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International Journal of Molecular... Jun 2023Skeletal muscle is continuously exposed during its activities to mechanical/oxidative damage [...].
Skeletal muscle is continuously exposed during its activities to mechanical/oxidative damage [...].
Topics: Oxidative Stress; Muscle, Skeletal
PubMed: 37373372
DOI: 10.3390/ijms241210227 -
Oxidative Medicine and Cellular... 2017
Topics: Female; Humans; Infections; Male; Oxidative Stress
PubMed: 28255425
DOI: 10.1155/2017/3496043 -
Oxidative Medicine and Cellular... 2017
Topics: Animals; Humans; Oxidative Stress; Reactive Oxygen Species; Stem Cells
PubMed: 29018510
DOI: 10.1155/2017/5047168 -
Oxidative Medicine and Cellular... 2017
Topics: Animals; Cardiovascular Diseases; Humans; Inflammation; Oxidative Stress
PubMed: 28536646
DOI: 10.1155/2017/5853238 -
Nutrients Jan 2019Inflammation and oxidative stress are important factors in the development of cardiovascular disease and atherosclerosis. The findings of our previous study suggest that... (Randomized Controlled Trial)
Randomized Controlled Trial
Inflammation and oxidative stress are important factors in the development of cardiovascular disease and atherosclerosis. The findings of our previous study suggest that 12 weeks consumption of tart cherry juice lowers the levels of systolic blood pressure (BP) and low-density lipoprotein (LDL) cholesterol in older adults. The present study investigated the effects of tart cherry juice on blood biomarkers of inflammation and oxidative stress. In this randomized-controlled clinical trial, a total of 37 men and women between the ages of 65⁻80 were randomly assigned to consume 480 mL of tart cherry juice or control drink daily for 12 weeks. Several blood biomarkers of inflammation and oxidative stress were assessed at baseline and after 12 weeks intervention. After the 12 weeks intervention, tart cherry juice significantly increased the plasma levels of DNA repair activity of 8-oxoguanine glycosylase ( < 0.0001) and lowered ( = 0.03) the mean c-reactive protein (CRP) level compared to the control group. There was a significant group effect observed for plasma CRP ( = 0.03) and malondialdehyde (MDA) ( = 0.03), and a borderline significant group effect observed for plasma oxidized low-density lipoprotein (OxLDL) ( = 0.07). Within group analysis showed that the plasma levels of CRP, MDA, and OxLDL decreased numerically by 25%, 3%, and 11%, respectively after 12 weeks of tart cherry juice consumption compared with corresponding baseline values. The present study suggests that the ability of tart cherry juice to reduce systolic BP and LDL cholesterol, in part, may be due to its anti-oxidative and anti-inflammatory properties. Larger and longer follow-up studies are needed to confirm these findings.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Fruit and Vegetable Juices; Gene Expression Regulation; Humans; Inflammation; Male; Oxidative Stress; Prunus avium; Random Allocation
PubMed: 30678193
DOI: 10.3390/nu11020228 -
Oxidative Medicine and Cellular... 2019
Topics: Amyloidosis; Animals; Humans; Inflammation; Oxidative Stress
PubMed: 31612076
DOI: 10.1155/2019/6024975 -
Oxidative Medicine and Cellular... 2017
Topics: Aging; Animals; Antioxidants; Chronic Disease; Humans; Oxidative Stress
PubMed: 28246551
DOI: 10.1155/2017/4310469 -
Molecules (Basel, Switzerland) May 2022Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress... (Review)
Review
Excess reactive oxygen species production and free radical formation can lead to oxidative stress that can damage cells, tissues, and organs. Cellular oxidative stress is defined as the imbalance between ROS production and antioxidants. This imbalance can lead to malfunction or structure modification of major cellular molecules such as lipids, proteins, and DNAs. During oxidative stress conditions, DNA and protein structure modifications can lead to various diseases. Various antioxidant-specific gene expression and signal transduction pathways are activated during oxidative stress to maintain homeostasis and to protect organs from oxidative injury and damage. The liver is more vulnerable to oxidative conditions than other organs. Antioxidants, antioxidant-specific enzymes, and the regulation of the antioxidant responsive element (ARE) genes can act against chronic oxidative stress in the liver. ARE-mediated genes can act as the target site for averting/preventing liver diseases caused by oxidative stress. Identification of these ARE genes as markers will enable the early detection of liver diseases caused by oxidative conditions and help develop new therapeutic interventions. This literature review is focused on antioxidant-specific gene expression upon oxidative stress, the factors responsible for hepatic oxidative stress, liver response to redox signaling, oxidative stress and redox signaling in various liver diseases, and future aspects.
Topics: Antioxidants; Genomics; Humans; Liver Diseases; Oxidative Stress; Reactive Oxygen Species
PubMed: 35630636
DOI: 10.3390/molecules27103159 -
Oxidative Medicine and Cellular... 2018The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant... (Review)
Review
The gut-brain axis is increasingly recognized as an important pathway of communication and of physiological regulation, and gut microbiota seems to play a significant role in this mutual relationship. Oxidative stress is one of the most important pathogenic mechanisms for both neurodegenerative diseases, such as Alzheimer's or Parkinson's, and acute conditions, such as stroke or traumatic brain injury. A peculiar microbiota type might increase brain inflammation and reactive oxygen species levels and might favor abnormal aggregation of proteins. Reversely, brain lesions of various etiologies result in alteration of gut properties and microbiota. These recent hypotheses could open a door for new therapeutic approaches in various neurological diseases.
Topics: Brain; Gastrointestinal Microbiome; Humans; Oxidative Stress
PubMed: 30622664
DOI: 10.1155/2018/2406594 -
BioMed Research International 2014If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by... (Review)
Review
If aging is due to or contributed by free radical reactions, as postulated by the free radical theory of aging, lifespan of organisms should be extended by administration of exogenous antioxidants. This paper reviews data on model organisms concerning the effects of exogenous antioxidants (antioxidant vitamins, lipoic acid, coenzyme Q, melatonin, resveratrol, curcumin, other polyphenols, and synthetic antioxidants including antioxidant nanoparticles) on the lifespan of model organisms. Mechanisms of effects of antioxidants, often due to indirect antioxidant action or to action not related to the antioxidant properties of the compounds administered, are discussed. The legitimacy of antioxidant supplementation in human is considered.
Topics: Aging; Antioxidants; Dietary Supplements; Evidence-Based Medicine; Humans; Longevity; Oxidative Stress; Reactive Oxygen Species; Treatment Outcome
PubMed: 24783202
DOI: 10.1155/2014/404680