-
Cancer Medicine Dec 2020To comprehensively compare the survival outcomes of clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC), the study cohort included ccRCC... (Comparative Study)
Comparative Study
To comprehensively compare the survival outcomes of clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC), the study cohort included ccRCC and pRCC patients in 2004-2017 from the Surveillance, Epidemiology, and End Results (SEER) database, which comprises 18 registries. Primary outcomes including overall mortality (OM) and cancer-specific mortality (CSM) were evaluated. Subgroup analyses were conducted for different ages, race, and disease stages. A total of 112,270 cases were eligible for the current analysis, including 92,209 cases of ccRCC and 20,061 cases of pRCC. Univariate analyses suggested that pRCC has a more favorable outcome than ccRCC in terms of CSM (HR: 0.72, 95% CI: 0.68-0.75, p < 0.001) and OM (HR: 0.90, 95% CI: 0.88-0.93, p < 0.001). Multivariate-adjusted HRs suggested that pRCC has worse survival outcomes than ccRCC (adjusted HR: 1.08 for CSM and 1.05 for OM, both p < 0.05). Subgroup analyses showed that pRCC had a significantly poorer prognosis than ccRCC among patients ≤45 years old (HR : 1.59, 95% CI: 1.31-1.93, p < 0.001; HR : 1.63, 95% CI: 1.40-1.90, p < 0.001). Among patients with distant metastasis, those with pRCC had a higher risk of CSM and OM than those with ccRCC (HR : 1.28, 95% CI: 1.19-1.39, p < 0.001; HR : 1.30, 95% CI: 1.21-1.40, p < 0.001). Propensity score analyses for patients ≤45 years old and those with metastasis showed similar results. The lack of information on pRCC subtypes in the SEER database was a limitation. In conclusion, pRCC has poorer survival outcomes than ccRCC among patients younger than 45 years old and patients with distant metastasis.
Topics: Adenocarcinoma, Papillary; Age Factors; Aged; Carcinoma, Renal Cell; Databases, Factual; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Propensity Score; SEER Program; Survival Analysis; Survival Rate; United States
PubMed: 33141518
DOI: 10.1002/cam4.3563 -
Modern Pathology : An Official Journal... Jan 2021Recent changes in the classification of cervical adenocarcinomas have re-categorized serous carcinoma as potentially nonexistent. However, clinical and pathological...
Recent changes in the classification of cervical adenocarcinomas have re-categorized serous carcinoma as potentially nonexistent. However, clinical and pathological profiles of cervical adenocarcinomas with serous-like morphological features have not been systematically evaluated using the latest taxonomy and biomarkers. We studied 14 cases of primary cervical carcinomas with serous-like morphologies (papillary and micropapillary patterns). None of these cases exhibited evidence of serous carcinoma involving the upper tracts. Patient ages ranged between 34 and 86 years, most presented with abnormal uterine bleeding. Histologically, ten cases were classified as human papillomavirus (HPV)-associated carcinomas (eight usual-type endocervical adenocarcinomas and two adenosquamous carcinomas), of which six exhibited a papillary pattern and four had a micropapillary pattern. The four remaining cases were HPV-independent gastric-type adenocarcinomas, which displayed a papillary pattern in one case and a micropapillary pattern in three others. All ten HPV-associated carcinomas displayed block positive p16 and wild-type p53 by immunohistochemistry, with nine of them confirmed by HPV testing. Two of the four gastric-type adenocarcinomas had mutation-type p53, one of which also being p16 block positive. HER2 overexpression was demonstrated in 3/14 (21.4%) cases (2 HPV-associated and 1 HPV-independent). PD-L1 expression was identified in 4/10 (40%) cases, all HPV-associated. Targeted next-generation sequencing was performed in two cases with a micropapillary pattern, revealing a missense variant in ATM in an HPV-associated tumor and missense variants in TP53 and SMARCB1 in an HPV-independent tumor. The results demonstrated that primary endocervical adenocarcinomas can mimic the appearance of serous carcinoma, while not representing serous carcinoma. Serous-like papillary and micropapillary patterns may be present in both HPV-associated and HPV-independent cervical carcinomas, but none of the cases studied were unequivocally serous upon detailed analysis. Our findings support the exclusion of "cervical serous carcinoma" from existing classifications of cervical adenocarcinoma.
