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Maxillary Ameloblastoma with Orbital Involvement: An Institutional Experience and Literature Review.Ophthalmic Plastic and Reconstructive... 2016To describe 8 patients with orbital involvement by ameloblastoma and to review the literature on this topic. (Review)
Review
PURPOSE
To describe 8 patients with orbital involvement by ameloblastoma and to review the literature on this topic.
METHODS
The electronic medical records and pathology databases of the Hospital of the University of Pennsylvania were searched to identify all patients with histopathologically confirmed ameloblastoma diagnosed between 1990 and 2015. PubMed database was searched for all well-documented cases of maxillary ameloblastoma and ameloblastic carcinoma ex-ameloblastoma with orbital involvement published in the English literature. The information collected on the compiled 23 patients included age, sex, clinical presentation, imaging findings, management, tumor histopathologic features, and follow up.
RESULTS
Review of medical records identified 8 patients with orbital involvement by ameloblastoma. Literature search yielded 15 patients with well-documented orbital involvement by ameloblastoma. Most tumors occurred in men (19 of 23, M:F = 4-5:1) with an average age of 56 years. The overall rates of recurrence, visual compromise, death, and confirmed disease-related mortality were 70% (16/23), 26% (6/23), 39% (9/23), and 22% (5/23), respectively. The initial surgical approach correlated with prognosis. The rates of recurrence, orbital exenteration, and mortality in the cohort managed with conservative surgery or partial maxillectomy were 57% (8/14), 29% (4/14), and 50% (7/14), respectively. In contrast, the patients initially managed with a radical resection had substantially lower frequencies of tumor recurrence (2/7, 29%), exenteration (1/7, 14%), and death (1/7, 14%). Malignant transformation to ameloblastic carcinoma occurred in the setting of recurrent disease in 3 patients and in 1 patient with prolonged duration of symptoms, suggestive of a long-standing tumor.
CONCLUSIONS
Maxillary ameloblastoma can rarely involve the orbit, leading to significant ocular morbidity and occasional mortality. Prompt radical resection of the tumor has the potential to decrease the likelihood of recurrence and visual compromise, and can improve survival.
Topics: Ameloblastoma; Humans; Maxillary Neoplasms; Neoplasm Invasiveness; Orbit; Orbital Neoplasms; Tomography, X-Ray Computed
PubMed: 26505234
DOI: 10.1097/IOP.0000000000000580 -
Asia-Pacific Journal of Ophthalmology... 2017The aim of this review article is to provide an update of the current literature on orbital tumors. The authors conducted a PubMed literature search of English language... (Review)
Review
The aim of this review article is to provide an update of the current literature on orbital tumors. The authors conducted a PubMed literature search of English language articles published between January 2014 and December 2016 using the following search items: orbit, tumors, lacrimal gland, lymphoma, hemangioma, lymphangioma. The authors included reviews, original articles, case series, and case reports with relevant new information. There is new information about the clinical spectrum of orbital tumors, capillary hemangioma, cavernous hemangioma, lymphangioma, orbital venous malformation, lacrimal gland tumors, and orbital lymphoma. This review highlights the current understanding, practice, and guidelines in the diagnosis and management of common tumors of the orbit.
