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Poultry Science May 1976Two experiments were conducted to investigate the effects of varying levels of pantothenic acid on the efficiency of energy utilization and changes in body composition...
Two experiments were conducted to investigate the effects of varying levels of pantothenic acid on the efficiency of energy utilization and changes in body composition of the growing chick. The results indicate that a pantothenic acid deficiency does not interfere with the chick's ability to obtain metabolizable energy from the diet. The data do show that the efficiency of energy utilization and body composition were markedly affected when chicks were fed diets deficient in pantothenic acid. In both experiments, protein, fat and energy stores were significantly reduced when pantothenic acid-deficient diets were fed. Increased estimates of heat increment per gram of diet were observed when levels of pantothenic acid below the N.R.C. (1971) recommended level of 10 mg. per kg of diet were fed.
Topics: Animal Feed; Animals; Body Composition; Body Weight; Chickens; Energy Metabolism; Male; Pantothenic Acid; Poultry Diseases; Vitamin B Deficiency
PubMed: 935060
DOI: 10.3382/ps.0550950 -
The Journal of Dermatological Treatment Dec 2024In dry skin (DS), skin-barrier function is easily disturbed and moisturizing factors in the stratum corneum are reduced. Despite being a common condition, DS is often... (Review)
Review
In dry skin (DS), skin-barrier function is easily disturbed and moisturizing factors in the stratum corneum are reduced. Despite being a common condition, DS is often overlooked in patients with advanced age or comorbid diseases. In September 2022, specialists in dermatology and skin care met to discuss unmet needs and management of patients with DS with existing medical conditions or DS induced by ongoing pharmacological treatments. There was consensus about the need to improve the current understanding and management of DS in patients with comorbidities, including type 2 diabetes, chronic kidney disease, radiodermatitis, and photodamaged skin. Clinical guidance related to optimal treatment of DS in patients with advanced age or comorbid diseases is needed. Dexpanthenol-containing emollients have been shown to provide rapid relief from the symptoms and clinical signs of skin inflammation and are well-tolerated and effective in terms of moisturizing and soothing DS and maintaining skin-barrier function. Thus, dexpanthenol-containing emollients may play an important role in future management of DS. Further research is needed to elucidate the efficacy of dexpanthenol across the spectrum of DS, irrespective of comorbidity status or age.
Topics: Humans; Emollients; Diabetes Mellitus, Type 2; Ichthyosis; Pharmaceutical Vehicles; Comorbidity; Pantothenic Acid
PubMed: 38565198
DOI: 10.1080/09546634.2024.2326171 -
European Journal of Biochemistry Nov 1970
Topics: Amidohydrolases; Animals; Carbon Isotopes; Cattle; Chemical Phenomena; Chemical Precipitation; Chemistry; Chromatography, DEAE-Cellulose; Cystamine; Cysteamine; Electrophoresis; Horses; Hot Temperature; Hydrogen-Ion Concentration; Hydrolases; Hydroxybutyrates; Kidney; Pantothenic Acid; Quaternary Ammonium Compounds; Species Specificity; Sulfates; Sulfides; Swine
PubMed: 5477303
DOI: 10.1111/j.1432-1033.1970.tb01119.x -
Journal of Bacteriology Mar 1951
Topics: Coenzyme A; Humans; Pantetheine; Pantothenic Acid
PubMed: 14824110
DOI: 10.1128/jb.61.3.283-291.1951 -
PLoS Pathogens Jul 2019Metabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis,...
Metabolically quiescent pathogens can persist in a viable non-replicating state for months or even years. For certain infectious diseases, such as tuberculosis, cryptococcosis, histoplasmosis, latent infection is a corollary of this dormant state, which has the risk for reactivation and clinical disease. During murine cryptococcosis and macrophage uptake, stress and host immunity induce Cryptococcus neoformans heterogeneity with the generation of a sub-population of yeasts that manifests a phenotype compatible with dormancy (low stress response, latency of growth). In this subpopulation, mitochondrial transcriptional activity is regulated and this phenotype has been considered as a hallmark of quiescence in stem cells. Based on these findings, we worked to reproduce this phenotype in vitro and then standardize the experimental conditions to consistently generate this dormancy in C. neoformans. We found that incubation of stationary phase yeasts (STAT) in nutriment limited conditions and hypoxia for 8 days (8D-HYPOx) was able to produced cells that mimic the phenotype obtained in vivo. In these conditions, mortality and/or apoptosis occurred in less than 5% of the yeasts compared to 30-40% of apoptotic or dead yeasts upon incubation in normoxia (8D-NORMOx). Yeasts in 8D-HYPOx harbored a lower stress response, delayed growth and less that 1% of culturability on agar plates, suggesting that these yeasts are viable but non culturable cells (VBNC). These VBNC were able to reactivate in the presence of pantothenic acid, a vitamin that is known to be involved in quorum sensing and a precursor of acetyl-CoA. Global metabolism of 8D-HYPOx cells showed some specific requirements and was globally shut down compared to 8D-NORMOx and STAT conditions. Mitochondrial analyses showed that the mitochondrial mass increased with mitochondria mostly depolarized in 8D-HYPOx compared to 8D-NORMox, with increased expression of mitochondrial genes. Proteomic and transcriptomic analyses of 8D-HYPOx revealed that the number of secreted proteins and transcripts detected also decreased compared to 8D-NORMOx and STAT, and the proteome, secretome and transcriptome harbored specific profiles that are engaged as soon as four days of incubation. Importantly, acetyl-CoA and the fatty acid pathway involving mitochondria are required for the generation and viability maintenance of VBNC. Altogether, these data show that we were able to generate for the first time VBNC phenotype in C. neoformans. This VBNC state is associated with a specific metabolism that should be further studied to understand dormancy/quiescence in this yeast.
