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Nutrients Nov 2022Variation in vitamin B levels has been associated with a range of diseases across the life-course, the causal nature of which remains elusive. We aimed to interrogate...
Variation in vitamin B levels has been associated with a range of diseases across the life-course, the causal nature of which remains elusive. We aimed to interrogate genetically predicted vitamin B status in relation to a plethora of clinical outcomes available in the UK Biobank. Genome-wide association study (GWAS) summary data obtained from a Danish and Icelandic cohort of 45,576 individuals were used to identify 8 genetic variants associated with vitamin B levels, serving as genetic instruments for vitamin B status in subsequent analyses. We conducted a Mendelian randomisation (MR)-phenome-wide association study (PheWAS) of vitamin B status with 945 distinct phenotypes in 439,738 individuals from the UK Biobank using these 8 genetic instruments to proxy alterations in vitamin B status. We used external GWAS summary statistics for replication of significant findings. Correction for multiple testing was taken into consideration using a 5% false discovery rate (FDR) threshold. MR analysis identified an association between higher genetically predicted vitamin B status and lower risk of vitamin B deficiency (including all B vitamin deficiencies), serving as a positive control outcome. We further identified associations between higher genetically predicted vitamin B status and a reduced risk of megaloblastic anaemia (OR = 0.35, 95% CI: 0.20-0.50) and pernicious anaemia (0.29, 0.19-0.45), which was supported in replication analyses. Our study highlights that higher genetically predicted vitamin B status is potentially protective of risk of vitamin B deficiency associated with pernicious anaemia diagnosis, and reduces risk of megaloblastic anaemia. The potential use of genetically predicted vitamin B status in disease diagnosis, progression and management remains to be investigated.
Topics: Humans; Anemia, Megaloblastic; Anemia, Pernicious; Genome-Wide Association Study; Vitamin B 12; Vitamin B 12 Deficiency; Vitamins; Mendelian Randomization Analysis
PubMed: 36501061
DOI: 10.3390/nu14235031 -
British Medical Journal Feb 1963
Topics: Anemia; Anemia, Pernicious; Diabetes Mellitus; Humans; Tracheophyta
PubMed: 13970159
DOI: 10.1136/bmj.1.5329.534 -
The Pan African Medical Journal 2023pernicious anemia is an autoimmune disease characterized by atrophic gastritis due to malabsorption of vitamin B12. Certain oral manifestations, such as Hunter´s...
INTRODUCTION
pernicious anemia is an autoimmune disease characterized by atrophic gastritis due to malabsorption of vitamin B12. Certain oral manifestations, such as Hunter´s glossitis and burning mouth syndrome, may precede the onset of this anemia. The aim of this study is to describe the clinical presentation, para-clinical aspects, the treatment, and the evolution of the pernicious anemia (PA) after treatment.
METHODS
retrospective study conducted at the Department of Haematology and Internal Medicine B of the Mohammed V Military Training Hospital in Rabat between January 2009 and December 2018. Thirty-four patients were enrolled with vitamin B12 deficiency, non-regenerative macrocytic anemia, a positive anti-intrinsic factor antibody and anti-parietal cell antibody and a histological diagnosis of atrophic gastritis in the presence or not of Helicobacter pylori. The qualitative variables were expressed in numbers and percentages, and the quantitative variables in mean and standard deviation. Multivariate analysis used the Fischer test; it was considered significant for a p < 0.05 value.
RESULTS
thirty-four cases were studied; the population study consists of 56% (n=19) of men and 44% (n=15) of women. The average age was 54.88± 9.14. The clinical manifestations of pernicious anemia are dominated by megaloblastic anemia 85.3% (n=29), followed by digestive 58.8%(n=20) and oral 55.9% (n=19) signs. Neurological manifestations were rarely found in 41% (n=14). Hunter´s glossitis 37% (n=7), stomatodynia 11% (n=2) were the most common oral manifestations accompanying pernicious anemia. The evolution was favorable in 79.4% (n=27) patients under substitution therapy with vitamin B12.
CONCLUSION
dentists´ involvement in the diagnosis of pernicious anemia is based on changes in oral mucous membranes, which have been reported in 55.9% of all patients. These oral changes may occur in the absence of symptomatic anemia.