Topics: Global Health; Humans; Morbidity; Neoplasm Staging; Ophthalmology; Orbital Neoplasms; Periodicals as Topic
PubMed: 28399335
DOI: 10.22608/APO.201736 -
Indian Journal of Ophthalmology 2009The purpose of this article is to review the literature for clinical presentation, treatment, outcome and complications of using radiotherapy for the treatment of... (Review)
Review
The purpose of this article is to review the literature for clinical presentation, treatment, outcome and complications of using radiotherapy for the treatment of orbital lymphoma. For this, MEDLINE, EMBASE, and the Cochrane Library were searched through January 2007 for published data on primary non-Hodgkin's lymphoma (NHL) of the orbit. The search was conducted in all document types, using the following terms "Non-Hodgkin's lymphoma, MALT (mucosa associated lymphoid tissue) and orbit". Data extracted were based on age, sex, therapeutic methods and outcome of treatment. When full articles were not available, abstracts were used as a source of information. Only those articles whose abstracts or full text were available in English were included in table. The review of reports of NHL of the orbit, in general, served as a source of information about its clinical behavior, treatment and overall prognosis. Fifty-six publications were identified, including six in languages other than English. There was no randomized trial. All the studies were retrospective. The studies were heterogeneous in patient number (3 to 112), histology, disease stage (IE to IV), radiotherapy doses used (4 to 53.8Gy), local control rates (65 to 100%), distant relapse rates (0 to 67%, from low grade to high grade) and five-year survival rates (33 to 100%). Three of the studies with a good number of patients also demonstrated clinical benefit with radiotherapy in terms of superior efficacy or less toxicity. Available data support the acceptance of radiotherapy as a standard therapeutic option in patients with low to intermediate grade orbital lymphoma. Toxicity of radiotherapy is mild if delivered precisely.
Topics: Databases, Factual; Humans; Lymphoma, Non-Hodgkin; Orbital Neoplasms; Treatment Outcome
PubMed: 19237780
DOI: 10.4103/0301-4738.44516 -
Tidsskrift For Den Norske Laegeforening... Nov 2000Orbital tumours are relatively uncommon, and few series of patients with such tumours have been reported from Scandinavia. Here we present the experience of a Norwegian...
BACKGROUND
Orbital tumours are relatively uncommon, and few series of patients with such tumours have been reported from Scandinavia. Here we present the experience of a Norwegian referral centre.
MATERIAL AND METHODS
We have retrospectively evaluated the records of 278 patients with orbital tumours hospitalized at the Department of Ophthalmology, Haukeland University Hospital from 1961 to 1999.
RESULTS
In 177 patients, a benign tumour was present, while 96 patients suffered from malignant disease. In five cases, the malignant potential of the tumour could not be assessed. A total of 71 different histological entities were observed. Surgical treatment performed at our department was in 22 patients exenteration, in 87 lateral orbitotomy, in 47 anterior orbitotomy and in 41 biopsy through an anterior approach.
INTERPRETATION
This series illustrates the wide panorama of space-occupying lesions that may be present in the orbit. Since the lesions are rare and management in many cases complex, the treatment should be centralized to an eye department with a defined interest in orbital disease.
Topics: Adolescent; Adult; Aged; Biopsy; Combined Modality Therapy; Female; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Orbit; Orbit Evisceration; Orbital Neoplasms; Retrospective Studies; Tomography, X-Ray Computed
PubMed: 11188377
DOI: No ID Found -
Asia-Pacific Journal of Ophthalmology... 2015Lymphoproliferative diseases of the orbit account for majority of orbital tumors. The pathologies range from reactive lymphoid hyperplasia to specific IgG4-related... (Review)
Review
Lymphoproliferative diseases of the orbit account for majority of orbital tumors. The pathologies range from reactive lymphoid hyperplasia to specific IgG4-related inflammation to malignant lymphomas. This review summarizes current concepts regarding pathology, clinical presentation, diagnosis, staging, and treatment strategies of major orbital lymphoproliferative diseases based on updated and relevant bibliography.
Topics: Antineoplastic Agents; Autoimmune Diseases; Humans; Immunoglobulin G; Lymphoma; Lymphoproliferative Disorders; Neoplasm Staging; Orbital Neoplasms; Radiotherapy
PubMed: 26065355
DOI: 10.1097/APO.0000000000000102 -
Medicine Sep 2019Neuroblastoma is one of the most common tumors found in children, and mostly arises in the adrenal gland and paravertebral regions. Orbital neuroblastoma metastasis is... (Review)
Review
RATIONALE
Neuroblastoma is one of the most common tumors found in children, and mostly arises in the adrenal gland and paravertebral regions. Orbital neuroblastoma metastasis is relatively rare, and is associated with poor prognosis. Since the symptoms and signs of orbital neuroblastoma are not specific, its diagnosis remains challenging.
