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CA: a Cancer Journal For Clinicians 1976
Topics: Adult; Aged; Balanitis; Bowen's Disease; Carcinoma in Situ; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Condylomata Acuminata; Erythroplasia; Humans; Leukoplakia; Male; Melanoma; Mesenchymoma; Middle Aged; Neoplasm Metastasis; Penile Neoplasms; Precancerous Conditions
PubMed: 819110
DOI: 10.3322/canjclin.26.3.130 -
Postgraduate Medical Journal Dec 1952
Topics: Humans; Male; Penile Neoplasms; Penis
PubMed: 13013886
DOI: 10.1136/pgmj.28.326.615 -
Urologia Internationalis 2024Extramammary Paget's disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, and clinical and pathological... (Review)
Review
INTRODUCTION
Extramammary Paget's disease of the scrotum and penis is a relatively rare cutaneous malignant tumor. At present, its pathogenesis, and clinical and pathological characteristics are not very clear. This is controversial regarding surgical margin width to decrease the high recurrence rate. This paper aimed to report the case and review the literature of extramammary Paget's disease of scrotum and penis.
CASE PRESENTATION
We presented the case of a 74-year-old male patient with the patchy erythema and pruritus in the perineum who was admitted to our department. Biopsy of the large plaque revealed Paget disease. Under the condition of ensuring negative surgical margins by rapid frozen pathology, a wide local excision of the lesion, bilateral orchiectomy, and adnexectomy were performed on the patient. Pathology revealed that many scattered vacuolated Paget cells were observed in the epidermal layer, and the diagnosis was Paget's disease of the scrotum and penis. The 2 cm outside the skin lesion was used as the initial surgical margin, and free skin flap transplantation was used to repair the surgical wound. The patient recovered well and was discharged 1 week after surgery.
CONCLUSION
Currently, histopathologic biopsy is the most important diagnostic method for EMPD. Once confirmed, for patients eligible for surgical intervention, wide local excision of the lesion and rapid intraoperative frozen pathological examination should be performed as soon as possible. The skin flap transplantation is the first choice for the repair of large-scale wound after surgery.
Topics: Humans; Male; Paget Disease, Extramammary; Scrotum; Aged; Penile Neoplasms; Genital Neoplasms, Male; Biopsy; Treatment Outcome
PubMed: 38368870
DOI: 10.1159/000536654 -
International Journal of Clinical and... 2015Keratoacanthoma is variously regarded as a benign epithelial tumor, characterized by a rapid-growing and solitary flesh-colored nodule with a central keratin plug on the...
Keratoacanthoma is variously regarded as a benign epithelial tumor, characterized by a rapid-growing and solitary flesh-colored nodule with a central keratin plug on the sun-exposed skin. Under certain circumstances, it can transform into squamous cell carcinoma. In this paper, we present a case of a 50-year-old man with a 2.5 × 3 × 2.2 cm mass on his penis stub-end. The patient was treat with a partial penectomy after further expert discussions and histopathology the lesion demonstrated penis keratoacanthoma. He received a partial penectomy again and the pathological result revealed squamous cell carcinoma this time. This case indicates that undergoing a partial penectomy on initial diagnosis of a penile tumor secondary to penile keratoacanthoma should be considered because of its high malignant potency. To our best knowledge, this is the first study to describe the malignant conversion of penis keratoacanthoma.
PubMed: 26885065
DOI: No ID Found -
Hinyokika Kiyo. Acta Urologica Japonica Jun 2010We report a case of verrucous carcinoma of the penis. A 62-year-old man, who presented with penile swelling and pain, was referred to our hospital. Although, penile... (Review)
Review
We report a case of verrucous carcinoma of the penis. A 62-year-old man, who presented with penile swelling and pain, was referred to our hospital. Although, penile tumor biopsy revealed no evidence of malignancy, the patient presented with penile swelling and discharge. The penis was surgically resected and urinary diversion was performed. The pathological examination of the resected glans revealed verrucous carcinoma of penis. Furthermore, in situ hybridization revealed human papilloma virus (HPV) infection. This clearly showed that the verrucous carcinoma of the penis resulted from the HPV infection. The patient has survived for 14 months after surgery without local recurrence or metastasis.
