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Transactions of the American... 1972
Topics: Adolescent; Adult; Blepharoptosis; Child; Diplopia; Female; Humans; Lipoma; Male; Neoplasm Recurrence, Local; Orbital Neoplasms; Postoperative Complications
PubMed: 4663672
DOI: No ID Found -
The British Journal of Ophthalmology Dec 1968
Topics: Aged; Humans; Keratoacanthoma; Male; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplasm Regression, Spontaneous; Orbital Neoplasms; Skin Transplantation
PubMed: 4882715
DOI: 10.1136/bjo.52.12.876 -
Scientific Reports Apr 2024To investigate the Raman spectral features of orbital rhabdomyosarcoma (ORMS) tissue and normal orbital tissue in vitro, and to explore the feasibility of Raman...
To investigate the Raman spectral features of orbital rhabdomyosarcoma (ORMS) tissue and normal orbital tissue in vitro, and to explore the feasibility of Raman spectroscopy for the optical diagnosis of ORMS. 23 specimens of ORMS and 27 specimens of normal orbital tissue were obtained from resection surgery and measured in vitro using Raman spectroscopy coupled to a fiber optic probe. The important spectral differences between the tissue categories were exploited for tissue classification with the multivariate statistical techniques of principal component analysis (PCA) and linear discriminant analysis (LDA). Compared to normal tissue, the Raman peak intensities located at 1450 and 1655 cm were significantly lower for ORMS (p < 0.05), while the peak intensities located at 721, 758, 1002, 1088, 1156, 1206, 1340, 1526 cm were significantly higher (p < 0.05). Raman spectra differences between normal tissue and ORMS could be attributed to the changes in the relative amounts of biochemical components, such as nucleic acids, tryptophan, phenylalanine, carotenoid and lipids. The Raman spectroscopy technique together with PCA-LDA modeling provides a diagnostic accuracy of 90.0%, sensitivity of 91.3%, and specificity of 88.9% for ORMS identification. Significant differences in Raman peak intensities exist between normal orbital tissue and ORMS. This work demonstrated for the first time that the Raman spectroscopy associated with PCA-LDA diagnostic algorithms has promising potential for accurate, rapid and noninvasive optical diagnosis of ORMS at the molecular level.
Topics: Spectrum Analysis, Raman; Humans; Rhabdomyosarcoma; Female; Male; Principal Component Analysis; Orbital Neoplasms; Child; Discriminant Analysis; Adolescent; Adult; Middle Aged; Child, Preschool; Young Adult
PubMed: 38679641
DOI: 10.1038/s41598-024-60520-w -
Transactions of the American... 1976Five patients presented with signs that were similar to but opposite from Duane's retraction syndrome. Most had a history of orbital trauma. On attempted abduction a... (Comparative Study)
Comparative Study
Five patients presented with signs that were similar to but opposite from Duane's retraction syndrome. Most had a history of orbital trauma. On attempted abduction a narrowing of the palpebral fissure and retraction of the globe was observed. Diplopia with lateral gaze was present. Roentgenograms (polytomograms) showed involvement of the medial orbital wall. Forced ductuin tests were positive. Surgical repair of the fracture and release of the entrapped muscle as determined by forced duction tests and by postoperative motility led to successful results.
Topics: Adult; Breast Neoplasms; Child; Constriction, Pathologic; Diagnosis, Differential; Duane Retraction Syndrome; Ethmoid Bone; Female; Humans; Male; Middle Aged; Neoplasm Metastasis; Oculomotor Muscles; Ophthalmoplegia; Orbit; Orbital Neoplasms; Skull Fractures; Syndrome
PubMed: 867622
DOI: No ID Found -
The British Journal of Ophthalmology May 1993
Review
Topics: Female; Hormones; Humans; Male; Meningioma; Orbital Neoplasms
PubMed: 8318470
DOI: 10.1136/bjo.77.5.313 -
Indian Journal of Ophthalmology Feb 2024To study the epidemiological profile of various pediatric orbital tumors and determine their clinicopathological correlation over 20 years.
