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Archives of Cardiovascular Diseases 2018
Topics: Diffusion of Innovation; Heart Defects, Congenital; Humans; Image Interpretation, Computer-Assisted; Imaging, Three-Dimensional; Models, Cardiovascular; Multimodal Imaging; Patient-Specific Modeling; Predictive Value of Tests
PubMed: 29997058
DOI: 10.1016/j.acvd.2018.05.002 -
Journal of Computer Assisted Tomography 2019The purpose of this article is to review the etiopathogenesis, molecular cytogenetics, histopathology, clinical features, and multimodality imaging features of desmoid... (Review)
Review
OBJECTIVE
The purpose of this article is to review the etiopathogenesis, molecular cytogenetics, histopathology, clinical features, and multimodality imaging features of desmoid fibromatosis. Recent advances in the management of desmoid fibromatosis will also be discussed.
CONCLUSIONS
Desmoid fibromatosis is a rare soft tissue neoplasm with a high incidence of local recurrence. Imaging plays an important role in the diagnosis and management of this disease.
Topics: Diagnostic Imaging; Fibromatosis, Aggressive; Humans; Multimodal Imaging; Soft Tissue Neoplasms
PubMed: 30211798
DOI: 10.1097/RCT.0000000000000790 -
Advances in Cancer Research 2014Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization... (Review)
Review
Molecular-genetic imaging of cancer using nonviral delivery systems has great potential for clinical application as a safe, efficient, noninvasive tool for visualization of various cellular processes including detection of cancer, and its attendant metastases. In recent years, significant effort has been expended in overcoming technical hurdles to enable clinical adoption of molecular-genetic imaging. This chapter will provide an introduction to the components of molecular-genetic imaging and recent advances on each component leading to safe, efficient clinical applications for detecting cancer. Combination with therapy, namely, generating molecular-genetic theranostic constructs, will provide further impetus for clinical translation of this promising technology.
Topics: Animals; Gene Expression; Humans; Multimodal Imaging; Neoplasms
PubMed: 25287688
DOI: 10.1016/B978-0-12-411638-2.00004-5 -
The British Journal of Radiology Sep 2020Functional imaging tools have emerged in the last few decades and are increasingly used to assess the function of the human heart . Positron emission tomography (PET) is... (Review)
Review
Functional imaging tools have emerged in the last few decades and are increasingly used to assess the function of the human heart . Positron emission tomography (PET) is used to evaluate myocardial metabolism and blood flow. Magnetic resonance imaging (MRI) is an essential tool for morphological and functional evaluation of the heart. In cardiology, PET is successfully combined with CT for hybrid cardiac imaging. The effective integration of two imaging modalities allows simultaneous data acquisition combining functional, structural and molecular imaging. After PET/CT has been successfully accepted for clinical practices, hybrid PET/MRI is launched. This review elaborates the current evidence of PET/MRI in cardiovascular imaging and its expected clinical applications for a comprehensive assessment of cardiovascular diseases while highlighting the advantages and limitations of this hybrid imaging approach.
Topics: Heart Diseases; Heart Neoplasms; Humans; Magnetic Resonance Imaging; Multimodal Imaging; Myocardial Ischemia; Organ Motion; Positron Emission Tomography Computed Tomography; Positron-Emission Tomography; Tomography, X-Ray Computed
PubMed: 32023123
DOI: 10.1259/bjr.20190836 -
European Journal of Nuclear Medicine... May 2014Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In... (Review)
Review
Hybrid cardiac single photon emission computed tomography (SPECT)/CT imaging allows combined assessment of anatomical and functional aspects of cardiac disease. In coronary artery disease (CAD), hybrid SPECT/CT imaging allows detection of coronary artery stenosis and myocardial perfusion abnormalities. The clinical value of hybrid imaging has been documented in several subsets of patients. In selected groups of patients, hybrid imaging improves the diagnostic accuracy to detect CAD compared to the single imaging techniques. Additionally, this approach facilitates functional interrogation of coronary stenoses and guidance with regard to revascularization procedures. Moreover, the anatomical information obtained from CT coronary angiography or coronary artery calcium scores (CACS) adds prognostic information over perfusion data from SPECT. The use of cardiac hybrid imaging has been favoured by the dissemination of dedicated hybrid systems and the release of dedicated image fusion software, which allow simple patient throughput for hybrid SPECT/CT studies. Further technological improvements such as more efficient detector technology to allow for low-radiation protocols, ultra-fast image acquisition and improved low-noise image reconstruction algorithms will be instrumental to further promote hybrid SPECT/CT in research and clinical practice.
Topics: Cardiac-Gated Single-Photon Emission Computer-Assisted Tomography; Coronary Angiography; Coronary Artery Disease; Humans; Image Processing, Computer-Assisted; Multimodal Imaging; Myocardial Perfusion Imaging; Tomography, X-Ray Computed
PubMed: 24658682
DOI: 10.1007/s00259-013-2566-9 -
Magnetic Resonance Imaging Clinics of... May 2017PET/MR is a promising multimodality imaging approach. Attenuation is by far the largest correction required for quantitative PET imaging. MR-based attenuation correction... (Review)
Review
PET/MR is a promising multimodality imaging approach. Attenuation is by far the largest correction required for quantitative PET imaging. MR-based attenuation correction have been extensively pursued, especially for brain imaging, in the past several years. In this article, we review atlas and direct imaging MR-based PET attenuation correction methods. The technical principles behind these methods are detailed and the advantages and disadvantages of these methods are discussed.