Topics: Carcinoma, Verrucous; Humans; Male; Middle Aged; Papillomavirus Infections; Penile Neoplasms
PubMed: 20610928
DOI: No ID Found -
Case Reports in Oncology May 2014Cutaneous metastatic implantation of non-muscle-invasive urothelial carcinoma via urine is a rare finding, and only few cases have been reported in the literature. Here,...
Cutaneous metastatic implantation of non-muscle-invasive urothelial carcinoma via urine is a rare finding, and only few cases have been reported in the literature. Here, we present a case of metastatic urothelial carcinoma of the prepuce and glans penis, which was suspected to be an implantation of non-muscle-invasive bladder cancer via urine. The patient had pseudophimosis of the penis, and contact with urine containing urothelial carcinoma cells was considered to be the cause of the metastatic implantation.
PubMed: 25232319
DOI: 10.1159/000365749 -
British Journal of Cancer 1997Four hundred and twenty-three wives of 671 men with cancer of the penis were compared with 444 wives of 569 men who did not have this disease. The risk among the wives...
Four hundred and twenty-three wives of 671 men with cancer of the penis were compared with 444 wives of 569 men who did not have this disease. The risk among the wives of patients with cancer of the penis of preinvasive and invasive cancer of the neck of the uterus was 1.75 (95% CI 0.42-7.37).
Topics: Aged; Carcinoma, Squamous Cell; Case-Control Studies; Confidence Intervals; Female; Humans; Information Systems; Male; Middle Aged; Norway; Odds Ratio; Penile Neoplasms; Registries; Risk Factors; Spouses; Uterine Cervical Neoplasms; Vaginal Neoplasms; Vulvar Neoplasms
PubMed: 9303367
DOI: 10.1038/bjc.1997.441 -
Medicine Jun 2017Metastasis to the penis from primary lung cancer is quite rare. To improve the understanding, we present a case diagnosed as penile metastasis from primary lung cancer... (Review)
Review
BACKGROUND
Metastasis to the penis from primary lung cancer is quite rare. To improve the understanding, we present a case diagnosed as penile metastasis from primary lung cancer and review the literature.
METHODS
One case report and retrospectively analysis penile cancer patient secondary from primary lung cancer.
RESULTS
The patient complained of perineal pain and burning on urination for about 2 months. On physical examination, painful nodular masses at the base of left side of the corpora cavernosa were found. 18F-fluorodeoxyglucose positron emission tomography/CT (PET/CT) scan showed that maximum standardized uptake value (SUVmax) in left side corpora cavernosa and right hilar increased to 12.0 and 13.5 respectively. On flexible bronchoscopy checking, stenosis of the opening of apical segmental and posterior segmental bronchi of right upper lobe was found. The lateral segmental bronchi of left lower lobe was obstructed by a neoplasm. The pathological result was primary pulmonary adenosquamous carcinoma (ASC). Two months later, total penectomy was performed. The pathological result was penile ASC derived from pulmonary. On reviewing the literature, there are 39 cases reported. The patient we present is the 40 one. The average age at diagnosis was (60.5 ± 10.7) years old. The most common symptom was mass, followed by priapism, pain. The overall survival time was (4.5 ± 3.9) months.
CONCLUSIONS
The penis may be a site of metastasis from lung cancer, especially for old patient. Metastasis to the penis usually indicates that the primary lung cancer is at an advanced stage and the prognosis is very poor.
