagulopathy and...
BACKGROUND
Postpolypectomy syndrome (PPS) is a rare postoperative complication of colonic polypectomy. It presents with abdominal pain and fever accompanied by coagulopathy and elevated inflammatory markers. Its prognosis is usually good, and it only requires outpatient treatment or observation in a general ward. However, it can be life-threatening.
CASE SUMMARY
The patient was a 58-year-old man who underwent two colonic polypectomies, each resulting in life-threatening sepsis, septic shock, and coagulopathy. Each of the notable manifestations was a rapid drop in blood pressure, an increase in heart rate, loss of consciousness, and heavy sweating, accompanied by shortness of breath and decreased oxygen in the finger pulse. Based on the criteria of organ dysfunction due to infection, we diagnosed him with sepsis. The patient also experienced severe gastrointestinal bleeding after the second operation. Curiously, he did not complain of any abdominal pain throughout the course of the illness. He had significantly elevated concentrations of inflammatory markers and coagulopathy. Except for the absence of abdominal pain, his fever, significant coagulopathy, and elevated inflammatory marker concentrations were all consistent with PPS. Abdominal computed tomography and superior mesenteric artery computed tomography angiography showed no free air or vascular damage. Thus, the diagnosis of colon perforation was not considered. The final blood culture results indicated . The patient was transferred to the intensive care unit and quickly improved after fluid resuscitation, antibiotic treatment, oxygen therapy, and blood transfusion.
CONCLUSION
PPS may induce dysregulation of the systemic inflammatory response, which can lead to sepsis or septic shock, even in the absence of abdominal pain.
PubMed: 37969719
DOI: 10.4240/wjgs.v15.i10.2343 -
EJVES Vascular Forum 2021Alarming outcomes have been reported following infected endovascular aortic aneurysm repair (EVAR) device explantation. Infected fenestrated EVAR (FEVAR) exposes...
INTRODUCTION
Alarming outcomes have been reported following infected endovascular aortic aneurysm repair (EVAR) device explantation. Infected fenestrated EVAR (FEVAR) exposes patients to even worse procedural risks.
REPORT
A 67 year old man with a prior history of FEVAR presented with impaired general condition, abdominal and back pain, and increased C reactive protein. Computed tomography angiography revealed a collection around the aortic graft bifurcation and F-fluorodeoxyglucose-positron emission tomography (FDG-PET) revealed increased FDG uptake at this level, confirmed by labelled white blood cells, all favouring graft infection. A thoracophrenolumbotomy was performed and revealed an aorto-enteric fistula which was treated by small bowel resection. The left renal artery was transected at the distal end of the bridging stent and a thoracorenal bypass was performed. The thoracic aorta was cross clamped above the coeliac trunk for complete graft excision. Meanwhile, the right kidney was perfused with 4°C Ringer lactate solution. reconstruction was accomplished with a bifurcated antimicrobial graft sutured below the superior mesenteric artery with re-implantation of the right renal artery. The patient was left with a laparostomy for definitive abdominal closure, restoration of the digestive tract, and omental wrap 72 hours later. Broad spectrum antibiotic therapy was initiated peri-operatively and reduced to sulfamethoxazole/trimethoprim for a total duration of six weeks after one sample was positive for Eleven months later, the patient was free from re-infection, with no fever or inflammatory syndrome.
DISCUSSION
Total explantation of stent grafts with tissue debridement and post-operative antibiotic therapy is the gold standard when dealing with infected EVAR. As with type IV thoraco-abdominal aneurysm open repair, FEVAR device explantation requires additional protective measures to prevent visceral ischaemia and renal impairment. In agreement with the European Society for Vascular Surgery guidelines, such patients should be referred to dedicated vascular centres with expertise in surgical repair, anaesthetics, and post-operative intensive care.
PubMed: 33937899
DOI: 10.1016/j.ejvsvf.2020.12.020 -
Revista Espanola de Quimioterapia :... Apr 2018
Topics: Adult; Anti-Bacterial Agents; Female; Humans; Moraxella; Moraxellaceae Infections; Sexually Transmitted Diseases, Bacterial; Vaginal Diseases
PubMed: 29616515
DOI: No ID Found -
Transplant International : Official... Oct 2008
Topics: Bacteremia; DNA, Bacterial; Diagnosis, Differential; Follow-Up Studies; Graft Rejection; Humans; Immunosuppressive Agents; Kidney Failure, Chronic; Kidney Transplantation; Male; Middle Aged; Moraxella; Moraxellaceae Infections; Polymerase Chain Reaction; Tomography, X-Ray Computed
PubMed: 18662367
DOI: 10.1111/j.1432-2277.2008.00727.x -
The Netherlands Journal of Medicine Nov 2014Granulomatous infections are commonly associated with mycobacteria, brucellosis, actinomycosis, nocardiosis, spirochetes, and fungi. Rarely, granuloma formation is a...
Granulomatous infections are commonly associated with mycobacteria, brucellosis, actinomycosis, nocardiosis, spirochetes, and fungi. Rarely, granuloma formation is a host response to other bacterial infection. Osteomyelitis and osteitis that reactivate many years after the primary episode is a known phenomenon. A reactivation that presents as a granulomatous disease is rare. We present a case of reactivated osteitis due to Moraxella osloensis with consecutive granuloma formation.
