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The Iowa Orthopaedic Journal 2018Parosteal osteosarcoma is a rare tumor with increased survival compared to conventional high-grade osteosarcoma. Due to this increased survival comes the need for...
BACKGROUND
Parosteal osteosarcoma is a rare tumor with increased survival compared to conventional high-grade osteosarcoma. Due to this increased survival comes the need for reconstructive options that provide good long-term functional results. Current treatment methods include geographic resection with allograft reconstruction versus resection and reconstruction with a distal femoral replacement.
PURPOSE
Our purpose was to compare the long-term functional outcomes of distal femoral replacements to allograft reconstructions, using the musculoskeletal tumor society (MSTS) scoring system.
METHODS
After querying our database, 12 patients were identified and completed a MSTS questionnaire.
RESULTS
There was no difference in functional outcomes between the cohorts at an average of 14 years follow up for the endoprosthetic group and 25 years of follow up for the geographic resection group.
CONCLUSION
At long-term follow-up, patients who undergo a distal femoral replacement for a parosteal osteosarcoma have no difference in functional outcomes compared to those who undergo an allograft reconstruction.Level of Evidence: IV.
Topics: Adolescent; Adult; Bone Transplantation; Databases, Factual; Female; Femoral Neoplasms; Femur; Follow-Up Studies; Humans; Limb Salvage; Male; Middle Aged; Osteosarcoma; Retrospective Studies; Surveys and Questionnaires; Treatment Outcome; Young Adult
PubMed: 30104942
DOI: No ID Found -
Scientific Reports Jan 2024Bone cancer is a rare in which cells in the bone grow out of control, resulting in destroying the normal bone tissue. A benign type of bone cancer is harmless and does...
Bone cancer is a rare in which cells in the bone grow out of control, resulting in destroying the normal bone tissue. A benign type of bone cancer is harmless and does not spread to other body parts, whereas a malignant type can spread to other body parts and might be harmful. According to Cancer Research UK (2021), the survival rate for patients with bone cancer is 40% and early detection can increase the chances of survival by providing treatment at the initial stages. Prior detection of these lumps or masses can reduce the risk of death and treat bone cancer early. The goal of this current study is to utilize image processing techniques and deep learning-based Convolution neural network (CNN) to classify normal and cancerous bone images. Medical image processing techniques, like pre-processing (e.g., median filter), K-means clustering segmentation, and, canny edge detection were used to detect the cancer region in Computer Tomography (CT) images for parosteal osteosarcoma, enchondroma and osteochondroma types of bone cancer. After segmentation, the normal and cancerous affected images were classified using various existing CNN-based models. The results revealed that AlexNet model showed a better performance with a training accuracy of 98%, validation accuracy of 98%, and testing accuracy of 100%.
Topics: Humans; Deep Learning; Early Detection of Cancer; Neural Networks, Computer; Tomography, X-Ray Computed; Computers; Bone Neoplasms; Osteosarcoma; Image Processing, Computer-Assisted
PubMed: 38273131
DOI: 10.1038/s41598-024-52719-8 -
Clinical Orthopaedics and Related... Jun 2008While low-grade juxtacortical and low-grade intramedullary osteogenic sarcomas are histologically indistinguishable, they have been studied as separate entities. We... (Comparative Study)
Comparative Study
UNLABELLED
While low-grade juxtacortical and low-grade intramedullary osteogenic sarcomas are histologically indistinguishable, they have been studied as separate entities. We retrospectively reviewed the clinical, radiographic, histologic features and treatment of 59 patients treated surgically to compare the rate of local recurrence, grade progression, and survival between low-grade intramedullary and low-grade juxtacortical osteogenic sarcoma. Forty-five (76%) patients were treated for low-grade juxtacortical osteogenic sarcoma and 14 (24%) were treated for low-grade intramedullary osteogenic sarcoma. Local recurrence rates of 7% were similar for both groups studied. The rate of distant metastases was also similar for both groups. . The rate of dedifferentiation for the entire group was 29%. Dedifferentiated lesions were treated with adjuvant chemotherapy in 16 of 17 cases. Recurrence preceded dedifferentiation in four cases. Five-year survival was over 90% in both groups. Low-grade intramedullary and low-grade juxtacortical osteogenic sarcoma were clinically indistinguishable with identical rates of local recurrence, distant metastases, dedifferentiation, and survival.
LEVEL OF EVIDENCE
Level III, therapeutic study. See the Guidelines for Authors for a complete description of levels of evidence.