Topics: Adenocarcinoma, Papillary; Adult; Aged; Aged, 80 and over; Alphapapillomavirus; Biomarkers, Tumor; Biopsy; Carcinoma, Adenosquamous; DNA Mutational Analysis; Female; Humans; Immunohistochemistry; Middle Aged; Mutation, Missense; Neoplasms, Cystic, Mucinous, and Serous; Predictive Value of Tests; Prognosis; Retrospective Studies; Terminology as Topic; Uterine Cervical Neoplasms
PubMed: 32699256
DOI: 10.1038/s41379-020-0627-8 -
Cancer Medicine May 2022
Topics: Adenocarcinoma of Lung; Adenocarcinoma, Papillary; Humans; Lung Neoplasms
PubMed: 35234357
DOI: 10.1002/cam4.4597 -
Polish Journal of Pathology : Official... 2022Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPA) is an extremely rare neoplasm that generally originates from the nasopharynx surface... (Review)
Review
Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma (TL-LGNPA) is an extremely rare neoplasm that generally originates from the nasopharynx surface epithelium. The case presented herein is of a 70-year-old male patient referred from another centre, who was observed to have this tumour together with squamous cell carcinoma. The clinicopathological findings of this combination are presented, which has very rarely been mentioned in the literature. Although the prognosis of TL-LGNPA is generally excellent, it may sometimes be combined with other tumours, and therefore it must be kept in mind that it could have a clinically more aggressive course.
Topics: Male; Humans; Aged; Thyroid Gland; Nasopharyngeal Neoplasms; Nasopharyngeal Carcinoma; Adenocarcinoma, Papillary; Carcinoma, Squamous Cell
PubMed: 36946273
DOI: 10.5114/pjp.2022.125569 -
Medicine Nov 2021Primary nasopharyngeal papillary adenocarcinoma is a rare nasopharyngeal neoplasm with a good prognosis and a low propensity for regional recurrence. To date, only few...
RATIONALE
Primary nasopharyngeal papillary adenocarcinoma is a rare nasopharyngeal neoplasm with a good prognosis and a low propensity for regional recurrence. To date, only few cases of primary nasopharyngeal papillary adenocarcinoma have been reported in the literature.
PATIENT CONCERNS
A 24-year-old female patient presented with intermittent hemoptysis and blood tinge nasal discharge.
DIAGNOSIS
An exophytic and pedunculated mass over the roof of the nasopharynx was found on nasopharyngoscope. Biopsy was done and the pathology confirmed well-differentiated primary nasopharyngeal papillary adenocarcinoma, strongly positive for CK7, and transcription termination factor 1; but negative for thyroglobulin. The final diagnosis was primary nasopharyngeal papillary adenocarcinoma, well-differentiated, pT1N0M0, stage I.
INTERVENTIONS
The patient underwent excision of nasopharyngeal tumor under sinuscopic assistance.
OUTCOMES
: No local recurrence or distant metastasis was noted during the 6 months of follow-up.
LESSONS
We aim at highlighting the importance of a thorough differential diagnosis of nasopharyngeal tumor. Further investigation is still needed for providing evidence to standardize the treatment protocol.
Topics: Adenocarcinoma, Papillary; Diagnosis, Differential; Female; Hemoptysis; Humans; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Nasopharynx; Young Adult
PubMed: 34871272
DOI: 10.1097/MD.0000000000027729 -
Cancer Research and Treatment Jan 2017Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a... (Review)
Review
PURPOSE
Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma.
MATERIALS AND METHODS
Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67. Additionally, hybridization investigation was utilized to identify the presence of small Epstein-Barr virus (EBV)-encoded RNA.
RESULTS
Histopathological analysis revealed florid proliferation of papillary structures lined by columnar epithelial cells with fibrovascular cores. Immunohistochemically, the neoplastic cells were positive for CKpan, CK7, TTF-1, vimentin, and EMA, but negative for thyroglobulin, CD15, S100, P40, CK20, CDX-2, and GFAP. The Ki-67-labeling index reached 5% in the most concentrated spot. hybridization for EBV was negative.
CONCLUSION
Due to the distinct rarity of low-grade thyroid-like papillary adenocarcinomaswith a favorable clinical outcome, a nationwide effort to raise public awareness of this neoplasm is required.
Topics: Adenocarcinoma, Papillary; Adolescent; Biomarkers; Biopsy; Carcinoma; Endoscopy; Female; Humans; Immunohistochemistry; Nasal Septum; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms
PubMed: 27384157
DOI: 10.4143/crt.2016.195 -
Pancreas Apr 2013Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer....
OBJECTIVES
Sex-determining region Y (SRY) box 9 (SOX9) is an important transcription factor required for development and has been implicated in several types of cancer. Sex-determining region Y box 9 has never been linked to pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) of the pancreas. The aim of this study was to investigate the relationship between SOX9 and PDAC and that between SOX9 and IPMN.
METHODS
Surgical specimens were obtained from 55 patients with PDAC and 68 patients with IPMN and were investigated using SOX9 immunohistochemical analysis.
RESULTS
The rate of SOX9 positive cells to total pancreatic duct epithelial cells in a normal pancreas was 82.7%. On the other hand, the SOX9 positive rate in PDAC was 0.8%. There was a significant difference between the normal pancreas and PDAC (P = 0.0002). In IPMN, the SOX9 positive rate gradually decreased according to tumor progression, with the following rates observed: intraductal papillary mucinous adenoma (66.3%); noninvasive intraductal papillary mucinous carcinoma (46.3%); minimally invasive intraductal papillary mucinous carcinoma (30.5%); and invasive carcinoma originating in intraductal papillary mucinous carcinoma (2.3%). There were significant differences between each group (P < 0.05).