PURPOSE
To study the epidemiological profile of various pediatric orbital tumors and determine their clinicopathological correlation over 20 years.
METHODS
A retrospective analysis of all pediatric patients with orbital tumors from the medical records between 1995 and 2015 was done. Tumors were categorized based on their cellular origin. Demographic details, clinical and histopathological diagnoses, frequency, and clinicopathological correlation were studied.
RESULTS
A total of 265 pediatric patients with orbital tumors were analyzed, of which 145 (54.7%) patients were males and 120 (45.3%) were females. The mean age was 7 years (median: 6 years; range: 10 days-16 years). The distribution of lesions in each group was as follows: vasculogenic, 76 (28.7%); lipogenic and myxoid, 66 (25%); myogenic, 31 (11.7%); optic nerve and meningeal, 22 (8.3%); lymphoid and lymphoproliferative, 18 (6.8%); secondary orbital tumors, 14 (5.2%); histiocytic, 9 (3.4%); miscellaneous, 9 (3.4%), lacrimal gland, 8 (3%); mesenchymal with neural differentiation, 6 (2%); osseous, 4 (1.5%), and fibrocystic, 2 (0.8%). The most common benign and malignant pediatric orbital tumors were dermoid cysts (65, 24.5%) and rhabdomyosarcoma (31, 11.7%). A statistically significant ( P < 0.0001) clinicopathological correlation was observed in 208 (83.2%) out of 250 biopsy-proven cases.
CONCLUSION
Pediatric orbital neoplasms include a broad spectrum of benign and malignant lesions. Vasculogenic tumors constitute the majority of them, followed by lipogenic and myxoid tumors. A thorough knowledge of the incidence, clinical profile, imaging features, and histopathology of specific orbital tumors aids in accurate diagnosis and their successful management.
Topics: Male; Female; Child; Humans; Orbital Neoplasms; Retrospective Studies; Rhabdomyosarcoma; Biopsy; Tertiary Care Centers
PubMed: 38099389
DOI: 10.4103/IJO.IJO_495_23 -
Postgraduate Medical Journal Aug 1990A male aged 19 presented with a protruding left eye increasing slowly for 3 years. On examination there was proptosis and downward displacement of the eye globe.
A male aged 19 presented with a protruding left eye increasing slowly for 3 years. On examination there was proptosis and downward displacement of the eye globe.
Topics: Adult; Exophthalmos; Histiocytoma, Benign Fibrous; Humans; Male; Orbital Neoplasms; Tomography, X-Ray Computed
PubMed: 2170964
DOI: 10.1136/pgmj.66.778.662 -
Medicine Nov 2020Ganglioneuroblastoma (GNB) is a transitional tumor of sympathetic origin that has never been described as primarily involving the orbit. Herein we report an extremely...
RATIONALE
Ganglioneuroblastoma (GNB) is a transitional tumor of sympathetic origin that has never been described as primarily involving the orbit. Herein we report an extremely rare case of GNB with primary orbital involvement and its treatment strategies.
PATIENT CONCERNS
A 9-year-old girl presented with progressive and recurring right orbital mass for 2 years.
DIAGNOSIS
Computed tomography (CT) showed a well-defined, well-circumscribed, and homogeneous extraconal soft tissue mass occupying most of the right superior orbital area. Magnetic resonance imaging (MRI) revealed that there was a neoplasm of the right superior orbit molding around the globe with long T1 and T2 signals, and contrast-enhanced MR image showed a heterogeneous enhancement of the mass. Histopathologic examinations were performed after surgery and the characteristics were consistent with a diagnosis of GNB.
INTERVENTIONS
Surgery was performed and the mass was completely resected.
OUTCOMES
Postoperatively, the patient was on a regular follow-up for 19 months and so far, has had no orbital mass recurrence.
