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Blood Jun 1948
Topics: Anemia, Pernicious; Folic Acid
PubMed: 18860343
DOI: No ID Found -
Journal of Clinical Pathology Nov 1971
Topics: Aged; Anemia, Pernicious; Arthritis, Rheumatoid; Female; Humans; Latex Fixation Tests; Male; Middle Aged; Rheumatoid Factor
PubMed: 5130544
DOI: 10.1136/jcp.24.8.764-c -
British Medical Journal Oct 1968The case histories are given of two patients, aged 38 and 35 years, who conceived while suffering from Addisonian pernicious anaemia. The relationship of these findings...
The case histories are given of two patients, aged 38 and 35 years, who conceived while suffering from Addisonian pernicious anaemia. The relationship of these findings to the routine use of folic acid during pregnancy is discussed.
Topics: Adult; Age Factors; Anemia, Pernicious; Female; Fertility; Folic Acid; Humans; Intrinsic Factor; Pregnancy; Pregnancy Complications, Hematologic; Vitamin B 12 Deficiency
PubMed: 5681053
DOI: 10.1136/bmj.4.5624.158 -
Polish Archives of Internal Medicine Sep 2020
Topics: Anemia, Pernicious; Autoantibodies; Dietary Supplements; Humans; Plasma; Vitamin B 12
PubMed: 32621669
DOI: 10.20452/pamw.15478 -
Journal of the Formosan Medical... Nov 2006About 5-10% of patients with myasthenia gravis concomitantly have other autoimmune diseases. However, the coexistence of myasthenia gravis and pernicious anemia is rare....
About 5-10% of patients with myasthenia gravis concomitantly have other autoimmune diseases. However, the coexistence of myasthenia gravis and pernicious anemia is rare. Here, we report a 73-year-old Taiwanese woman who developed myasthenia gravis 5 months after the onset of pernicious anemia. Her myasthenic and pernicious anemia symptoms markedly improved after pyridostigmine, prednisolone and hydroxocobalamine treatment. It is important to recognize concurrence of myasthenia gravis and pernicious anemia in the same patient because the therapeutic results for both diseases are rewarding.
Topics: Aged; Anemia, Pernicious; Female; Humans; Myasthenia Gravis; Taiwan
PubMed: 17098697
DOI: 10.1016/S0929-6646(09)60181-9 -
The American Journal of Gastroenterology Mar 2022Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute.
INTRODUCTION
Pernicious anemia (PA) is a risk factor for gastric cancer. Other autoimmune conditions may also contribute.
METHODS
In a case-control study, we evaluated 47 autoimmune conditions among 39,125 gastric cancers and 200,000 cancer-free controls.
RESULTS
Six conditions were associated with increased gastric cancer risk (range of adjusted odds ratios: 1.28-1.93, P < 0.05): PA, membranous nephropathy, primary biliary cirrhosis, pure red cell aplasia, primary sclerosing cholangitis, and Graves disease. PA was associated with 8 other autoimmune conditions (adjusted odds ratios: 1.57-4.54, P < 0.05).
DISCUSSION
Autoimmune conditions associated with gastric cancer or PA may reflect effects of autoimmune gastritis or other carcinogenic pathways.
Topics: Adult; Aged; Anemia, Pernicious; Autoimmune Diseases; Case-Control Studies; Humans; Stomach Neoplasms; United States
PubMed: 35029169
DOI: 10.14309/ajg.0000000000001622 -
Blood Sep 1952
Topics: Anemia; Anemia, Pernicious; Erythrocyte Indices; Erythrocytes; Humans
PubMed: 14953944
DOI: No ID Found -
British Medical Journal Dec 1949
Topics: Anemia; Anemia, Pernicious; Humans
PubMed: 15397500
DOI: 10.1136/bmj.2.4641.1367 -
Medical Principles and Practice :... 2008The aim of the study was to evaluate the role of vitamin B(12) in patients with pernicious anemia. (Clinical Trial)
Clinical Trial
OBJECTIVE
The aim of the study was to evaluate the role of vitamin B(12) in patients with pernicious anemia.
MATERIALS AND METHODS
This study was conducted prospectively at the Turgut Ozal Medical Center, Department of Hematology, between April and November 2002. Absolute numbers and ratio of the surface antigens of T and B lymphocyte subgroups, CD4/CD8 ratio were calculated in order to evaluate changes in leukocyte and lymphocyte numbers; natural killer (NK) cell count, serum C3, C4, and levels of immunoglobulins G, A, and M were also measured to evaluate vitamin B(12) effect on immunity. Values obtained before treatment with cyanocobalamin were compared with those found during peak reticulocyte count.
RESULTS
In vitamin B(12)-deficient patients, absolute numbers of CD4+ and especially CD8+ lymphocytes were found to be decreased; CD4/CD8 ratio increased, and NK cell activity was depressed. After cyanocobalamin treatment, absolute numbers and percentage of lymphocyte subgroups were elevated. Increased CD4/CD8 ratio and depressed NK cell activity were restored and levels of C3, C4, and immunoglobulins were elevated.
CONCLUSION
These findings suggest that vitamin B(12) has important immunomodulatory effects on cellular immunity, and abnormalities in the immune system in pernicious anemia are restored by vitamin B(12) replacement therapy.
Topics: Adolescent; Adult; Aged; Anemia, Pernicious; CD4-CD8 Ratio; Complement System Proteins; Female; Humans; Immunity; Immunoglobulins; Lymphocyte Subsets; Male; Middle Aged; Prospective Studies; Vitamin B 12
PubMed: 18287797
DOI: 10.1159/000112967 -
California Medicine Dec 1952The newer hematinics are merely refinements of preexisting forms of treatment, but they have aided particularly in a better understanding of the deficiency states. The...
The newer hematinics are merely refinements of preexisting forms of treatment, but they have aided particularly in a better understanding of the deficiency states. The intrinsic factor of Castle has not been isolated from the gastric juice, and the interrelationships of this substance with the extrinsic factor (vitamin B(12)) and folic acid have not been defined at this time. Vitamin B(12) appears to be the active principle of refined liver extract and alone is probably adequate treatment for pernicious anemia. The other varieties of megaloblastic anemia may result from deficiency of vitamin B(12) or folic acid, although generally treatment with the latter brings about complete and lasting remission. The use of multihematinics and multivitamin preparations containing folic acid is to be condemned, particularly because of the possibility of their obscuring anemia and thwarting diagnosis of pernicious anemia until neurologic complications have taken place. Saccharated oxide of iron is a relatively safe preparation for intravenous administration, but the indications for its use are few. Because the body has no mechanism for iron excretion, only the amount of iron necessary to make up a deficiency should be given, although there is no definite evidence that hemochromatosis results from overdosage.
Topics: Anemia; Anemia, Iron-Deficiency; Anemia, Megaloblastic; Anemia, Pernicious; Folic Acid; Hematinics; Humans; Intrinsic Factor; Iron; Iron Compounds; Iron Metabolism Disorders; Liver Extracts; Substance-Related Disorders; Vitamin B 12; Vitamins
PubMed: 13009494
DOI: No ID Found