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Pathology, Research and Practice Apr 2024Ovarian fibromas are benign tumors that can present peculiar morphological features not studied sufficiently.
BACKGROUND
Ovarian fibromas are benign tumors that can present peculiar morphological features not studied sufficiently.
MATERIAL AND METHODS
In this retrospective study, 75 consecutive cases of ovarian fibroma were morphologically compared with 46 thecomas, 16 granulosa cell tumors, and 5 sclerosing stroma tumors for the following factors: the growth pattern as diffuse or nodular, the presence of hyaline plaques, necrosis, keloid-like sclerosis, calcifications, cystic degeneration, fibrous or edematous stroma, prominent vascularity, lutein cells, cellularity, scant or abundant cytoplasm, prominent cell membranes, nuclear grooves, atypia, and mitotic activity.
RESULTS
The tumors differed significantly in terms of hyaline plaques presence, nuclear grooves, growth pattern, stroma type, tumor cellularity, cytoplasm, prominence of cell membranes, atypia, mitotic activity, and prominent vascularity.
CONCLUSION
Ovarian fibromas can present some maybe unexpected features rather frequently, such as cystic degeneration, hyaline plaques, prominent vascularity, increased cellularity, and some mitotic activity, thus their presence should not always prompt to an alternative diagnosis.
Topics: Female; Humans; Thecoma; Granulosa Cell Tumor; Retrospective Studies; Ovarian Neoplasms; Sex Cord-Gonadal Stromal Tumors; Fibroma
PubMed: 38447489
DOI: 10.1016/j.prp.2024.155236 -
Annals of African Medicine 2019
Topics: Abdominal Pain; Acute Pain; Adult; Female; Fibroma; Humans; Ovarian Neoplasms; Ovary; Tomography, X-Ray Computed; Ultrasonography
PubMed: 31823957
DOI: 10.4103/aam.aam_2_19 -
Cancer Control : Journal of the Moffitt... Jul 2015Computed tomography obtained as part of a urinary tract assessment in a 68-year-old woman incidentally detected a solid adnexal mass. Bilateral salpingo-oophorectomy...
Computed tomography obtained as part of a urinary tract assessment in a 68-year-old woman incidentally detected a solid adnexal mass. Bilateral salpingo-oophorectomy revealed a unilateral, 4-cm, white to tan-yellow colored, focally calcified, left ovarian mass. Microscopically, the tumor was composed of bland fibroblasts, abundant collagen, and areas of calcification with a minor component composed of nests of epithelial cells with nuclear clefts focally evident, some of which contained central lumens with eosinophilic secretions. The major considerations were fibromatous overgrowth in a Brenner tumor or ovarian fibroma with minor sex cord elements. Immunostains for cytokeratin 7 showed diffuse positivity in the epithelial nests, whereas cytokeratin 20 and inhibin were negative, further supporting the diagnosis of a Brenner tumor.
Topics: Aged; Brenner Tumor; Female; Fibroma; Humans; Ovarian Neoplasms; Sex Cord-Gonadal Stromal Tumors
PubMed: 26351894
DOI: 10.1177/107327481502200316 -
British Medical Journal May 1961
Topics: Ascites; Female; Fibroma; Humans; Hydrothorax; Medical Records; Meigs Syndrome; Ovarian Neoplasms
PubMed: 13740675
DOI: 10.1136/bmj.1.5237.1440