Topics: Bone Diseases, Infectious; Diagnosis, Differential; Female; Granuloma; Humans; Middle Aged; Moraxellaceae Infections; Osteitis; Recurrence
PubMed: 25431395
DOI: No ID Found -
MSphere Feb 2019Insertion sequences (IS) are fundamental mediators of genome plasticity with the potential to generate phenotypic variation with significant evolutionary outcomes. Here,...
Insertion sequences (IS) are fundamental mediators of genome plasticity with the potential to generate phenotypic variation with significant evolutionary outcomes. Here, a recently active miniature inverted-repeat transposon element (MITE) was identified in a derivative of ATCC 17978 after being subjected to stress conditions. Transposition of the novel element led to the disruption of the gene, resulting in a characteristic hypermotile phenotype. DNA identity shared between the terminal inverted repeats of this MITE and coresident IS elements, together with the generation of 9-bp target site duplications, provides strong evidence that IS elements were responsible for mobilization of the MITE (designated MITE ) within this strain. A wider genome-level survey identified MITE in 30 additional genomes at various frequencies and one genome. Ninety MITE copies could be identified, of which 40% had target site duplications, indicating recent transposition events. Elements ranged between 111 and 114 bp; 90% were 113 bp in length. Using the MITE consensus sequence, putative outward-facing σ70 promoter sequences in both orientations were identified. The identification of transcripts originating from the promoter in one direction supports the proposal that the element can influence neighboring host gene transcription. The location of MITE varied significantly between and within genomes, preferentially integrating into AT-rich regions. Additionally, a copy of MITE was identified in a novel 8.5-kb composite transposon, Tn, in the CCUG 350 chromosome. Overall, this study shows that MITE is the most abundant nonautonomous element currently found in One of the most important weapons in the armory of is its impressive genetic plasticity, facilitating rapid genetic mutations and rearrangements as well as integration of foreign determinants carried by mobile genetic elements. Of these, IS are considered one of the key forces shaping bacterial genomes and ultimately evolution. We report the identification of a novel nonautonomous IS-derived element present in multiple bacterial species from the family and its recent translocation into the locus in the ATCC 17978 genome. The latter finding adds new knowledge to only a limited number of documented examples of MITEs in the literature and underscores the plastic nature of the locus in MITE , and its predicted parent(s), may be a source of substantial adaptive evolution within environmental and clinically relevant bacterial pathogens and, thus, have broad implications for niche-specific adaptation.
Topics: Acinetobacter baumannii; DNA Transposable Elements; Evolution, Molecular; Genome, Bacterial; Inverted Repeat Sequences; Moraxellaceae
PubMed: 30787115
DOI: 10.1128/mSphereDirect.00028-19 -
BioMed Research International 2020Larval and adult mosquito stages harbor different extracellular microbes exhibiting various functions in their digestive tract including host-parasite interactions....
BACKGROUND
Larval and adult mosquito stages harbor different extracellular microbes exhibiting various functions in their digestive tract including host-parasite interactions. Midgut symbiotic bacteria can be genetically exploited to express molecules within the vectors, altering vector competency and potential for disease transmission. Therefore, identification of mosquito gut inhabiting microbiota is of ample importance before developing novel vector control strategies that involve modification of vectors.
METHOD
Adult mosquitoes of , , and were collected from selected Medical Officer of Health (MOH) areas in the Gampaha district of Sri Lanka. Midgut lysates of the field-caught non-blood-fed female mosquitoes were cultured in Plate Count Agar medium, and Prokaryotic 16S ribosomal RNA partial genes of the isolated bacteria colonies were amplified followed by DNA sequencing. Diversity indices were used to assess the diversity and richness of the bacterial isolates in three mosquito species. The distribution pattern of bacterial isolates between different mosquito species was assessed by Distance-Based Redundancy Analysis (dbRDA).
RESULTS
A total of 20 bacterial species (, , , , , , , , , , sp., , , , sp., , , , , and ) were identified. All of these species belonged to three phyla, , , and , out of which phylum (71.1%) was the most prominent. The least number of species was recorded from . The relative distribution of midgut microbes in different mosquito species differed significantly among mosquito species (Chi-square, = 486.091; = 36; ≤ 0.001). Midgut microbiota of and indicated a similarity of 21.51%, while shared a similarity of 6.92% with the cluster of above two species. The gut microbiota of was also significantly more diverse and more evenly distributed compared to Simpson's diversity, Margalef's diversity, and Menhinick's diversity indices were higher in . Of the recorded species, and strains of nonpathogenic species in family (, , , and ) can be recommended as potential candidates for paratransgenesis.
CONCLUSION
The relative distribution of midgut microbes in different mosquito species differed significantly among the three studied adult mosquito species. The present data strongly encourage further investigations to explore the potential usage of these microbes through paratransgenic approach for novel eco-friendly vector control strategies.
Topics: Animals; Bacteria; Bacteria, Aerobic; Bacteriological Techniques; Culex; Culicidae; Female; Gastrointestinal Microbiome; Sri Lanka
PubMed: 33083488
DOI: 10.1155/2020/8732473