Topics: Brain; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography
PubMed: 28390526
DOI: 10.1016/j.mric.2016.12.001 -
Proceedings of the National Academy of... May 2021Multimodal imaging-the ability to acquire images of an object through more than one imaging mode simultaneously-has opened additional perspectives in areas ranging from...
Multimodal imaging-the ability to acquire images of an object through more than one imaging mode simultaneously-has opened additional perspectives in areas ranging from astronomy to medicine. In this paper, we report progress toward combining optical and magnetic resonance (MR) imaging in such a "dual" imaging mode. They are attractive in combination because they offer complementary advantages of resolution and speed, especially in the context of imaging in scattering environments. Our approach relies on a specific material platform, microdiamond particles hosting nitrogen vacancy (NV) defect centers that fluoresce brightly under optical excitation and simultaneously "hyperpolarize" lattice [Formula: see text] nuclei, making them bright under MR imaging. We highlight advantages of dual-mode optical and MR imaging in allowing background-free particle imaging and describe regimes in which either mode can enhance the other. Leveraging the fact that the two imaging modes proceed in Fourier-reciprocal domains (real and k-space), we propose a sampling protocol that accelerates image reconstruction in sparse-imaging scenarios. Our work suggests interesting possibilities for the simultaneous optical and low-field MR imaging of targeted diamond nanoparticles.
Topics: Fluorescence; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Multimodal Imaging; Nanoparticles; Nitrogen; Optical Imaging; Phantoms, Imaging
PubMed: 34001612
DOI: 10.1073/pnas.2023579118 -
Magnetic Resonance Imaging Clinics of... May 2017Combined PET/MR imaging scanners capable of acquiring simultaneously the complementary information provided by the 2 imaging modalities are now available for human use.... (Review)
Review
Combined PET/MR imaging scanners capable of acquiring simultaneously the complementary information provided by the 2 imaging modalities are now available for human use. After addressing the hardware challenges for integrating the 2 imaging modalities, most of the efforts in the field have focused on developing MR-based attenuation correction methods for neurologic and whole-body applications, implementing approaches for improving one modality by using the data provided by the other and exploring research and clinical applications that could benefit from the synergistic use of the multimodal data.
Topics: Humans; Magnetic Resonance Imaging; Multimodal Imaging; Positron-Emission Tomography
PubMed: 28390525
DOI: 10.1016/j.mric.2017.01.002 -
PET Clinics Apr 2019PET-based cardiac nuclear imaging plays a large role in the management of ischemic heart disease. Compared with conventional single-photon emission CT myocardial... (Review)
Review
PET-based cardiac nuclear imaging plays a large role in the management of ischemic heart disease. Compared with conventional single-photon emission CT myocardial perfusion imaging, PET provides superior accuracy in diagnosis of coronary artery disease and, with the incorporation of myocardial blood flow and coronary flow reserve, adds value in assessing prognosis for established coronary and microvascular disease. This review describes these and other uses of PET in ischemic heart disease, including assessing myocardial viability in ischemic cardiomyopathy. Developments in novel PET flow tracers and molecular imaging tools to assess atherosclerotic plaque vulnerability, vascular calcification, and vascular remodeling also are described.
Topics: Computed Tomography Angiography; Coronary Artery Disease; Coronary Circulation; Cost-Benefit Analysis; Fractional Flow Reserve, Myocardial; Humans; Multimodal Imaging; Myocardial Ischemia; Myocardial Perfusion Imaging; Positron-Emission Tomography; Prognosis; Radiopharmaceuticals; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon
PubMed: 30826019
DOI: 10.1016/j.cpet.2018.12.003 -
Journal of Nanobiotechnology Mar 2021Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great...
BACKGROUND
Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy.
RESULTS
Herein, we successfully design and construct BiVO/FeO@polydopamine (PDA) superparticles (SPs) for computed tomography (CT)/photoacoustic (PA)/magnetic resonance (MR) multimodal imaging and radiotherapy (RT)/photothermal therapy (PTT) synergistic therapy toward oral epithelial carcinoma. On the one hand, BiVO NPs endow BiVO/FeO@PDA SPs with impressive X-ray absorption capability due to the high X-ray attenuation coefficient of Bi, which is beneficial for their utilization as radiosensitizers for CT imaging and RT. On the other hand, FeO NPs impart BiVO/FeO@PDA SPs with the superparamagnetic property as a T-weighted contrast agent for MR imaging. Importantly, the aggregation of FeO NPs in SPs and the presence of PDA shell greatly improve the photothermal conversion capability of SPs, making BiVO/FeO@PDA SPs as an ideal photothermal transducer for PA imaging and PTT. By integrating advantages of various imaging modalities (CT/PA/MR) and therapeutic strategies (RT/PTT), our BiVO/FeO@PDA SPs exhibit the sensitive multimodal imaging feature and superior synergistic therapeutic efficacy on tumors.
CONCLUSIONS
Since there are many kinds of building blocks with unique properties appropriating for self-assembly, our work may largely enrich the library of nanomateirals for tumor diagnosis and treatment.
Topics: Animals; Bismuth; Contrast Media; Ferric Compounds; Humans; Indoles; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Multimodal Imaging; Nanoparticles; Phototherapy; Polymers; Tomography, X-Ray Computed; Vanadates
PubMed: 33781296
DOI: 10.1186/s12951-021-00802-x