CONCLUSIONS
Our data suggested that SOX9 might contribute to carcinogenesis in PDAC and IPMN.
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adenocarcinoma, Papillary; Adenoma; Aged; Carcinoma, Pancreatic Ductal; Carcinoma, Papillary; Female; Humans; Immunohistochemistry; Male; Middle Aged; Pancreatic Ducts; Pancreatic Neoplasms; SOX9 Transcription Factor
PubMed: 23146920
DOI: 10.1097/MPA.0b013e318269d281 -
The Pan African Medical Journal 2016Villoglandular papillary adenocarcinoma (VPA) is a very rare subtype of adenocarcinoma of the uterine cervix, but a well-recognized variant of cervical adenocarcinoma...
Villoglandular papillary adenocarcinoma (VPA) is a very rare subtype of adenocarcinoma of the uterine cervix, but a well-recognized variant of cervical adenocarcinoma with a favorable prognosis and generally occurring in women of child-bearing age. Herein, we report a case of VPA diagnosed and managed successfully with conservative measure. This management is particularly desirable in young women to preserve reproductive capability.
Topics: Adenocarcinoma, Papillary; Adult; Female; Fertility Preservation; Humans; Prognosis; Treatment Outcome; Uterine Cervical Neoplasms
PubMed: 28293348
DOI: 10.11604/pamj.2016.25.232.10305 -
The Journal of Thoracic and... Mar 2014To evaluate the clinical effect of the presence of a micropapillary or solid subtype on the outcomes in lung adenocarcinoma and to determine the predictors of such a... (Comparative Study)
Comparative Study
OBJECTIVE
To evaluate the clinical effect of the presence of a micropapillary or solid subtype on the outcomes in lung adenocarcinoma and to determine the predictors of such a histopathologic diagnosis.
METHODS
A total of 511 patients with lung adenocarcinoma ≤3 cm were included. According to the presence of micropapillary or solid subtypes, we classified the patients into 4 subgroups: both subtypes absent (MP-/S-, n = 87), either subtype present (MP+/S-, n = 207 and MP-/S+, n = 196), and both present (MP+/S+, n = 21) to determine the association between the micropapillary or solid subtype and survival outcome or clinical and imaging conditions. Univariate and multivariate analyses were undertaken to determine the parameters, allowing the prediction of the presence of the micropapillary or solid subtype.
RESULTS
Overall survival (OS) and disease-free survival (DFS) differed significantly among the 4 subgroups (P < .001 and P = .004, respectively). The MP-/S- tumors showed better DFS than those containing either the micropapillary or solid subtype. Patients with the micropapillary subtype had significantly worse OS than patients without the micropapillary subtype. This difference remained significant, together with stage, after adjustment for gender, age, adjuvant therapy, tumor size, and solid subtype (DFS and OS, P = .016 and P = .002, respectively). On multivariate analysis, greater than stage I, tumor size ≥2.5 cm, solid mass, and maximal standardized uptake value of ≥7 were independent predictors of the presence of a micropapillary or solid subtype.
CONCLUSIONS
Micropapillary and solid subtypes are common in tumors greater than stage I, with size ≥2.5 cm, pure solid type, and maximal standardized uptake value of ≥7, which were predictors for poor DFS. The presence of the micropapillary subtype was a single prognostic factor for OS.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Adenocarcinoma, Papillary; Adult; Aged; Aged, 80 and over; Disease Progression; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lung Neoplasms; Male; Middle Aged; Multivariate Analysis; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Proportional Hazards Models; Retrospective Studies; Risk Factors; Time Factors; Tumor Burden
PubMed: 24199757
DOI: 10.1016/j.jtcvs.2013.09.045 -
Histopathology Feb 2022Elastin and collagen are the main components of the lung connective tissue network, and together provide the lung with elasticity and tensile strength. In pulmonary... (Review)
Review
Elastin and collagen are the main components of the lung connective tissue network, and together provide the lung with elasticity and tensile strength. In pulmonary pathology, elastin staining is used to variable extents in different countries. These uses include evaluation of the pleura in staging, and the distinction of invasion from collapse of alveoli after surgery (iatrogenic collapse). In the latter, elastin staining is used to highlight distorted but pre-existing alveolar architecture from true invasion. In addition to variable levels of use and experience, the interpretation of elastin staining in some adenocarcinomas leads to interpretative differences between collapsed lepidic patterns and true papillary patterns. This review aims to summarise the existing data on the use of elastin staining in pulmonary pathology, on the basis of literature data and morphological characteristics. The effect of iatrogenic collapse and the interpretation of elastin staining in pulmonary adenocarcinomas is discussed in detail, especially for the distinction between lepidic patterns and papillary carcinoma.
Topics: Adenocarcinoma of Lung; Adenocarcinoma, Papillary; Collagen; Diagnosis, Differential; Elastin; Histocytochemistry; Humans; Lung Neoplasms; Pleura; Pulmonary Alveoli
PubMed: 34355407
DOI: 10.1111/his.14537