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Gut Jun 1986A survey of the smoking habits of 1217 outpatients undergoing upper gastrointestinal endoscopy was carried out over an 18 month period. Six hundred and twenty four were...
A survey of the smoking habits of 1217 outpatients undergoing upper gastrointestinal endoscopy was carried out over an 18 month period. Six hundred and twenty four were current smokers, 248 ex-smokers and 345 non-smokers. 11.9% of smokers had gastric ulcers, 7.7% of ex-smokers (p less than 0.025) and 4.6% of non-smokers (p less than 0.001). 2.8% of smokers had duodenal ulcers, 6.8% of ex-smokers (p less than 0.01) and 6.1% of non-smokers (p less than 0.001). There was a dose response effect between the number of cigarettes smoked and duodenal and gastric ulceration. Gastric cancer was also more frequent in smokers than non-smokers (p less than 0.01), but macroscopic oesophagitis less frequent (p less than 0.001). The results confirm the association between smoking and peptic ulcer.
Topics: Endoscopy; Female; Gastrointestinal Diseases; Humans; London; Male; Peptic Ulcer; Smoking
PubMed: 3721287
DOI: 10.1136/gut.27.6.648 -
Science Progress 2002There are many diseases where the cause is unknown and this makes a specific treatment difficult. In many cases all that can be achieved is amelioration of the illness.... (Review)
Review
There are many diseases where the cause is unknown and this makes a specific treatment difficult. In many cases all that can be achieved is amelioration of the illness. Peptic ulcer disease was one such condition no more that 20 years ago. The management was drastic--either an operation or life-long medication in order to reduce the acid secreted by the stomach. However, the cause of this condition was discovered in 1983. Although initially sceptical, the medical fraternity now almost universally endorse Helicobacter pylori as the cause of the majority of stomach ulcers. Peptic ulcers can now be cured by antibiotics. This is a major shift in medical practice. Continued investigations on Helicobacter pylori are bringing to light other possible associations with disease as well as delineating plausible biological mechanisms for disease pathogenesis.
Topics: Autoantibodies; Cell Communication; Cell Cycle; Cytotoxins; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Stomach Neoplasms
PubMed: 11969117
DOI: 10.3184/003685002783238898 -
Annals of Surgery May 1970
Topics: Adult; Aged; Female; Gastric Juice; Humans; Hypercalcemia; Hyperparathyroidism; Male; Middle Aged; Peptic Ulcer; Racial Groups; Sex Factors; United States; Zollinger-Ellison Syndrome
PubMed: 5441360
DOI: 10.1097/00000658-197005000-00003 -
Annals of Surgery May 1958
Topics: Peptic Ulcer; Stomach Neoplasms; Stomach Ulcer
PubMed: 13521694
DOI: 10.1097/00000658-195805000-00020 -
British Medical Journal Oct 1953
Topics: Humans; Peptic Ulcer; Stomach Ulcer
PubMed: 13094044
DOI: No ID Found -
Annals of Agricultural and... 2002The aim of the study was to determine the relationship between the prevalence of peptic ulcer and the occurrence of selected socio-economic features among Polish rural...
The aim of the study was to determine the relationship between the prevalence of peptic ulcer and the occurrence of selected socio-economic features among Polish rural population. The study was conducted based on the all- Polish representative study of the state of health of rural population, and covered a group of 6,512 rural inhabitants aged 20-64 -- 3,107 males and 3,405 females selected by two-stage stratified sampling. Peptic ulcer was diagnosed in 348 people in the study (5.3%): 250 males (8.0%) and 98 females (2.9%). Duodenal ulcer occurred in 3.2% of people examined, followed by gastric ulcer -- 1.2%, duodenal and gastric ulcer -- 0.2%, and 0.9% of patients underwent surgical procedures due to peptic ulcer. Peptic ulcer occurred more frequently among people with a lower education level (lack of education -- 7.8%, elementary school education -- 5.8%), compared to those with higher education categories (elementary vocational -- 4.9%, secondary school and college -- 3.7%). The disease was more often diagnosed among respondents who described their material standard as poor (7.7%), compared to those who described this standard as good (4.0%). Among people who considered their material standard as poor, gastric ulcer was noted more frequently than duodenal ulcer. A correlation was observed between the prevalence of peptic ulcer and such socio-economic features of Polish rural population as the level of education and material standard.
Topics: Adolescent; Adult; Educational Status; Female; Humans; Male; Middle Aged; Peptic Ulcer; Poland; Prevalence; Rural Population; Social Class; Surveys and Questionnaires
PubMed: 12088402
DOI: No ID Found -
Deutsches Arzteblatt International Dec 2009Helicobacter pylori-associated diseases and gastroduodenal ulcer disease are common conditions of major clinical and economic importance. There is thus a need for a...
BACKGROUND
Helicobacter pylori-associated diseases and gastroduodenal ulcer disease are common conditions of major clinical and economic importance. There is thus a need for a guideline that incorporates the scientific knowledge gained in recent years and that takes specific aspects of the situation in Germany into account with regard to epidemiology, resistance status, diagnostic evaluation, and treatment.