Topics: Carcinoma, Adenosquamous; Fatal Outcome; Humans; Lung Neoplasms; Male; Middle Aged; Penile Neoplasms
PubMed: 28658136
DOI: 10.1097/MD.0000000000007307 -
Medicine Jan 2015The purpose of this study was to report the clinical characteristics, treatments, and outcomes of secondary penile cancers and review the literature of this rare... (Meta-Analysis)
Meta-Analysis Review
The purpose of this study was to report the clinical characteristics, treatments, and outcomes of secondary penile cancers and review the literature of this rare condition.The records of 8 patients with metastatic penile cancer treated at our hospital from 2006 to 2013 were analyzed. A search of medical databases was conducted.Patient symptoms included penile mass (n = 7, 5 had concomitant pain) and acute urine retention (n = 1). The primary cancers included bladder, lung, gastric, liver, and prostate malignancies and 1 case of pulmonary epithelioid hemangioendothelioma. The longest time from diagnosis of the primary cancer to metastatic penile cancer was 16 years and the shortest was 7 months. Six patients were treated with phallectomy, 1 with resection of the mass, and 1 with only a biopsy because of advanced metastatic disease. Five patients are deceased at the time of this report, and the longest and shortest survival times (from the diagnosis of primary cancer to the death) were 16 years and 9 months, respectively. The literature review identified 17 cases reported since 2011, bringing the total number of reported cases to 480. Genitourinary cancer, primarily bladder and prostate, account for approximately 70 of the primary cancer sites and gastrointestinal cancers account for approximately 21%. Approximately half of the patients had died of their disease within 1 year of the diagnosis of penile metastasis.The prognosis of metastatic penile cancer is poor. Most primary cancers are in the urologic or gastrointestinal systems. Surgery and adjunctive therapy may improve symptoms, but fail to prolong survival.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Fatal Outcome; Humans; Male; Middle Aged; Penile Neoplasms
PubMed: 25569637
DOI: 10.1097/MD.0000000000000132 -
BMC Cancer May 2019To evaluate the prognostic value of Lymphovascular Invasion (LVI) in patients with squamous cell carcinoma of the penis (SCCP) following surgery.
BACKGROUND
To evaluate the prognostic value of Lymphovascular Invasion (LVI) in patients with squamous cell carcinoma of the penis (SCCP) following surgery.
PATIENTS AND METHODS
This retrospective study analyzed the data of 891 eligible patients with SCCP who were diagnosed between 2010 and 2014, obtained from the Surveillance, Epidemiology, and End Results (SEER) database. The patients were categorized by LVI, age, grade, T stage, lymph nodes status, distant metastasis, regional lymph nodes removed, and surgery. Overall survival (OS) and penile carcinoma-specific survival (PCSS) were evaluated by Kaplan-Meier method and Cox proportional hazards regression model.
RESULTS
The presence of LVI was significantly associated with increased risk of advanced T stage, high grade, lymph node metastasis, and distant metastasis (P < 0.001 for all). In Kaplan-Meier analyses, patients with the presence of LVI had significantly lower OS and PCSS than those with the absence of LVI (P < 0.001 for both,). The presence of LVI was also significantly associated with poorer OS and worse PCSS in patients with Tx + Ta + T1 stage (P = 0.007, P < 0.001), N0 stage (P < 0.001, P = 0.040), grade 1 (P = 0.001, P < 0.001), grade 2 (P = 0.001, P = 0.014), no distant metastasis (P < 0.001 for both), no regional lymph nodes removed (P < 0.001 for both), Non-radical surgery (P < 0.001 for both) and radical surgery(P = 0.037, P = 0.002). In multivariate analyses, the presence of LVI in patients with SCCP following surgery was found to be a significant independent predictor of decreased OS (hazard ratio 1.403, P = 0.039).
CONCLUSIONS
The LVI status might be a crucial prognostic indicator for overall survival in patients with SCCP.
Topics: Carcinoma, Squamous Cell; Female; Humans; Kaplan-Meier Estimate; Lymphatic Metastasis; Male; Neoplasm Grading; Neoplasm Staging; Penile Neoplasms; Prognosis; Retrospective Studies; SEER Program
PubMed: 31113402
DOI: 10.1186/s12885-019-5714-1