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British Medical Journal Aug 1965
Topics: Amenorrhea; Female; Humans; Menstruation; Ovarian Diseases; Ovary; Sex Chromosome Disorders
PubMed: 20722181
DOI: 10.1136/bmj.2.5458.383 -
Proceedings of the Royal Society of... Mar 1972
Topics: Atrophy; Endometriosis; Female; Genital Diseases, Female; Humans; Ovarian Diseases; Ovarian Neoplasms; Ovary; Pelvic Neoplasms; Pneumoperitoneum, Artificial; Polycystic Ovary Syndrome; Radiography; Uterus
PubMed: 5083328
DOI: No ID Found -
The Journal of Clinical Endocrinology... Apr 2022
Topics: Female; Humans; Incidence; Longitudinal Studies; Metabolic Syndrome; Polycystic Ovary Syndrome
PubMed: 34979554
DOI: 10.1210/clinem/dgab936 -
Women's Health (London, England) Aug 2015
Review
Topics: Endometriosis; Female; Gynecologic Surgical Procedures; Humans; Infertility, Female; Laparoscopy; Ovarian Diseases; Pelvic Pain; Women's Health
PubMed: 26441217
DOI: 10.2217/whe.15.52 -
Protein & Cell Jan 2017The endoplasmic reticulum (ER) is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane... (Review)
Review
The endoplasmic reticulum (ER) is the principal organelle responsible for several specific cellular functions including synthesis and folding of secretory or membrane proteins, lipid metabolism, and Ca storage. Different physiological as well as pathological stress conditions can, however, perturb ER homeostasis, giving rise to an accumulation of unfolded or misfolded proteins in the ER lumen, a condition termed ER stress. To deal with an increased folding demand, cells activate the unfolded protein response (UPR), which is initially protective but can become detrimental if ER stress is severe and prolonged. Accumulating evidence demonstrates a link between the UPR and ovarian development and function, including follicular growth and maturation, follicular atresia, and corpus luteum biogenesis. Additionally, ER stress and the UPR may also play an important role in the ovary under pathological conditions. Understanding the molecular mechanisms related to the dual role of unfolded protein response in the ovarian physiology and pathology may reveal the pathogenesis of some reproductive endocrine diseases and provide a new guidance to improve the assisted reproductive technology. Here we review the current literature and discuss concepts and progress in understanding the UPR, and we also analyze the role of ER stress and the UPR in the ovary.
Topics: Animals; Apoptosis; Calcium; Endoplasmic Reticulum; Female; Humans; Lipid Metabolism; Ovarian Diseases; Ovary; Unfolded Protein Response
PubMed: 27638465
DOI: 10.1007/s13238-016-0312-3 -
Diagnostic Pathology Feb 2016Massive ovarian oedema is a rare non-neoplastic clinicopathologic entity has a higher incidence in women during their second and third life decade. The oedema can be... (Review)
Review
BACKGROUND
Massive ovarian oedema is a rare non-neoplastic clinicopathologic entity has a higher incidence in women during their second and third life decade. The oedema can be presented in one or both ovaries as a result of partial intermittent torsion of the ovarian pedicle that interferes to the venal and lymphatic drainage of the ovary.
CASE PRESENTATION
We present a clinical case of a 16 year old with massive ovarian oedema and we performed a review of the literature. The pathophysiology of this entity is very complex. We tried to perform a complete review of the literature and focus on the complexity of this entity as far as its pathophysiological backround is concerned and as far as its clinical presentation is concerned.
CONCLUSIONS
In conclusion, massive ovarian oedema is a rare, multi disease mimicking clinical entity, with an acute or progressive clinical presentation. It has also to be a part of our differential diagnosis in cases of acute abdominal pain and we have to try to treat her conservatively, in order to preserve fertility.
Topics: Adolescent; Biopsy; Diagnosis, Differential; Edema; Female; Humans; Ovarian Diseases; Predictive Value of Tests; Tomography, X-Ray Computed
PubMed: 26843454
DOI: 10.1186/s13000-016-0469-3 -
Fertility and Sterility Oct 2002To discuss current ideas about therapy for endometriosis derived from new observations generated by using molecular biology techniques and in vivo animal models of... (Review)
Review
OBJECTIVE
To discuss current ideas about therapy for endometriosis derived from new observations generated by using molecular biology techniques and in vivo animal models of disease.
METHOD(S)
The MEDLINE database was reviewed for English-language articles on new drugs that affect the endocrine or immunologic system, the possibility that endometriosis has multiple forms, and the association of endometriosis with cancer. Specific attention was given to in vivo studies in animals or humans.
CONCLUSION(S)
Among the novel potential candidate drugs, aromatase inhibitors and raloxifene should be considered for treatment of postmenopausal women with endometriosis. Notable observations have emerged from studies of immunomodulators and antiinflammatory agents in animal models of disease. These findings must be confirmed in women. The histogenesis of ovarian endometriomas is still unclear, thus limiting new experimental approaches to this form of disease. Given the low but established risk for malignant transformation of endometriosis, efforts should be directed toward identification of susceptibility loci for the disease and its potential transformation into cancer.
Topics: Adjuvants, Immunologic; Animals; Anti-Inflammatory Agents; Aromatase Inhibitors; Endometriosis; Enzyme Inhibitors; Female; Humans; Immunity, Cellular; MEDLINE; Ovarian Cysts; Ovarian Diseases; Ovarian Neoplasms; Postmenopause; Raloxifene Hydrochloride; Rectal Diseases; Selective Estrogen Receptor Modulators; Vaginal Diseases
PubMed: 12372439
DOI: 10.1016/s0015-0282(02)03233-8 -
Taiwanese Journal of Obstetrics &... Dec 2011
Topics: Female; Gynecologic Surgical Procedures; Humans; Laparoscopy; Ovarian Diseases; Pregnancy; Pregnancy Complications; Torsion Abnormality
PubMed: 22212309
DOI: 10.1016/j.tjog.2011.10.002 -
Endocrinology Aug 2021Declining female fertility has become a global health concern. It results partially from an abnormal circadian clock caused by unhealthy diet and sleep habits in modern... (Review)
Review
Declining female fertility has become a global health concern. It results partially from an abnormal circadian clock caused by unhealthy diet and sleep habits in modern life. The circadian clock system is a hierarchical network consisting of central and peripheral clocks. It not only controls the sleep-wake and feeding-fasting cycles but also coordinates and maintains the required reproductive activities in the body. Physiologically, the reproductive processes are governed by the hypothalamic-pituitary-gonadal (HPG) axis in a time-dependent manner. The HPG axis releases hormones, generates female characteristics, and achieves fertility. Conversely, an abnormal daily rhythm caused by aberrant clock genes or abnormal environmental stimuli contributes to disorders of the female reproductive system, such as polycystic ovarian syndrome and premature ovarian insufficiency. Therefore, breaking the "time code" of the female reproductive system is crucial. In this paper, we review the interplay between circadian clocks and the female reproductive system and present its regulatory principles, moving from normal physiology regulation to disease etiology.
Topics: Animals; Biological Clocks; Circadian Rhythm; Female; Humans; Hypothalamo-Hypophyseal System; Ovarian Diseases; Ovary
PubMed: 34125877
DOI: 10.1210/endocr/bqab117 -
Diagnostic and Interventional Imaging Mar 2020
Topics: Diagnosis, Differential; Female; Humans; Magnetic Resonance Imaging; Ovarian Diseases; Ovarian Neoplasms
PubMed: 32113576
DOI: 10.1016/j.diii.2020.02.008