Topics: Adolescent; Adult; Aged; Bone Neoplasms; Child; Cohort Studies; Disease-Free Survival; Female; Humans; Male; Middle Aged; Osteosarcoma, Juxtacortical; Retrospective Studies; Sarcoma, Ewing; Survival Rate; Treatment Outcome
PubMed: 18425560
DOI: 10.1007/s11999-008-0251-2 -
Medicine Jul 2020Fibro-osseous pseudotumor of the digit is a rare benign lesion of subcutaneous tissue that typically arises in the parabone site of the proximal phalanx in young adult...
INTRODUCTION
Fibro-osseous pseudotumor of the digit is a rare benign lesion of subcutaneous tissue that typically arises in the parabone site of the proximal phalanx in young adult females. The lesion is histopathologically characterized by fibroblastic proliferation and osteoid formation. Good prognosis following complete surgical excision of the tumor has been reported, with a very low recurrence rate and no reports of malignant transformation. Despite its benign clinical behavior, the lesion can be mistaken for a malignant neoplasm, such as an extraskeletal or parosteal osteosarcoma, in case of rapid growth, thereby rendering the diagnosis challenging.
PATIENT CONCERNS
We report the case of a 30-year-old right-handed male who presented to our hospital with a rapidly growing mass on the dorsal aspect of the right little finger.
DIAGNOSIS
The patient was suspected to have soft tissue tumor of the little finger. The lesion could be considered a malignant tumor on the basis of clinical findings.
INTERVENTIONS
The patient underwent surgery for exploration and excision of the mass.
OUTCOMES
The excised mass was diagnosed to be fibro-osseous pseudotumor of the digit upon histological assessment. Postoperatively, the wound healed without complications. At postoperative 6 months, there were no signs or symptoms of recurrence, and the patient returned to his premorbid functional status.
CONCLUSION
Following the detection of a soft tissue mass with clinicopathological features of pseudomalignancy in the digit, clinicians should consider fibro-osseous pseudotumor of the digit as a possible diagnosis, thereby avoiding unnecessary aggressive surgery.
Topics: Adult; Bone Neoplasms; Diagnosis, Differential; Fibroma, Ossifying; Fibrous Dysplasia of Bone; Fingers; Humans; Magnetic Resonance Imaging; Male; Soft Tissue Neoplasms; Tomography, X-Ray Computed
PubMed: 32664136
DOI: 10.1097/MD.0000000000021116 -
International Orthopaedics Oct 2006Data from 44 patients (23 males, 21 females) with a median age of 39 (range 13-80) years who underwent total hip arthroplasty for proximal femoral tumours (1994-2004)...
Data from 44 patients (23 males, 21 females) with a median age of 39 (range 13-80) years who underwent total hip arthroplasty for proximal femoral tumours (1994-2004) were analysed. The histological diagnoses included 14 metastases, six osteosarcomas, six chondrosarcomas, four Ewing's sarcomas, four giant cell tumours, three malignant fibrous histiocytomas, two parosteal and two periosteal osteosarcomas, and one each primary neuroectodermal tumour, myeloid disease, and aneurysmal bone cyst. Twenty-one patients (48%) had pathological fractures. The cause of the pathological fracture was metastasis in 12 patients (57%). Twenty-eight patients (64%) had soft tissue invasion. Complications observed in 17 patients (37%) were local recurrence in two, postoperative haematoma in two, dislocation of prosthesis in five, deep infection in six, and one patient died of myocardial infarction in the early postoperative period. During our midterm survival analysis, functional results were excellent in 25% of patients, good in 57%, fair in 12%, and poor in 6%.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Female; Femoral Neoplasms; Humans; Male; Middle Aged; Osteosarcoma; Postoperative Complications; Survival Analysis; Treatment Outcome
PubMed: 16821012
DOI: 10.1007/s00264-006-0124-9 -
Cureus Sep 2021Osteomas are most common among all primary bone tumors of skull bones. They are usually asymptomatic due to their small size and slow growth. They are found incidentally...
Osteomas are most common among all primary bone tumors of skull bones. They are usually asymptomatic due to their small size and slow growth. They are found incidentally on imaging studies forĀ other neurologic symptoms. Osteoma may be single or multiple when present. They should be differentiated from meningiomas, chordomas, schwannomas, and parosteal osteosarcoma by using different diagnostic methods, including histopathologic study. During routine dissection for MBBS students in an 87 years old female cadaver, we found multiple (seven in number) irregular, lobulated bony masses/structures. Their positions were different with respect to the layers of meninges. Some were present between the dura mater and arachnoid mater compressing the adjacent brain tissues forming impressions on them, and some were outside the dura mater. So, into the previously existing classification, we want to add a new variety under the type b category, i.e., mixed type (intraparenchymal, dural, skull vault) as pointed under the subtype V, which is found in our case.