LESSONS
Herein we present a rare case of GNB primarily involving the orbit, and the findings showed that GNB could originate from the orbit. The patient underwent surgical tumor resection. The histopathological and immunohistochemical features were consistent with the diagnosis of GNB. For this case, there was no recurrence for 19 months after complete surgical excision of the tumor; however, a regular long-term follow-up is required.
Topics: Child; Female; Ganglioneuroblastoma; Humans; Magnetic Resonance Imaging; Orbital Neoplasms; Tomography, X-Ray Computed
PubMed: 33157934
DOI: 10.1097/MD.0000000000022922 -
A correlation study between IgH gene rearrangement and orbital lymphoma removal operation prognosis.European Review For Medical and... Jun 2017To explore the relationship between IgH gene rearrangement and orbital MALT (mucose-associated lymphoid tissue) lymphoma removal operation prognosis, and to quantify the...
OBJECTIVE
To explore the relationship between IgH gene rearrangement and orbital MALT (mucose-associated lymphoid tissue) lymphoma removal operation prognosis, and to quantify the effect of IgH gene rearrangement on primary orbital MALT lymphoma prognosis.
PATIENTS AND METHODS
Fifty-eight patient cases with primary orbital MALT lymphoma were included in this study. Orbital lymphoma specimens were embedded in paraffin for sectioning. IgH gene rearrangement was detected using PCR. The correlation between IgH gene rearrangement and the patient recurrence and survival rates were determined using statistical analysis. The aforementioned rates were calculated and a survival curve was determined. p-values lower than 0.05 was considered statistically significant.
RESULTS
We found that the 5-year disease-free survival rate was 90.8% in patients with orbital MALT lymphoma (mean value 56.7 months, range 52-60 months). The use of IgH gene rearrangement detection methods found that the non-recurrence rate of primary orbital MALT lymphoma cases was 79.3%. Survival analysis revealed that IgH gene rearrangement was significantly correlated with recurrence of orbital MALT lymphoma (p<0.001).
CONCLUSIONS
IgH gene rearrangement detection can be improved by the combined usage of multiple primer pairs, especially family specific primers. In the future, detection of IgH gene rearrangement may be used as a novel marker to predict the prognosis of patients with primary orbital MALT lymphoma.
Topics: Adolescent; Adult; Aged; Disease-Free Survival; Female; Gene Rearrangement; Genes, Immunoglobulin Heavy Chain; Humans; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Male; Middle Aged; Neoplasm Recurrence, Local; Orbital Neoplasms; Prognosis
PubMed: 28678330
DOI: No ID Found -
Transactions of the American... 1988While the number of orbital surgeons is limited, it is hoped these can be recognized and patients referred to them by ophthalmologists not interested or trained in that...
While the number of orbital surgeons is limited, it is hoped these can be recognized and patients referred to them by ophthalmologists not interested or trained in that specialty. Let the orbital surgeon determine whether he can handle the problem in 1 to 2 days, or whether a neurosurgeon should do the procedure or make it a joint effort. It may well involve other specialty team effort approaches. It is essential to have an understanding of x-rays, CT, angiography, and MRI techniques and films. Sit with these specialists to learn more and help to avoid negative, misdiagnosis reports in the interest of the patient. Use judgement in helping the patient decide on ophthalmic or the more extensive neurosurgical approach after careful study and what is in their best interest. The team approach is used in well established medical centers with the ophthalmologist and neurosurgeon (or other specialist) working together in the best interest of the patient. This is more interesting and keeps the ophthalmologist in the mainstream of medicine.
Topics: Adult; Aged; Angiography; Child; Child, Preschool; Conjunctiva; Craniotomy; Female; Humans; Male; Middle Aged; Orbit; Orbital Diseases; Orbital Neoplasms; Tomography, X-Ray Computed
PubMed: 2979017
DOI: No ID Found