METHODS
This level-S3 consensus guideline was developed in accordance with the recommendations of the Association of Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF). It was commissioned by the German Association for Digestive and Metabolic Diseases (Deutsche Gesellschaft für Verdauungs- und Stoffwechselkrankheiten, DGVS) and prepared in cooperation with other scientific societies. After search terms were compiled, a systematic, IT-supported literature search was performed in the PubMed and Cochrane databases. The search was restricted to articles that appeared in German or English from 2000 onward.
RESULTS
H. pylori infection can be accurately diagnosed either non-invasively (with a (13)C-urea breath test or a stool antigen test) or invasively (with a rapid urease test, by histology, or by culture). Gastric and duodenal ulcer and gastric MALT lymphoma are absolute indications for eradication therapy; relative indications include functional dyspepsia, the prevention of gastric cancer in persons at risk, the initiation of long-term treatment with non-steroidal anti-inflammatory drugs (NSAID), and the prior occurrence of gastroduodenal complications with the use of either NSAID or acetylsalicylic acid (ASA). First-line therapy consists of a proton-pump inhibitor (PPI) and clarithromycin combined with either metronidazole or amoxicillin, given for at least one week.
CONCLUSION
This guideline enables the structured, evidence-based diagnosis and treatment of H. pylori infection and associated conditions, as well as of gastroduodenal ulcer disease.
Topics: Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer
PubMed: 20038978
DOI: 10.3238/arztebl.2009.0801 -
The Yale Journal of Biology and Medicine 1998
Review
Topics: China; Duodenal Ulcer; Helicobacter Infections; Helicobacter pylori; Humans; Peptic Ulcer; Stomach Neoplasms
PubMed: 9713949
DOI: No ID Found -
Computational Intelligence and... 2022The incidence rate of peptic ulcer is increasing gradually. Medical images can meet the needs of patients as an auxiliary diagnosis and treatment method for peptic...
The incidence rate of peptic ulcer is increasing gradually. Medical images can meet the needs of patients as an auxiliary diagnosis and treatment method for peptic ulcer. However, in the long-term treatment, the actual effect is average, and the diagnosis effect of gastrointestinal diseases will gradually deteriorate. In this paper, we use an image enhancement algorithm to study the mechanism of peptic ulcer from the perspective of a medical image. In this paper, 56 images of children with peptic ulcer were selected, and the gastroscopy based on the image enhancement algorithm provided technical support for the rapid diagnosis of patients with peptic ulcer. Experimental results show that the clinical features of peptic ulcer have different characteristics according to the age difference of patients, which can play a positive role in promoting the treatment of patients of different ages.
Topics: Algorithms; Child; Gastroscopy; Humans; Image Enhancement; Peptic Ulcer
PubMed: 35814556
DOI: 10.1155/2022/3716829 -
Annals of Agricultural and... 2000The paper presents the results of observations concerning the effect of cigarette smoking on the prevalence of peptic ulcer among 6,512 rural inhabitants aged 20-64,...
The paper presents the results of observations concerning the effect of cigarette smoking on the prevalence of peptic ulcer among 6,512 rural inhabitants aged 20-64, selected by two-stage sampling. Of these, 2,506 (38.6%) were regular smokers. In order to determine precisely the negative effect of smoking on the human body the nicotinic index was used (N.I.), calculated by multiplying the number of cigarettes smoked daily by the period of smoking (years). The three-stage scale of the nicotinic index was applied: I degrees - N.I. < 100, II degrees - N.I. = 100-300, III degrees - N.I. > 300. The mean value of the nicotinic index calculated for the total number of smokers in the study was 290.3. A statistically significant higher N.I. was observed in patients with peptic ulcer - 432.5, compared to patients with other diseases - 337.2, and healthy individuals - 203.3. Among patients with peptic ulcer the highest percentage of people with N.I. > 300 was noted (59.0%), compared to patients with other diseases (42.9%) and those who were healthy (22. 6%). The differences observed between patients with peptic ulcer and those of the remaining groups were highly statistically significant (p<0.001). The percentage of people with the lowest value of the nicotinic index (N.I.<100) in individual groups was: in patients with peptic ulcer - 13.5% (the lowest), among patients with other diseases - 25.0%, in the group of healthy individuals - 38.5% (the highest). An increase was noted in the incidence of peptic ulcer with the value of the nicotinic index. Peptic ulcer occurred in 3.8% of patients with N.I. < 100, in 6.4% of those with N.I. = 100-300, and in 13.2% of patients with N.I. > 300. An increase in the percentage of patients with the nicotinic index was observed irrespective of the site of ulcer. It became most evident among patients who underwent surgical treatment due to peptic ulcer, where the highest value of the nicotinic index (N.I. > 300) was noted in 79.5%, in patients with gastric and duodenal ulcer - 66.7% and those with gastric ulcer - 59.6%. A positive correlation was observed between peptic ulcer incidence rates, complications of the disease and the value of the nicotinic index. The relationship between state of health and the value of the nicotinic index was confirmed. The results of the study showed that the nicotinic index was useful for determining the negative effect of cigarette smoking on the human body.
Topics: Adult; Female; Humans; Incidence; Male; Middle Aged; Peptic Ulcer; Poland; Rural Population; Smoking
PubMed: 11153041
DOI: No ID Found