Topics: Male; Humans; Female; Middle Aged; Anemia, Pernicious; Retrospective Studies; Cross-Sectional Studies; Morocco; Gastritis, Atrophic; Military Personnel; Vitamin B 12; Autoantibodies; Glossitis; Hospitals
PubMed: 37663641
DOI: 10.11604/pamj.2023.45.79.34204 -
Blood Jul 1949
Topics: Anemia; Anemia, Pernicious; Hematinics; Vitamin B 12; Vitamin B Complex
PubMed: 18150160
DOI: No ID Found -
Biermer anemia: Hematologic characteristics of 66 patients in a Clinical Hematology Unit at Senegal.Medecine Et Sante Tropicales Nov 2016Hematological manifestations can lead to diagnosis of pernicious anemia, also known as Biermer disease and Biermer anemia. This disease has been little studied among...
Hematological manifestations can lead to diagnosis of pernicious anemia, also known as Biermer disease and Biermer anemia. This disease has been little studied among black Africans. Our aim is to describe its diagnostic and therapeutic aspects and outcome in our practice. This descriptive study retrospectively examined the records of 66 patients with pernicious anemia seen at the Clinical Hematology Unit of Le Dantec Hospital in Senegal from January 1, 2000, to June 30, 2014. Symptoms were anemic syndrome (40 cases), hemolytic anemia (13), anemic heart failure (7), isolated pallor of the mucous membranes (5), and venous thrombosis (2). Their mean hemoglobin on diagnosis was 6.52 g/dL [1.3-15.2 g/dL], macrocytosis (52), normocytosis (14), hypochromia (4), thrombocytopenia (39), and leukopenia (28 cases). Cytopenia was associated with pancytopenia (25) and bicytopenia (18). Cytologic abnormalities were documented in 42 cases: megaloblastic erythrosis (37 cases) and hypersegmented neutrophils (24 cases). After vitamin B12 therapy - intramuscular (52) or oral (14) -, a reticulocyte crisis was noted on the 8th day and followed by correction of the blood count. Macrocytic anemia, frequently associated with thrombocytopenia and/or leukopenia, is the main hematologic sign evoking pernicious anemia. Venous thrombosis is a rare circumstance of diagnosis that must not be ignored. Intramuscular or oral vitamin B12 is recognized to be effective in these cases and reverses hematological manifestations.
Topics: Anemia, Pernicious; Female; Hematology; Hospital Units; Humans; Male; Middle Aged; Retrospective Studies; Senegal
PubMed: 28073728
DOI: 10.1684/mst.2016.0625 -
British Medical Journal Mar 1947
Topics: Anemia; Anemia, Pernicious; Tracheophyta
PubMed: 20343198
DOI: 10.1136/bmj.1.4496.307-i -
Blood Sep 1956
Topics: Anemia; Anemia, Pernicious
PubMed: 13355891
DOI: No ID Found -
Clinical Medicine (London, England) Feb 2018We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The...
We present the case of a 67-year-old man who suffered an acute anaphylactic reaction during red cell transfusion due to the presence of anti-IgA antibodies. The incidence and clinical relevance of anti-IgA antibodies in IgA deficiency is reviewed, and the wider investigation and management of acute transfusion reactions is also discussed. This case highlights the need to consider the potential risks of blood component transfusion against the purported benefit.
Topics: Aged; Anemia, Pernicious; Antibodies, Anti-Idiotypic; Erythrocyte Transfusion; Humans; IgA Deficiency; Immunoglobulin A; Male; Transfusion Reaction; Treatment Outcome; Vitamin B 12; Vitamin B Complex
PubMed: 29436447
DOI: 10.7861/clinmedicine.18-1-95 -
Pediatric Endocrinology, Diabetes, and... 2015
Review
Topics: Anemia, Pernicious; Autoimmune Diseases; Diabetes Mellitus, Type 1; Gastritis; Humans
PubMed: 27776198
DOI: 10.18544/PEDM-21.04.0040 -
The Primary Care Companion For CNS... Mar 2021
Topics: Anemia, Pernicious; Humans; Nitrous Oxide; Polyneuropathies; Vitamin B 12; Vitamins
PubMed: 34000117
DOI: 10.4088/PCC.20l02751