Topics: Animals; Cryptococcosis; Cryptococcus neoformans; Culture Media; Fatty Acids; Fungal Proteins; Humans; Mice; Microbial Viability; Mitochondria; Oxygen; Pantothenic Acid; Phenotype; Transcriptome
PubMed: 31356623
DOI: 10.1371/journal.ppat.1007945 -
The Cornell Veterinarian Jul 1982We describe the pathologic changes of single or simultaneous dietary deprivations of biotin (B) and pantothenic acid (PA) in lake trout, Salvelinus namaycush. A...
We describe the pathologic changes of single or simultaneous dietary deprivations of biotin (B) and pantothenic acid (PA) in lake trout, Salvelinus namaycush. A deficiency of PA produced gross signs of anorexia, inanition, emaciation, gill abnormalities and high mortality. In B-deficient fish, growth retardation reached statistically significant levels (P less than 0.05) after week 10, but gill and liver lesions were observed earlier. Anorexia and reduced weight gain were observed earlier in fish deprived of both nutrients than in those deficient in B alone. All B-deficient trout fed PA survived the study, and were less anorexic, anemic and emaciated than were those fed B without PA. Deposition of glycogen was greater in kidney tubules of B-deficient fish than in those lacking both vitamins. However, lesions interpreted to be mitochondrial conglutination and cellular necrosis of renal tubules and pancreatic acini were more exaggerated in fish fed neither nutrient than in those deprived of only one. Both vitamins are needed for energy transfer metabolism and their absence in metabolically active tissues causes lesions that resemble those reported for cellular anoxia.
Topics: Animal Nutritional Physiological Phenomena; Animals; Biotin; Fish Diseases; Kidney; Liver; Pancreas; Pantothenic Acid; Salmonidae; Trout
PubMed: 7105759
DOI: No ID Found -
Journal of Nutritional Science and... 2013D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from... (Comparative Study)
Comparative Study
D-Pantethine is a compound in which two molecules of D-pantetheine bind through an S-S linkage. D-Pantethine is available from commercial sources as well as from D-pantothenic acid. We investigated if D-pantethine has the same vitamin activity as D-pantothenic acid by comparing the recovery from a deficiency of D-pantothenic acid in rats. D-Pantothenic acid-deficient rats were developed by weaning rats on a diet lacking D-pantothenic acid for 47 d. At that time, the urinary excretion of D-pantothenic acid was almost zero, and the body weight extremely low, compared with the control (p<0.05); the contents of free D-pantothenic acid were also significantly reduced in comparison with those of controls (p<0.05). D-Pantothenic acid-deficient rats were administered a diet containing D-pantothenic acid or D-pantethine for 7 d. D-Pantethine and D-pantothenic acid contents of the diets were equimolar in forms of D-pantothenic acid. We compared various parameters concerning nutritional status between rats fed D-pantothenic acid- and D-pantethine-containing diets. The recoveries of body weight, tissue weights, and tissue concentrations of free D-pantothenic acid, dephospho-CoA, CoA, and acetyl-CoA were identical between rats fed diets containing D-pantothenic acid and D-pantethine. Thus, the biological efficiency for recovering from a deficiency of D-pantothenic acid in rats was equivalent between D-pantothenic acid and D-pantethine.
Topics: Acetyl Coenzyme A; Animals; Body Weight; Coenzyme A; Diet; Male; Organ Size; Pantetheine; Pantothenic Acid; Rats; Rats, Wistar; Vitamins; Weaning
PubMed: 23727638
DOI: 10.3177/jnsv.59.93 -
Poultry Science Jan 1991Two experiments were conducted using a total of 288 Hy-Line W-36 day-old pullets in each experiment. The pullets were randomly assigned to one of the six dietary...