PATIENT CONCERNS
A 3-year-old girl presented with periorbital ecchymoses (raccoon eyes) and proptosis for 40 days.
DIAGNOSES
Abdominal magnetic resonance imaging (MRI) and sonography analysis revealed a large mass in the left adrenal gland (primary tumor). The computed tomography and MRI further revealed multiple soft tissue masses in the skull and both orbits with erosion of the adjacent bones (the metastasis). The histological analysis of the tumor removed from the right orbit confirmed the diagnosis of neuroblastoma.
INTERVENTIONS
The mass on the right face was surgically removed.
OUTCOMES
The patient exhibited no deteriorative signs at the 6-month follow-up.
LESSONS
Clinical manifestations, such as periorbital ecchymoses and proptosis, in combination with radiological analysis and histological findings, are important for the diagnosis of orbital neuroblastoma metastasis.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Child, Preschool; Ecchymosis; Exophthalmos; Female; Humans; Neuroblastoma; Orbital Neoplasms
PubMed: 31490393
DOI: 10.1097/MD.0000000000017038 -
Journal of the American Veterinary... Apr 2018
Topics: Animals; Cat Diseases; Cats; Corneal Ulcer; Diagnosis, Differential; Diagnostic Techniques, Ophthalmological; Entropion; Fatal Outcome; Male; Neoplasms, Muscle Tissue; Orbital Neoplasms
PubMed: 29595387
DOI: 10.2460/javma.252.8.937 -
Journal of the American Veterinary... May 2018
Topics: Animals; Cat Diseases; Cats; Diagnosis, Differential; Eye Enucleation; Eyelid Neoplasms; Male; Orbital Neoplasms; Teratoma
PubMed: 29701523
DOI: 10.2460/javma.252.10.1223 -
Transactions of the American... 1974
Topics: Child; Humans; Orbital Neoplasms; Prognosis; Retinoblastoma; Time Factors
PubMed: 4462255
DOI: No ID Found -
The British Journal of Ophthalmology Dec 1997Orbital granulocytic sarcoma is a localised tumour composed of cells of myeloid origin. Histological diagnosis can be difficult in patients with poorly differentiated...
AIM
Orbital granulocytic sarcoma is a localised tumour composed of cells of myeloid origin. Histological diagnosis can be difficult in patients with poorly differentiated orbital tumours and no evidence of systemic leukaemia. The naphthol AS-D chloracetate esterase (Leder stain) and immunohistochemical stains for lysozyme and MAC387 were used to determine the staining characteristics of these tumours. A case series of seven patients with orbital granulocytic sarcoma is presented.
METHODS
Seven patients with orbital granulocytic sarcoma were studied. Haematoxylin and eosin, Leder, and lysozyme stained sections were available in seven cases. Unstained formalin fixed paraffin embedded sections of seven cases were available for immunohistochemical evaluation using the avidin-biotin-complex technique for MAC387.
RESULTS
The mean age of presentation of the orbital tumour was 8.8 years. Four patients presented with an orbital tumour before any systemic manifestations of leukaemia. In two cases the diagnosis of the orbital tumour and systemic leukaemia was made simultaneously. There was one case of established systemic myeloid leukaemia in remission with the subsequent development of orbital granulocytic sarcoma. Six of seven cases (86%) were positive for the Leder stain. Five of seven cases (71%) showed positive immunoreactivity with lysozyme. The immunohistochemical stain for MAC387 was positive in all seven cases (100%) including one case that was negative for both lysozyme and Leder stains.
CONCLUSIONS
Orbital granulocytic sarcoma is a tumour that affects children and can present with rapidly progressive proptosis. This tumour may develop before, during, or after the occurrence of systemic leukaemia. The combination of Leder and lysozyme stains is useful in the diagnosis of orbital granulocytic sarcoma. MAC387 may be a more reliable marker for orbital granulocytic sarcoma.
Topics: Acute Disease; Adolescent; Child; Exophthalmos; Female; Humans; Infant; Leukemia, Myeloid; Male; Orbital Neoplasms
PubMed: 9497470
DOI: 10.1136/bjo.81.12.1084