PubMed: 34659951
DOI: 10.7759/cureus.17737 -
Clinics in Shoulder and Elbow Dec 2021A large parosteal osteoma arising on the surface of the right clavicle of a 39-year-old male patient was suspected preoperatively as a parosteal osteosarcoma. The lesion...
A large parosteal osteoma arising on the surface of the right clavicle of a 39-year-old male patient was suspected preoperatively as a parosteal osteosarcoma. The lesion was treated with wide resection and allograft reconstruction. In this case report, we discuss the accurate diagnosis and appropriate surgical treatment for unusual clavicular tumors.
PubMed: 34823310
DOI: 10.5397/cise.2021.00465 -
Journal of Orthopaedic Surgery (Hong... Dec 2004We describe the treatment of an uncommonly late presentation of a recurrent parosteal osteosarcoma of the distal femur. The osteosarcoma had originally been detected 20...
We describe the treatment of an uncommonly late presentation of a recurrent parosteal osteosarcoma of the distal femur. The osteosarcoma had originally been detected 20 years earlier, and had been treated with wide excision and mega-prosthesis to reconstruct the femur. The tumour recurred in close proximity to the femur prosthesis and encased half the femoral stem. Because there was a large piece of metal at the site of recurrence, which might have interfered with computed tomography and magnetic resonance imaging, ultrasonography was used to locate the lesion. The tumour was successfully treated with wide local re-excision. This case emphasises the importance of the long-term follow-up of patients with parosteal osteosarcoma.
Topics: Adult; Female; Femoral Neoplasms; Humans; Neoplasm Recurrence, Local; Osteosarcoma; Prostheses and Implants; Radiography
PubMed: 15621920
DOI: 10.1177/230949900401200225 -
World Journal of Orthopedics Aug 2015A case of florid reactive periostitis ossificans (RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less...
A case of florid reactive periostitis ossificans (RPO) arising in a long bone is presented. This is a rare bone proliferation with a pronounced periosteal reaction. Less than 100 cases have been described in the literature with far fewer outside the bones of the hand, feet, fingers, and toes. Although the etiology is unknown, a relationship to preceding trauma is suggested. The imaging and histologic features show an overlap with other bone lesions including bizarre parosteal osteochondromatous proliferation, subungual exostosis, and malignant surface tumors of bone and cartilage which include, periosteal and parosteal osteosarcoma. It is important to recognize the clinical presentation and diagnostic features of RPO as a benign entity so that it is not mistaken for a more aggressive neoplasm. We present a case of a right distal humeral lesion that on histopathological review revealed florid RPO. This diagnosis was not suspected on imaging studies, but was made on open biopsy of the mass. The patient remains disease free, years postoperatively. In addition to presenting this unique case report, we review the pertinent literature, and offer a differential diagnosis and treatment strategy for its management.
PubMed: 26301184
DOI: 10.5312/wjo.v6.i7.559 -
Head and Neck Pathology Jun 2012Bizarre parosteal osteochondromatous proliferation (BPOP) also eponymically called "Nora's lesion", is a rare benign reactive bone lesion first reported in 1983. BPOP...
Bizarre parosteal osteochondromatous proliferation (BPOP) also eponymically called "Nora's lesion", is a rare benign reactive bone lesion first reported in 1983. BPOP occurs classically on the bones of the hands and feet and long bones. This lesion can easily be confused, both clinically and microscopically, with other benign and malignant lesions of bone, including osteochondroma, parosteal osteosarcoma, myositis ossificans and reactive periostitis. BPOP has been reported to have a high rate of recurrence. Only 3 cases of BPOP of the head and neck have been reported in the literature, of which one involved the maxilla. We present a rare case of BPOP involving the mandible in a 10 year old African American male. Microscopically, a fibro-cartilaginous cap giving rise to a proliferation of variably mineralized osteophytic finger-like projections of bone was seen. Multiple trabeculae of "blue bone" were noted as well as numerous atypical appearing chondrocytes. The lesion recurred within 4 months following the initial excision but has not recurred to date after the second local excision. To the best of our knowledge, this is the first report of BPOP arising in the mandible. In addition, we discuss the clinical and microscopic features, differential diagnosis, and prognosis of this rare entity. We present a case of BPOP of the mandible and believe this is the first report of such a case in the mandible.
Topics: Child; Humans; Male; Mandible; Mandibular Neoplasms; Neoplasm Recurrence, Local; Osteochondroma
PubMed: 22094873
DOI: 10.1007/s12105-011-0311-x