Two experiments were conducted using a total of 288 Hy-Line W-36 day-old pullets in each experiment. The pullets were randomly assigned to one of the six dietary treatments that consisted 0, .3, .6, .9, 1.8, or 3.6 mg supplemental pantothenic acid/kg of a corn and soybean meal basal diet (4.8 mg/kg). Six replicates of eight pullets per replicate were used per treatment in each experiment. Feed and water were provided for ad libitum access. The pullets were housed in battery brooder pens with raised wire floors. Body weight, body weight gain, average feed consumption per day, total feed consumption, and feed conversion were determined at 3 and 6 wk of age (WOA). The birds were observed for any signs of pantothenic acid deficiency. At the end of a 6-wk experimental period, the pullets previously receiving the diets containing either 0 or 3.6 mg supplemental pantothenic acid/kg of diet were raised to sexual maturity and their age at sexual maturity, body weight at 24 WOA, and average number of eggs per pullet through 32 WOA were measured in both of the experiments. No differences (P greater than .05) in total body weight, body weight gain, average feed consumption per day, total feed consumption, and feed conversion were observed in any of the supplemental pantothenic acid treatments from 0 to 3 and 3 to 6 WOA. None of birds during the experimental period showed any signs of deficiency.(ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Animals; Chickens; Eating; Female; Oviposition; Pantothenic Acid; Random Allocation; Sexual Maturation; Weight Gain
PubMed: 2017421
DOI: 10.3382/ps.0700080 -
Skin Research and Technology : Official... Jan 2024Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.
BACKGROUND
Sensitive skin is a common condition affecting a significant proportion of the population, and there is a growing demand for effective and safe management.
AIM
To evaluate the efficacy and safety of a cream containing panthenol, prebiotics, and probiotic lysate as an optimal care for facial sensitive skin.
METHODS
A total of 110 participants (64 in group A and 46 in group B) with facial sensitive skin applied the cream twice daily for 28 days. Group A evaluated their sensitive skin, product efficacy, and product use experience at D0 (15 min), D1, D14, and D28. In group B, skin barrier function-related indicators were measured at baseline and on D1, D7, D14, and D28. Dermatologists evaluated tolerance for all participants.
RESULTS
After 28 days of use, in group A, 100% of participants reported mildness and comfort with product use. Participants demonstrated significant improvements in skin barrier function-related indicators, including increased stratum corneum moisture content, reduced erythema index, elevated sebum content, decreased trans-epidermal water loss, and diminished skin redness parameter a* value (all p < 0.05). Dermatologist evaluations revealed excellent tolerance among all participants.
CONCLUSION
The panthenol-enriched cream with prebiotics and probiotic lysate exhibited substantial clinical efficacy in ameliorating facial sensitive skin conditions, coupled with a high safety profile.
Topics: Humans; Prebiotics; Probiotics; Pantothenic Acid; Facial Dermatoses; Emollients
PubMed: 38186043
DOI: 10.1111/srt.13540 -
Medicina Oral, Patologia Oral Y Cirugia... Sep 2020The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a... (Randomized Controlled Trial)
Randomized Controlled Trial
Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial.
BACKGROUND
The aim of this study was to evaluate and compare the postoperative effect of a topic gel containing chlorhexidine, chitosan, allantoine and dexpanthenol versus a placebo for pain and inflammation control after third molar surgery.
MATERIAL AND METHODS
A gel combining 0.2% chlorhexdine, 0.5% chitosan, 5% dexpanthenol, 0.15% allantoin and 0.01% sodium saccharin was selected for this split mouth randomized controlled and double-blind trial including 36 patients with bilaterally and symmetrically impacted lower third molars. The teeth (n=72) were randomly divided into two groups before surgical removal: control group (CG; in which a placebo was given) and experimental group (EG). Swelling, trismus, postoperative pain, wound healing and complications were measured and recorded in order to evaluate differences between the placebo and experimental product.
RESULTS
Five patients suffered from an alveolitis in the CG (13.9%), and none in the study group (0%), but no statistically significant difference was found (p=0.063). From day 0 to day 7, trismus and swelling were significantly less pronounced in the EG, and wound healing was considered 'good' in 22.2% for the CG and 97.2% for the EG (p<0.001). Mean VAS scores during the seven postoperative days were statistically lower in the study (2.56±1,19) compared to the placebo group (3.25±1.6) (p=0.002). The mean consumption of analgesic pills during the first 92 hours was also statistically lower in the EG (0.26±0.51) in comparison to the CG (0.56±0.67) (p=0.003).
CONCLUSIONS
The use of an experimental gel containing chlorhexidine, chitosan, allantoine and dexpanthenol seems to significantly reduce postoperative pain, trismus and signs of inflammation. Future studies should further evaluate, if the gel is effective in dry socket preventing after third molar removal.
Topics: Allantoin; Chitosan; Chlorhexidine; Double-Blind Method; Edema; Humans; Inflammation; Molar, Third; Pain, Postoperative; Pantothenic Acid; Prospective Studies; Tooth Extraction; Tooth, Impacted; Trismus
PubMed: 32683390
DOI: 10.4317/medoral.23661