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Clinical & Experimental Optometry Mar 2011
Topics: Child; Deafness; Humans; Hypopigmentation; Iris Diseases; Male; Pigmentation Disorders; Waardenburg Syndrome
PubMed: 21352370
DOI: 10.1111/j.1444-0938.2010.00533.x -
Sultan Qaboos University Medical Journal Nov 2022
Topics: Humans; Purpura; Pigmentation Disorders; Exanthema; Eczema
PubMed: 36407701
DOI: 10.18295/squmj.1.2022.004 -
The Journal of Investigative Dermatology Jul 2007There is a continual need for compounds that effectively modulate melanin synthesis. To identify novel pigmentation modulators and their cellular targets, chemical... (Review)
Review
There is a continual need for compounds that effectively modulate melanin synthesis. To identify novel pigmentation modulators and their cellular targets, chemical genetic screenings were performed with triazine-based combinatorial libraries that include various linkers as intrinsic components of the small molecules in the library. The linker provides a ready means of attachment to beads, eliminating several common time-consuming downstream steps in the isolation of cellular targets for the small molecules of interest. Twelve compounds were identified as novel pigmentation modulators from various screenings performed in normal and albino murine melanocytes and zebrafish. Target identification by affinity chromatography revealed unexpected roles for prohibitin and mitochondrial F1F0-adenotriphosphatase in the regulation of mammalian pigmentation. The identification of prohibitin, a "scaffold protein", as a propigmentation effector represents a novel mechanism by which propigmentary signals are transduced. Results from our screenings provide potential active agents and targets for the medical and aesthetic treatment of disorders of pigmentation.
Topics: Animals; Genetic Testing; Humans; Melanins; Melanocytes; Mice; Mitochondrial Proton-Translocating ATPases; Molecular Biology; Pigmentation Disorders; Prohibitins; Repressor Proteins; Skin Pigmentation; Triazines; Zebrafish
PubMed: 17568802
DOI: 10.1038/sj.jid.5700852 -
CMAJ : Canadian Medical Association... Aug 2017
Topics: Biopsy; Child; Diagnosis, Differential; Humans; Male; Melanocytes; Nail Diseases; Nails; Pigmentation Disorders
PubMed: 28847781
DOI: 10.1503/cmaj.170256 -
Dermatologie (Heidelberg, Germany) Apr 2023Dermoscopy is an important tool in general dermatology. (Review)
Review
BACKGROUND
Dermoscopy is an important tool in general dermatology.
OBJECTIVES
To show differences of light and dark skin in nonneoplastic diseases with focus on dermoscopy.
MATERIALS AND METHODS
Using previously published studies, dermoscopic differences of various skin types as well as features of inflammatory diseases and pigmentary changes are illustrated.
RESULTS
Certain structures are more difficult to assess in dermoscopy of dark skin (e.g., vessels), while other structures (e.g., follicular openings) are more prominent.
CONCLUSIONS
The majority of studies on dermoscopy are from studies that predominantly included individuals with fair skin types. Further studies of individuals with skin type IV or higher are needed to improve diagnosis in these patients.
Topics: Humans; Dermoscopy; Skin; Skin Neoplasms; Pigmentation Disorders; Hypopigmentation
PubMed: 36859732
DOI: 10.1007/s00105-023-05121-w -
Journal of Medical Genetics Dec 1988
Topics: Humans; Leukoplakia; Nail Diseases; Pigmentation Disorders; Skin Neoplasms; Syndrome
PubMed: 3236366
DOI: 10.1136/jmg.25.12.843 -
Journal of Cutaneous Pathology Feb 2023Sarcoidosis is a systemic inflammatory disorder characterized by the formation of non-caseating granulomas. Cutaneous involvement of sarcoidosis is common and has a wide... (Review)
Review
Sarcoidosis is a systemic inflammatory disorder characterized by the formation of non-caseating granulomas. Cutaneous involvement of sarcoidosis is common and has a wide variety of clinical presentations. Herein, we present a case of cutaneous sarcoidosis mimicking pigmented purpuric dermatosis (PPD) in a 26-year-old female treated with topical tofacitinib cream and a literature review of all other reported cases of cutaneous sarcoidosis with PPD-like features.
Topics: Female; Humans; Adult; Pigmentation Disorders; Purpura; Sarcoidosis; Granuloma
PubMed: 36070081
DOI: 10.1111/cup.14326 -
International Journal of Molecular... Jun 2021Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for... (Review)
Review
Hyper-activated melanocytes are the major cause of skin hyper-pigmentary disorders, such as freckles and melasma. Increasing efforts have been made to search for materials with depigmenting activity to develop functional cosmetics. As a result, numerous materials have been reported to have depigmenting activity but some of them are known to cause unwanted side effects. Consequently, anti-pigmentary natural compounds without concern of toxicity are in great demand. Virtually all sorts of natural sources have been investigated to find anti-pigmentary natural compounds. This review summarizes recently reported anti-pigmentary natural compounds and their mode of action from the ocean, plants, and bacteria.
Topics: Biological Products; Humans; Phytotherapy; Pigmentation Disorders; Plant Extracts; Skin Pigmentation
PubMed: 34201391
DOI: 10.3390/ijms22126206 -
Photobiomodulation, Photomedicine, and... May 2023
Topics: Humans; Pigmentation Disorders; Low-Level Light Therapy
PubMed: 37159405
DOI: 10.1089/photob.2023.0040 -
Romanian Journal of Morphology and... 2010Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent...
Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent comedone-like lesions and pitted scars. The diagnosis includes acanthosis nigricans as well as other reticulate pigmentary disorders classified into: dyschromatrosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH) and reticulate acropigmentation of Kitamura (RAPK). We present a 35-year-old woman, which presented with flexural hyperpigmentation considerate as acanthosis nigricans. At a close clinical and histopathological examination, we obtained sure data for Dowling-Degos disease, with a possible familial history of this disease in her son. We review the literature data concerning this disease.
Topics: Adult; Diagnosis, Differential; Female; Genetic Diseases, Inborn; Humans; Pigmentation Disorders
PubMed: 20191141
DOI: No ID Found